Project Details


This represents a competitive renewal of NIDA contract N01DA29305,
entitled "Assessment of Potential Cocaine Treatment Medications in
Rodents". The objectives of this research and development contract is
to determine the effects of compounds in the rodent locomotor activity
and drug discrimination procedures as a means of evaluating their
potential efficacy as cocaine treatment medications. These tests have
been selected by NIDA Medication Development Division's (MDD)
Cocaine Treatment Discovery Program (CTDP) because they are
believed to represent model systems that may be predictive of clinical
efficacy of pharmacotherapies for cocaine dependence. The data
generated by this contract will be utilized by the NIDA/MDD/CTDP in
the selection of compounds for additional preclinical evaluation and
subsequent development as pharmacotherapies for cocaine
dependence. Briefly, the Contractor will be screening compounds in
the mouse locomotor activity and rat drug discrimination test. We
respect to the locomotor activity procedure, the effect of the
compound, administered alone and in combination with cocaine, on
locomotor activity in mice will be assessed. Depending on results
obtained from the locomotor activity test, the compound will either be
evaluated for the ability to antagonize the discriminative (subjective)
effects of cocaine or to substitute for the discriminative (subjective)
effects of cocaine. The anticipated end results of this contract will be
written reports detailing study findings.
Effective start/end date30/09/9729/09/98