Brain-selective estrogen therapy for menopausal hot flushes in an advanced translational animal model

  • PUCHE, ADAM (CoPI)
  • Merchenthaler, Istvan (PI)
  • PUCHE, ADAM (CoPI)
  • Prókai, László (CoPI)
  • MERCHENTHALER, ISTVAN JOZSEF (CoPI)
  • Prokai, Laszlo (CoPI)

Project Details

Description

NARRATIVE Despite the high in incidence of deleterious symptoms associated with menopause in women, the only effective treatment to block these symptoms remains estrogen-based therapies which carry significantly elevated risks of breast/uterus cancer in patients on these therapies. There is a critical need to have a safer alternative to estrogen therapy to alleviate the menopausal symptoms, hot flushes in particular, without the peripheral side-effects. This advanced translational project test if the novel prodrug DHED, which is biologically inert in the periphery but converted to estrogen selectively and only in the brain, can prevent hot flushes while having no peripheral effects on breast/uterus.
StatusActive
Effective start/end date15/01/2131/12/22

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