17 β-estradiol attenuates poststroke depression and increases neurogenesis in female ovariectomized rats

Yifan Cheng, Qiaoer Su, Bei Shao, Jianhua Cheng, Hong Wang, Liuqing Wang, Zhenzhen Lin, Linhui Ruan, Qichuan ZhuGe, Kunlin Jin

Research output: Contribution to journalArticle

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Abstract

Studies have linked neurogenesis to the beneficial actions of specific antidepressants. However, whether 17β-estradiol (E2), an antidepressant, can ameliorate poststroke depression (PSD) and whether E 2-mediated improvement of PSD is associated with neurogenesis are largely unexplored. In the present study, we found that depressive-like behaviors were observed at the first week after focal ischemic stroke in female ovariectomized (OVX) rats, as measured by sucrose preference and open field test, suggesting that focal cerebral ischemia could induce PSD. Three weeks after middle cerebral artery occlusion (MCAO), rats were treated with E 2 for consecutive 14 days. We found that E2-treated rats had significantly improving ischemia-induced depression-like behaviors in the forced-swimming test and sucrose preference test, compared to vehicle-treated group. In addition, we also found that BrdU- and doublecortin (DCX)-positive cells in the dentate gyrus of the hippocampus and the subventricular zone (SVZ) were significantly increased in ischemic rats after E2 treatment, compared to vehicle-treated group. Our data suggest that focal cerebral ischemia can induce PSD, and E2 can ameliorate PSD. In addition, newborn neurons in the hippocampus may play an important role in E2-mediated antidepressant like effect after ischemic stroke.

Original languageEnglish
Article number392434
JournalBioMed Research International
Volume2013
DOIs
StatePublished - 9 Dec 2013

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Neurogenesis
Rats
Estradiol
Depression
Antidepressive Agents
Sucrose
Brain Ischemia
Bromodeoxyuridine
Stroke
Neurons
Parahippocampal Gyrus
Lateral Ventricles
Middle Cerebral Artery Infarction
Cells
Dentate Gyrus
Hippocampus
Ischemia

Cite this

Cheng, Yifan ; Su, Qiaoer ; Shao, Bei ; Cheng, Jianhua ; Wang, Hong ; Wang, Liuqing ; Lin, Zhenzhen ; Ruan, Linhui ; ZhuGe, Qichuan ; Jin, Kunlin. / 17 β-estradiol attenuates poststroke depression and increases neurogenesis in female ovariectomized rats. In: BioMed Research International. 2013 ; Vol. 2013.
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17 β-estradiol attenuates poststroke depression and increases neurogenesis in female ovariectomized rats. / Cheng, Yifan; Su, Qiaoer; Shao, Bei; Cheng, Jianhua; Wang, Hong; Wang, Liuqing; Lin, Zhenzhen; Ruan, Linhui; ZhuGe, Qichuan; Jin, Kunlin.

In: BioMed Research International, Vol. 2013, 392434, 09.12.2013.

Research output: Contribution to journalArticle

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N2 - Studies have linked neurogenesis to the beneficial actions of specific antidepressants. However, whether 17β-estradiol (E2), an antidepressant, can ameliorate poststroke depression (PSD) and whether E 2-mediated improvement of PSD is associated with neurogenesis are largely unexplored. In the present study, we found that depressive-like behaviors were observed at the first week after focal ischemic stroke in female ovariectomized (OVX) rats, as measured by sucrose preference and open field test, suggesting that focal cerebral ischemia could induce PSD. Three weeks after middle cerebral artery occlusion (MCAO), rats were treated with E 2 for consecutive 14 days. We found that E2-treated rats had significantly improving ischemia-induced depression-like behaviors in the forced-swimming test and sucrose preference test, compared to vehicle-treated group. In addition, we also found that BrdU- and doublecortin (DCX)-positive cells in the dentate gyrus of the hippocampus and the subventricular zone (SVZ) were significantly increased in ischemic rats after E2 treatment, compared to vehicle-treated group. Our data suggest that focal cerebral ischemia can induce PSD, and E2 can ameliorate PSD. In addition, newborn neurons in the hippocampus may play an important role in E2-mediated antidepressant like effect after ischemic stroke.

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