Impact of brain estrogens on cognition and brain aging in a non-human primate

  • Prokai, Laszlo (CoPI)
  • LACREUSE, AGNES (PI)
  • MERCHENTHALER, ISTVAN JOZSEF (CoPI)
  • Merchenthaler, Istvan (CoPI)
  • LACREUSE, AGNES (CoPI)
  • Prókai, László (CoPI)

Project Details

Description

NARRATIVE Breast cancer patients using aromatase inhibitors (AIs) as an adjuvant therapy often report severe side effects, including hot flashes, cognitive impairment, insomnia and mood changes. Despite long-term use in humans, little is known about the long-term effects of AIs on brain function. This proposal uses a primate model to understand how AIs affect the brain and behavior and to test whether a drug that delivers estrogens exclusively to the brain can safely alleviate these deficits.
StatusActive
Effective start/end date1/01/2131/12/22

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