PHYSIOLOGY AND PATHOPHYSIOLOGY OF THE MICROCIRCULATION

  • Barron, Kirk (PI)
  • DIANA, JOHN (PI)
  • PREWITT, BRUCE (PI)
  • BATTARBEE, HAROLD (PI)
  • KLITZMAN, BRUCE (PI)
  • FLEMING, BERNARD (PI)

Project Details

Description

The overall objective is to sudy the manner in which microcirculatory
structure and physiologic function are correlated. The program is a
coordinated effort by six investigators, with specialized interests and
methodologies, to systematically study the physiologic mechanisms
associated with the control of microcirculatory pressure, blood flow and
molecular exchange. In three projects microcirculatory alterations in the
pathophysiologic states of hypertension and hypoxia are addressed.

The approach to the work will include studies using both the whole organ
and microvessel approach. The former approach includes lumped parameter
measurements, while the latter includes direct measurement of microvascular
variables. Every effort will be made to focus and correlate the
information derived from the two different approaches to arrive at an
overall understanding of the phenomena under study. Each investigator will
apply his particular and special expertise toward testing specific
hypotheses while the interaction between all investigators should provide a
stimulating environment for the solution to problems and the generation of
both new ideas and new directions for research.

This application has components of study which are related to neural,
hormonal, metabolic, myogenic and physical microvascular mechanisms. It is
believed that a concerted research effort by a group of interacting
individuals should yield important new insights into the physiology and
pathophysiology of the microcirculation.
StatusFinished
Effective start/end date30/09/8529/09/86