Maternal vascular responses to extracellular mitochondrial DNA during pregnancy

Project Details


Hypertensive disorders of pregnancy, including preeclampsia, have devastating effects on the maternal
cardiovascular system, are leading causes of maternal deaths, and increase risk for future cardiovascular
disease. The proposed research is expected to lead to the discovery of novel mechanisms that contribute to
the etiology of maternal vascular dysfunction in pregnancies with preeclampsia. This contribution will be
important in the development of pharmacological strategies that will allow the inhibition of interactions between
placenta-derived factors and the maternal vascular system, alleviating the symptoms of preeclampsia and
reducing cardiovascular risk so all women can live longer and more fulfilling lives.
Effective start/end date1/01/2131/12/22


  • National Heart, Lung, and Blood Institute: $419,752.00
  • National Heart, Lung, and Blood Institute: $366,143.00


Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.