• 1599 Citations
  • 20 h-Index
20002021

Research output per year

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Personal profile

Area of Expertise

My research has been focused on a gene that I cloned about 20 years ago when we tried to identify host factors involved in HIV virus propagation. We have first found that this gene encoded a critical molecule for HIV virus propagation. We have obtained some evidence to show that this molecule could also be important for controlling emergence of undetectable virus when treated with HIV drugs. We are currently working to gain a better understanding of the process. This line of research has been my main research interest.
My other line of research is focused on how various blood cells are derived from their common ancestor, called stem cells, which also originated from the same above-mentioned gene/molecule. We have shown that this gene/molecule plays an important role in the production of various blood cells from stem cells as well as the maintenance of the stem cells’ ability to generate themselves. We are extending this line of research by creating several types of stem cells-derived organoids and using these organoids to model HIV infection.
My research primarily involves use of cell biology and molecular biology techniques.

Education/Academic qualification

MD, Xian Medical University

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Projects

Research Output

Atrial fibrillation and electrophysiology in transgenic mice with cardiac-restricted overexpression of FKBP12

Pan, Z., Ai, T., Chang, P. C., Liu, Y., Liu, J., Maruyama, M., Homsi, M., Fishbein, M. C., Rubart, M., Lin, S. F., Xiao, D., Chen, H., Chen, P. S., Shou, W. & Li, B. Y., Feb 2019, In : American Journal of Physiology - Heart and Circulatory Physiology. 316, 2, p. H371-H379

Research output: Contribution to journalArticle

  • 1 Scopus citations
    Open Access
  • Tat expression led to increased histone 3 tri-methylation at lysine 27 and contributed to HIV latency in astrocytes through regulation of MeCP2 and Ezh2 expression

    Liu, Y., Niu, Y., Li, L., Timani, K. A., He, V. L., Sanburns, C., Xie, J. & He, J. J., 1 Aug 2019, In : Journal of NeuroVirology. 25, 4, p. 508-519 12 p.

    Research output: Contribution to journalArticle

  • Doxycycline-inducible and astrocyte-specific HIV-1 Tat transgenic mice (iTat) as an HIV/neuroAIDS model

    Langford, D., Kim, B. O., Zou, W., Fan, Y., Rahimain, P., Liu, Y. & He, J. J., 15 Nov 2018, In : Journal of NeuroVirology. 24, 2, p. 168-179 12 p.

    Research output: Contribution to journalReview article

  • 7 Scopus citations

    LUMA in cardiac development and function

    Liu, Y., Chen, V. H. S. & Shou, W., 1 Mar 2018, In : Cardiovascular Research. 114, 3, p. 347-348 2 p.

    Research output: Contribution to journalEditorial