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2010
2 Citations (Scopus)

[Glu2]TRH dose-dependently attenuates TRH-evoked analeptic effect in mice

Nguyen, V., Zharikova, A. D., Prokai-Tatrai, K. & Prokai, L., 1 Apr 2010, In : Brain Research Bulletin. 82, 1-2, p. 83-86 4 p.

Research output: Contribution to journalArticle

Central Nervous System Stimulants
Central Nervous System
Thyrotropin-Releasing Hormone
Cholinergic Agents
Acetylcholine
29 Citations (Scopus)
Carbonylation
Electrospray ionization
Liquid chromatography
Spectrometry
Peptides
8 Citations (Scopus)

Simultaneous measurement of 17β-estradiol, 17α-estradiol and estrone by GC-isotope dilution MS-MS

Prokai-Tatrai, K., Bonds, D. & Prokai, L., 1 Feb 2010, In : Chromatographia. 71, 3-4, p. 311-315 5 p.

Research output: Contribution to journalArticle

Estrone
Isotopes
Dilution
Estradiol
Estrogens
2011
8 Citations (Scopus)

Prodrug design for brain delivery of small- and medium-sized neuropeptides

Prokai-Tatrai, K. & Prokai, L., 24 Oct 2011, Neuropeptides: Methods and Protocols. Merighi, A. (ed.). p. 313-336 24 p. (Methods in Molecular Biology; vol. 789).

Research output: Chapter in Book/Report/Conference proceedingChapter

Prodrugs
Neuropeptides
Brain
Blood-Brain Barrier
Peptides
27 Citations (Scopus)

Protein targets for carbonylation by 4-hydroxy-2-nonenal in rat liver mitochondria

Guo, J., Prokai-Tatrai, K., Nguyen, V., Rauniyar, N., Ughy, B. & Prokai, L., 19 Oct 2011, In : Journal of Proteomics. 74, 11, p. 2370-2379 10 p.

Research output: Contribution to journalArticle

Protein Carbonylation
Carbonylation
Mitochondria
Liver Mitochondrion
Liver
23 Citations (Scopus)
Liquid chromatography
Tandem Mass Spectrometry
Liquid Chromatography
Mass spectrometry
Peptides
2012
18 Citations (Scopus)
Flecainide
Metabolites
Chromatography
Isotopes
Dilution
9 Citations (Scopus)
Nitration
Methylation
Liquid chromatography
Liquid Chromatography
Isotopes
2013
34 Citations (Scopus)

17β-estradiol eye drops protect the retinal ganglion cell layer and preserve visual function in an in vivo model of glaucoma

Prokai-Tatrai, K., Xin, H., Nguyen, V., Szarka, S., Blazics, B., Prokai, L. & Koulen, P., 5 Aug 2013, In : Molecular Pharmaceutics. 10, 8, p. 3253-3261 9 p.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Ophthalmic Solutions
Intraocular Pressure
Glaucoma
Estradiol
3 Citations (Scopus)

Design and exploratory neuropharmacological evaluation of novel thyrotropin-releasing hormone analogs and their brain-targeting bioprecursor prodrugs

Prokai-Tatrai, K., Nguyen, V., Szarka, S., Konya, K. & Prokai, L., 22 May 2013, In : Pharmaceutics. 5, 2, p. 318-328 11 p.

Research output: Contribution to journalArticle

Thyrotropin-Releasing Hormone
Prodrugs
Brain
Central Nervous System Stimulants
Cholinergic Agents
7 Citations (Scopus)
Oxidative stress
Quantitative Structure-Activity Relationship
Phenols
antioxidants
Antioxidants
22 Citations (Scopus)
Estrone
Estradiol
Assays
Estrogens
High Pressure Liquid Chromatography
2014
13 Citations (Scopus)
Liquid chromatography
Liquid Chromatography
Isotopes
Design of experiments
Mass spectrometry
5 Citations (Scopus)

Selective chemoprecipitation to enrich nitropeptides from complex proteomes for mass-spectrometric analysis

Prokai, L., Guo, J. & Prokai-Tatrai, K., Apr 2014, In : Nature Protocols. 9, 4, p. 882-895 14 p.

Research output: Contribution to journalArticle

Proteome
Peptides
Nitration
Mass spectrometry
Esters
2015
19 Citations (Scopus)

The prodrug DHED selectively delivers 17β-estradiol to the brain for treating estrogen-responsive disorders

Prokai, L., Nguyen, V., Szarka, S., Garg, P., Sabnis, G., Bimonte-Nelson, H. A., McLaughlin, K. J., Talboom, J. S., Conrad, C. D., Shughrue, P. J., Gould, T. D., Brodie, A., Merchenthaler, I., Koulen, P. & Prokai-Tatrai, K., 22 Jul 2015, In : Science Translational Medicine. 7, 297, 297ra113.

Research output: Contribution to journalArticle

Prodrugs
Estradiol
Estrogens
Brain
Menopause
2016
7 Citations (Scopus)

A comparative evaluation of treatments with 17β-estradiol and its brain-selective prodrug in a double-transgenic mouse model of Alzheimer's disease

Tschiffely, A. E., Schuh, R. A., Prokai-Tatrai, K., Prokai, L. & Ottinger, M. A., 1 Jul 2016, In : Hormones and Behavior. 83, p. 39-44 6 p.

Research output: Contribution to journalArticle

Prodrugs
Transgenic Mice
Estradiol
Alzheimer Disease
Brain
6 Citations (Scopus)

Treatment with an orally bioavailable prodrug of 17β-estradiol alleviates hot flushes without hormonal effects in the periphery

Merchenthaler, I., Lane, M., Sabnis, G., Brodie, A., Nguyen, V., Prokai, L. & Prokai-Tatrai, K., 1 Aug 2016, In : Scientific Reports. 6, 30721.

Research output: Contribution to journalArticle

Prodrugs
Estradiol
Estrogens
Skin Temperature
Brain
2018
1 Citation (Scopus)
Prodrugs
Estradiol
Brain
Estrogens
Neurology
7 Citations (Scopus)

An exploratory investigation of brain-selective estrogen treatment in males using a mouse model of Alzheimer's disease

Tschiffely, A. E., Schuh, R. A., Prokai-Tatrai, K., Ottinger, M. A. & Prokai, L., 1 Feb 2018, In : Hormones and Behavior. 98, p. 16-21 6 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Estrogens
Brain
Estradiol
Amyloid beta-Protein Precursor
1 Citation (Scopus)

Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes–2

Muñoz-Torrero, D., Mangoni, A. A., Liu, H., Hulme, C., Rautio, J., Karaman, R., De Sousa, M. E., Prokai-Tatrai, K., Sabatier, J. M., Siciliano, C., Luque, F. J., Kokotos, G., Ragno, R., Collina, S., Guillou, C., Tschow, M. G. & Agrofoglio, L. A., 1 Jan 2018, In : Molecules. 23, 1, 65.

Research output: Contribution to journalReview article

Molecular Targeted Therapy
Pharmaceutical Chemistry
Drug Discovery
drugs
chemistry

Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes-3

Mangoni, A. A., Tuccinardi, T., Collina, S., Vanden Eynde, J. J., Mu oz-Torrero, D., Karaman, R., Siciliano, C., Emília de Sousa, M., Prokai-Tatrai, K., Rautio, J., Guillou, C., G tschow, M., Galdiero, S., Liu, H., Agrofoglio, L. A., Sabatier, J. M., Hulme, C., Kokotos, G., You, Q. & Gomes, P. A. C., 1 Jan 2018, In : Molecules. 23, 7, 1596.

Research output: Contribution to journalReview article

Pharmaceutical Preparations
Pharmaceutical Chemistry
2019
1 Citation (Scopus)

Brain delivery of thyrotropin-releasing hormone via a novel prodrug approach

Prokai-Tatrai, K., De La Cruz, D. L., Nguyen, V., Ross, B. P., Toth, I. & Prokai, L., Jul 2019, In : Pharmaceutics. 11, 7, 349.

Research output: Contribution to journalArticle

Open Access
Thyrotropin-Releasing Hormone
Prodrugs
prolyl oligopeptidase
Brain
Peptides
1 Citation (Scopus)

Breakthroughs in medicinal chemistry: New targets and mechanisms, New Drugs, New Hopes-5

Mangoni, A. A., Eynde, J. J. V., Jampilek, J., Hadjipavlou-Litina, D., Liu, H., Reynisson, J., Sousa, M. E., Gomes, P. A. C., Prokai-Tatrai, K., Tuccinardi, T., Sabatier, J. M., Luque, F. J., Rautio, J., Karaman, R., Vasconcelos, M. H., Gemma, S., Galdiero, S., Hulme, C., Collina, S., Gütschow, M. & 6 others, Kokotos, G., Siciliano, C., Capasso, R., Agrofoglio, L. A., Ragno, R. & Muñoz-Torrero, D., 1 Jan 2019, In : Molecules. 24, 13, 2415.

Research output: Contribution to journalReview article

Open Access
Pharmaceutical Chemistry
drugs
chemistry
Pharmaceutical Preparations

Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes-4

Mangoni, A. A., Guillou, C., Eynde, J. J. V., Hulme, C., Jampilek, J., Li, W., Prokai-Tatrai, K., Rautio, J., Collina, S., Tuccinardi, T., Sousa, M. E., Sabatier, J. M., Galdiero, S., Karaman, R., Kokotos, G., Torri, G., Javier Luque, F., Helena Vasconcelos, M., Hadjipavlou-Litina, D., Siciliano, C. & 5 others, Gütschow, M., Ragno, R., Gomes, P. A. C., Agrofoglio, L. A. & Muñoz-Torrero, D., 1 Jan 2019, In : Molecules. 24, 1, p. 1-12 12 p.

Research output: Contribution to journalReview article

Pharmaceutical Chemistry
drugs
chemistry
Pharmaceutical Preparations