TY - JOUR
T1 - α-Adrenergic Vasoconstrictor Tone Limits Right Coronary Blood Flow in Exercising Dogs
AU - Zong, Pu
AU - Sun, Wei
AU - Setty, Srinath
AU - Tune, Johnathan D.
AU - Downey, H. Fred
PY - 2004/4
Y1 - 2004/4
N2 - In exercising dogs, increased myocardial O2 consumption (MVO2) of the left ventricle is met primarily by hyperemia, whereas increased O2 extraction makes a greater contribution to right ventricular (RV) O2 supply. We hypothesized that α-adrenergic vasoconstrictor tone limits right coronary (RC) blood flow during exercise, forcing increased O2 extraction. This tone might also contribute to lesser RC vascular conductance at rest. Accordingly, RV O2 balance was examined at rest and during graded treadmill exercise before and during α-adrenergic blockade with phentolamine (1 mg/kg, iv, n = 6). The transmural distribution of RC flow was measured with radiolabeled microspheres in 4 additional dogs. At rest, α-adrenergic receptor blockade did not significantly increase RC flow or conductance. During exercise, α-adrenergic blockade increased RC flow and conductance responses to increased RV MVO2 by 25% and 60%, respectively. The transmural distribution of RC flow was not altered by exercise or by α-adrenergic blockade. Before α-adrenergic blockade, hyperemia provided 39%-66% of the additional O2 consumed by the right ventricle during graded exercise; after α-adrenergic blockade, hyperemia contributed 74%-85%. After α-adrenergic blockade, the slope of the relationship between RC venous PO2 and RV MVO2 became less steep, reflecting less O2 extraction due to enhanced hyperemia. Additional experiments were conducted on 5 anesthetized, open-chest dogs with constant RC perfusion pressure and β-adrenergic blockade. The RC flow response to intracoronary norepinephrine was shifted to the left compared with that measured in the left coronary circulation, consistent with observations in the conscious exercising dogs. In conclusion, α-adrenergic vasoconstrictor tone does not restrict resting RC blood flow, but during exercise, this tone transmurally blunts RC hyperemia and forces the right ventricle to mobilize its O2 extraction reserve. This effect is more pronounced than has been reported for the left ventricle.
AB - In exercising dogs, increased myocardial O2 consumption (MVO2) of the left ventricle is met primarily by hyperemia, whereas increased O2 extraction makes a greater contribution to right ventricular (RV) O2 supply. We hypothesized that α-adrenergic vasoconstrictor tone limits right coronary (RC) blood flow during exercise, forcing increased O2 extraction. This tone might also contribute to lesser RC vascular conductance at rest. Accordingly, RV O2 balance was examined at rest and during graded treadmill exercise before and during α-adrenergic blockade with phentolamine (1 mg/kg, iv, n = 6). The transmural distribution of RC flow was measured with radiolabeled microspheres in 4 additional dogs. At rest, α-adrenergic receptor blockade did not significantly increase RC flow or conductance. During exercise, α-adrenergic blockade increased RC flow and conductance responses to increased RV MVO2 by 25% and 60%, respectively. The transmural distribution of RC flow was not altered by exercise or by α-adrenergic blockade. Before α-adrenergic blockade, hyperemia provided 39%-66% of the additional O2 consumed by the right ventricle during graded exercise; after α-adrenergic blockade, hyperemia contributed 74%-85%. After α-adrenergic blockade, the slope of the relationship between RC venous PO2 and RV MVO2 became less steep, reflecting less O2 extraction due to enhanced hyperemia. Additional experiments were conducted on 5 anesthetized, open-chest dogs with constant RC perfusion pressure and β-adrenergic blockade. The RC flow response to intracoronary norepinephrine was shifted to the left compared with that measured in the left coronary circulation, consistent with observations in the conscious exercising dogs. In conclusion, α-adrenergic vasoconstrictor tone does not restrict resting RC blood flow, but during exercise, this tone transmurally blunts RC hyperemia and forces the right ventricle to mobilize its O2 extraction reserve. This effect is more pronounced than has been reported for the left ventricle.
KW - Coronary circulation
KW - Myocardial oxygen consumption
KW - Right ventricle
KW - Transmural blood flow
KW - α-adrenergic blockade
UR - http://www.scopus.com/inward/record.url?scp=1642362591&partnerID=8YFLogxK
U2 - 10.1177/153537020422900405
DO - 10.1177/153537020422900405
M3 - Article
C2 - 15044714
AN - SCOPUS:1642362591
VL - 229
SP - 312
EP - 322
JO - Experimental Biology and Medicine
JF - Experimental Biology and Medicine
SN - 1535-3702
IS - 4
ER -