Abstract
The spatiotemporal distribution of cytosolic Ca 2+ ions is a key determinant of neuronal behavior and survival. Distinct sources of Ca 2+ ions including ligand- and voltage-gated Ca 2+ channels contribute to intracellular Ca 2+ homeostasis. Many normal physiological and therapeutic neuronal functions are Ca 2+-dependent, however an excess of cytosolic Ca 2+ or a lack of the appropriate balance between Ca 2+ entry and clearance may destroy cellular integrity and cause cellular death. Therefore, the existence of optimal spatiotemporal patterns of cytosolic Ca 2+ elevations and thus, optimal activation of ligand- and voltage-gated Ca 2+ ion channels are postulated to benefit neuronal function and survival. Alpha7 nicotinic -acetylcholine receptors (nAChRs) are highly permeable to Ca 2+ ions and play an important role in modulation of neurotransmitter release, gene expression and neuroprotection in a variety of neuronal and non-neuronal cells. In this review, the focus is placed on α7 nAChR-mediated currents and Ca 2+ influx and how this source of Ca 2+ entry compares to NMDA receptors in supporting cytosolic Ca 2+ homeostasis, neuronal function and survival.
| Original language | English |
|---|---|
| Title of host publication | Calcium Signaling |
| Pages | 603-638 |
| Number of pages | 36 |
| DOIs | |
| State | Published - 24 Apr 2012 |
Publication series
| Name | Advances in Experimental Medicine and Biology |
|---|---|
| Volume | 740 |
| ISSN (Print) | 0065-2598 |
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Keywords
- ACh
- Alzheimer
- Auditory
- Ca
- Choline
- Cognition
- Cognitive
- Dementia
- Extrasynaptic
- Gating
- Ion channel
- NMDA
- Neuroprotection
- Neurotoxicity
- Nicotinic
- PNU-120596
- Permeability
- Positive allosteric modulator
- Receptor
- Schizophrenia
- Synaptic
- Trauma
- α7 nAChR
Cite this
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α7 nicotinic ACh receptors as a ligand-gated source of Ca 2+ ions : The search for a Ca 2+ optimum. / Uteshev-Gaard, Victor V.
Calcium Signaling. 2012. p. 603-638 (Advances in Experimental Medicine and Biology; Vol. 740).Research output: Chapter in Book/Report/Conference proceeding › Chapter
TY - CHAP
T1 - α7 nicotinic ACh receptors as a ligand-gated source of Ca 2+ ions
T2 - The search for a Ca 2+ optimum
AU - Uteshev-Gaard, Victor V.
PY - 2012/4/24
Y1 - 2012/4/24
N2 - The spatiotemporal distribution of cytosolic Ca 2+ ions is a key determinant of neuronal behavior and survival. Distinct sources of Ca 2+ ions including ligand- and voltage-gated Ca 2+ channels contribute to intracellular Ca 2+ homeostasis. Many normal physiological and therapeutic neuronal functions are Ca 2+-dependent, however an excess of cytosolic Ca 2+ or a lack of the appropriate balance between Ca 2+ entry and clearance may destroy cellular integrity and cause cellular death. Therefore, the existence of optimal spatiotemporal patterns of cytosolic Ca 2+ elevations and thus, optimal activation of ligand- and voltage-gated Ca 2+ ion channels are postulated to benefit neuronal function and survival. Alpha7 nicotinic -acetylcholine receptors (nAChRs) are highly permeable to Ca 2+ ions and play an important role in modulation of neurotransmitter release, gene expression and neuroprotection in a variety of neuronal and non-neuronal cells. In this review, the focus is placed on α7 nAChR-mediated currents and Ca 2+ influx and how this source of Ca 2+ entry compares to NMDA receptors in supporting cytosolic Ca 2+ homeostasis, neuronal function and survival.
AB - The spatiotemporal distribution of cytosolic Ca 2+ ions is a key determinant of neuronal behavior and survival. Distinct sources of Ca 2+ ions including ligand- and voltage-gated Ca 2+ channels contribute to intracellular Ca 2+ homeostasis. Many normal physiological and therapeutic neuronal functions are Ca 2+-dependent, however an excess of cytosolic Ca 2+ or a lack of the appropriate balance between Ca 2+ entry and clearance may destroy cellular integrity and cause cellular death. Therefore, the existence of optimal spatiotemporal patterns of cytosolic Ca 2+ elevations and thus, optimal activation of ligand- and voltage-gated Ca 2+ ion channels are postulated to benefit neuronal function and survival. Alpha7 nicotinic -acetylcholine receptors (nAChRs) are highly permeable to Ca 2+ ions and play an important role in modulation of neurotransmitter release, gene expression and neuroprotection in a variety of neuronal and non-neuronal cells. In this review, the focus is placed on α7 nAChR-mediated currents and Ca 2+ influx and how this source of Ca 2+ entry compares to NMDA receptors in supporting cytosolic Ca 2+ homeostasis, neuronal function and survival.
KW - ACh
KW - Alzheimer
KW - Auditory
KW - Ca
KW - Choline
KW - Cognition
KW - Cognitive
KW - Dementia
KW - Extrasynaptic
KW - Gating
KW - Ion channel
KW - NMDA
KW - Neuroprotection
KW - Neurotoxicity
KW - Nicotinic
KW - PNU-120596
KW - Permeability
KW - Positive allosteric modulator
KW - Receptor
KW - Schizophrenia
KW - Synaptic
KW - Trauma
KW - α7 nAChR
UR - http://www.scopus.com/inward/record.url?scp=84859914196&partnerID=8YFLogxK
U2 - 10.1007/978-94-007-2888-2_27
DO - 10.1007/978-94-007-2888-2_27
M3 - Chapter
C2 - 22453962
AN - SCOPUS:84859914196
SN - 9789400728875
T3 - Advances in Experimental Medicine and Biology
SP - 603
EP - 638
BT - Calcium Signaling
ER -