α1-Adrenoceptor subtypes and the regulation of peripheral hemodynamics in the conscious rat

Michael T. Piascik, John W. Kusiak, Kirk W. Barron

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

The peripheral hemodynamic effects of SZL-49, a prazosin analog capable of selectively inactivating the α1a-adrenoceptor subtype, was evaluated in the conscious rat. One hour after SZL-49 administration, total peripheral vascular resistance and arterial blood pressure significantly decreased and cardiac output and heart rate increased. Twenty-four hours after SZL-49, blood pressure returned to control preinjection levels while peripheral resistance remained decreased and cardiac output and heart rate were elevated. The phenylephrine dose-response curves for mean arterial blood pressure and total peripheral vascular resistance were shifted to the right but the maximal responses were not decreased. These data show that the α1a receptor plays a role in the tonic maintenance of arterial blood pressure. The α1b receptor appears to participate in the response to exogenously administered agonists.

Original languageEnglish
Pages (from-to)273-278
Number of pages6
JournalEuropean Journal of Pharmacology
Volume186
Issue number2-3
DOIs
StatePublished - 21 Sep 1990

Keywords

  • (Arterial blood pressure regulation)
  • Blood pressure (arterial)
  • α-Adrenoceptor subtypes
  • α-Adrenoceptors

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