@inbook{ea9fe9c1b4c7472294a8f35faccd8340,
title = "α7 nicotinic ACh receptors as a ligand-gated source of Ca 2+ ions: The search for a Ca 2+ optimum",
abstract = "The spatiotemporal distribution of cytosolic Ca 2+ ions is a key determinant of neuronal behavior and survival. Distinct sources of Ca 2+ ions including ligand- and voltage-gated Ca 2+ channels contribute to intracellular Ca 2+ homeostasis. Many normal physiological and therapeutic neuronal functions are Ca 2+-dependent, however an excess of cytosolic Ca 2+ or a lack of the appropriate balance between Ca 2+ entry and clearance may destroy cellular integrity and cause cellular death. Therefore, the existence of optimal spatiotemporal patterns of cytosolic Ca 2+ elevations and thus, optimal activation of ligand- and voltage-gated Ca 2+ ion channels are postulated to benefit neuronal function and survival. Alpha7 nicotinic -acetylcholine receptors (nAChRs) are highly permeable to Ca 2+ ions and play an important role in modulation of neurotransmitter release, gene expression and neuroprotection in a variety of neuronal and non-neuronal cells. In this review, the focus is placed on α7 nAChR-mediated currents and Ca 2+ influx and how this source of Ca 2+ entry compares to NMDA receptors in supporting cytosolic Ca 2+ homeostasis, neuronal function and survival.",
keywords = "ACh, Alzheimer, Auditory, Ca, Choline, Cognition, Cognitive, Dementia, Extrasynaptic, Gating, Ion channel, NMDA, Neuroprotection, Neurotoxicity, Nicotinic, PNU-120596, Permeability, Positive allosteric modulator, Receptor, Schizophrenia, Synaptic, Trauma, α7 nAChR",
author = "Uteshev, {Victor V.}",
note = "Funding Information: I thank Dr. William Kem and Dr. Hong Xing for providing images of chemical structures of PNU-120596 and 5-HI. This work was supported by the NIH grant R01 DK082625 to VU.",
year = "2012",
doi = "10.1007/978-94-007-2888-2_27",
language = "English",
isbn = "9789400728875",
series = "Advances in Experimental Medicine and Biology",
pages = "603--638",
booktitle = "Calcium Signaling",
}