• 2146 Citations
  • 25 h-Index
1985 …2020

Research output per year

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Research Output

  • 2146 Citations
  • 25 h-Index
  • 57 Article
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Article
2020

C1-CBP-vancomycin: Impact of a Vancomycin C-Terminus Trimethylammonium Cation on Pharmacological Properties and Insights into Its Newly Introduced Mechanism of Action

Wu, Z. C., Isley, N. A., Okano, A., Weiss, W. J. & Boger, D. L., 7 Feb 2020, In : Journal of Organic Chemistry. 85, 3, p. 1365-1375 11 p.

Research output: Contribution to journalArticle

DAV131A Protects Hamsters from Lethal Clostridioides difficile Infection Induced by Fluoroquinolones

Saint-Lu, N., Burdet, C., Sablier-Gallis, F., Corbel, T., Nevière, A., Sayah-Jeanne, S., Pulse, M., Weiss, W., Ferreira, S., Andremont, A., Mentré, F. & de Gunzburg, J., 1 Jan 2020, In : Antimicrobial agents and chemotherapy. 64, 1, e01196-19.

Research output: Contribution to journalArticle

1 Scopus citations

Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- And Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections

Liu, B., Trout, R. E. L., Chu, G. H., Mcgarry, D., Jackson, R. W., Hamrick, J. C., Daigle, D. M., Cusick, S. M., Pozzi, C., De Luca, F., Benvenuti, M., Mangani, S., Docquier, J. D., Weiss, W. J., Pevear, D. C., Xerri, L. & Burns, C. J., 26 Mar 2020, In : Journal of Medicinal Chemistry. 63, 6, p. 2789-2801 13 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations
2019

In Vivo Efficacy of Novel Monobactam LYS228 in Murine Models of Carbapenemase-Producing Klebsiella pneumoniae Infection

Weiss, W. J., Pulse, M. E., Nguyen, P. & Growcott, E. J., Apr 2019, In : Antimicrobial agents and chemotherapy. 63, 4, e02214-18.

Research output: Contribution to journalArticle

1 Scopus citations

Liposomal mupirocin holds promise for systemic treatment of invasive Staphylococcus aureus infections

Goldmann, O., Cern, A., Muesken, M., Rohde, M., Weiss, W., Barenholz, Y. & Medina, E., 28 Dec 2019, In : Journal of Controlled Release. 316, p. 292-301 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Pharmacological, toxicological, and dose range assessment of OG716, a novel lantibiotic for the treatment of clostridium difficile-associated infection

Pulse, M. E., Weiss, W. J., Kers, J. A., DeFusco, A. W., Park, J. H. & Handfield, M., Apr 2019, In : Antimicrobial agents and chemotherapy. 63, 4, e01904-18.

Research output: Contribution to journalArticle

2 Scopus citations

Treatment and prevention of recurrent Clostridium difficile infection with functionalized bovine antibody-enriched whey in a hamster primary infection model

Heidebrecht, H. J., Weiss, W. J., Pulse, M., Lange, A., Gisch, K., Kliem, H., Mann, S., Pfaffl, M. W., Kulozik, U. & von Eichel-Streiber, C., Feb 2019, In : Toxins. 11, 2, 98.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2018

Activity of meropenem-vaborbactam against carbapenem- resistant enterobacteriaceae in a murine model of pyelonephritis

Weiss, W. J., Pulse, M. E., Nguyen, P., Peterson, K., Silva, J., Simecka, J. W., Valtierra, D., Sabet, M. & Griffith, D. C., Jan 2018, In : Antimicrobial agents and chemotherapy. 62, 1, e01439.

Research output: Contribution to journalArticle

8 Scopus citations

Antibiotic-induced dysbiosis predicts mortality in an animal model of clostridium difficile infection

Burdet, C., Sayah-Jeanne, S., Nguyen, T. T., Hugon, P., Sablier-Gallis, F., Saint-Lu, N., Corbel, T., Ferreira, S., Pulse, M., Weiss, W., Andremont, A., Mentré, F. & De Gunzburg, J., Oct 2018, In : Antimicrobial agents and chemotherapy. 62, 10, e00925.

Research output: Contribution to journalArticle

5 Scopus citations

Mutacin 1140 lantibiotic variants are efficacious against Clostridium difficile infection

Kers, J. A., Sharp, R. E., Defusco, A. W., Park, J. H., Xu, J., Pulse, M. E., Weiss, W. J. & Handfield, M., 16 Mar 2018, In : Frontiers in Microbiology. 9, MAR, 415.

Research output: Contribution to journalArticle

14 Scopus citations

OG716: Designing a fit-for-purpose lantibiotic for the treatment of Clostridium difficile infections

Kers, J. A., DeFusco, A. W., Park, J. H., Xu, J., Pulse, M. E., Weiss, W. J. & Handfield, M., Jun 2018, In : PLoS ONE. 13, 6, e0197467.

Research output: Contribution to journalArticle

8 Scopus citations
2017

Can ceftazidime-avibactam and aztreonam overcome β-lactam resistance conferred by metallo-β-lactamases in Enterobacteriaceae?

Marshall, S., Hujer, A. M., Rojas, L. J., Papp-Wallace, K. M., Humphries, R. M., Spellberg, B., Hujer, K. M., Marshall, E. K., Rudin, S. D., Perez, F., Wilson, B. M., Wasserman, R. B., Chikowski, L., Paterson, D. L., Vila, A. J., Van Duin, D., Kreiswirth, B. N., Chambers, H. F., Fowler, V. G., Jacobs, M. R. & 3 others, Pulse, M. E., Weiss, W. J. & Bonomo, R. A., Apr 2017, In : Antimicrobial agents and chemotherapy. 61, 4, e02243-16.

Research output: Contribution to journalArticle

76 Scopus citations

Fluorocycline TP-271 is potent against complicated community-acquired bacterial pneumonia pathogens

Grossman, T. H., Fyfe, C., O'Brien, W., Hackel, M., Minyard, M. B., Waites, K. B., Dubois, J., Murphy, T. M., Slee, A. M., Weiss, W. J. & Sutcliffe, J. A., 1 Jan 2017, In : mSphere. 2, 1, e00004-17.

Research output: Contribution to journalArticle

9 Scopus citations

Protection of hamsters from mortality by reducing fecal moxifloxacin concentration with DAV131A in a model of moxifloxacin-induced Clostridium difficile colitis

Burdet, C., Sayah-Jeanne, S., Nguyen, T. T., Miossec, C., Saint-Lu, N., Pulse, M., Weiss, W., Andremont, A., Mentré, F. & De Gunzburg, J., 1 Jan 2017, In : Antimicrobial agents and chemotherapy. 61, 10

Research output: Contribution to journalArticle

5 Scopus citations

Targeting alpha toxin to mitigate its lethal toxicity in ferret and rabbit models of Staphylococcus aureus necrotizing pneumonia

Diep, B. A., Hilliard, J. J., Le, V. T. M., Tkaczyk, C., Le, H. N., Tran, V. G., Rao, R. L., Dip, E. C., Pereira-Franchi, E. P., Cha, P., Jacobson, S., Broome, R., Cheng, L. I., Weiss, W., Prokai, L., Nguyen, V., Stover, C. K. & Sellman, B. R., Apr 2017, In : Antimicrobial agents and chemotherapy. 61, 4, 02456-16.

Research output: Contribution to journalArticle

17 Scopus citations
2016

Antibacterial activity of the novel semisynthetic lantibiotic NVB333 in vitro and in experimental infection models

Boakes, S., Weiss, W., Vinson, M., Wadman, S. & Dawson, M. J., 1 Dec 2016, In : Journal of Antibiotics. 69, 12, p. 850-857 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Critical role of alpha-toxin and protective effects of its neutralization by a human antibody in acute bacterial skin and skin structure infections

Le, V. T. M., Tkaczyk, C., Chau, S., Rao, R. L., Dip, E. C., Pereira-Franchi, E. P., Cheng, L., Lee, S., Koelkebeck, H., Hilliard, J. J., Yu, X. Q., Datta, V., Nguyen, V., Weiss, W., Prokai, L., O'Day, T., Stover, C. K., Sellman, B. R. & Diep, B. A., 1 Oct 2016, In : Antimicrobial agents and chemotherapy. 60, 10, p. 5640-5648 9 p.

Research output: Contribution to journalArticle

17 Scopus citations
2015

Anti-alpha-toxin monoclonal antibody and antibiotic combination therapy improves disease outcome and accelerates healing in a staphylococcus aureus dermonecrosis model

Hilliard, J. J., Datta, V., Tkaczyk, C., Hamilton, M., Sadowska, A., Jones-Nelson, O., O'Day, T., Weiss, W. J., Szarka, S., Nguyen, V., Prokai, L., Suzich, J. A., Stover, C. K. & Sellmana, B. R., 1 Jan 2015, In : Antimicrobial agents and chemotherapy. 59, 1, p. 299-308 10 p.

Research output: Contribution to journalArticle

33 Scopus citations
2014

In vivo assessment of smt 19969 in a hamster model of clostridium difficile infection

Weiss, W., Pulse, M. & Vickers, R., 1 Oct 2014, In : Antimicrobial agents and chemotherapy. 58, 10, p. 5714-5718 5 p.

Research output: Contribution to journalArticle

22 Scopus citations
2013

Perturbation of Staphylococcus aureus gene expression by the enoyl-acyl carrier protein reductase inhibitor AFN-1252

Parsons, J. B., Kukula, M., Jackson, P., Pulse, M., Simecka, J., Valtierra, D., Weiss, W., Kaplan, N. & Rock, C. O., 1 May 2013, In : Antimicrobial agents and chemotherapy. 57, 5, p. 2182-2190 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Tissue penetration and antimicrobial activity of standard- and high-dose trimethoprim/sulfamethoxazole and linezolid in patients with diabetic foot infection

Stein, G. E., Throckmorton, J. K., Scharmen, A. E., Weiss, W. J., Prokai, L., Smith, C. L. & Havlichek, D. H., 1 Dec 2013, In : Journal of Antimicrobial Chemotherapy. 68, 12, p. 2852-2858 7 p., dkt267.

Research output: Contribution to journalArticle

14 Scopus citations
2011

Evaluation of ceftazidime and NXL104 in two murine models of infection due to KPC-producing Klebsiella pneumoniae

Endimiani, A., Hujer, K. M., Hujer, A. M., Pulse, M. E., Weiss, W. J. & Bonomo, R. A., 1 Jan 2011, In : Antimicrobial agents and chemotherapy. 55, 1, p. 82-85 4 p.

Research output: Contribution to journalArticle

67 Scopus citations

Small molecule inhibitors of staphylococcus aureus RnpA alter cellular mRNA turnover, exhibit antimicrobial activity, and attenuate pathogenesis

Olson, P. D., Kuechenmeister, L. J., Anderson, K. L., Daily, S., Beenken, K. E., Roux, C. M., Reniere, M. L., Lewis, T. L., Weiss, W. J., Pulse, M., Nguyen, P., Simecka, J. W., Morrison, J. M., Sayood, K., Asojo, O. A., Smeltzer, M. S., Skaar, E. P. & Dunman, P. M., 1 Feb 2011, In : PLoS Pathogens. 7, 2, e1001287.

Research output: Contribution to journalArticle

41 Scopus citations
2008

5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of β-lactamases

Venkatesan, A. M., Agarwal, A., Abe, T., Ushirogochi, H., Ado, M., Tsuyoshi, T., Dos Santos, O., Li, Z., Francisco, G., Lin, Y. I., Petersen, P. J., Yang, Y., Weiss, W. J., Shlaes, D. M. & Mansour, T. S., 15 Feb 2008, In : Bioorganic and Medicinal Chemistry. 16, 4, p. 1890-1902 13 p.

Research output: Contribution to journalArticle

50 Scopus citations
16 Scopus citations
2006

Structure-activity relationship of 6-methylidene penems bearing 6,5 bicyclic heterocycles as broad-spectrum β-lactamase inhibitors: Evidence for 1,4-thiazepine intermediates with C7 R stereochemistry by computational methods

Venkatesan, A. M., Agarwal, A., Abe, T., Ushirogochi, H., Yamamura, I., Ado, M., Tsuyoshi, T., Dos Santos, O., Gu, Y., Sum, F. W., Li, Z., Francisco, G., Lin, Y. I., Petersen, P. J., Yang, Y., Kumagai, T., Weiss, W. J., Shlaes, D. M., Knox, J. R. & Mansour, T. S., 27 Jul 2006, In : Journal of Medicinal Chemistry. 49, 15, p. 4623-4637 15 p.

Research output: Contribution to journalArticle

37 Scopus citations
2004

Effect of srtA and srtB gene expression on the virulence of Staphylococcus aureus in animal models of infection

Weiss, W. J., Lenoy, E., Murphy, T., Tardio, L. A., Burgio, P., Projan, S. J., Schneewind, O. & Alksne, L., 1 Mar 2004, In : Journal of Antimicrobial Chemotherapy. 53, 3, p. 480-486 7 p.

Research output: Contribution to journalArticle

76 Scopus citations

Hydrophobic acetal and ketal derivatives of mannopeptimycin-α and desmethylhexahydromannopeptimycin-α: Semisynthetic glycopeptides with potent activity against Gram-positive bacteria

Dushin, R. G., Wang, T. Z., Sum, P. E., He, H., Sutherland, A. G., Ashcroft, J. S., Graziani, E. I., Koehn, F. E., Bradford, P. A., Petersen, P. J., Wheless, K. L., How, D., Torres, N., Lenoy, E. B., Weiss, W. J., Lang, S. A., Projan, S. J., Shlaes, D. M. & Mansour, T. S., 1 Jul 2004, In : Journal of Medicinal Chemistry. 47, 14, p. 3487-3490 4 p.

Research output: Contribution to journalArticle

32 Scopus citations

In vitro and in vivo activities of novel 6-methylidene penems as β-lactamase inhibitors

Weiss, W. J., Petersen, P. J., Murphy, T. M., Tardio, L. A., Yang, Y., Bradford, P. A., Venkatesan, A. M., Abe, T., Isoda, T., Mihira, A., Ushirogochi, H., Takasake, T., Projan, S., O'Connell, J. & Mansour, T. S., 1 Dec 2004, In : Antimicrobial agents and chemotherapy. 48, 12, p. 4589-4596 8 p.

Research output: Contribution to journalArticle

40 Scopus citations

In Vivo Efficacy and Pharmacokinetics of AC98-6446, a Novel Cyclic Glycopeptide, in Experimental Infection Models

Weiss, W. J., Murphy, T., Lenoy, E. & Young, M., 1 May 2004, In : Antimicrobial agents and chemotherapy. 48, 5, p. 1708-1712 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

Mannopeptimycin esters and carbonates, potent antibiotic agents against drug-resistant bacteria

He, H., Shen, B., Petersen, P. J., Weiss, W. J., Yang, H. Y., Wang, T. Z., Dushin, R. G., Koehn, F. E. & Carter, G. T., 5 Jan 2004, In : Bioorganic and Medicinal Chemistry Letters. 14, 1, p. 279-282 4 p.

Research output: Contribution to journalArticle

25 Scopus citations

Novel imidazole substituted 6-methylidene-penems as broad-spectrum β-lactamase inhibitors

Venkatesan, A. M., Agarwal, A., Abe, T., Ushirogochi, H., Yamamura, I., Kumagai, T., Petersen, P. J., Weiss, W. J., Lenoy, E., Yang, Y., Shlaes, D. M., Ryan, J. L. & Mansour, T. S., 15 Nov 2004, In : Bioorganic and Medicinal Chemistry. 12, 22, p. 5807-5817 11 p.

Research output: Contribution to journalArticle

36 Scopus citations

Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum β-lactamase inhibitors: Crystallographic structures show unexpected binding of 1,4-thiazepine intermediates

Venkatesan, A. M., Gu, Y., Santos, O. D., Abe, T., Agarwal, A., Yang, Y., Petersen, P. J., Weiss, W. J., Mansour, T. S., Nukaga, M., Hujer, A. M., Bonomo, R. A. & Knox, J. R., 16 Dec 2004, In : Journal of Medicinal Chemistry. 47, 26, p. 6556-6568 13 p.

Research output: Contribution to journalArticle

74 Scopus citations
2003

Activities of tigecycline (GAR-936) against Legionella pneumophila in vitro and in guinea pigs with L. pneumophila pneumonia

Edelstein, P. H., Weiss, W. J. & Edelstein, M. A. C., 1 Feb 2003, In : Antimicrobial agents and chemotherapy. 47, 2, p. 533-540 8 p.

Research output: Contribution to journalArticle

61 Scopus citations

Inhalation efficacy of RFI-641 in an African green monkey model of RSV infection

Weiss, W. J., Murphy, T., Lynch, M. E., Frye, J., Buklan, A., Gray, B., Lenoy, E., Mitelman, S., O'Connell, J., Quartuccio, S. & Huntley, C., Apr 2003, In : Journal of Medical Primatology. 32, 2, p. 82-88 7 p.

Research output: Contribution to journalArticle

36 Scopus citations

Mannopeptimycins, new cyclic glycopeptide antibiotics produced by Streptomyces hygroscopicus LL-AC98: Antibacterial and mechanistic activities

Singh, M. P., Petersen, P. J., Weiss, W. J., Janso, J. E., Luckman, S. W., Lenoy, E. B., Bradford, P. A., Testa, R. T. & Greenstein, M., 1 Jan 2003, In : Antimicrobial agents and chemotherapy. 47, 1, p. 62-69 8 p.

Research output: Contribution to journalArticle

81 Scopus citations

Novel ether derivatives of mannopeptimycin glycopeptide antibiotic

Sum, P. E., How, D., Torres, N., Petersen, P. J., Lenoy, E. B., Weiss, W. J. & Mansour, T. S., 24 Mar 2003, In : Bioorganic and Medicinal Chemistry Letters. 13, 6, p. 1151-1155 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

Novel α-pyrones produced by a marine Pseudomonas sp. F92S91: Taxonomy and biological activities

Singh, M. P., Kong, F., Janso, J. E., Arias, D. A., Suarez, P. A., Bernan, V. S., Petersen, P. J., Weiss, W. J., Carter, G. & Greenstein, M., Dec 2003, In : Journal of Antibiotics. 56, 12, p. 1033-1044 12 p.

Research output: Contribution to journalArticle

39 Scopus citations
2002

In vitro and in vivo activities of tigecycline (GAR-936), daptomycin, and comparative antimicrobial agents against glycopeptide-intermediate Staphylococcus aureus and other resistant gram-positive pathogens

Petersen, P. J., Bradford, P. A., Weiss, W. J., Murphy, T. M., Sum, P. E. & Projan, S. J., 1 Aug 2002, In : Antimicrobial agents and chemotherapy. 46, 8, p. 2595-2601 7 p.

Research output: Contribution to journalArticle

146 Scopus citations

RFI-641, a potent respiratory syncytial virus inhibitor

Huntley, C. C., Weiss, W. J., Gazumyan, A., Buklan, A., Feld, B., Hu, W., Jones, T. R., Murphy, T., Nikitenko, A. A., O'Hara, B., Prince, G., Quartuccio, S., Raifeld, Y. E., Wyde, P. & O'Connell, J. F., 28 Feb 2002, In : Antimicrobial agents and chemotherapy. 46, 3, p. 841-847 7 p.

Research output: Contribution to journalArticle

66 Scopus citations
2000

In vivo pharmacodynamic activities of two glycylcyclines (GAR-936 and WAY 152,288) against various gram-positive and gram-negative bacteria

Van Ogtrop, M. L., Andes, D., Stamstad, T. J., Conklin, B., Weiss, W. J., Craig, W. A. & Vesga, O., 1 Apr 2000, In : Antimicrobial agents and chemotherapy. 44, 4, p. 943-949 7 p.

Research output: Contribution to journalArticle

151 Scopus citations

Saccharomicins, novel heptadecaglycoside antibiotics produced by Saccharothrix espanaensis: Antibacterial and mechanistic activities

Singh, M. P., Petersen, P. J., Weiss, W. J., Kong, F. & Greenstein, M., 7 Aug 2000, In : Antimicrobial agents and chemotherapy. 44, 8, p. 2154-2159 6 p.

Research output: Contribution to journalArticle

47 Scopus citations

Therapeutic efficacy of GAR-936, a novel glycylcycline, in a rat model of experimental endocarditis

Murphy, T. M., Deitz, J. M., Petersen, P. J., Mikels, S. M. & Weiss, W. J., 9 Nov 2000, In : Antimicrobial agents and chemotherapy. 44, 11, p. 3022-3027 6 p.

Research output: Contribution to journalArticle

72 Scopus citations
1999

In vitro activities of aminomethyl-substituted analogs of novel tetrahydrofuranyl carbapenems

Weiss, W. J., Petersen, P. J., Jacobus, N. V., Lin, Y. I., Bitha, P. & Testa, R. T., Mar 1999, In : Antimicrobial agents and chemotherapy. 43, 3, p. 454-459 6 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

In vitro and in vivo antibacterial activities of a novel glycylcycline, the 9-t-butylglycylamido derivative of minocycline (GAR-936)

Petersen, P. J., Jacobus, N. V., Weiss, W. J., Sum, P. E. & Testa, R. T., Apr 1999, In : Antimicrobial agents and chemotherapy. 43, 4, p. 738-744 7 p.

Research output: Contribution to journalArticle

Open Access
340 Scopus citations

In vivo activities of peptidic prodrugs of novel aminomethyl tetrahydrofuranyl-1β-methylcarbapenems

Weiss, W. J., Mikels, S. M., Petersen, P. J., Jacobus, N. V., Bitha, P., Lin, Y. I. & Testa, R. T., Mar 1999, In : Antimicrobial agents and chemotherapy. 43, 3, p. 460-464 5 p.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations
1997

Mono and bis double ester prodrugs of novel aminomethyl-THF 1β-methylcarbapenems

Lin, Y. I., Bitha, P., Li, Z., Sakya, S. M., Strohmeyer, T. W., Lang, S. A., Yang, Y., Bhachech, N., Weiss, W. J., Petersen, P. J., Jacobus, N. V., Bush, K. & Testa, R. T., 22 Jul 1997, In : Bioorganic and Medicinal Chemistry Letters. 7, 14, p. 1811-1816 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Peptidic prodrugs of novel aminomethyl-THF 1β-methylcarbapenems

Lin, Y. I., Bitha, P., Sakya, S. M., Li, Z., Lang, S. A., Yang, Y., Bhachech, N., Weiss, W. J., Petersen, P. J., Jacobus, N. V., Bush, K. & Testa, R. T., 8 Jul 1997, In : Bioorganic and Medicinal Chemistry Letters. 7, 13, p. 1665-1670 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

Synthesis and structure-activity relationship of novel THF 1β-methylcarbapenems II

Lin, Y. I., Bitha, P., Sakya, S. M., Lang, S. A., Yang, Y., Weiss, W. J., Petersen, P. J., Bush, K. & Testa, R. T., 2 Dec 1997, In : Bioorganic and Medicinal Chemistry Letters. 7, 23, p. 3063-3068 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Synthesis and structure-activity relationships of novel THF 1β- methylcarbapenems

Lin, Y. I., Bitha, P., Sakya, S. M., Strohmeyer, T. W., Li, Z., Lee, V. J., Lang, S. A., Yang, Y., Bhachech, N., Weiss, W. J., Petersen, P. J., Jacobus, N. V., Bush, K., Testa, R. T. & Tally, F. P., 8 Jul 1997, In : Bioorganic and Medicinal Chemistry Letters. 7, 13, p. 1671-1676 6 p.

Research output: Contribution to journalArticle

18 Scopus citations