Keyphrases
Cell-based
100%
Small Molecule Activation
100%
Fragile X Syndrome
100%
Potassium Channel
100%
Ion Channels
80%
Fragile X Mental Retardation Protein
80%
Slack Channel
60%
High-throughput Screening
40%
Small Molecules
40%
Fragile X Mental Retardation 1 (FMR1)
40%
Intellectual Disability
40%
Novel Treatments
20%
Treatment Strategy
20%
Cell Membrane
20%
RNA-binding Protein
20%
Tool Compound
20%
Medicinal Chemistry
20%
Monogenic
20%
Cellular Efflux
20%
Pharmacotherapy
20%
Therapeutic Potential
20%
Protein Expression
20%
Potential Treatments
20%
Family Members
20%
KCNT1
20%
Molecular Targets
20%
Autism Spectrum Disorder
20%
Holistic Evaluation
20%
HEK293 Cells
20%
Membrane Potential
20%
Neuronal Activity
20%
Ion Channel Activity
20%
Flux Assay
20%
Hit Optimization
20%
Structure-activity Relationship
20%
Membrane Permeability
20%
Chemical Scaffolds
20%
Cell Behavior
20%
Higher-order Cognitive Functions
20%
Water-filling
20%
X-linked Disorder
20%
Screening Approach
20%
Optimization Approach
20%
Voltage-clamp Electrophysiology
20%
Synthesized Compounds
20%
Gene Silencing
20%
Biochemistry, Genetics and Molecular Biology
Small Molecule
100%
Potassium Channel
100%
Intellectual Disability
66%
High Throughput Screening
66%
Voltage Clamp
33%
Structure Activity Relation
33%
Cell Membrane
33%
RNA-binding Protein
33%
Gene Silencing
33%
Membrane Permeability
33%
KCNT1
33%
Neuronal Activity
33%
Electrophysiology
33%
Cognition
33%
Mouse
33%
Protein Expression
33%
Cell Function
33%
Membrane Potential
33%
HEK 293 Cells
33%
Neuroscience
Ion Channel
100%
Potassium Channel
100%
Fragile X Syndrome
100%
Fragile X Mental Retardation Protein
80%
Epileptic Absence
40%
Electrophysiology
20%
Neuronal Activity
20%
KCNT1
20%
Gene Silencing
20%
Membrane Potential
20%
Voltage Clamp
20%
HEK 293 Cells
20%
Protein Expression
20%
Pervasive Developmental Disorder
20%
Cell Membrane
20%
RNA-binding Protein
20%
Cognitive Function
20%
Cell Function
20%
Membrane Permeability
20%