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Personal profile

Area of Expertise

The focus of my research lab is to apply and assess a safe intermittent-hypoxia (IH) procedure as a physical-conditioning regimen to preserve and improve the heart and brain functions in humans. Repeated intermittent-hypoxia induces cyclic, brief, and moderate decreases in blood oxygen concentration, and increases heart rate and breathing rate. We have found that IH conditioning is a safe, novel, and effective way to improve heart function and to optimize oxygen delivery to the brain. We believe this IH intervention is beneficial for older adults, especially those who cannot participate in regular physical activities because of the limitations associated with age-related declining physical or mental functions. Moreover, repeated low-dose intermittent-hypoxia can promote and mobilize the growth factors for healthy nerve system and blood vessel. These physiological and neurobiological reactions and adaptations to IH conditioning may have multi-faceted influences on prevention and treatment for mild Alzheimer’s disease and cognitive impairment associated with aging.

Education/Academic qualification

PhD in Physiology, Yale University

MA in Exercise Science, Shanghai Institute of Physical Education

BA in Physical Education, Shanghai Teachers University

Fingerprint Dive into the research topics where Xiangrong Shi is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Projects 2009 2017

Research Output 1984 2018

  • 1807 Citations
  • 23 h-Index
  • 63 Article
  • 2 Conference contribution
  • 1 Review article

Risk factors associated with poor physical fitness in three- to six-year-old children in tujia-nationality settlement of China

Liu, X., Xiang, Z., Liu, C., Shi, X., Yi, X., Cheng, M., Schenck, H. & Bates, J., 1 Jan 2018, In : Evidence-based Complementary and Alternative Medicine. 2018, 5702190.

Research output: Contribution to journalArticleResearchpeer-review

Physical Fitness
Ethnic Groups
3 Citations (Scopus)

Aerobic exercise training improves orthostatic tolerance in aging humans

Xu, D., Wang, H., Chen, S., Ross, S. E., Liu, H., Yurvati, A., Raven, P. B. & Shi, X., 1 Jan 2017, In : Medicine and Science in Sports and Exercise. 49, 4, p. 728-735 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Lower Body Negative Pressure
Arterial Pressure

Enhanced cerebral perfusion during brief exposures to cyclic intermittent hypoxemia

Liu, X., Xu, D., Hall, J. R., Ross, S. E., Chen, S., Liu, H., Mallet, R. T. & Shi, X., 1 Dec 2017, In : Journal of applied physiology (Bethesda, Md. : 1985). 123, 6, p. 1689-1697 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Middle Cerebral Artery
3 Citations (Scopus)

The risk factors of 9-year follow-up on hypertension in middle-aged people in Tujia-Nationality settlement of China

Liu, X., Liu, C., Schenck, H., Yi, X., Wang, H. & Shi, X., 1 Dec 2017, In : Journal of Human Hypertension. 31, 12, p. 838-842 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Ethnic Groups
Confidence Intervals
2 Citations (Scopus)

The Risk Factors of High Blood Pressure among Young Adults in the Tujia-Nationality Settlement of China

Liu, X., Xiang, Z., Shi, X., Schenck, H., Yi, X., Ni, R. & Liu, C., 1 Jan 2017, In : BioMed Research International. 2017, 8315603.

Research output: Contribution to journalArticleResearchpeer-review

Blood pressure
Ethnic Groups
Young Adult