Abstract
Studies have linked neurogenesis to the beneficial actions of specific antidepressants. However, whether 17β-estradiol (E2), an antidepressant, can ameliorate poststroke depression (PSD) and whether E 2-mediated improvement of PSD is associated with neurogenesis are largely unexplored. In the present study, we found that depressive-like behaviors were observed at the first week after focal ischemic stroke in female ovariectomized (OVX) rats, as measured by sucrose preference and open field test, suggesting that focal cerebral ischemia could induce PSD. Three weeks after middle cerebral artery occlusion (MCAO), rats were treated with E 2 for consecutive 14 days. We found that E2-treated rats had significantly improving ischemia-induced depression-like behaviors in the forced-swimming test and sucrose preference test, compared to vehicle-treated group. In addition, we also found that BrdU- and doublecortin (DCX)-positive cells in the dentate gyrus of the hippocampus and the subventricular zone (SVZ) were significantly increased in ischemic rats after E2 treatment, compared to vehicle-treated group. Our data suggest that focal cerebral ischemia can induce PSD, and E2 can ameliorate PSD. In addition, newborn neurons in the hippocampus may play an important role in E2-mediated antidepressant like effect after ischemic stroke.
| Original language | English |
|---|---|
| Article number | 392434 |
| Journal | BioMed Research International |
| Volume | 2013 |
| DOIs | |
| State | Published - 9 Dec 2013 |
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17 β-estradiol attenuates poststroke depression and increases neurogenesis in female ovariectomized rats. / Cheng, Yifan; Su, Qiaoer; Shao, Bei; Cheng, Jianhua; Wang, Hong; Wang, Liuqing; Lin, Zhenzhen; Ruan, Linhui; ZhuGe, Qichuan; Jin, Kunlin.
In: BioMed Research International, Vol. 2013, 392434, 09.12.2013.Research output: Contribution to journal › Article
TY - JOUR
T1 - 17 β-estradiol attenuates poststroke depression and increases neurogenesis in female ovariectomized rats
AU - Cheng, Yifan
AU - Su, Qiaoer
AU - Shao, Bei
AU - Cheng, Jianhua
AU - Wang, Hong
AU - Wang, Liuqing
AU - Lin, Zhenzhen
AU - Ruan, Linhui
AU - ZhuGe, Qichuan
AU - Jin, Kunlin
PY - 2013/12/9
Y1 - 2013/12/9
N2 - Studies have linked neurogenesis to the beneficial actions of specific antidepressants. However, whether 17β-estradiol (E2), an antidepressant, can ameliorate poststroke depression (PSD) and whether E 2-mediated improvement of PSD is associated with neurogenesis are largely unexplored. In the present study, we found that depressive-like behaviors were observed at the first week after focal ischemic stroke in female ovariectomized (OVX) rats, as measured by sucrose preference and open field test, suggesting that focal cerebral ischemia could induce PSD. Three weeks after middle cerebral artery occlusion (MCAO), rats were treated with E 2 for consecutive 14 days. We found that E2-treated rats had significantly improving ischemia-induced depression-like behaviors in the forced-swimming test and sucrose preference test, compared to vehicle-treated group. In addition, we also found that BrdU- and doublecortin (DCX)-positive cells in the dentate gyrus of the hippocampus and the subventricular zone (SVZ) were significantly increased in ischemic rats after E2 treatment, compared to vehicle-treated group. Our data suggest that focal cerebral ischemia can induce PSD, and E2 can ameliorate PSD. In addition, newborn neurons in the hippocampus may play an important role in E2-mediated antidepressant like effect after ischemic stroke.
AB - Studies have linked neurogenesis to the beneficial actions of specific antidepressants. However, whether 17β-estradiol (E2), an antidepressant, can ameliorate poststroke depression (PSD) and whether E 2-mediated improvement of PSD is associated with neurogenesis are largely unexplored. In the present study, we found that depressive-like behaviors were observed at the first week after focal ischemic stroke in female ovariectomized (OVX) rats, as measured by sucrose preference and open field test, suggesting that focal cerebral ischemia could induce PSD. Three weeks after middle cerebral artery occlusion (MCAO), rats were treated with E 2 for consecutive 14 days. We found that E2-treated rats had significantly improving ischemia-induced depression-like behaviors in the forced-swimming test and sucrose preference test, compared to vehicle-treated group. In addition, we also found that BrdU- and doublecortin (DCX)-positive cells in the dentate gyrus of the hippocampus and the subventricular zone (SVZ) were significantly increased in ischemic rats after E2 treatment, compared to vehicle-treated group. Our data suggest that focal cerebral ischemia can induce PSD, and E2 can ameliorate PSD. In addition, newborn neurons in the hippocampus may play an important role in E2-mediated antidepressant like effect after ischemic stroke.
UR - http://www.scopus.com/inward/record.url?scp=84889046000&partnerID=8YFLogxK
U2 - 10.1155/2013/392434
DO - 10.1155/2013/392434
M3 - Article
C2 - 24307996
AN - SCOPUS:84889046000
VL - 2013
JO - BioMed research international
JF - BioMed research international
SN - 2314-6133
M1 - 392434
ER -