Projects per year
Personal profile
Area of Expertise
The main focus of my research is to discover and develop bioactive natural products from microorganisms as drugs or drug leads for the treatment of cancer, infectious diseases, or other human medical conditions. In addition, I recently initiated a collaborative project for the engineering of novel oncolytic virus for cancer chemoimmunotherapy.
Key words: anti-aging, anti-cancer, anti-infective, crowd-sourcing, crowd-funding, drug discovery, drug development, natural product, synthetic biology, chemoimmunotherapy, contract service
Key words: anti-aging, anti-cancer, anti-infective, crowd-sourcing, crowd-funding, drug discovery, drug development, natural product, synthetic biology, chemoimmunotherapy, contract service
Education/Academic qualification
PhD in Botany & Microbiology, Michigan State University
MS in Phytochemistry, Institute of Botany of the Chinese Academy of Sciences
BS in Microbiology, Huazhong Agricultural University
Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.
Multigene Family
Medicine & Life Sciences
Histone Deacetylase Inhibitors
Medicine & Life Sciences
Polyketide Synthases
Medicine & Life Sciences
Burkholderia
Medicine & Life Sciences
Peptide Synthases
Medicine & Life Sciences
Biosynthesis
Chemical Compounds
Genes
Chemical Compounds
Biological Products
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2013 2018
- 3 Finished
High-Resolution Tandem Mass Spectrometer for Advanced Biomolecular Research
Prokai, L., Forster, M. & Cheng, Y. (.
27/01/17 → 31/01/18
Project: Research
Discover and Engineer New Histone Deacetylase Inhibitors as Anticancer Agents
NCI: National Cancer Institute
1/06/13 → 31/05/15
Project: Research
Research Output 1998 2019
Origin and bioactivities of thiosulfinated FK228
Liu, X., Currens, G. C., Xue, L. & Cheng, Y., 1 Jan 2019, In : MedChemComm. 10, 4, p. 538-542 5 p.Research output: Contribution to journal › Article › Research › peer-review
Bioactivity
Silica Gel
Burkholderia
Histone Deacetylases
romidepsin
1
Citation
(Scopus)
Chromobacterium spp. mediate their anti-Plasmodium activity through secretion of the histone deacetylase inhibitor romidepsin
Saraiva, R. G., Huitt-Roehl, C. R., Tripathi, A., Cheng, Y., Bosch, J., Townsend, C. A. & Dimopoulos, G., 1 Dec 2018, In : Scientific Reports. 8, 1, 6176.Research output: Contribution to journal › Article › Research › peer-review
Chromobacterium
histone deacetylase
Plasmodium
secretion
antimalarials
Genomics-guided discovery of a new and significantly better source of anticancer natural drug FK228
Liu, X., Xie, F., Doughty, L. B., Wang, Q., Zhang, L., Liu, X. & Cheng, Y., 1 Dec 2018, In : Synthetic and Systems Biotechnology. 3, 4, p. 268-274 7 p.Research output: Contribution to journal › Article › Research › peer-review
Genomics
Fermentation
Genes
Pharmaceutical Preparations
Bioreactors
1
Citation
(Scopus)
Mechanistic studies of DepR in regulating FK228 biosynthesis in Chromobacterium violaceum no. 968
Qiao, Y., Tong, T., Xue, J., Lin, W., Deng, Z., Cheng, Y. & Zhu, D., 1 Apr 2018, In : PLoS ONE. 13, 4, e0196173.Research output: Contribution to journal › Article › Research › peer-review
Chromobacterium
Chromobacterium violaceum
Biosynthesis
biosynthesis
Assays
3
Citations
(Scopus)
Developing new targeting strategy for androgen receptor variants in castration resistant prostate cancer
Wang, B., Lo, U. G., Wu, K., Kapur, P., Liu, X., Huang, J., Chen, W., Hernandez, E., Santoyo, J., Ma, S. H., Pong, R. C., He, D., Cheng, Y. & Hsieh, J. T., 15 Nov 2017, In : International Journal of Cancer. 141, 10, p. 2121-2130 10 p.Research output: Contribution to journal › Article › Research › peer-review
Castration
Androgen Receptors
Prostatic Neoplasms
RNA Splice Sites
Survival