• 1011 Citations
  • 20 h-Index
1990 …2021
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Personal profile

Area of Expertise

Many neurological disorders remain untreatable and continue to cause incalculable losses to productivity, independence, and overall quality of life among patients globally. Currently available approaches to the treatment of ischemic stroke and traumatic brain injury do not adequately meet clinical and social demands. Discovery and development of drugs with clinical efficacy presents tremendous intellectual and commercial challenges.
Dr. Uteshev was trained as a neuro-pharmacologist and his lab focuses on developing novel therapeutic strategies and pharmacological tools to treat ischemic stroke, traumatic brain injury, and other challenging neurological disorders linked to brain injury and inflammation. The primary focus is the cholinergic system and α7 nicotinic acetylcholine receptors (nAChRs). These receptors are commonly expressed throughout the body including neuronal, glial, and immune tissues. A balanced activation of α7 nAChRs inhibits inflammation and elevates brain resistance to ischemic and traumatic injury. Accordingly, whenever a brain injury occurs, two simultaneous processes are automatically initiated as the injury stimulates α7 nAChRs: first, the brain tissue near the site of injury becomes protected from spreading injury; and second, the injury-induced inflammation is mitigated to prevent additional injury by the immune system. Positive allosteric modulators (PAMs) of α7 nAChRs hold considerable promise as stroke and TBI treatment. PAMs augment α7 activation by endogenous agonists, choline, and ACh, allowing for a gentle modulation of immune response and recovery from injury.

Education/Academic qualification

MS in Biophysics, Moscow Institute of Physics and Technology

BS in General Physics, Moscow Institute of Physics and Technology

PhD in Physiology, University of Toronto

Fingerprint Dive into the research topics where Victor Uteshev is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2011 2021

Research Output 1990 2019

  • 1011 Citations
  • 20 h-Index
  • 43 Article
  • 4 Chapter
  • 1 Editorial
  • 1 Letter

Expression and function of transient receptor potential ankyrin 1 ion channels in the caudal nucleus of the solitary tract

Feng, L., Uteshev-Gaard, V. V. & Premkumar, L. S., 1 May 2019, In : International journal of molecular sciences. 20, 9, 2065.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Ankyrins
Solitary Nucleus
navigation technology satellites
Ion Channels
nuclei

Treatment duration affects cytoprotective efficacy of positive allosteric modulation of α7 nAChRs after focal ischemia in rats

Gaidhani, N. & Uteshev-Gaard, V. V., 1 Oct 2018, In : Pharmacological Research. 136, p. 121-132 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Ischemia
Middle Cerebral Artery Infarction
Therapeutics
Stroke
Brain Injuries
3 Citations (Scopus)

Boosting Endogenous Resistance of Brain to Ischemia

Sun, F., Johnson, S. R., Jin, K. & Uteshev-Gaard, V. V., 1 Apr 2017, In : Molecular Neurobiology. 54, 3, p. 2045-2059 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Nicotinic Receptors
Brain Ischemia
Stroke
Wounds and Injuries
Intranasal Administration
4 Citations (Scopus)
Isoflurane
Brain Injuries
Young Adult
Ischemia
Anesthesia
3 Citations (Scopus)

Stroke Cytoprotection: Can Repeating History with New Expectations Really Be the Path to Success in Stroke Research?

Lapchak, P. A. & Uteshev-Gaard, V. V., 1 Apr 2017, In : Translational Stroke Research. 8, 2, p. 104-106 3 p.

Research output: Contribution to journalLetterResearchpeer-review