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Personal profile

Area of Expertise

Pre-Clinical Services evaluate new therapies against infections using animal models. These studies are done in collaboration with pharmaceutical and academic researchers, and several of these therapies are now being used clinically to treat patients.

Education/Academic qualification

MS in Biology, Fairleigh Dickinson University

BS in Microbiology, Rutgers University

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Anti-Bacterial Agents Medicine & Life Sciences
Staphylococcus aureus Medicine & Life Sciences
Clostridium difficile Medicine & Life Sciences
meropenem Medicine & Life Sciences
Clostridium Infections Medicine & Life Sciences
Piperacillin Medicine & Life Sciences
Infection Medicine & Life Sciences
Carbapenems Medicine & Life Sciences

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Projects 2011 2019

Research Output 1985 2019

  • 1979 Citations
  • 24 h-Index
  • 52 Article

Pharmacological, toxicological, and dose range assessment of OG716, a novel lantibiotic for the treatment of clostridium difficile-associated infection

Pulse, M. E., Weiss, W., Kers, J. A., DeFusco, A. W., Park, J. H. & Handfield, M., 1 Apr 2019, In : Antimicrobial Agents and Chemotherapy. e01904-18.

Research output: Contribution to journalArticleResearchpeer-review

Bacteriocins
Clostridium difficile
Toxicology
Pharmacology
Mesocricetus

Treatment and prevention of recurrent Clostridium difficile infection with functionalized bovine antibody-enriched whey in a hamster primary infection model

Heidebrecht, H. J., Weiss, W., Pulse, M., Lange, A., Gisch, K., Kliem, H., Mann, S., Pfaffl, M. W., Kulozik, U. & von Eichel-Streiber, C., 1 Feb 2019, In : Toxins. 11, 2, 98.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Clostridium Infections
Clostridium
Clostridium difficile
Cricetinae
Antibodies
6 Citations (Scopus)

Activity of meropenem-vaborbactam against carbapenem- resistant enterobacteriaceae in a murine model of pyelonephritis

Weiss, W., Pulse, M. E., Nguyen, P., Peterson, K., Silva, J., Simecka, J., Valtierra, D., Sabet, M. & Griffith, D. C., 1 Jan 2018, In : Antimicrobial Agents and Chemotherapy. 62, 1, e01439.

Research output: Contribution to journalArticleResearchpeer-review

meropenem
Carbapenems
Pyelonephritis
Enterobacteriaceae
Klebsiella pneumoniae
1 Citation (Scopus)

Antibiotic-induced dysbiosis predicts mortality in an animal model of clostridium difficile infection

Burdet, C., Sayah-Jeanne, S., Nguyen, T. T., Hugon, P., Sablier-Gallis, F., Saint-Lu, N., Corbel, T., Ferreira, S., Pulse, M., Weiss, W., Andremont, A., Mentré, F. & De Gunzburg, J., 1 Oct 2018, In : Antimicrobial Agents and Chemotherapy. 62, 10, e00925.

Research output: Contribution to journalArticleResearchpeer-review

Dysbiosis
Clostridium Infections
Clostridium difficile
Animal Models
Anti-Bacterial Agents
7 Citations (Scopus)

Mutacin 1140 lantibiotic variants are efficacious against Clostridium difficile infection

Kers, J. A., Sharp, R. E., Defusco, A. W., Park, J. H., Xu, J., Pulse, M. E., Weiss, W. & Handfield, M., 16 Mar 2018, In : Frontiers in Microbiology. 9, MAR, 415.

Research output: Contribution to journalArticleResearchpeer-review

Clostridium Infections
Bacteriocins
Clostridium difficile
Half-Life
Pharmacology