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Personal profile

Area of Expertise

The focus of my research lab is to apply and assess a safe intermittent-hypoxia (IH) procedure as a physical-conditioning regimen to preserve and improve the heart and brain functions in humans. Repeated intermittent-hypoxia induces cyclic, brief, and moderate decreases in blood oxygen concentration, and increases heart rate and breathing rate. We have found that IH conditioning is a safe, novel, and effective way to improve heart function and to optimize oxygen delivery to the brain. We believe this IH intervention is beneficial for older adults, especially those who cannot participate in regular physical activities because of the limitations associated with age-related declining physical or mental functions. Moreover, repeated low-dose intermittent-hypoxia can promote and mobilize the growth factors for healthy nerve system and blood vessel. These physiological and neurobiological reactions and adaptations to IH conditioning may have multi-faceted influences on prevention and treatment for mild Alzheimer’s disease and cognitive impairment associated with aging.

Education/Academic qualification

PhD in Physiology, Yale University

MA in Exercise Science, Shanghai Institute of Physical Education

BA in Physical Education, Shanghai Teachers University

Fingerprint Dive into the research topics where Xiangrong Shi is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Projects 2009 2018

Research Output 1984 2020

  • 1874 Citations
  • 23 h-Index
  • 66 Article
  • 2 Conference contribution
  • 1 Review article

Intermittent Hypoxia Training for Treating Mild Cognitive Impairment: A Pilot Study

Wang, H., Shi, X., Schenck, H., Hall, J. R., Ross, S. E., Kline, G. P., Chen, S., Mallet, R. T. & Chen, P., 1 Jan 2020, In : American journal of Alzheimer's disease and other dementias. 35, p. 1533317519896725

Research output: Contribution to journalArticle

Open Access
Word Association Tests
Trail Making Test
Brain Hypoxia
Verbal Learning
Short-Term Memory

Reduced cerebrovascular and cardioventilatory responses to intermittent hypoxia in elderly

Liu, X., Chen, X., Kline, G., Ross, S. E., Hall, J. R., Ding, Y., Mallet, R. T. & Shi, X., Jan 2020, In : Respiratory Physiology and Neurobiology. 271, 103306.

Research output: Contribution to journalArticle

Blood Vessels
Heart Rate
Young Adult

Effects of exercise training on the autophagy-related muscular proteins expression in ovariectomized rats

Zhong, W., Shi, X., Yuan, H., Bu, H., Wu, L. & Wang, R., 1 Jan 2019, In : Frontiers in Physiology. 10, JUN, 735.

Research output: Contribution to journalArticle

Open Access
Skeletal Muscle
Microtubule-Associated Proteins

Risk factors associated with poor physical fitness in three- to six-year-old children in tujia-nationality settlement of China

Liu, X., Xiang, Z., Liu, C., Shi, X., Yi, X., Cheng, M., Schenck, H. & Bates, J., 1 Jan 2018, In : Evidence-based Complementary and Alternative Medicine. 2018, 5702190.

Research output: Contribution to journalArticle

Physical Fitness
Ethnic Groups
4 Citations (Scopus)

Aerobic exercise training improves orthostatic tolerance in aging humans

Xu, D., Wang, H., Chen, S., Ross, S., Liu, H., Olivencia-Yurvati, A., Raven, P. B. & Shi, X., 1 Jan 2017, In : Medicine and Science in Sports and Exercise. 49, 4, p. 728-735 8 p.

Research output: Contribution to journalArticle

Lower Body Negative Pressure
Arterial Pressure