PROJECT NARRATIVE Chronic inflammation plays prominently into the development and progression of hypertension, which is a major risk factor for cardiovascular disease. The cholinergic anti-inflammatory pathway and the hypothalamic-pituitary-adrenal (HPA) axis are endogenous mechanisms that regulate chronic inflammation; both of these pathways may be mediated by the parasympathetic vagus nerve. The studies proposed will investigate whether dysfunction at the level of the vagal efferents and afferents contribute to aberrant inflammatory responses and subsequently the pathogenesis of hypertension in a clinically-relevant mouse model of chronic inflammation.
|Effective start/end date||1/01/18 → 31/12/22|
- National Heart, Lung, and Blood Institute
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