2B4+ CD8+ T cells play an inhibitory role against constrained HIV epitopes

Kim N. Aldy, Nathan C. Horton, Porunelloor Mathew, Stephen O. Mathew

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17 Scopus citations

Abstract

Cytotoxic T cells play a critical role in the control of HIV and the progression of infected individuals to AIDS. 2B4 (CD244) is a member of the SLAM family of receptors that regulate lymphocyte development and function. The expression of 2B4 on CD8+ T cells was shown to increase during AIDS disease progression. However, the functional role of 2B4+ CD8+ T cells against HIV infection is not known. Here, we have examined the functional role of 2B4+ CD8+ T cells during and after stimulation with HLA B14 or B27 restricted HIV epitopes. Interestingly, IFN-γ secretion and cytotoxic activity of 2B4+ CD8+ T cells stimulated with HIV peptides were significantly decreased when compared to influenza peptide stimulated 2B4+ CD8+ T cells. The expression of the signaling adaptor molecule SAP was downregulated in 2B4+ CD8+ T cells upon HIV peptide stimulation. These results suggest that 2B4+ CD8+ T cells play an inhibitory role against constrained HIV epitopes underlying the inability to control the virus during disease progression.

Original languageEnglish
Pages (from-to)503-507
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume405
Issue number3
DOIs
StatePublished - 18 Feb 2011

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Keywords

  • 2B4
  • B lymphoblastoid cell line (BLCL)
  • Cell surface receptor
  • Cytotoxic T lymphocyte (CTL)
  • HIV epitopes

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