The focus of my research lab is to apply and assess a safe intermittent-hypoxia (IH) procedure as a physical-conditioning regimen to preserve and improve the heart and brain functions in humans. Repeated intermittent-hypoxia induces cyclic, brief, and moderate decreases in blood oxygen concentration, and increases heart rate and breathing rate. We have found that IH conditioning is a safe, novel, and effective way to improve heart function and to optimize oxygen delivery to the brain. We believe this IH intervention is beneficial for older adults, especially those who cannot participate in regular physical activities because of the limitations associated with age-related declining physical or mental functions. Moreover, repeated low-dose intermittent-hypoxia can promote and mobilize the growth factors for healthy nerve system and blood vessel. These physiological and neurobiological reactions and adaptations to IH conditioning may have multi-faceted influences on prevention and treatment for mild Alzheimer’s disease and cognitive impairment associated with aging.