• 1515 Citations
  • 19 h-Index
20002021
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Personal profile

Area of Expertise

My research has been focused on a gene that I cloned about 20 years ago when we tried to identify host factors involved in HIV virus propagation. We have first found that this gene encoded a critical molecule for HIV virus propagation. We have obtained some evidence to show that this molecule could also be important for controlling emergence of undetectable virus when treated with HIV drugs. We are currently working to gain a better understanding of the process. This line of research has been my main research interest.
My other line of research is focused on how various blood cells are derived from their common ancestor, called stem cells, which also originated from the same above-mentioned gene/molecule. We have shown that this gene/molecule plays an important role in the production of various blood cells from stem cells as well as the maintenance of the stem cells’ ability to generate themselves. We are extending this line of research by creating several types of stem cells-derived organoids and using these organoids to model HIV infection.
My research primarily involves use of cell biology and molecular biology techniques.

Education/Academic qualification

MD, Xian Medical University

Fingerprint Dive into the research topics where Ying Liu is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 3 Similar Profiles
HIV-1 Medicine & Life Sciences
Astrocytes Medicine & Life Sciences
tat Gene Products Medicine & Life Sciences
HIV Medicine & Life Sciences
Viruses Chemical Compounds
Hematopoiesis Medicine & Life Sciences
Proteins Medicine & Life Sciences
Transgenic Mice Medicine & Life Sciences

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Projects 2016 2021

Research Output 2000 2019

Atrial fibrillation and electrophysiology in transgenic mice with cardiac-restricted overexpression of FKBP12

Pan, Z., Ai, T., Chang, P. C., Liu, Y., Liu, J., Maruyama, M., Homsi, M., Fishbein, M. C., Rubart, M., Lin, S. F., Xiao, D., Chen, H., Chen, P. S., Shou, W. & Li, B. Y., 1 Feb 2019, In : American Journal of Physiology - Heart and Circulatory Physiology. 316, 2, p. H371-H379

Research output: Contribution to journalArticleResearchpeer-review

Tacrolimus Binding Protein 1A
Electrophysiology
Atrial Fibrillation
Transgenic Mice
Tacrolimus Binding Proteins
Open Access
National Institute of Neurological Disorders and Stroke
Organized Financing
Astrocytes
Histones
Methylation

Tat expression led to increased histone 3 tri-methylation at lysine 27 and contributed to HIV latency in astrocytes through regulation of MeCP2 and Ezh2 expression

Liu, Y., Niu, Y., Li, L., Timani, K. A., He, V. L., Sanburns, C., Xie, J. & He, J. J., 1 Jan 2019, In : Journal of NeuroVirology.

Research output: Contribution to journalArticleResearchpeer-review

Astrocytes
Histones
Methylation
Lysine
HIV
4 Citations (Scopus)

Doxycycline-inducible and astrocyte-specific HIV-1 Tat transgenic mice (iTat) as an HIV/neuroAIDS model

Langford, D., Kim, B. O., Zou, W., Fan, Y., Rahimain, P., Liu, Y. & He, J. J., 15 Nov 2018, In : Journal of NeuroVirology. 24, 2, p. 168-179 12 p.

Research output: Contribution to journalReview articleResearchpeer-review

Doxycycline
Astrocytes
Transgenic Mice
HIV-1
HIV

LUMA in cardiac development and function

Liu, Y., Chen, V. H. S. & Shou, W., 1 Mar 2018, In : Cardiovascular Research. 114, 3, p. 347-348 2 p.

Research output: Contribution to journalEditorialResearch