REVERSE CHOLESTEROL TRANSPORT

Project Details

Description

Data from epidemiological studies have consistently shown that elevated
levels of high density lipoproteins (HDL) are an index of protection
against coronary heart disease. However, the mechanism whereby HDL is
involved in the prevention and or reversal of atherosclerosis is not
clear. One of the mechanisms whereby HDL has been proposed to function
as a protector against atherosclerosis is referred to as reverse
cholesterol transport. In this system, HDL functions jointly with the
enzyme lecithin:cholesterol acyltransferase (LCAT) and the cholesteryl
ester transfer protein (CETP) in a system to facilitate the clearance of
cholesterol from the plasma. Although reverse cholesterol transport has
originally been proposed by Glomset as a physiologically essential
mechanism that returns the peripheral cholesterol to the liver, much of
this hypothesis remains clinically unsubstantiated. Key elements of
knowledge are still lacking that would allow the linking of cholesterol
efflux from cells and tissues with specific events in HDL metabolism.
the purpose of the proposed symposium is to provide a forum for the
exchange of ideas particularly unpublished recent findings in this area.
We held a symposium in 1989 that was very enthusiastically received in
the scientific community. The proposed symposium is a continuation of
the effort to promote the knowledge available on the metabolism of HDL
and its relationship to atherosclerosis and coronary heart disease.
StatusFinished
Effective start/end date1/01/9331/12/93