TY - JOUR
T1 - α1-Adrenoceptor subtypes and the regulation of peripheral hemodynamics in the conscious rat
AU - Piascik, Michael T.
AU - Kusiak, John W.
AU - Barron, Kirk W.
N1 - Funding Information:
This work was supported by funds from the National Institutes of Health HL-38120 (to MTP), HL 36552 (to KWB), a Grant-in-aid from the American Heart Association (901244 to MTP), the American Heart Association-Kentucky Affiliate (to MTP and KWB) and KY-THRI 5-42078 (to KWB). The authors would like to thank Ruth Oremius and Terry Pruitt for their expert technical assistance.
PY - 1990/9/21
Y1 - 1990/9/21
N2 - The peripheral hemodynamic effects of SZL-49, a prazosin analog capable of selectively inactivating the α1a-adrenoceptor subtype, was evaluated in the conscious rat. One hour after SZL-49 administration, total peripheral vascular resistance and arterial blood pressure significantly decreased and cardiac output and heart rate increased. Twenty-four hours after SZL-49, blood pressure returned to control preinjection levels while peripheral resistance remained decreased and cardiac output and heart rate were elevated. The phenylephrine dose-response curves for mean arterial blood pressure and total peripheral vascular resistance were shifted to the right but the maximal responses were not decreased. These data show that the α1a receptor plays a role in the tonic maintenance of arterial blood pressure. The α1b receptor appears to participate in the response to exogenously administered agonists.
AB - The peripheral hemodynamic effects of SZL-49, a prazosin analog capable of selectively inactivating the α1a-adrenoceptor subtype, was evaluated in the conscious rat. One hour after SZL-49 administration, total peripheral vascular resistance and arterial blood pressure significantly decreased and cardiac output and heart rate increased. Twenty-four hours after SZL-49, blood pressure returned to control preinjection levels while peripheral resistance remained decreased and cardiac output and heart rate were elevated. The phenylephrine dose-response curves for mean arterial blood pressure and total peripheral vascular resistance were shifted to the right but the maximal responses were not decreased. These data show that the α1a receptor plays a role in the tonic maintenance of arterial blood pressure. The α1b receptor appears to participate in the response to exogenously administered agonists.
KW - (Arterial blood pressure regulation)
KW - Blood pressure (arterial)
KW - α-Adrenoceptor subtypes
KW - α-Adrenoceptors
UR - http://www.scopus.com/inward/record.url?scp=0024987929&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(90)90443-A
DO - 10.1016/0014-2999(90)90443-A
M3 - Article
C2 - 1981186
AN - SCOPUS:0024987929
SN - 0014-2999
VL - 186
SP - 273
EP - 278
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 2-3
ER -