• 1093 Citations
  • 16 h-Index
20022019
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Personal profile

Area of Expertise

Research in my laboratory is primarily focused on identifying and developing innovative approaches for cancer diagnostics and treatment. The strategy involves identifying novel compounds that have anti-cancer activity, target differentially expressed cancer specific genes, and work synergistically with standard therapeutic treatments.
The current focus is on targeting proteins such as the transcription factors (Specificity protein family) and inhibitor of apoptosis proteins (IAP family).
Another area of research being pursued is the health disparity in breast cancer. Mortality rates among black women with breast cancer is significantly higher compared to white women. Besides factors like socio-economic status, education level, or access to healthcare that play an important role, there is strong evidence for inherent differences in biology of the tumors between different racial groups. We are currently investigating markers that are differentially expressed among various racial background for use as potential diagnostic and therapeutic targets.

Education/Academic qualification

PhD in Biochemistry, Indian Institute of Science Bangalore

MS in Biotechnology, Indian Institute of Technology

BS in Chemistry, Bombay University

Fingerprint Dive into the research topics where Umesh Sankpal is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 1 Similar Profiles
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Neoplasms Medicine & Life Sciences
Pancreatic Neoplasms Medicine & Life Sciences
Sp1 Transcription Factor Medicine & Life Sciences
Sp Transcription Factors Medicine & Life Sciences
DNA Medicine & Life Sciences
Cell Proliferation Medicine & Life Sciences
Growth Medicine & Life Sciences

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Projects 2015 2016

Research Output 2002 2019

  • 1093 Citations
  • 16 h-Index
  • 31 Article
  • 5 Review article
  • 1 Comment/debate
1 Citation (Scopus)

Clotam enhances anti-proliferative effect of vincristine in Ewing sarcoma cells

Shelake, S., Sankpal, U. T., Eslin, D., Bowman, P., Simecka, J., Raut, S. L., Ray, A. & Basha, R. M., 15 Feb 2019, In : Apoptosis. 24, 1-2, p. 21-32 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Ewing's Sarcoma
Vincristine
Cells
Caspase 7
Cell Survival

Combination of clotam and vincristine enhances anti-proliferative effect in medulloblastoma cells

Patil, S., Sankpal, U. T., Hurtado, M., Bowman, P., Murray, J., Borgmann, K., Ghorpade, A., Sutphin, R., Eslin, D. & Basha, R. M., 15 Jul 2019, In : Gene. 705, p. 67-76 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Medulloblastoma
Vincristine
tolfenamic acid
Cell Cycle
Apoptosis
1 Citation (Scopus)

Copper-tolfenamic acid: evaluation of stability and anti-cancer activity

Hurtado, M., Sankpal, U. T., Chhabra, J., Brown, D. T., Maram, R., Patel, R., Gurung, R. K., Simecka, J., Holder, A. A. & Basha, R. M., 15 Feb 2019, In : Investigational New Drugs. 37, 1, p. 27-34 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Copper
Neoplasms
Powders
tolfenamic acid
Cell Line
3 Citations (Scopus)

Investigational agents to enhance the efficacy of chemotherapy or radiation in pancreatic cancer

Hurtado, M., Sankpal, U. T., Ranjan, A. P., Maram, R., Vishwanatha, J. K., Nagaraju, G. P., El-Rayes, B. F. & Basha, R. M., 1 Jun 2018, In : Critical Reviews in Oncology/Hematology. 126, p. 201-207 7 p.

Research output: Contribution to journalReview articleResearchpeer-review

Pancreatic Neoplasms
Curcumin
Radiation
Drug Therapy
Non-Steroidal Anti-Inflammatory Agents

Novel survivin inhibitor for suppressing pancreatic cancer cells growth via downregulating Sp1 and Sp3 transcription factors

Hurtado, M., Sankpal, U. T., Kaba, A., Mahammad, S., Chhabra, J., Brown, D. T., Gurung, R. K., Holder, A. A., Vishwanatha, J. K. & Basha, R. M., 1 Dec 2018, In : Cellular Physiology and Biochemistry. 51, 4, p. 1894-1907 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Sp3 Transcription Factor
Sp1 Transcription Factor
Pancreatic Neoplasms
Down-Regulation
Growth