William Weiss

Mono and bis double ester prodrugs of novel aminomethyl-THF 1β-methylcarbapenems

Lin, Y. I., Bitha, P., Li, Z., Sakya, S. M., Strohmeyer, T. W., Lang, S. A., Yang, Y., Bhachech, N., Weiss, W. J., Petersen, P. J., Jacobus, N. V., Bush, K. & Testa, R. T., 22 Jul 1997, In: Bioorganic and Medicinal Chemistry Letters. 7, 14, p. 1811-1816 6 p.

Research output: Contribution to journal › Article › peer-review

In vitro and in vivo antibacterial activities of a novel glycylcycline, the 9-t-butylglycylamido derivative of minocycline (GAR-936)

Petersen, P. J., Jacobus, N. V., Weiss, W. J., Sum, P. E. & Testa, R. T., Apr 1999, In: Antimicrobial agents and chemotherapy. 43, 4, p. 738-744 7 p.

Research output: Contribution to journal › Article › peer-review

Critical role of alpha-toxin and protective effects of its neutralization by a human antibody in acute bacterial skin and skin structure infections

Le, V. T. M., Tkaczyk, C., Chau, S., Rao, R. L., Dip, E. C., Pereira-Franchi, E. P., Cheng, L., Lee, S., Koelkebeck, H., Hilliard, J. J., Yu, X. Q., Datta, V., Nguyen, V., Weiss, W., Prokai, L., O'Day, T., Stover, C. K., Sellman, B. R. & Diep, B. A., 1 Oct 2016, In: Antimicrobial agents and chemotherapy. 60, 10, p. 5640-5648 9 p.

Research output: Contribution to journal › Article › peer-review

RFI-641, a potent respiratory syncytial virus inhibitor

Huntley, C. C., Weiss, W. J., Gazumyan, A., Buklan, A., Feld, B., Hu, W., Jones, T. R., Murphy, T., Nikitenko, A. A., O'Hara, B., Prince, G., Quartuccio, S., Raifeld, Y. E., Wyde, P. & O'Connell, J. F., 2002, In: Antimicrobial agents and chemotherapy. 46, 3, p. 841-847 7 p.

Research output: Contribution to journal › Article › peer-review

Novel imidazole substituted 6-methylidene-penems as broad-spectrum β-lactamase inhibitors

Venkatesan, A. M., Agarwal, A., Abe, T., Ushirogochi, H., Yamamura, I., Kumagai, T., Petersen, P. J., Weiss, W. J., Lenoy, E., Yang, Y., Shlaes, D. M., Ryan, J. L. & Mansour, T. S., 15 Nov 2004, In: Bioorganic and Medicinal Chemistry. 12, 22, p. 5807-5817 11 p.

Research output: Contribution to journal › Article › peer-review

In vitro and in vivo activities of novel 6-methylidene penems as β-lactamase inhibitors

Weiss, W. J., Petersen, P. J., Murphy, T. M., Tardio, L. A., Yang, Y., Bradford, P. A., Venkatesan, A. M., Abe, T., Isoda, T., Mihira, A., Ushirogochi, H., Takasake, T., Projan, S., O'Connell, J. & Mansour, T. S., Dec 2004, In: Antimicrobial agents and chemotherapy. 48, 12, p. 4589-4596 8 p.

Research output: Contribution to journal › Article › peer-review

Can ceftazidime-avibactam and aztreonam overcome β-lactam resistance conferred by metallo-β-lactamases in Enterobacteriaceae?

Marshall, S., Hujer, A. M., Rojas, L. J., Papp-Wallace, K. M., Humphries, R. M., Spellberg, B., Hujer, K. M., Marshall, E. K., Rudin, S. D., Perez, F., Wilson, B. M., Wasserman, R. B., Chikowski, L., Paterson, D. L., Vila, A. J., Van Duin, D., Kreiswirth, B. N., Chambers, H. F., Fowler, V. G. & Jacobs, M. R. & 3 others, Pulse, M. E., Weiss, W. J. & Bonomo, R. A., Apr 2017, In: Antimicrobial agents and chemotherapy. 61, 4, e02243-16.

Research output: Contribution to journal › Article › peer-review

In vivo activities of peptidic prodrugs of novel aminomethyl tetrahydrofuranyl-1β-methylcarbapenems

Weiss, W. J., Mikels, S. M., Petersen, P. J., Jacobus, N. V., Bitha, P., Lin, Y. I. & Testa, R. T., Mar 1999, In: Antimicrobial agents and chemotherapy. 43, 3, p. 460-464 5 p.

Research output: Contribution to journal › Article › peer-review

In Vitro And In Vivo Characterization Of Novel 8-Methoxy Derivatives Of Chlortetracycline

Cacciapuoti, A., Moss, E. L., Menzel, F., Cramer, C. A., Weiss, W., Loebenberg, D., Loebenberg, H. & Miller, G. H., 1987, In: The Journal of Antibiotics. 40, 10, p. 1426-1430 5 p.

Research output: Contribution to journal › Article › peer-review

Peptidic prodrugs of novel aminomethyl-THF 1β-methylcarbapenems

Lin, Y. I., Bitha, P., Sakya, S. M., Li, Z., Lang, S. A., Yang, Y., Bhachech, N., Weiss, W. J., Petersen, P. J., Jacobus, N. V., Bush, K. & Testa, R. T., 8 Jul 1997, In: Bioorganic and Medicinal Chemistry Letters. 7, 13, p. 1665-1670 6 p.

Research output: Contribution to journal › Article › peer-review

Synthesis and structure-activity relationships of novel THF 1β- methylcarbapenems

Lin, Y. I., Bitha, P., Sakya, S. M., Strohmeyer, T. W., Li, Z., Lee, V. J., Lang, S. A., Yang, Y., Bhachech, N., Weiss, W. J., Petersen, P. J., Jacobus, N. V., Bush, K., Testa, R. T. & Tally, F. P., 8 Jul 1997, In: Bioorganic and Medicinal Chemistry Letters. 7, 13, p. 1671-1676 6 p.

Research output: Contribution to journal › Article › peer-review

In vivo pharmacodynamic activities of two glycylcyclines (GAR-936 and WAY 152,288) against various gram-positive and gram-negative bacteria

Van Ogtrop, M. L., Andes, D., Stamstad, T. J., Conklin, B., Weiss, W. J., Craig, W. A. & Vesga, O., Apr 2000, In: Antimicrobial agents and chemotherapy. 44, 4, p. 943-949 7 p.

Research output: Contribution to journal › Article › peer-review

Tissue penetration and antimicrobial activity of standard- and high-dose trimethoprim/sulfamethoxazole and linezolid in patients with diabetic foot infection

Stein, G. E., Throckmorton, J. K., Scharmen, A. E., Weiss, W. J., Prokai, L., Smith, C. L. & Havlichek, D. H., Dec 2013, In: Journal of Antimicrobial Chemotherapy. 68, 12, p. 2852-2858 7 p., dkt267.

Research output: Contribution to journal › Article › peer-review

DAV131A Protects Hamsters from Lethal Clostridioides difficile Infection Induced by Fluoroquinolones

Saint-Lu, N., Burdet, C., Sablier-Gallis, F., Corbel, T., Nevière, A., Sayah-Jeanne, S., Pulse, M., Weiss, W., Ferreira, S., Andremont, A., Mentré, F. & de Gunzburg, J., 2020, In: Antimicrobial agents and chemotherapy. 64, 1, e01196-19.

Research output: Contribution to journal › Article › peer-review

FDA public workshop summary: Advancing animal models for antibacterial drug development

Byrne, J. M., Waack, U., Weinstein, E. A., Joshi, A., Shurland, S. M., Iarikov, D., Bulitta, J. B., Diep, B. A., Guina, T., Hope, W. W., Lawrenz, M. B., Lepak, A. J., Luna, B. M., Miesel, L., Phipps, A. J., Walsh, T. J., Weiss, W., Amini, T. & Farley, J. J., Jan 2021, In: Antimicrobial agents and chemotherapy. 65, 1, e01983-20.

Research output: Contribution to journal › Review article › peer-review

In Vivo Efficacy of Novel Monobactam LYS228 in Murine Models of Carbapenemase-Producing Klebsiella pneumoniae Infection

Weiss, W. J., Pulse, M. E., Nguyen, P. & Growcott, E. J., Apr 2019, In: Antimicrobial agents and chemotherapy. 63, 4, e02214-18.

Research output: Contribution to journal › Article › peer-review

Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens

Ma, Z., He, S., Yuan, Y., Zhuang, Z., Liu, Y., Wang, H., Chen, J., Xu, X., Ding, C., Molodtsov, V., Lin, W., Robertson, G. T., Weiss, W. J., Pulse, M., Nguyen, P., Duncan, L., Doyle, T., Ebright, R. H. & Lynch, A. S., 24 Mar 2022, In: Journal of Medicinal Chemistry. 65, 6, p. 4481-4495 15 p.

Research output: Contribution to journal › Article › peer-review

Oral Immunotherapy with Human Secretory Immunoglobulin A Improves Survival in the Hamster Model of Clostridioides difficile Infection

Chiari, E. F., Weiss, W., Simon, M. R., Kiessig, S. T., Pulse, M., Brown, S. C., Gerding, H. R., Mandago, M., Gisch, K. & Von Eichel-Streiber, C., 15 Oct 2021, In: Journal of Infectious Diseases. 224, 8, p. 1394-1397 4 p.

Research output: Contribution to journal › Article › peer-review

An mRNA-based platform for the delivery of pathogen-specific IgA into mucosal secretions

Deal, C. E., Richards, A. F., Yeung, T., Maron, M. J., Wang, Z., Lai, Y. T., Fritz, B. R., Himansu, S., Narayanan, E., Liu, D., Koleva, R., Licht, S., Hsiao, C. J., Rajlic, I. L., Koch, H., Kleyman, M., Pulse, M. E., Weiss, W. J., Doering, J. E. & Lindberg, S. K. & 3 others, Mantis, N. J., Carfi, A. & Plante, O. J., 21 Nov 2023, In: Cell Reports Medicine. 4, 11, 101253.

Research output: Contribution to journal › Article › peer-review

Inhalation efficacy of RFI-641 in an African green monkey model of RSV infection

Weiss, W. J., Murphy, T., Lynch, M. E., Frye, J., Buklan, A., Gray, B., Lenoy, E., Mitelman, S., O'Connell, J., Quartuccio, S. & Huntley, C., Apr 2003, In: Journal of Medical Primatology. 32, 2, p. 82-88 7 p.

Research output: Contribution to journal › Article › peer-review

In vitro and in vivo activities of LJC10,627, a new carbapenem with stability to dehydropeptidase I

Petersen, P. J., Jacobus, N. V., Weiss, W. J. & Testa, R. T., 1991, In: Antimicrobial agents and chemotherapy. 35, 1, p. 203-207 5 p.

Research output: Contribution to journal › Article › peer-review

Fluorocycline TP-271 is potent against complicated community-acquired bacterial pneumonia pathogens

Grossman, T. H., Fyfe, C., O'Brien, W., Hackel, M., Minyard, M. B., Waites, K. B., Dubois, J., Murphy, T. M., Slee, A. M., Weiss, W. J. & Sutcliffe, J. A., 1 Jan 2017, In: mSphere. 2, 1, e00004-17.

Research output: Contribution to journal › Article › peer-review

Anti-alpha-toxin monoclonal antibody and antibiotic combination therapy improves disease outcome and accelerates healing in a staphylococcus aureus dermonecrosis model

Hilliard, J. J., Datta, V., Tkaczyk, C., Hamilton, M., Sadowska, A., Jones-Nelson, O., O'Day, T., Weiss, W. J., Szarka, S., Nguyen, V., Prokai, L., Suzich, J. A., Stover, C. K. & Sellmana, B. R., 1 Jan 2015, In: Antimicrobial agents and chemotherapy. 59, 1, p. 299-308 10 p.

Research output: Contribution to journal › Article › peer-review

Protection of hamsters from mortality by reducing fecal moxifloxacin concentration with DAV131A in a model of moxifloxacin-induced Clostridium difficile colitis

Burdet, C., Sayah-Jeanne, S., Nguyen, T. T., Miossec, C., Saint-Lu, N., Pulse, M., Weiss, W., Andremont, A., Mentré, F. & De Gunzburg, J., 2017, In: Antimicrobial agents and chemotherapy. 61, 10

Research output: Contribution to journal › Article › peer-review

Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum β-lactamase inhibitors: Crystallographic structures show unexpected binding of 1,4-thiazepine intermediates

Venkatesan, A. M., Gu, Y., Santos, O. D., Abe, T., Agarwal, A., Yang, Y., Petersen, P. J., Weiss, W. J., Mansour, T. S., Nukaga, M., Hujer, A. M., Bonomo, R. A. & Knox, J. R., 16 Dec 2004, In: Journal of Medicinal Chemistry. 47, 26, p. 6556-6568 13 p.

Research output: Contribution to journal › Article › peer-review

William Weiss, MS

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