NATURAL AND EXPERIMENTAL ATHEROSCLEROSIS

  • Dory, Ladislav (PI)
  • STRONG, JACK (PI)
  • OALMANN, MARGARET (PI)
  • BHATTACHARYYA, ASHIM (PI)
  • MALCOM, GRAY (PI)
  • BAKER, NORDEAN (PI)
  • NEWMAN, WILLIAM (PI)
  • STARY, HERBERT (PI)

Project Details

Description

The ultimate objective of this research is to determine the etiology and
pathogenesis of atherosclerosis and its sequelae. This objective is approached
by combining morphologic, experimental, epidemiologic, chemical, immunochemical,
cytologic and biometric methods. The possible etiologic relationships of
certain environmental factors and disease states to arterial lesions, coronary
heart disease and sudden death are being studied using a community pathology
approach. This study of a 100 percent sample of deceased men, 24-44 years of
age, from the biracial community of New Orleans includes a detailed examination
of the heart, coronary arteries, and the postmortem characteristics of the 80
percent of deaths which are autopsied. An explanation for an apparent anomalous
difference in coronary heart disease in young Negro and Caucasian men is being
sought. Experimental studies in nonhuman primates are being used to study the
mechanisms of development and regression of diet-induced arterial lesions.
Factors causing variability in rate of development or regression of diet-induced
atherosclerotic lesions are being studied. Cholesterol and lipoprotein
metabolism is also being investigated in primate animals to obtain an
understanding of the mechanisms responsible for the large differences in serum
cholesterol or lipoprotein concentrations among animals. Archived coronary
arteries, aortas, and associated clinical data obtained from 24,000 autopsies
from 19 geographic and racial groups are being used to obtain a better
understanding of the natural history of human atherosclerosis and its geographic
distribution.
StatusFinished
Effective start/end date1/01/901/01/90