Projects per year
Personal profile
Area of Expertise
The focus of my research lab is to apply and assess a safe intermittent-hypoxia (IH) procedure as a physical-conditioning regimen to preserve and improve the heart and brain functions in humans. Repeated intermittent-hypoxia induces cyclic, brief, and moderate decreases in blood oxygen concentration, and increases heart rate and breathing rate. We have found that IH conditioning is a safe, novel, and effective way to improve heart function and to optimize oxygen delivery to the brain. We believe this IH intervention is beneficial for older adults, especially those who cannot participate in regular physical activities because of the limitations associated with age-related declining physical or mental functions. Moreover, repeated low-dose intermittent-hypoxia can promote and mobilize the growth factors for healthy nerve system and blood vessel. These physiological and neurobiological reactions and adaptations to IH conditioning may have multi-faceted influences on prevention and treatment for mild Alzheimer’s disease and cognitive impairment associated with aging.
Education/Academic qualification
MA in Exercise Science, Shanghai Institute of Physical Education
BA in Physical Education, Shanghai Teachers University
PhD in Physiology, Yale University
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Projects
- 5 Finished
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Intermittent Hypoxia - Novel Intervention for Treatment of Mild Cognitive Impairment
Texas A&M Health Science Center
1/10/15 → 30/07/18
Project: Research
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Intermittent Hypoxia as a Therapy for Cognitive Loss in Aging: A Proof-of-Concept Pilot Study
1/09/15 → 31/08/16
Project: Research
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Wrist-Based Non-Invasive Wearable Sensors for Continuous Blood Pressure Monitoring using Pulse Transit Time
1/05/13 → 30/04/14
Project: Research
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Cranial Osteopathy and Cerebral Tissue Oxygenation
American Osteopathic Association
1/09/09 → 30/08/10
Project: Research
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Determinants of student’s physical activity: a 12-month follow-up study in Ningxia province
Huang, W., Shi, X., Wang, Y., Li, X., Gao, P., Lu, J. & Zhuang, J., Dec 2021, In: BMC Public Health. 21, 1, 512.Research output: Contribution to journal › Article › peer-review
Open Access -
Intermittent Hypoxic Preconditioning: A Potential New Powerful Strategy for COVID-19 Rehabilitation
Cai, M., Chen, X., Shan, J., Yang, R., Guo, Q., Bi, X., Xu, P., Shi, X., Chu, L. & Wang, L., 30 Apr 2021, In: Frontiers in Pharmacology. 12, 643619.Research output: Contribution to journal › Review article › peer-review
Open Access -
Intermittent Hypoxia Training for Treating Mild Cognitive Impairment: A Pilot Study
Wang, H., Shi, X., Schenck, H., Hall, J. R., Ross, S. E., Kline, G. P., Chen, S., Mallet, R. T. & Chen, P., 2020, In: American journal of Alzheimer's disease and other dementias. 35Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Reduced cerebrovascular and cardioventilatory responses to intermittent hypoxia in elderly
Liu, X., Chen, X., Kline, G., Ross, S. E., Hall, J. R., Ding, Y., Mallet, R. T. & Shi, X., Jan 2020, In: Respiratory Physiology and Neurobiology. 271, 103306.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Wuqinxi exercise improves hand dexterity in patients with Parkinson’s disease
Wang, T., Xiao, G., Li, Z., Jie, K., Shen, M., Jiang, Y., Wang, Z., Shi, X. & Zhuang, J., 2020, In: Evidence-based Complementary and Alternative Medicine. 2020, 8352176.Research output: Contribution to journal › Article › peer-review
Open Access