• 1140 Citations
  • 17 h-Index
20022019
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Research Output 2002 2019

  • 1140 Citations
  • 17 h-Index
  • 31 Article
  • 5 Review article
  • 1 Comment/debate
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Article
2019
1 Citation (Scopus)

Clotam enhances anti-proliferative effect of vincristine in Ewing sarcoma cells

Shelake, S., Sankpal, U. T., Eslin, D., Bowman, W. P., Simecka, J. W., Raut, S., Ray, A. & Basha, R., 15 Feb 2019, In : Apoptosis. 24, 1-2, p. 21-32 12 p.

Research output: Contribution to journalArticle

Ewing's Sarcoma
Vincristine
Cells
Caspase 7
Cell Survival
1 Citation (Scopus)

Combination of clotam and vincristine enhances anti-proliferative effect in medulloblastoma cells

Patil, S., Sankpal, U. T., Hurtado, M., Bowman, W. P., Murray, J., Borgmann, K., Ghorpade, A., Sutphin, R., Eslin, D. & Basha, R., 15 Jul 2019, In : Gene. 705, p. 67-76 10 p.

Research output: Contribution to journalArticle

Medulloblastoma
Vincristine
tolfenamic acid
Cell Cycle
Apoptosis
2 Citations (Scopus)

Copper-tolfenamic acid: evaluation of stability and anti-cancer activity

Hurtado, M., Sankpal, U. T., Chhabra, J., Brown, D. T., Maram, R., Patel, R., Gurung, R. K., Simecka, J., Holder, A. A. & Basha, R., 15 Feb 2019, In : Investigational New Drugs. 37, 1, p. 27-34 8 p.

Research output: Contribution to journalArticle

Copper
Neoplasms
Powders
tolfenamic acid
Cell Line
2018
2 Citations (Scopus)

Novel survivin inhibitor for suppressing pancreatic cancer cells growth via downregulating Sp1 and Sp3 transcription factors

Hurtado, M., Sankpal, U. T., Kaba, A., Mahammad, S., Chhabra, J., Brown, D. T., Gurung, R. K., Holder, A. A., Vishwanatha, J. K. & Basha, R., 1 Dec 2018, In : Cellular Physiology and Biochemistry. 51, 4, p. 1894-1907 14 p.

Research output: Contribution to journalArticle

Sp3 Transcription Factor
Sp1 Transcription Factor
Pancreatic Neoplasms
Down-Regulation
Growth
2017
11 Citations (Scopus)

Targeting specificity protein 1 transcription factor and survivin using tolfenamic acid for inhibiting Ewing sarcoma cell growth

Shelake, S., Sankpal, U. T., Paul Bowman, W., Wise, M., Ray, A. & Basha, R., 1 Apr 2017, In : Investigational New Drugs. 35, 2, p. 158-165 8 p.

Research output: Contribution to journalArticle

Sp1 Transcription Factor
Ewing's Sarcoma
Growth
Neoplasms
Proteasome Inhibitors
6 Citations (Scopus)

Tolfenamic acid-induced alterations in genes and pathways in pancreatic cancer cells

Sankpal, U. T., Goodison, S., Jones-Pauley, M., Hurtado, M., Zhang, F. & Basha, R., 1 Jan 2017, In : Oncotarget. 8, 9, p. 14593-14603 11 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Genes
Anti-Inflammatory Agents
Neoplasms
Pharmaceutical Preparations
2016
13 Citations (Scopus)

Association of Sp1 and survivin in epithelial ovarian cancer: Sp1 inhibitor and cisplatin, a novel combination for inhibiting epithelial ovarian cancer cell proliferation

Sankpal, U. T., Ingersoll, S. B., Ahmad, S., Holloway, R. W., Bhat, V. B., Simecka, J. W., Daniel, L., Kariali, E., Vishwanatha, J. K. & Basha, R., 1 Oct 2016, In : Tumor Biology. 37, 10, p. 14259-14269 11 p.

Research output: Contribution to journalArticle

Cisplatin
Cell Proliferation
Proteins
Proteomics
Reactive Oxygen Species
31 Citations (Scopus)

Combination of Tolfenamic acid and curcumin induces colon cancer cell growth inhibition through modulating specific transcription factors and reactive oxygen species

Sankpal, U. T., Nagaraju, G. P., Gottipolu, S. R., Hurtado, M., Jordan, C. G., Simecka, J. W., Shoji, M., El-Rayes, B. & Basha, R., 1 Jan 2016, In : Oncotarget. 7, 3, p. 3186-3200 15 p.

Research output: Contribution to journalArticle

Curcumin
Colonic Neoplasms
Reactive Oxygen Species
Transcription Factors
Growth
17 Citations (Scopus)
Spices
Curcumin
NF-kappa B
Pancreatic Neoplasms
Cell Cycle
2015
5 Citations (Scopus)

Combination of 13 cis-retinoic acid and tolfenamic acid induces apoptosis and effectively inhibits high-risk neuroblastoma cell proliferation

Shelake, S., Eslin, D., Sutphin, R. M., Sankpal, U. T., Wadwani, A., Kenyon, L. E., Tabor-Simecka, L., Bowman, W. P., Vishwanatha, J. K. & Basha, R., 1 Nov 2015, In : International Journal of Developmental Neuroscience. 46, p. 92-99 8 p.

Research output: Contribution to journalArticle

Isotretinoin
Neuroblastoma
Tretinoin
Cell Proliferation
Apoptosis
2014
6 Citations (Scopus)

Anti-leukemic response of a NSAID, tolfenamic acid

Sutphin, R. M., Connelly, S. F., Lee, C. M., Sankpal, U. T., Eslin, D., Khan, M., Pius, H. & Basha, R., Jun 2014, In : Targeted Oncology. 9, 2, p. 135-144 10 p.

Research output: Contribution to journalArticle

Non-Steroidal Anti-Inflammatory Agents
Cell Cycle
tolfenamic acid
Neoplasms
Cell Survival
2013
14 Citations (Scopus)

Anticancer activity of tolfenamic acid in medulloblastoma: A preclinical study

Eslin, D., Lee, C., Sankpal, U. T., Maliakal, P., Sutphin, R. M., Abraham, L. & Basha, R. M., 20 May 2013, In : Tumor Biology. 34, 5, p. 2781-2789 9 p.

Research output: Contribution to journalArticle

Medulloblastoma
Protein Transport
Tumor Burden
Nude Mice
Cell Survival
17 Citations (Scopus)

Cellular and organismal toxicity of the anti-cancer small molecule, tolfenamic acid: A pre-clinical evaluation

Sankpal, U. T., Lee, C. M., Connelly, S. F., Kayaleh, O., Eslin, D., Sutphin, R., Goodison, S., Adwan, L., Zawia, N. H., Lichtenberger, L. M. & Basha, R., 1 Jan 2013, In : Cellular Physiology and Biochemistry. 32, 3, p. 675-686 12 p.

Research output: Contribution to journalArticle

Neoplasms
Nude Mice
Hematocrit
Clinical Trials, Phase I
Growth
20 Citations (Scopus)

Tolfenamic acid inhibits neuroblastoma cell proliferation and induces apoptosis: A novel therapeutic agent for neuroblastoma

Eslin, D., Sankpal, U. T., Lee, C., Sutphin, R. M., Maliakal, P., Currier, E., Sholler, G., Khan, M. & Basha, R. M., 1 May 2013, In : Molecular Carcinogenesis. 52, 5, p. 377-386 10 p.

Research output: Contribution to journalArticle

Neuroblastoma
Cell Proliferation
Apoptosis
Caspase 7
Therapeutics
2012
11 Citations (Scopus)

Chemopreventive effects of tolfenamic acid against esophageal tumorigenesis in rats

Maliakal, P., Abdelrahim, M., Sankpal, U. T., Maliakal, C., Baker, C. H., Safe, S., Herrera, L. J., Abudayyeh, A., Kaja, S. & Basha, R., 1 Jun 2012, In : Investigational New Drugs. 30, 3, p. 853-861 9 p.

Research output: Contribution to journalArticle

Carcinogenesis
Neoplasms
Esophageal Neoplasms
nitrosobenzylmethylamine
Tumor Burden
30 Citations (Scopus)

Small molecule tolfenamic acid inhibits PC-3 cell proliferation and invasion in vitro, and tumor growth in orthotopic mouse model for prostate cancer

Sankpal, U. T., Abdelrahim, M., Connelly, S. F., Lee, C. M., Madero-Visbal, R., Colon, J., Smith, J., Safe, S., Maliakal, P. & Basha, R. M., 1 Nov 2012, In : Prostate. 72, 15, p. 1648-1658 11 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Cell Proliferation
Growth
Neoplasms
Cyclin D3
5 Citations (Scopus)

Tolfenamic acid suppresses cytochrome P450 2E1 expression in mouse liver

Siddiqi, S. A., Shukoor, M. I., Tiwari, S., Sankpal, U. T., Maliakal, P., Connelly, S. F., Siddiqi, S. & Basha, R. M., 1 Jan 2012, In : Integrative Biology (United Kingdom). 4, 9, p. 1122-1129 8 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2E1
Liver
Rats
Carcinogens
Cytochrome P-450 Enzyme System
2011

Nexus between hepatic enzyme modulation and cancer

Maliakal, C., Pius, H., Lee, C. M. & Sankpal, U. T., 1 Oct 2011, In : Current Trends in Biotechnology and Pharmacy. 5, 4, p. 1372-1382 11 p.

Research output: Contribution to journalArticle

Carcinogens
Liver
Enzymes
Neoplasms
Environmental Carcinogens
9 Citations (Scopus)

Relevance of drug metabolizing enzyme activity modulation by tea polyphenols in the inhibition of esophageal tumorigenesis

Maliakal, P., Sankpal, U. T., Basha, R. M., Maliakal, C., Ledford, A. & Wanwimolruk, S., 1 Sep 2011, In : Medicinal chemistry. 7, 5, p. 480-487 8 p.

Research output: Contribution to journalArticle

Polyphenols
Tea
Carcinogenesis
Enzymes
Pharmaceutical Preparations
28 Citations (Scopus)

Therapeutic applications of NSAIDS in cancer: Special emphasis on tolfenamic acid

Basha, R. M., Baker, C. T., Sankpal, U. T., Ahmad, S., Safe, S., Abbruzzese, J. L. & Abdelrahim, M., 1 Jan 2011, In : Frontiers in Bioscience - Scholar. 3 S, 2, p. 797-805 9 p.

Research output: Contribution to journalArticle

Anti-Inflammatory Agents
Pharmaceutical Preparations
Neoplasms
Therapeutics
Incidence
40 Citations (Scopus)

Tolfenamic acid inhibits ovarian cancer cell growth and decreases the expression of c-Met and survivin through suppressing specificity protein transcription factors

Basha, R. M., Ingersoll, S. B., Sankpal, U. T., Ahmad, S., Baker, C. H., Edwards, J. R., Holloway, R. W., Kaja, S. & Abdelrahim, M., 1 Jul 2011, In : Gynecologic Oncology. 122, 1, p. 163-170 8 p.

Research output: Contribution to journalArticle

Sp Transcription Factors
Ovarian Neoplasms
Growth
Neoplasms
Proto-Oncogene Proteins c-met
2009
13 Citations (Scopus)

Activation of KATP channels increases anticancer drug delivery to brain tumors and survival

Ningaraj, N. S., Sankpal, U. T., Khaitan, D., Meister, E. A. & Vats, T., 14 Jan 2009, In : European Journal of Pharmacology. 602, 2-3, p. 188-193 6 p.

Research output: Contribution to journalArticle

temozolomide
KATP Channels
Brain Neoplasms
Survival
Pharmaceutical Preparations
16 Citations (Scopus)

Modulation of KCa channels increases anticancer drug delivery to brain tumors and prolongs survival in xenograft model

Ningaraj, N. S., Sankpal, U. T., Khaitan, D., Meister, E. A. & Vats, T. S., 15 Oct 2009, In : Cancer Biology and Therapy. 8, 20, p. 1924-1933 10 p.

Research output: Contribution to journalArticle

temozolomide
Heterografts
Brain Neoplasms
Survival
Pharmaceutical Preparations
73 Citations (Scopus)

Role of KCNMA1 gene in breast cancer invasion and metastasis to brain

Khaitan, D., Sankpal, U. T., Weksler, B., Meister, E. A., Romero, I. A., Couraud, P. O. & Ningaraj, N. S., 29 Jul 2009, In : BMC Cancer. 9, 258.

Research output: Contribution to journalArticle

Breast Neoplasms
Neoplasm Metastasis
Brain
Genes
Transendothelial and Transepithelial Migration
2008
227 Citations (Scopus)

DNA methylation inhibitor 5-aza-2′-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B

Palii, S. S., Van Emburgh, B. O., Sankpal, U. T., Brown, K. D. & Robertson, K. D., 1 Jan 2008, In : Molecular and Cellular Biology. 28, 2, p. 752-771 20 p.

Research output: Contribution to journalArticle

decitabine
DNA Methylation
DNA Damage
Genome
Ataxia Telangiectasia
2004
80 Citations (Scopus)

DNMT3B interacts with hSNF2H chromatin remodeling enzyme, HDACs 1 and 2, and components of the histone methylation system

Geiman, T. M., Sankpal, U. T., Robertson, A. K., Zhao, Y., Zhao, Y. & Robertson, K. D., 28 May 2004, In : Biochemical and Biophysical Research Communications. 318, 2, p. 544-555 12 p.

Research output: Contribution to journalArticle

Methylation
Chromatin Assembly and Disassembly
Methyltransferases
Histones
Chromatin
57 Citations (Scopus)

Effects of chromatin structure on the enzymatic and DNA binding functions of DNA methyltransferases DNMT1 and Dnmt3a in vitro

Robertson, A. K., Geiman, T. M., Sankpal, U. T., Hager, G. L. & Robertson, K. D., 10 Sep 2004, In : Biochemical and Biophysical Research Communications. 322, 1, p. 110-118 9 p.

Research output: Contribution to journalArticle

Methyltransferases
Chromatin
Chromatin Assembly and Disassembly
Epigenomics
DNA
92 Citations (Scopus)

Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery

Geiman, T. M., Sankpal, U. T., Robertson, A. K., Chen, Y., Mazumdar, M., Heale, J. T., Schmiesing, J. A., Kim, W., Yokomori, K., Zhao, Y. & Robertson, K. D., 20 Jul 2004, In : Nucleic Acids Research. 32, 9, p. 2716-2729 14 p.

Research output: Contribution to journalArticle

Methyltransferases
Chromosomes
Genomic Instability
DNA Methylation
Mitosis
98 Citations (Scopus)

Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription

Ling, Y., Sankpal, U. T., Robertson, A. K., McNally, J. G., Karpova, T. & Robertson, K. D., 10 Mar 2004, In : Nucleic Acids Research. 32, 2, p. 598-610 13 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Sumoylation
Methyltransferases
Genomic Imprinting
Ubiquitin-Protein Ligases
2002
23 Citations (Scopus)

Mutational analysis of conserved residues in Hhal DNA methyltransferase

Sankpal, U. T. & Rao, D. N., 15 Jun 2002, In : Nucleic Acids Research. 30, 12, p. 2628-2638 11 p.

Research output: Contribution to journalArticle

Methyltransferases
DNA
Amino Acids
Methionine
S-Adenosylmethionine
15 Citations (Scopus)

Water-assisted dual mode cofactor recognition by HhaI DNA methyltransferase

Swaminathan, C. P., Sankpal, U. T., Rao, D. N. & Surolia, A., 8 Feb 2002, In : Journal of Biological Chemistry. 277, 6, p. 4042-4049 8 p.

Research output: Contribution to journalArticle

S-Adenosylmethionine
Methyltransferases
Homocysteine
Water
DNA