• 1939 Citations
  • 25 h-Index
19982019
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Personal profile

Area of Expertise

The main focus of my research is to discover and develop bioactive natural products from microorganisms as drugs or drug leads for the treatment of cancer, infectious diseases, or other human medical conditions. In addition, I recently initiated a collaborative project for the engineering of novel oncolytic virus for cancer chemoimmunotherapy.
Key words: anti-aging, anti-cancer, anti-infective, crowd-sourcing, crowd-funding, drug discovery, drug development, natural product, synthetic biology, chemoimmunotherapy, contract service

Education/Academic qualification

PhD in Botany & Microbiology, Michigan State University

MS in Phytochemistry, Institute of Botany of the Chinese Academy of Sciences

BS in Microbiology, Huazhong Agricultural University

Fingerprint Dive into the research topics where Yiqiang (Eric) Cheng is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Multigene Family Medicine & Life Sciences
Histone Deacetylase Inhibitors Medicine & Life Sciences
Polyketide Synthases Medicine & Life Sciences
Burkholderia Medicine & Life Sciences
Peptide Synthases Medicine & Life Sciences
Biosynthesis Chemical Compounds
Genes Chemical Compounds
Biological Products Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2013 2018

Research Output 1998 2019

Origin and bioactivities of thiosulfinated FK228

Liu, X., Currens, G. C., Xue, L. & Cheng, Y., 1 Jan 2019, In : MedChemComm. 10, 4, p. 538-542 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Bioactivity
Silica Gel
Burkholderia
Histone Deacetylases
romidepsin
1 Citation (Scopus)

Chromobacterium spp. mediate their anti-Plasmodium activity through secretion of the histone deacetylase inhibitor romidepsin

Saraiva, R. G., Huitt-Roehl, C. R., Tripathi, A., Cheng, Y., Bosch, J., Townsend, C. A. & Dimopoulos, G., 1 Dec 2018, In : Scientific Reports. 8, 1, 6176.

Research output: Contribution to journalArticleResearchpeer-review

Chromobacterium
histone deacetylase
Plasmodium
secretion
antimalarials
2 Citations (Scopus)

Genomics-guided discovery of a new and significantly better source of anticancer natural drug FK228

Liu, X., Xie, F., Doughty, L. B., Wang, Q., Zhang, L., Liu, X. & Cheng, Y., 1 Dec 2018, In : Synthetic and Systems Biotechnology. 3, 4, p. 268-274 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Genomics
Fermentation
Genes
Pharmaceutical Preparations
Bioreactors
2 Citations (Scopus)

Mechanistic studies of DepR in regulating FK228 biosynthesis in Chromobacterium violaceum no. 968

Qiao, Y., Tong, T., Xue, J., Lin, W., Deng, Z., Cheng, Y. & Zhu, D., 1 Apr 2018, In : PLoS ONE. 13, 4, e0196173.

Research output: Contribution to journalArticleResearchpeer-review

Chromobacterium
Chromobacterium violaceum
Biosynthesis
biosynthesis
Assays
4 Citations (Scopus)

Developing new targeting strategy for androgen receptor variants in castration resistant prostate cancer

Wang, B., Lo, U. G., Wu, K., Kapur, P., Liu, X., Huang, J., Chen, W., Hernandez, E., Santoyo, J., Ma, S. H., Pong, R. C., He, D., Cheng, Y. & Hsieh, J. T., 15 Nov 2017, In : International Journal of Cancer. 141, 10, p. 2121-2130 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Castration
Androgen Receptors
Prostatic Neoplasms
RNA Splice Sites
Survival