• 1177 Citations
  • 18 h-Index
20022020

Research output per year

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Personal profile

Area of Expertise

Research in my laboratory is primarily focused on identifying and developing innovative approaches for cancer diagnostics and treatment. The strategy involves identifying novel compounds that have anti-cancer activity, target differentially expressed cancer specific genes, and work synergistically with standard therapeutic treatments.
The current focus is on targeting proteins such as the transcription factors (Specificity protein family) and inhibitor of apoptosis proteins (IAP family).
Another area of research being pursued is the health disparity in breast cancer. Mortality rates among black women with breast cancer is significantly higher compared to white women. Besides factors like socio-economic status, education level, or access to healthcare that play an important role, there is strong evidence for inherent differences in biology of the tumors between different racial groups. We are currently investigating markers that are differentially expressed among various racial background for use as potential diagnostic and therapeutic targets.

Education/Academic qualification

BS in Chemistry, Bombay University

PhD in Biochemistry, Indian Institute of Science Bangalore

MS in Biotechnology, Indian Institute of Technology

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Projects

Research Output

  • 1177 Citations
  • 18 h-Index
  • 33 Article
  • 5 Review article
  • 1 Comment/debate

Next generation sequencing and functional pathway analysis to understand the mechanism of action of copper-tolfenamic acid against pancreatic cancer cells

Hurtado, M., Prokai, L., Sankpal, U. T., Levesque, B., Maram, R., Chhabra, J., Brown, D. T., Gurung, R. K., Holder, A. A., Vishwanatha, J. K. & Basha, R., Feb 2020, In : Process Biochemistry. 89, p. 155-164 10 p.

Research output: Contribution to journalArticle

  • Clotam enhances anti-proliferative effect of vincristine in Ewing sarcoma cells

    Shelake, S., Sankpal, U. T., Eslin, D., Bowman, W. P., Simecka, J. W., Raut, S., Ray, A. & Basha, R., 15 Feb 2019, In : Apoptosis. 24, 1-2, p. 21-32 12 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Combination of clotam and vincristine enhances anti-proliferative effect in medulloblastoma cells

    Patil, S., Sankpal, U. T., Hurtado, M., Bowman, W. P., Murray, J., Borgmann, K., Ghorpade, A., Sutphin, R., Eslin, D. & Basha, R., 15 Jul 2019, In : Gene. 705, p. 67-76 10 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Copper-tolfenamic acid: evaluation of stability and anti-cancer activity

    Hurtado, M., Sankpal, U. T., Chhabra, J., Brown, D. T., Maram, R., Patel, R., Gurung, R. K., Simecka, J., Holder, A. A. & Basha, R., 15 Feb 2019, In : Investigational New Drugs. 37, 1, p. 27-34 8 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Impact of the microbiome on the immune system

    Lambring, C. B., Siraj, S., Patel, K., Sankpal, U. T., Mathew, S. & Basha, R., 1 Jan 2019, In : Critical Reviews in Immunology. 39, 5, p. 313-328 16 p.

    Research output: Contribution to journalArticle