Projects per year
Personal profile
Area of Expertise
Dr. Dong’s research interests include pharmaceutical analysis/bioanalysis, drug formulation, and delivery. She develops novel formulation nanotechnologies to improve bioavailability of oral drugs and deliver macromolecules such as siRNAs and proteins. In addition to novel drug formulations, her lab evaluates these formulations for therapeutic efficacy (e.g. anticancer drugs), pharmacokinetics, and biodistribution. Thus, her lab has the capacity to perform bioassays for both small molecules and macromolecules. Additionally, she collaborates with the clinical pharmacy to test stability of compounding medications and Y-site compatibility.
Education/Academic qualification
BS in Industrial Analysis
MS in Applied Chemistry, East China University of Science and Technology
PhD in Pharmaceutical Sciences, University of Kentucky
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Projects
- 5 Finished
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Novel Formulation Technology to Enhance Oral Absorption of Water-insoluble Drugs
1/07/20 → 30/06/21
Project: Research
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Nanoparticle Drug Delivery to Overcome Multidrug Resistance to Cancer
1/04/14 → 31/08/15
Project: Research
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Nerve Growth Factor Nanoparticles to Cross the Blood-Brain Barrier
Dong, X. & Dong, X.
National Institute of Neurological Disorders and Stroke
1/02/14 → 31/01/17
Project: Research
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Nerve Growth Factor Nanoparticles to Cross the Blood-Brain Barrier
NINDS: Neurological Disorders & Stroke
1/02/14 → 31/01/17
Project: Research
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Nerve Growth Factor Nanoparticles to Cross the Blood-Brain Barrier
1/02/14 → 31/01/17
Project: Research
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Development of in situ self-assembly nanoparticles to encapsulate lopinavir and ritonavir for long-acting subcutaneous injection
Tanaudommongkon, I., Tanaudommongkon, A. & Dong, X., Jun 2021, In: Pharmaceutics. 13, 6, 904.Research output: Contribution to journal › Article › peer-review
Open Access -
Quantitative measurements of IR780 in formulations and tissues
Wang, J., Zhang, J., Nguyen, N. T. D., Chen, Y. A., Hsieh, J. T. & Dong, X., 5 Feb 2021, In: Journal of Pharmaceutical and Biomedical Analysis. 194, 113780.Research output: Contribution to journal › Article › peer-review
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Anticancer Efficacy of Oral Docetaxel Nanoformulation for Metronomic Chemotherapy in Metastatic Lung Cancer
Le, S., Chang, C. M., Nguyen, T., Liu, Y., Chen, Y. A., Hernandez, E., Kapur, P., Hsieh, J. T., Johnston, K. & Dong, X., 1 May 2020, In: Journal of Biomedical Nanotechnology. 16, 5, p. 583-593 11 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Curcumin nanoparticles and their cytotoxicity in docetaxel-resistant castration-resistant prostate cancer cells
Tanaudommongkon, I., Tanaudommongkon, A., Prathipati, P., Nguyen, J. T., Keller, E. T. & Dong, X., Aug 2020, In: Biomedicines. 8, 8, 253.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Determination of metformin bio-distribution by LC-MS/MS in mice treated with a clinically relevant paradigm
Chaudhari, K., Wang, J., Xu, Y., Winters, A., Wang, L., Dong, X., Cheng, E. Y., Liu, R. & Yang, S. H., Jun 2020, In: PLoS ONE. 15, 6, e0234571.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations