Brain-selective estrogen therapy for menopausal hot flushes in an advanced translational animal model

Project Details


Despite the high in incidence of deleterious symptoms associated with menopause in women, the only
effective treatment to block these symptoms remains estrogen-based therapies which carry significantly
elevated risks of breast/uterus cancer in patients on these therapies. There is a critical need to have a safer
alternative to estrogen therapy to alleviate the menopausal symptoms, hot flushes in particular, without the
peripheral side-effects. This advanced translational project test if the novel prodrug DHED, which is biologically
inert in the periphery but converted to estrogen selectively and only in the brain, can prevent hot flushes while
having no peripheral effects on breast/uterus.
Effective start/end date15/01/2131/12/22


  • National Institute on Aging: $532,566.00


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