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2019

Origin and bioactivities of thiosulfinated FK228

Liu, X., Currens, G. C., Xue, L. & Cheng, Y., 1 Jan 2019, In : MedChemComm. 10, 4, p. 538-542 5 p.

Research output: Contribution to journalArticle

Bioactivity
Silica Gel
Burkholderia
Histone Deacetylases
romidepsin

Overexpression of somatostatin receptor type 2 in neuroendocrine tumors for improved Ga68-DOTATATE imaging and treatment

Guenter, R., Aweda, T., Carmona Matos, D. M., Jang, S., Whitt, J., Cheng, Y. Q., Liu, X. M., Chen, H., Lapi, S. E. & Jaskula-Sztul, R., 1 Jan 2019, (Accepted/In press) In : Surgery (United States).

Research output: Contribution to journalArticle

Neuroendocrine Tumors
Histone Deacetylase Inhibitors
Neuroendocrine Cells
Therapeutics
Tumor Cell Line

Pulmonary carcinoid surface receptor modulation using histone deacetylase inhibitors

Guenter, R. E., Aweda, T., Matos, D. M. C., Whitt, J., Chang, A. W., Cheng, E. Y., Liu, X. M., Chen, H., Lapi, S. E. & Jaskula-Sztul, R., Jun 2019, In : Cancers. 11, 6, 767.

Research output: Contribution to journalArticle

Open Access
Histone Deacetylase Inhibitors
Carcinoid Tumor
Lung
Somatostatin
Positron-Emission Tomography

The ADEP biosynthetic gene cluster in Streptomyces hawaiiensis NRRL 15010 reveals an accessory clpP gene as a novel antibiotic resistance factor

Thomy, D., Culp, E., Adamek, M., Cheng, E. Y., Ziemert, N., Wright, G. D., Sass, P. & Brötz-Oesterhelt, H., 1 Jan 2019, In : Applied and Environmental Microbiology. 85, 20, e01292-19.

Research output: Contribution to journalArticle

antibiotic resistance
R Factors
Streptomyces
Multigene Family
Microbial Drug Resistance
2018
5 Citations (Scopus)

Chromobacterium spp. mediate their anti-Plasmodium activity through secretion of the histone deacetylase inhibitor romidepsin

Saraiva, R. G., Huitt-Roehl, C. R., Tripathi, A., Cheng, Y. Q., Bosch, J., Townsend, C. A. & Dimopoulos, G., 1 Dec 2018, In : Scientific Reports. 8, 1, 6176.

Research output: Contribution to journalArticle

Chromobacterium
histone deacetylase
Plasmodium
secretion
antimalarials
3 Citations (Scopus)

Genomics-guided discovery of a new and significantly better source of anticancer natural drug FK228

Liu, X., Xie, F., Doughty, L. B., Wang, Q., Zhang, L., Liu, X. & Cheng, Y., 1 Dec 2018, In : Synthetic and Systems Biotechnology. 3, 4, p. 268-274 7 p.

Research output: Contribution to journalArticle

Genomics
Fermentation
Genes
Pharmaceutical Preparations
Bioreactors
2 Citations (Scopus)

Mechanistic studies of DepR in regulating FK228 biosynthesis in Chromobacterium violaceum no. 968

Qiao, Y., Tong, T., Xue, J., Lin, W., Deng, Z., Cheng, Y. Q. & Zhu, D., Apr 2018, In : PLoS ONE. 13, 4, e0196173.

Research output: Contribution to journalArticle

Chromobacterium
Chromobacterium violaceum
Biosynthesis
biosynthesis
Assays
2017
4 Citations (Scopus)

Developing new targeting strategy for androgen receptor variants in castration resistant prostate cancer

Wang, B., Lo, U. G., Wu, K., Kapur, P., Liu, X., Huang, J., Chen, W., Hernandez, E., Santoyo, J., Ma, S. H., Pong, R. C., He, D., Cheng, Y. & Hsieh, J. T., 15 Nov 2017, In : International Journal of Cancer. 141, 10, p. 2121-2130 10 p.

Research output: Contribution to journalArticle

Castration
Androgen Receptors
Prostatic Neoplasms
RNA Splice Sites
Survival
6 Citations (Scopus)

Histone deacetylase inhibitor thailandepsin-A activates Notch signaling and suppresses neuroendocrine cancer cell growth in vivo

Jang, S., Janssen, A., Aburjania, Z., Robers, M. B., Harrison, A., Dammalapati, A., Cheng, Y. Q., Chen, H. & Jaskula-Sztul, R., 1 Jan 2017, In : Oncotarget. 8, 41, p. 70828-70840 13 p.

Research output: Contribution to journalArticle

Neuroendocrine Cells
Histone Deacetylase Inhibitors
Growth
Neoplasms
Protein Isoforms
2016
3 Citations (Scopus)

HDAC inhibitor-mediated epigenetic regulation of glaucoma-associated TGFβ2 in the trabecular meshwork

Bermudez, J. Y., Webber, H. C., Patel, G. C., Liu, X., Cheng, Y. Q., Clark, A. F. & Mao, W., Jul 2016, In : Investigative Ophthalmology and Visual Science. 57, 8, p. 3698-3707 10 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Histone Deacetylase Inhibitors
Epigenomics
Glaucoma
Acetylation
4 Citations (Scopus)
Burkholderia
Metabolic engineering
Metabolic Engineering
Fermentation
Purification
29 Citations (Scopus)

KE108-conjugated unimolecular micelles loaded with a novel HDAC inhibitor thailandepsin-A for targeted neuroendocrine cancer therapy

Chen, G., Jaskula-Sztul, R., Harrison, A., Dammalapati, A., Xu, W., Cheng, Y., Chen, H. & Gong, S., 1 Aug 2016, In : Biomaterials. 97, p. 22-33 12 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Micelles
Neoplasms
Neuroendocrine Cells
Therapeutics
29 Citations (Scopus)

Thailandepsin A-loaded and octreotide-functionalized unimolecular micelles for targeted neuroendocrine cancer therapy

Jaskula-Sztul, R., Xu, W., Chen, G., Harrison, A., Dammalapati, A., Nair, R., Cheng, Y., Gong, S. & Chen, H., 1 Jun 2016, In : Biomaterials. 91, p. 1-10 10 p.

Research output: Contribution to journalArticle

Octreotide
Micelles
Neoplasms
Glycols
Bearings (structural)
2015
4 Citations (Scopus)

Determination of thailandepsin B in rat plasma with a LC-MS/MS method

Cheng, Z., Ding, L., Zhang, Y., Chen, G., Chen, C., Cheng, Y. Q. & Jiang, H., 1 Jan 2015, In : Bioanalysis. 7, 1, p. 39-52 14 p.

Research output: Contribution to journalArticle

formic acid
Dichlorvos
Histone Deacetylase Inhibitors
Pharmacokinetics
Hydrochloric Acid
15 Citations (Scopus)

Disulfide cross-linked micelles of novel HDAC inhibitor thailandepsin A for the treatment of breast cancer

Xiao, K., Li, Y. P., Wang, C., Ahmad, S., Vu, M., Kuma, K., Cheng, Y. Q. & Lam, K. S., 1 Oct 2015, In : Biomaterials. 67, p. 183-193 11 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Micelles
Disulfides
Breast Neoplasms
Cells
259 Citations (Scopus)

Minimum Information about a Biosynthetic Gene cluster

Medema, M. H., Kottmann, R., Yilmaz, P., Cummings, M., Biggins, J. B., Blin, K., De Bruijn, I., Chooi, Y. H., Claesen, J., Coates, R. C., Cruz-Morales, P., Duddela, S., Düsterhus, S., Edwards, D. J., Fewer, D. P., Garg, N., Geiger, C., Gomez-Escribano, J. P., Greule, A., Hadjithomas, M. & 134 others, Haines, A. S., Helfrich, E. J. N., Hillwig, M. L., Ishida, K., Jones, A. C., Jones, C. S., Jungmann, K., Kegler, C., Kim, H. U., Kötter, P., Krug, D., Masschelein, J., Melnik, A. V., Mantovani, S. M., Monroe, E. A., Moore, M., Moss, N., Nützmann, H. W., Pan, G., Pati, A., Petras, D., Reen, F. J., Rosconi, F., Rui, Z., Tian, Z., Tobias, N. J., Tsunematsu, Y., Wiemann, P., Wyckoff, E., Yan, X., Yim, G., Yu, F., Xie, Y., Aigle, B., Apel, A. K., Balibar, C. J., Balskus, E. P., Barona-Gómez, F., Bechthold, A., Bode, H. B., Borriss, R., Brady, S. F., Brakhage, A. A., Caffrey, P., Cheng, Y. Q., Clardy, J., Cox, R. J., De Mot, R., Donadio, S., Donia, M. S., Van Der Donk, W. A., Dorrestein, P. C., Doyle, S., Driessen, A. J. M., Ehling-Schulz, M., Entian, K. D., Fischbach, M. A., Gerwick, L., Gerwick, W. H., Gross, H., Gust, B., Hertweck, C., Höfte, M., Jensen, S. E., Ju, J., Katz, L., Kaysser, L., Klassen, J. L., Keller, N. P., Kormanec, J., Kuipers, O. P., Kuzuyama, T., Kyrpides, N. C., Kwon, H. J., Lautru, S., Lavigne, R., Lee, C. Y., Linquan, B., Liu, X., Liu, W., Luzhetskyy, A., Mahmud, T., Mast, Y., Méndez, C., Metsä-Ketelä, M., Micklefield, J., Mitchell, D. A., Moore, B. S., Moreira, L. M., Müller, R., Neilan, B. A., Nett, M., Nielsen, J., O'Gara, F., Oikawa, H., Osbourn, A., Osburne, M. S., Ostash, B., Payne, S. M., Pernodet, J. L., Petricek, M., Piel, J., Ploux, O., Raaijmakers, J. M., Salas, J. A., Schmitt, E. K., Scott, B., Seipke, R. F., Shen, B., Sherman, D. H., Sivonen, K., Smanski, M. J., Sosio, M., Stegmann, E., Süssmuth, R. D., Tahlan, K., Thomas, C. M., Tang, Y., Truman, A. W., Viaud, M., Walton, J. D., Walsh, C. T., Weber, T., Van Wezel, G. P., Wilkinson, B., Willey, J. M., Wohlleben, W., Wright, G. D., Ziemert, N., Zhang, C., Zotchev, S. B., Breitling, R., Takano, E. & Glöckner, F. O., 18 Aug 2015, In : Nature Chemical Biology. 11, 9, p. 625-631 7 p.

Research output: Contribution to journalReview article

Multigene Family
Information Storage and Retrieval
Fungi
Bacteria

Production of Thailandepsin a from burkholderia thailandensis E264/pBMTL3-tdpR fermentation

Hui, J. Y., Wang, W., Cheng, Y. & Zhang, X. H., 1 Jun 2015, In : Gao Xiao Hua Xue Gong Cheng Xue Bao/Journal of Chemical Engineering of Chinese Universities. 29, 3, p. 593-599 7 p.

Research output: Contribution to journalArticle

Fermentation
Genes
Transcription
Glucose
Resins
82 Citations (Scopus)

Target engagement and drug residence time can be observed in living cells with BRET

Robers, M. B., Dart, M. L., Woodroofe, C. C., Zimprich, C. A., Kirkland, T. A., Machleidt, T., Kupcho, K. R., Levin, S., Hartnett, J. R., Zimmerman, K., Niles, A. L., Ohana, R. F., Daniels, D. L., Slater, M., Wood, M. G., Cong, M., Cheng, Y. Q. & Wood, K. V., 3 Dec 2015, In : Nature Communications. 6, 10091.

Research output: Contribution to journalArticle

Bioluminescence
bioluminescence
Energy Transfer
Energy transfer
drugs
2014
30 Citations (Scopus)

Genome-guided discovery of diverse natural products from Burkholderia sp.

Liu, X. & Cheng, Y. Q., 1 Feb 2014, In : Journal of Industrial Microbiology and Biotechnology. 41, 2, p. 275-284 10 p.

Research output: Contribution to journalReview article

Burkholderia
Biological Products
Genes
Genome
Multigene Family
4 Citations (Scopus)
Multigene Family
Genes
Pseudomonas
Chromobacterium
Histone Deacetylases
19 Citations (Scopus)

The novel histone deacetylase inhibitor thailandepsin A inhibits anaplastic thyroid cancer growth

Weinlander, E., Somnay, Y., Harrison, A. D., Wang, C., Cheng, Y., Jaskula-Sztul, R., Yu, X. M. & Chen, H., 1 Jan 2014, In : Journal of Surgical Research. 190, 1, p. 191-197 7 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Apoptosis
Growth
Cell Cycle Proteins
Flow Cytometry
7 Citations (Scopus)

The structural basis of an NADP+-independent dithiol oxidase in FK228 biosynthesis

Li, J., Wang, C., Zhang, Z. M., Cheng, Y. Q. & Zhou, J., 20 Feb 2014, In : Scientific Reports. 4, 4145.

Research output: Contribution to journalArticle

Thioredoxin-Disulfide Reductase
NADP
Oxidoreductases
Biological Products
Disulfides
2013
26 Citations (Scopus)

Activation of ClpP protease by ADEP antibiotics: Insights from hydrogen exchange mass spectrometry

Sowole, M. A., Alexopoulos, J. A., Cheng, Y., Ortega, J. & Konermann, L., 15 Nov 2013, In : Journal of Molecular Biology. 425, 22, p. 4508-4519 12 p.

Research output: Contribution to journalArticle

Hydrogen
Mass Spectrometry
Peptide Hydrolases
Anti-Bacterial Agents
Ligands
10 Citations (Scopus)

Effects of thailanstatins on glucocorticoid response in trabecular meshwork and steroid-induced glaucoma

Jain, A., Liu, X., Wordinger, R. J., Yorio, T., Cheng, Y. Q. & Clark, A. F., 10 May 2013, In : Investigative Ophthalmology and Visual Science. 54, 5, p. 3137-3142 6 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Glaucoma
Glucocorticoids
Steroids
Intraocular Pressure
72 Citations (Scopus)

Genomics-guided discovery of thailanstatins A, B, and C as pre-mRNA splicing inhibitors and antiproliferative agents from Burkholderia thailandensis MSMB43

Liu, X., Biswas, S., Berg, M. G., Antapli, C. M., Xie, F., Wang, Q., Tang, M. C., Tang, G. L., Zhang, L., Dreyfuss, G. & Cheng, Y., 26 Apr 2013, In : Journal of Natural Products. 76, 4, p. 685-693 9 p.

Research output: Contribution to journalArticle

Spliceosomes
Burkholderia
RNA Precursors
Multigene Family
Genomics
21 Citations (Scopus)

Inactivation of cyclic di-GMP binding protein TDE0214 affects the motility, biofilm formation, and virulence of Treponema denticola

Bian, J., Liu, X., Cheng, Y. Q. & Li, C., 11 Sep 2013, In : Journal of Bacteriology. 195, 17, p. 3897-3905 9 p.

Research output: Contribution to journalArticle

Treponema denticola
Cyclic GMP
Biofilms
Virulence
Spirochaetales
14 Citations (Scopus)

Isolation and characterization of spliceostatin B, a new analogue of FR901464, from Pseudomonas sp. No. 2663

Liu, X., Biswas, S., Tang, G. L. & Cheng, Y. Q., 1 Sep 2013, In : Journal of Antibiotics. 66, 9, p. 555-558 4 p.

Research output: Contribution to journalArticle

Spiro Compounds
Spliceosomes
Pyrans
Molecular Models
Enzyme Inhibitors
13 Citations (Scopus)

Structural determinants stabilizing the axial channel of ClpP for substrate translocation

Alexopoulos, J., Ahsan, B., Homchaudhuri, L., Husain, N., Cheng, Y. & Ortega, J., 1 Oct 2013, In : Molecular Microbiology. 90, 1, p. 167-180 14 p.

Research output: Contribution to journalArticle

Peptide Hydrolases
Escherichia
Amino Acid Substitution
Bacillus subtilis
Gram-Negative Bacteria
2012
1 Citation (Scopus)

Cyclo(-l-prolyl-l-valinyl-) from Burkholderia thailandensis MSMB43

Liu, X. Y., Wang, C. & Cheng, Y. Q., 1 Nov 2012, In : Acta Crystallographica Section E: Structure Reports Online. 68, 11, p. o3182-o3183

Research output: Contribution to journalArticle

Molecules
molecules
Pyrazines
Atoms
Dipeptides
28 Citations (Scopus)

Discovery and activity profiling of thailandepsins A through F, potent histone deacetylase inhibitors, from Burkholderia thailandensis E264

Wang, C., Flemming, C. J. & Cheng, Y. Q., Aug 2012, In : MedChemComm. 3, 8, p. 976-981 6 p.

Research output: Contribution to journalArticle

Depsipeptides
Burkholderia
Histone Deacetylase Inhibitors
Enzyme Assays
Assays
8 Citations (Scopus)
Burkholderia
Fermentation
Adsorbents
Resins
Histone Deacetylases
5 Citations (Scopus)

FK228 from Burkholderia thailandensis MSMB43

Liu, X. Y., Wang, C. & Cheng, Y., 1 Sep 2012, In : Acta Crystallographica Section E: Structure Reports Online. 68, 9

Research output: Contribution to journalArticle

Hydrogen bonds
hydrogen bonds
configurations
Molecular structure
acetates
12 Citations (Scopus)

Revised genome sequence of Burkholderia thailandensis MSMB43 with improved annotation

Zhuo, Y., Liu, L., Wang, Q., Liu, X., Ren, B., Liu, M., Ni, P., Cheng, Y. Q. & Zhang, L., 1 Sep 2012, In : Journal of Bacteriology. 194, 17, p. 4749-4750 2 p.

Research output: Contribution to journalComment/debate

Burkholderia
Biological Products
Genome
Bacteria
22 Citations (Scopus)
Histone Deacetylase Inhibitors
Epigenomics
Ovarian Neoplasms
DNA Damage
Cell Survival
2011
43 Citations (Scopus)

Activators of Cylindrical Proteases as Antimicrobials: Identification and Development of Small Molecule Activators of ClpP Protease

Leung, E., Datti, A., Cossette, M., Goodreid, J., McCaw, S. E., Mah, M., Nakhamchik, A., Ogata, K., El Bakkouri, M., Cheng, Y. Q., Wodak, S. J., Eger, B. T., Pai, E. F., Liu, J., Gray-Owen, S., Batey, R. A. & Houry, W. A., 23 Sep 2011, In : Chemistry and Biology. 18, 9, p. 1167-1178 12 p.

Research output: Contribution to journalArticle

Peptide Hydrolases
Adenosine Triphosphate
Molecules
Serine Proteases
Proteins
46 Citations (Scopus)

Biosynthesis of himastatin: Assembly line and characterization of three cytochrome P450 enzymes involved in the post-tailoring oxidative steps

Ma, J., Wang, Z., Huang, H., Luo, M., Zuo, D., Wang, B., Sun, A., Cheng, Y. Q., Zhang, C. & Ju, J., 16 Aug 2011, In : Angewandte Chemie - International Edition. 50, 34, p. 7797-7802 6 p.

Research output: Contribution to journalArticle

Biosynthesis
Cytochrome P-450 Enzyme System
Genes
Cytochromes
Proteins
14 Citations (Scopus)

New insights into the genetic organization of the FK228 biosynthetic gene cluster in chromobacterium violaceum No. 968

Potharla, V. Y., Wesener, S. R. & Cheng, Y. Q., Feb 2011, In : Applied and Environmental Microbiology. 77, 4, p. 1508-1511 4 p.

Research output: Contribution to journalArticle

Chromobacterium
Chromobacterium violaceum
Multigene Family
multigene family
gene
25 Citations (Scopus)

Reconstitution of the FK228 biosynthetic pathway reveals cross talk between modular polyketide synthases and fatty acid synthase

Wesener, S. R., Potharla, V. Y. & Cheng, Y. Q., 1 Feb 2011, In : Applied and Environmental Microbiology. 77, 4, p. 1501-1507 7 p.

Research output: Contribution to journalArticle

Polyketide Synthases
polyketide synthases
Fatty Acid Synthases
fatty-acid synthase
Biosynthetic Pathways
5 Citations (Scopus)

Thailandepsin A

Wang, C. & Cheng, Y. Q., 1 Nov 2011, In : Acta Crystallographica Section E: Structure Reports Online. 67, 11, p. o2948-o2949

Research output: Contribution to journalArticle

Hydrogen bonds
Depsipeptides
hydrogen bonds
Stereochemistry
stereochemistry
78 Citations (Scopus)

Thailandepsins: Bacterial products with potent histone deacetylase inhibitory activities and broad-spectrum antiproliferative activities

Wang, C., Henkes, L. M., Doughty, L. B., He, M., Wang, D., Meyer-Almes, F. J. & Cheng, Y. Q., 28 Oct 2011, In : Journal of Natural Products. 74, 10, p. 2031-2038 8 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Genes
Histone Deacetylase Inhibitors
Multigene Family
Assays
2010
92 Citations (Scopus)

Acyldepsipeptide antibiotics induce the formation of a structured axial channel in ClpP: A model for the ClpX/ClpA-bound state of ClpP

Li, D. H. S., Chung, Y. S., Gloyd, M., Joseph, E., Ghirlando, R., Wright, G. D., Cheng, Y., Maurizi, M. R., Guarné, A. & Ortega, J., 24 Sep 2010, In : Chemistry and Biology. 17, 9, p. 959-969 11 p.

Research output: Contribution to journalArticle

Protein Unfolding
Adenosine Triphosphatases
Anti-Bacterial Agents
Holoenzymes
Escherichia coli
21 Citations (Scopus)

Yersinia ironomics: Comparison of iron transporters among Yersinia pestis biotypes and its nearest neighbor, Yersinia pseudotuberculosis

Forman, S., Paulley, J. T., Fetherston, J. D., Cheng, Y. & Perry, R. D., 1 Apr 2010, In : BioMetals. 23, 2, p. 275-294 20 p.

Research output: Contribution to journalArticle

Yersinia pseudotuberculosis
Yersinia pestis
Yersinia
biotypes
transporters