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Research Output 1985 2019

  • 2052 Citations
  • 24 h-Index
  • 53 Article
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Article
2019
1 Citation (Scopus)

In Vivo Efficacy of Novel Monobactam LYS228 in Murine Models of Carbapenemase-Producing Klebsiella pneumoniae Infection

Weiss, W., Pulse, M. E., Nguyen, P. & Growcott, E. J., 1 Apr 2019, In : Antimicrobial agents and chemotherapy. 63, 4, e02214-18.

Research output: Contribution to journalArticle

Klebsiella Infections
Monobactams
Carbapenems
Klebsiella pneumoniae
Uranyl Nitrate
1 Citation (Scopus)

Pharmacological, toxicological, and dose range assessment of OG716, a novel lantibiotic for the treatment of clostridium difficile-associated infection

Pulse, M. E., Weiss, W. J., Kers, J. A., DeFusco, A. W., Park, J. H. & Handfield, M., Apr 2019, In : Antimicrobial agents and chemotherapy. 63, 4, e01904-18.

Research output: Contribution to journalArticle

Bacteriocins
Clostridium difficile
Toxicology
Pharmacology
Mesocricetus
1 Citation (Scopus)

Treatment and prevention of recurrent Clostridium difficile infection with functionalized bovine antibody-enriched whey in a hamster primary infection model

Heidebrecht, H. J., Weiss, W. J., Pulse, M., Lange, A., Gisch, K., Kliem, H., Mann, S., Pfaffl, M. W., Kulozik, U. & von Eichel-Streiber, C., Feb 2019, In : Toxins. 11, 2, 98.

Research output: Contribution to journalArticle

Open Access
Clostridium Infections
Clostridium
Clostridium difficile
Cricetinae
Antibodies
2018
7 Citations (Scopus)

Activity of meropenem-vaborbactam against carbapenem- resistant enterobacteriaceae in a murine model of pyelonephritis

Weiss, W., Pulse, M. E., Nguyen, P., Peterson, K., Silva, J., Simecka, J., Valtierra, D., Sabet, M. & Griffith, D. C., 1 Jan 2018, In : Antimicrobial agents and chemotherapy. 62, 1, e01439.

Research output: Contribution to journalArticle

meropenem
Carbapenems
Pyelonephritis
Enterobacteriaceae
Klebsiella pneumoniae
3 Citations (Scopus)

Antibiotic-induced dysbiosis predicts mortality in an animal model of clostridium difficile infection

Burdet, C., Sayah-Jeanne, S., Nguyen, T. T., Hugon, P., Sablier-Gallis, F., Saint-Lu, N., Corbel, T., Ferreira, S., Pulse, M., Weiss, W., Andremont, A., Mentré, F. & De Gunzburg, J., Oct 2018, In : Antimicrobial agents and chemotherapy. 62, 10, e00925.

Research output: Contribution to journalArticle

Dysbiosis
Clostridium Infections
Clostridium difficile
Animal Models
Anti-Bacterial Agents
11 Citations (Scopus)

Mutacin 1140 lantibiotic variants are efficacious against Clostridium difficile infection

Kers, J. A., Sharp, R. E., Defusco, A. W., Park, J. H., Xu, J., Pulse, M. E., Weiss, W. J. & Handfield, M., 16 Mar 2018, In : Frontiers in Microbiology. 9, MAR, 415.

Research output: Contribution to journalArticle

Clostridium Infections
Bacteriocins
Clostridium difficile
Half-Life
Pharmacology
7 Citations (Scopus)

OG716: Designing a fit-for-purpose lantibiotic for the treatment of Clostridium difficile infections

Kers, J. A., DeFusco, A. W., Park, J. H., Xu, J., Pulse, M. E., Weiss, W. J. & Handfield, M., Jun 2018, In : PLoS ONE. 13, 6, e0197467.

Research output: Contribution to journalArticle

Clostridium Infections
Clostridium difficile
Clostridium
Bacteriocins
bacteriocins
2017
56 Citations (Scopus)

Can ceftazidime-avibactam and aztreonam overcome β-lactam resistance conferred by metallo-β-lactamases in Enterobacteriaceae?

Marshall, S., Hujer, A. M., Rojas, L. J., Papp-Wallace, K. M., Humphries, R. M., Spellberg, B., Hujer, K. M., Marshall, E. K., Rudin, S. D., Perez, F., Wilson, B. M., Wasserman, R. B., Chikowski, L., Paterson, D. L., Vila, A. J., Van Duin, D., Kreiswirth, B. N., Chambers, H. F., Fowler, V. G., Jacobs, M. R. & 3 others, Pulse, M. E., Weiss, W. J. & Bonomo, R. A., Apr 2017, In : Antimicrobial agents and chemotherapy. 61, 4, e02243-16.

Research output: Contribution to journalArticle

Aztreonam
Lactams
Enterobacteriaceae
Thigh
Infection
7 Citations (Scopus)

Fluorocycline TP-271 is potent against complicated community-acquired bacterial pneumonia pathogens

Grossman, T. H., Fyfe, C., O'Brien, W., Hackel, M., Minyard, M. B., Waites, K. B., Dubois, J., Murphy, T. M., Slee, A. M., Weiss, W. J. & Sutcliffe, J. A., 1 Jan 2017, In : mSphere. 2, 1, e00004-17.

Research output: Contribution to journalArticle

Bacterial Pneumonia
Methicillin-Resistant Staphylococcus aureus
Haemophilus influenzae
Streptococcus pneumoniae
Haemophilus Infections
3 Citations (Scopus)

Protection of hamsters from mortality by reducing fecal moxifloxacin concentration with DAV131A in a model of moxifloxacin-induced Clostridium difficile colitis

Burdet, C., Sayah-Jeanne, S., Nguyen, T. T., Miossec, C., Saint-Lu, N., Pulse, M., Weiss, W., Andremont, A., Mentré, F. & De Gunzburg, J., 1 Jan 2017, In : Antimicrobial agents and chemotherapy. 61, 10

Research output: Contribution to journalArticle

Clostridium difficile
Colitis
Cricetinae
Mortality
Clostridium Infections
13 Citations (Scopus)

Targeting alpha toxin to mitigate its lethal toxicity in ferret and rabbit models of Staphylococcus aureus necrotizing pneumonia

Diep, B. A., Hilliard, J. J., Le, V. T. M., Tkaczyk, C., Le, H. N., Tran, V. G., Rao, R. L., Dip, E. C., Pereira-Franchi, E. P., Cha, P., Jacobson, S., Broome, R., Cheng, L. I., Weiss, W., Prokai, L., Nguyen, V., Stover, C. K. & Sellman, B. R., 1 Apr 2017, In : Antimicrobial agents and chemotherapy. 61, 4, 02456-16.

Research output: Contribution to journalArticle

Staphylococcal Pneumonia
Ferrets
Rabbits
Linezolid
Passive Immunization
2016
13 Citations (Scopus)

Antibacterial activity of the novel semisynthetic lantibiotic NVB333 in vitro and in experimental infection models

Boakes, S., Weiss, W., Vinson, M., Wadman, S. & Dawson, M. J., 1 Dec 2016, In : Journal of Antibiotics. 69, 12, p. 850-857 8 p.

Research output: Contribution to journalArticle

Bacteriocins
Methicillin-Resistant Staphylococcus aureus
Theoretical Models
Area Under Curve
Vancomycin
15 Citations (Scopus)

Critical role of alpha-toxin and protective effects of its neutralization by a human antibody in acute bacterial skin and skin structure infections

Le, V. T. M., Tkaczyk, C., Chau, S., Rao, R. L., Dip, E. C., Pereira-Franchi, E. P., Cheng, L., Lee, S., Koelkebeck, H., Hilliard, J. J., Yu, X. Q., Datta, V., Nguyen, V., Weiss, W., Prokai, L., O'Day, T., Stover, C. K., Sellman, B. R. & Diep, B. A., 1 Oct 2016, In : Antimicrobial agents and chemotherapy. 60, 10, p. 5640-5648 9 p.

Research output: Contribution to journalArticle

Skin
Antibodies
Infection
Linezolid
Methicillin-Resistant Staphylococcus aureus
2015
30 Citations (Scopus)

Anti-alpha-toxin monoclonal antibody and antibiotic combination therapy improves disease outcome and accelerates healing in a staphylococcus aureus dermonecrosis model

Hilliard, J. J., Datta, V., Tkaczyk, C., Hamilton, M., Sadowska, A., Jones-Nelson, O., O'Day, T., Weiss, W., Szarka, S., Nguyen, V., Prokai, L., Suzich, J. A., Stover, C. K. & Sellmana, B. R., 1 Jan 2015, In : Antimicrobial agents and chemotherapy. 59, 1, p. 299-308 10 p.

Research output: Contribution to journalArticle

Linezolid
Staphylococcus aureus
Vancomycin
Monoclonal Antibodies
Anti-Bacterial Agents
2014
21 Citations (Scopus)

In vivo assessment of smt 19969 in a hamster model of clostridium difficile infection

Weiss, W., Pulse, M. & Vickers, R., 1 Oct 2014, In : Antimicrobial agents and chemotherapy. 58, 10, p. 5714-5718 5 p.

Research output: Contribution to journalArticle

Clostridium Infections
Clostridium difficile
Cricetinae
Vancomycin
Recurrence
2013
23 Citations (Scopus)

Perturbation of Staphylococcus aureus gene expression by the enoyl-acyl carrier protein reductase inhibitor AFN-1252

Parsons, J. B., Kukula, M., Jackson, P., Pulse, M., Simecka, J., Valtierra, D., Weiss, W., Kaplan, N. & Rock, C. O., 1 May 2013, In : Antimicrobial agents and chemotherapy. 57, 5, p. 2182-2190 9 p.

Research output: Contribution to journalArticle

Acyl Carrier Protein
Staphylococcus aureus
Oxidoreductases
Gene Expression
Virulence Factors
14 Citations (Scopus)

Tissue penetration and antimicrobial activity of standard- and high-dose trimethoprim/sulfamethoxazole and linezolid in patients with diabetic foot infection

Stein, G. E., Throckmorton, J. K., Scharmen, A. E., Weiss, W. J., Prokai, L., Smith, C. L. & Havlichek, D. H., 1 Dec 2013, In : Journal of Antimicrobial Chemotherapy. 68, 12, p. 2852-2858 7 p., dkt267.

Research output: Contribution to journalArticle

Linezolid
Diabetic Foot
Sulfamethoxazole Drug Combination Trimethoprim
Infection
Streptococcus
2011
65 Citations (Scopus)

Evaluation of ceftazidime and NXL104 in two murine models of infection due to KPC-producing Klebsiella pneumoniae

Endimiani, A., Hujer, K. M., Hujer, A. M., Pulse, M. E., Weiss, W. J. & Bonomo, R. A., 1 Jan 2011, In : Antimicrobial agents and chemotherapy. 55, 1, p. 82-85 4 p.

Research output: Contribution to journalArticle

Ceftazidime
Klebsiella pneumoniae
Infection
Thigh
Intraperitoneal Injections
38 Citations (Scopus)

Small molecule inhibitors of staphylococcus aureus RnpA alter cellular mRNA turnover, exhibit antimicrobial activity, and attenuate pathogenesis

Olson, P. D., Kuechenmeister, L. J., Anderson, K. L., Daily, S., Beenken, K. E., Roux, C. M., Reniere, M. L., Lewis, T. L., Weiss, W. J., Pulse, M., Nguyen, P., Simecka, J. W., Morrison, J. M., Sayood, K., Asojo, O. A., Smeltzer, M. S., Skaar, E. P. & Dunman, P. M., 1 Feb 2011, In : PLoS Pathogens. 7, 2, e1001287.

Research output: Contribution to journalArticle

RNA Stability
Staphylococcus aureus
Messenger RNA
Vancomycin
Methicillin-Resistant Staphylococcus aureus
2008
47 Citations (Scopus)

5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of β-lactamases

Venkatesan, A. M., Agarwal, A., Abe, T., Ushirogochi, H., Ado, M., Tsuyoshi, T., Dos Santos, O., Li, Z., Francisco, G., Lin, Y. I., Petersen, P. J., Yang, Y., Weiss, W. J., Shlaes, D. M. & Mansour, T. S., 15 Feb 2008, In : Bioorganic and Medicinal Chemistry. 16, 4, p. 1890-1902 13 p.

Research output: Contribution to journalArticle

Bearings (structural)
meropenem
Bacteria
Transmission electron microscopy
Sulbactam
16 Citations (Scopus)
Electrospray ionization
Levofloxacin
Electrospray Ionization Mass Spectrometry
Catheters
Liquid chromatography
2006
36 Citations (Scopus)

Structure-activity relationship of 6-methylidene penems bearing 6,5 bicyclic heterocycles as broad-spectrum β-lactamase inhibitors: Evidence for 1,4-thiazepine intermediates with C7 R stereochemistry by computational methods

Venkatesan, A. M., Agarwal, A., Abe, T., Ushirogochi, H., Yamamura, I., Ado, M., Tsuyoshi, T., Dos Santos, O., Gu, Y., Sum, F. W., Li, Z., Francisco, G., Lin, Y. I., Petersen, P. J., Yang, Y., Kumagai, T., Weiss, W. J., Shlaes, D. M., Knox, J. R. & Mansour, T. S., 27 Jul 2006, In : Journal of Medicinal Chemistry. 49, 15, p. 4623-4637 15 p.

Research output: Contribution to journalArticle

Thiazepines
Structure-Activity Relationship
Thiophenes
Piperacillin
Enzymes
2004
72 Citations (Scopus)

Effect of srtA and srtB gene expression on the virulence of Staphylococcus aureus in animal models of infection

Weiss, W. J., Lenoy, E., Murphy, T., Tardio, L. A., Burgio, P., Projan, S. J., Schneewind, O. & Alksne, L., 1 Mar 2004, In : Journal of Antimicrobial Chemotherapy. 53, 3, p. 480-486 7 p.

Research output: Contribution to journalArticle

Virulence
Staphylococcus aureus
Animal Models
Gene Expression
Arthritis
32 Citations (Scopus)

Hydrophobic acetal and ketal derivatives of mannopeptimycin-α and desmethylhexahydromannopeptimycin-α: Semisynthetic glycopeptides with potent activity against Gram-positive bacteria

Dushin, R. G., Wang, T. Z., Sum, P. E., He, H., Sutherland, A. G., Ashcroft, J. S., Graziani, E. I., Koehn, F. E., Bradford, P. A., Petersen, P. J., Wheless, K. L., How, D., Torres, N., Lenoy, E. B., Weiss, W. J., Lang, S. A., Projan, S. J., Shlaes, D. M. & Mansour, T. S., 1 Jul 2004, In : Journal of Medicinal Chemistry. 47, 14, p. 3487-3490 4 p.

Research output: Contribution to journalArticle

Acetals
Glycopeptides
Disaccharides
Gram-Positive Bacteria
Mannose
40 Citations (Scopus)

In vitro and in vivo activities of novel 6-methylidene penems as β-lactamase inhibitors

Weiss, W., Petersen, P. J., Murphy, T. M., Tardio, L. A., Yang, Y., Bradford, P. A., Venkatesan, A. M., Abe, T., Isoda, T., Mihira, A., Ushirogochi, H., Takasake, T., Projan, S., O'Connell, J. & Mansour, T. S., 1 Dec 2004, In : Antimicrobial agents and chemotherapy. 48, 12, p. 4589-4596 8 p.

Research output: Contribution to journalArticle

Piperacillin
meropenem
Enzymes
Citrobacter
Serratia
21 Citations (Scopus)

In Vivo Efficacy and Pharmacokinetics of AC98-6446, a Novel Cyclic Glycopeptide, in Experimental Infection Models

Weiss, W., Murphy, T., Lenoy, E. & Young, M., 1 May 2004, In : Antimicrobial agents and chemotherapy. 48, 5, p. 1708-1712 5 p.

Research output: Contribution to journalArticle

Glycopeptides
Theoretical Models
Pharmacokinetics
Vancomycin
Thigh
25 Citations (Scopus)

Mannopeptimycin esters and carbonates, potent antibiotic agents against drug-resistant bacteria

He, H., Shen, B., Petersen, P. J., Weiss, W., Yang, H. Y., Wang, T. Z., Dushin, R. G., Koehn, F. E. & Carter, G. T., 5 Jan 2004, In : Bioorganic and Medicinal Chemistry Letters. 14, 1, p. 279-282 4 p.

Research output: Contribution to journalArticle

Methicillin Resistance
Methicillin
Carbonates
Vancomycin
Staphylococcus
36 Citations (Scopus)

Novel imidazole substituted 6-methylidene-penems as broad-spectrum β-lactamase inhibitors

Venkatesan, A. M., Agarwal, A., Abe, T., Ushirogochi, H., Yamamura, I., Kumagai, T., Petersen, P. J., Weiss, W., Lenoy, E., Yang, Y., Shlaes, D. M., Ryan, J. L. & Mansour, T. S., 15 Nov 2004, In : Bioorganic and Medicinal Chemistry. 12, 22, p. 5807-5817 11 p.

Research output: Contribution to journalArticle

Lactams
Bacteria
Anti-Bacterial Agents
Enzymes
meropenem
74 Citations (Scopus)

Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum β-lactamase inhibitors: Crystallographic structures show unexpected binding of 1,4-thiazepine intermediates

Venkatesan, A. M., Gu, Y., Santos, O. D., Abe, T., Agarwal, A., Yang, Y., Petersen, P. J., Weiss, W. J., Mansour, T. S., Nukaga, M., Hujer, A. M., Bonomo, R. A. & Knox, J. R., 16 Dec 2004, In : Journal of Medicinal Chemistry. 47, 26, p. 6556-6568 13 p.

Research output: Contribution to journalArticle

Thiazepines
Structure-Activity Relationship
Serine
R388
Piperacillin
2003
61 Citations (Scopus)

Activities of tigecycline (GAR-936) against Legionella pneumophila in vitro and in guinea pigs with L. pneumophila pneumonia

Edelstein, P. H., Weiss, W. & Edelstein, M. A. C., 1 Feb 2003, In : Antimicrobial agents and chemotherapy. 47, 2, p. 533-540 8 p.

Research output: Contribution to journalArticle

Legionella pneumophila
Pneumonia
Guinea Pigs
Azithromycin
Erythromycin
36 Citations (Scopus)

Inhalation efficacy of RFI-641 in an African green monkey model of RSV infection

Weiss, W., Murphy, T., Lynch, M. E., Frye, J., Buklan, A., Gray, B., Lenoy, E., Mitelman, S., O'Connell, J., Quartuccio, S. & Huntley, C., 1 Jan 2003, In : Journal of Medical Primatology. 32, 2, p. 82-88 7 p.

Research output: Contribution to journalArticle

Cercopithecus aethiops
Respiratory Syncytial Virus Infections
Inhalation
breathing
throat
78 Citations (Scopus)

Mannopeptimycins, new cyclic glycopeptide antibiotics produced by Streptomyces hygroscopicus LL-AC98: Antibacterial and mechanistic activities

Singh, M. P., Petersen, P. J., Weiss, W. J., Janso, J. E., Luckman, S. W., Lenoy, E. B., Bradford, P. A., Testa, R. T. & Greenstein, M., 1 Jan 2003, In : Antimicrobial agents and chemotherapy. 47, 1, p. 62-69 8 p.

Research output: Contribution to journalArticle

Glycopeptides
Streptomyces
Anti-Bacterial Agents
Disaccharides
Staphylococcus
21 Citations (Scopus)

Novel ether derivatives of mannopeptimycin glycopeptide antibiotic

Sum, P. E., How, D., Torres, N., Petersen, P. J., Lenoy, E. B., Weiss, W. & Mansour, T. S., 24 Mar 2003, In : Bioorganic and Medicinal Chemistry Letters. 13, 6, p. 1151-1155 5 p.

Research output: Contribution to journalArticle

Ether
Anti-Bacterial Agents
Derivatives
Acetals
Methicillin Resistance
36 Citations (Scopus)

Novel α-pyrones produced by a marine Pseudomonas sp. F92S91: Taxonomy and biological activities

Singh, M. P., Kong, F., Janso, J. E., Arias, D. A., Suarez, P. A., Bernan, V. S., Petersen, P. J., Weiss, W., Carter, G. & Greenstein, M., 1 Jan 2003, In : Journal of Antibiotics. 56, 12, p. 1033-1044 12 p.

Research output: Contribution to journalArticle

Pyrones
Pseudomonas
Triclosan
Cerulenin
Membranes
2002
146 Citations (Scopus)

In vitro and in vivo activities of tigecycline (GAR-936), daptomycin, and comparative antimicrobial agents against glycopeptide-intermediate Staphylococcus aureus and other resistant gram-positive pathogens

Petersen, P. J., Bradford, P. A., Weiss, W., Murphy, T. M., Sum, P. E. & Projan, S. J., 1 Aug 2002, In : Antimicrobial agents and chemotherapy. 46, 8, p. 2595-2601 7 p.

Research output: Contribution to journalArticle

Daptomycin
Glycopeptides
Anti-Infective Agents
Staphylococcus aureus
Calcium
66 Citations (Scopus)

RFI-641, a potent respiratory syncytial virus inhibitor

Huntley, C. C., Weiss, W. J., Gazumyan, A., Buklan, A., Feld, B., Hu, W., Jones, T. R., Murphy, T., Nikitenko, A. A., O'Hara, B., Prince, G., Quartuccio, S., Raifeld, Y. E., Wyde, P. & O'Connell, J. F., 28 Feb 2002, In : Antimicrobial agents and chemotherapy. 46, 3, p. 841-847 7 p.

Research output: Contribution to journalArticle

Respiratory Syncytial Viruses
Human respiratory syncytial virus
Sigmodontinae
Cercopithecus aethiops
Cell Fusion
2000
148 Citations (Scopus)

In vivo pharmacodynamic activities of two glycylcyclines (GAR-936 and WAY 152,288) against various gram-positive and gram-negative bacteria

Van Ogtrop, M. L., Andes, D., Stamstad, T. J., Conklin, B., Weiss, W. J., Craig, W. A. & Vesga, O., 1 Apr 2000, In : Antimicrobial agents and chemotherapy. 44, 4, p. 943-949 7 p.

Research output: Contribution to journalArticle

Gram-Negative Bacteria
Klebsiella pneumoniae
Streptococcus pneumoniae
Escherichia coli
Tetracycline
45 Citations (Scopus)

Saccharomicins, novel heptadecaglycoside antibiotics produced by Saccharothrix espanaensis: Antibacterial and mechanistic activities

Singh, M. P., Petersen, P. J., Weiss, W., Kong, F. & Greenstein, M., 7 Aug 2000, In : Antimicrobial Agents and Chemotherapy. 44, 8, p. 2154-2159 6 p.

Research output: Contribution to journalArticle

Staphylococcus aureus
Yeasts
Anti-Bacterial Agents
Actinobacteria
Lethal Dose 50
72 Citations (Scopus)

Therapeutic efficacy of GAR-936, a novel glycylcycline, in a rat model of experimental endocarditis

Murphy, T. M., Deitz, J. M., Petersen, P. J., Mikels, S. M. & Weiss, W. J., 9 Nov 2000, In : Antimicrobial agents and chemotherapy. 44, 11, p. 3022-3027 6 p.

Research output: Contribution to journalArticle

Endocarditis
Vancomycin
Theoretical Models
Enterococcus faecalis
Methicillin-Resistant Staphylococcus aureus
1999
16 Citations (Scopus)

In vitro activities of aminomethyl-substituted analogs of novel tetrahydrofuranyl carbapenems

Weiss, W. J., Petersen, P. J., Jacobus, N. V., Lin, Y. I., Bitha, P. & Testa, R. T., Mar 1999, In : Antimicrobial agents and chemotherapy. 43, 3, p. 454-459 6 p.

Research output: Contribution to journalArticle

biapenem
Carbapenems
meropenem
Imipenem
Methicillin
336 Citations (Scopus)

In vitro and in vivo antibacterial activities of a novel glycylcycline, the 9-t-butylglycylamido derivative of minocycline (GAR-936)

Petersen, P. J., Jacobus, N. V., Weiss, W. J., Sum, P. E. & Testa, R. T., 1 Apr 1999, In : Antimicrobial agents and chemotherapy. 43, 4, p. 738-744 7 p.

Research output: Contribution to journalArticle

Minocycline
Gram-Negative Aerobic Bacteria
Gram-Negative Anaerobic Bacteria
Tetracycline Resistance
Methicillin-Resistant Staphylococcus aureus
23 Citations (Scopus)

In vivo activities of peptidic prodrugs of novel aminomethyl tetrahydrofuranyl-1β-methylcarbapenems

Weiss, W., Mikels, S. M., Petersen, P. J., Jacobus, N. V., Bitha, P., Lin, Y. I. & Testa, R. T., 1 Mar 1999, In : Antimicrobial Agents and Chemotherapy. 43, 3, p. 460-464 5 p.

Research output: Contribution to journalArticle

Prodrugs
Oral Administration
Infection
Amino Acids
Carbapenems
1997
9 Citations (Scopus)

Mono and bis double ester prodrugs of novel aminomethyl-THF 1β-methylcarbapenems

Lin, Y. I., Bitha, P., Li, Z., Sakya, S. M., Strohmeyer, T. W., Lang, S. A., Yang, Y., Bhachech, N., Weiss, W. J., Petersen, P. J., Jacobus, N. V., Bush, K. & Testa, R. T., 22 Jul 1997, In : Bioorganic and Medicinal Chemistry Letters. 7, 14, p. 1811-1816 6 p.

Research output: Contribution to journalArticle

Prodrugs
Esters
Derivatives
1 beta-methylcarbapenem
14 Citations (Scopus)

Peptidic prodrugs of novel aminomethyl-THF 1β-methylcarbapenems

Lin, Y. I., Bitha, P., Sakya, S. M., Li, Z., Lang, S. A., Yang, Y., Bhachech, N., Weiss, W. J., Petersen, P. J., Jacobus, N. V., Bush, K. & Testa, R. T., 8 Jul 1997, In : Bioorganic and Medicinal Chemistry Letters. 7, 13, p. 1665-1670 6 p.

Research output: Contribution to journalArticle

Prodrugs
Derivatives
Amino Acids
Dipeptides
1 beta-methylcarbapenem
5 Citations (Scopus)

Synthesis and structure-activity relationship of novel THF 1β-methylcarbapenems II

Lin, Y. I., Bitha, P., Sakya, S. M., Lang, S. A., Yang, Y., Weiss, W., Petersen, P. J., Bush, K. & Testa, R. T., 2 Dec 1997, In : Bioorganic and Medicinal Chemistry Letters. 7, 23, p. 3063-3068 6 p.

Research output: Contribution to journalArticle

Structure-Activity Relationship
Derivatives
1 beta-methylcarbapenem
18 Citations (Scopus)

Synthesis and structure-activity relationships of novel THF 1β- methylcarbapenems

Lin, Y. I., Bitha, P., Sakya, S. M., Strohmeyer, T. W., Li, Z., Lee, V. J., Lang, S. A., Yang, Y., Bhachech, N., Weiss, W. J., Petersen, P. J., Jacobus, N. V., Bush, K., Testa, R. T. & Tally, F. P., 8 Jul 1997, In : Bioorganic and Medicinal Chemistry Letters. 7, 13, p. 1671-1676 6 p.

Research output: Contribution to journalArticle

meropenem
Escherichia coli Infections
Carbapenems
Imipenem
Structure-Activity Relationship
1995
24 Citations (Scopus)

Susceptibility of enterococci, methicillin-resistant staphylococcus aureus and streptococcus pneumoniae to the glycylcyclines

Weiss, W., Jacobus, N. V., Petersen, P. J. & Testa, R. T., 1 Jul 1995, In : Journal of Antimicrobial Chemotherapy. 36, 1, p. 225-230 6 p.

Research output: Contribution to journalArticle

Staphylococcal Pneumonia
Enterococcus
Methicillin-Resistant Staphylococcus aureus
Streptococcus pneumoniae
Teicoplanin
1991
74 Citations (Scopus)

In vitro and in vivo activities of LJC10,627, a new carbapenem with stability to dehydropeptidase I

Petersen, P. J., Jacobus, N. V., Weiss, W. & Testa, R. T., 1 Jan 1991, In : Antimicrobial Agents and Chemotherapy. 35, 1, p. 203-207 5 p.

Research output: Contribution to journalArticle

dipeptidase 1
biapenem
Carbapenems
Imipenem
Staphylococcal Infections
1989
81 Citations (Scopus)

Comparative in vitro and in vivo activities of piperacillin combined with the β-lactamase inhibitors tazobactam, clavulanic acid, and sulbactam

Kuck, N. A., Jacobus, N. V., Petersen, P. J., Weiss, W. & Testa, R. T., 1 Jan 1989, In : Antimicrobial Agents and Chemotherapy. 33, 11, p. 1964-1969 6 p.

Research output: Contribution to journalArticle

Sulbactam
Clavulanic Acid
Piperacillin
Morganella
Klebsiella pneumoniae
8 Citations (Scopus)

In vitro and in vivo efficacy of YTR-803H and piperacillin combinations versus β-lactamase-producing bacteria

Kuck, N. A., Petersen, P. J., Weiss, W. & Testa, R. T., 1 Jan 1989, In : Journal of Chemotherapy. 1, 3, p. 155-161 7 p.

Research output: Contribution to journalArticle

Clavulanic Acids
Penicillanic Acid
Penicillin Resistance
Cefoxitin
Piperacillin