Umesh Sankpal

Small molecule tolfenamic acid inhibits PC-3 cell proliferation and invasion in vitro, and tumor growth in orthotopic mouse model for prostate cancer

Sankpal, U. T., Abdelrahim, M., Connelly, S. F., Lee, C. M., Madero-Visbal, R., Colon, J., Smith, J., Safe, S., Maliakal, P. & Basha, R., Nov 2012, In: Prostate. 72, 15, p. 1648-1658 11 p.

Research output: Contribution to journal › Article › peer-review

Cellular and organismal toxicity of the anti-cancer small molecule, tolfenamic acid: A pre-clinical evaluation

Sankpal, U. T., Lee, C. M., Connelly, S. F., Kayaleh, O., Eslin, D., Sutphin, R., Goodison, S., Adwan, L., Zawia, N. H., Lichtenberger, L. M. & Basha, R., 2013, In: Cellular Physiology and Biochemistry. 32, 3, p. 675-686 12 p.

Research output: Contribution to journal › Article › peer-review

Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription

Ling, Y., Sankpal, U. T., Robertson, A. K., McNally, J. G., Karpova, T. & Robertson, K. D., 2004, In: Nucleic Acids Research. 32, 2, p. 598-610 13 p.

Research output: Contribution to journal › Article › peer-review

Combination of Tolfenamic acid and curcumin induces colon cancer cell growth inhibition through modulating specific transcription factors and reactive oxygen species

Sankpal, U. T., Nagaraju, G. P., Gottipolu, S. R., Hurtado, M., Jordan, C. G., Simecka, J. W., Shoji, M., El-Rayes, B. & Basha, R., 2016, In: Oncotarget. 7, 3, p. 3186-3200 15 p.

Research output: Contribution to journal › Article › peer-review

Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery

Geiman, T. M., Sankpal, U. T., Robertson, A. K., Chen, Y., Mazumdar, M., Heale, J. T., Schmiesing, J. A., Kim, W., Yokomori, K., Zhao, Y. & Robertson, K. D., 2004, In: Nucleic Acids Research. 32, 9, p. 2716-2729 14 p.

Research output: Contribution to journal › Article › peer-review

Impact of the microbiome on the immune system

Lambring, C. B., Siraj, S., Patel, K., Sankpal, U. T., Mathew, S. & Basha, R., 2019, In: Critical Reviews in Immunology. 39, 5, p. 313-328 16 p.

Research output: Contribution to journal › Article › peer-review

Combination of 13 cis-retinoic acid and tolfenamic acid induces apoptosis and effectively inhibits high-risk neuroblastoma cell proliferation

Shelake, S., Eslin, D., Sutphin, R. M., Sankpal, U. T., Wadwani, A., Kenyon, L. E., Tabor-Simecka, L., Bowman, W. P., Vishwanatha, J. K. & Basha, R., 1 Nov 2015, In: International Journal of Developmental Neuroscience. 46, p. 92-99 8 p.

Research output: Contribution to journal › Article › peer-review

DNA methylation inhibitor 5-aza-2′-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B

Palii, S. S., Van Emburgh, B. O., Sankpal, U. T., Brown, K. D. & Robertson, K. D., Jan 2008, In: Molecular and Cellular Biology. 28, 2, p. 752-771 20 p.

Research output: Contribution to journal › Article › peer-review

Water-assisted dual mode cofactor recognition by HhaI DNA methyltransferase

Swaminathan, C. P., Sankpal, U. T., Rao, D. N. & Surolia, A., 8 Feb 2002, In: Journal of Biological Chemistry. 277, 6, p. 4042-4049 8 p.

Research output: Contribution to journal › Article › peer-review

DNMT3B interacts with hSNF2H chromatin remodeling enzyme, HDACs 1 and 2, and components of the histone methylation system

Geiman, T. M., Sankpal, U. T., Robertson, A. K., Zhao, Y., Zhao, Y. & Robertson, K. D., 28 May 2004, In: Biochemical and Biophysical Research Communications. 318, 2, p. 544-555 12 p.

Research output: Contribution to journal › Article › peer-review

Mutational analysis of conserved residues in Hhal DNA methyltransferase

Sankpal, U. T. & Rao, D. N., 15 Jun 2002, In: Nucleic Acids Research. 30, 12, p. 2628-2638 11 p.

Research output: Contribution to journal › Article › peer-review

Therapeutic applications of NSAIDS in cancer: Special emphasis on tolfenamic acid

Basha, R., Baker, C. T., Sankpal, U. T., Ahmad, S., Safe, S., Abbruzzese, J. L. & Abdelrahim, M., 1 Jan 2011, In: Frontiers in Bioscience - Scholar. 3 S, 2, p. 797-805 9 p.

Research output: Contribution to journal › Article › peer-review

Tolfenamic acid inhibits ovarian cancer cell growth and decreases the expression of c-Met and survivin through suppressing specificity protein transcription factors

Basha, R., Ingersoll, S. B., Sankpal, U. T., Ahmad, S., Baker, C. H., Edwards, J. R., Holloway, R. W., Kaja, S. & Abdelrahim, M., Jul 2011, In: Gynecologic Oncology. 122, 1, p. 163-170 8 p.

Research output: Contribution to journal › Article › peer-review

Small molecule tolfenamic acid and dietary spice curcumin treatment enhances antiproliferative effect in pancreatic cancer cells via suppressing Sp1, disrupting NF-kB translocation to nucleus and cell cycle phase distribution

Basha, R., Connelly, S. F., Sankpal, U. T., Nagaraju, G. P., Patel, H., Vishwanatha, J. K., Shelake, S., Tabor-Simecka, L., Shoji, M., Simecka, J. W. & El-Rayes, B., 1 May 2016, In: Journal of Nutritional Biochemistry. 31, p. 77-87 11 p.

Research output: Contribution to journal › Article › peer-review

Targeted molecular therapeutic options for hepatocellular carcinoma

Sridhar, S., Sharma, I., Sankpal, U. T., Ghabach, B., Narra, K., Neerukonda, L. & Basha, R., 2020, In: Critical Reviews in Oncogenesis. 25, 1, p. 47-55 9 p.

Research output: Contribution to journal › Article › peer-review

Relevance of drug metabolizing enzyme activity modulation by tea polyphenols in the inhibition of esophageal tumorigenesis

Maliakal, P., Sankpal, U. T., Basha, R., Maliakal, C., Ledford, A. & Wanwimolruk, S., Sep 2011, In: Medicinal chemistry. 7, 5, p. 480-487 8 p.

Research output: Contribution to journal › Article › peer-review

Tolfenamic acid suppresses cytochrome P450 2E1 expression in mouse liver

Siddiqi, S. A., Shukoor, M. I., Tiwari, S., Sankpal, U. T., Maliakal, P., Connelly, S. F., Siddiqi, S. & Basha, R., Sep 2012, In: Integrative Biology (United Kingdom). 4, 9, p. 1122-1129 8 p.

Research output: Contribution to journal › Article › peer-review

Novel survivin inhibitor for suppressing pancreatic cancer cells growth via downregulating Sp1 and Sp3 transcription factors

Hurtado, M., Sankpal, U. T., Kaba, A., Mahammad, S., Chhabra, J., Brown, D. T., Gurung, R. K., Holder, A. A., Vishwanatha, J. K. & Basha, R., 1 Dec 2018, In: Cellular Physiology and Biochemistry. 51, 4, p. 1894-1907 14 p.

Research output: Contribution to journal › Article › peer-review

Tolfenamic acid inhibits neuroblastoma cell proliferation and induces apoptosis: A novel therapeutic agent for neuroblastoma

Eslin, D., Sankpal, U. T., Lee, C., Sutphin, R. M., Maliakal, P., Currier, E., Sholler, G., Khan, M. & Basha, R., May 2013, In: Molecular Carcinogenesis. 52, 5, p. 377-386 10 p.

Research output: Contribution to journal › Article › peer-review

Copper-tolfenamic acid: evaluation of stability and anti-cancer activity

Hurtado, M., Sankpal, U. T., Chhabra, J., Brown, D. T., Maram, R., Patel, R., Gurung, R. K., Simecka, J., Holder, A. A. & Basha, R., 15 Feb 2019, In: Investigational New Drugs. 37, 1, p. 27-34 8 p.

Research output: Contribution to journal › Article › peer-review

Targeting specificity protein 1 transcription factor and survivin using tolfenamic acid for inhibiting Ewing sarcoma cell growth

Shelake, S., Sankpal, U. T., Paul Bowman, W., Wise, M., Ray, A. & Basha, R., 1 Apr 2017, In: Investigational New Drugs. 35, 2, p. 158-165 8 p.

Research output: Contribution to journal › Article › peer-review

Nexus between hepatic enzyme modulation and cancer

Maliakal, C., Pius, H., Lee, C. M. & Sankpal, U. T., Oct 2011, In: Current Trends in Biotechnology and Pharmacy. 5, 4, p. 1372-1382 11 p.

Research output: Contribution to journal › Article › peer-review

Modulation of K_Ca channels increases anticancer drug delivery to brain tumors and prolongs survival in xenograft model

Ningaraj, N. S., Sankpal, U. T., Khaitan, D., Meister, E. A. & Vats, T. S., 15 Oct 2009, In: Cancer Biology and Therapy. 8, 20, p. 1924-1933 10 p.

Research output: Contribution to journal › Article › peer-review

Next generation sequencing and functional pathway analysis to understand the mechanism of action of copper-tolfenamic acid against pancreatic cancer cells

Hurtado, M., Prokai, L., Sankpal, U. T., Levesque, B., Maram, R., Chhabra, J., Brown, D. T., Gurung, R. K., Holder, A. A., Vishwanatha, J. K. & Basha, R., Feb 2020, In: Process Biochemistry. 89, p. 155-164 10 p.

Research output: Contribution to journal › Article › peer-review

Effects of chromatin structure on the enzymatic and DNA binding functions of DNA methyltransferases DNMT1 and Dnmt3a in vitro

Robertson, A. K., Geiman, T. M., Sankpal, U. T., Hager, G. L. & Robertson, K. D., 10 Sep 2004, In: Biochemical and Biophysical Research Communications. 322, 1, p. 110-118 9 p.

Research output: Contribution to journal › Article › peer-review

Umesh Sankpal, PhD

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