Projects per year
Personal profile
Area of Expertise
Research in my laboratory is primarily focused on identifying and developing innovative approaches for cancer diagnostics and treatment. The strategy involves identifying novel compounds that have anti-cancer activity, target differentially expressed cancer specific genes, and work synergistically with standard therapeutic treatments.
The current focus is on targeting proteins such as the transcription factors (Specificity protein family) and inhibitor of apoptosis proteins (IAP family).
Another area of research being pursued is the health disparity in breast cancer. Mortality rates among black women with breast cancer is significantly higher compared to white women. Besides factors like socio-economic status, education level, or access to healthcare that play an important role, there is strong evidence for inherent differences in biology of the tumors between different racial groups. We are currently investigating markers that are differentially expressed among various racial background for use as potential diagnostic and therapeutic targets.
The current focus is on targeting proteins such as the transcription factors (Specificity protein family) and inhibitor of apoptosis proteins (IAP family).
Another area of research being pursued is the health disparity in breast cancer. Mortality rates among black women with breast cancer is significantly higher compared to white women. Besides factors like socio-economic status, education level, or access to healthcare that play an important role, there is strong evidence for inherent differences in biology of the tumors between different racial groups. We are currently investigating markers that are differentially expressed among various racial background for use as potential diagnostic and therapeutic targets.
Education/Academic qualification
BS in Chemistry, Bombay University
PhD in Biochemistry, Indian Institute of Science Bangalore
MS in Biotechnology, Indian Institute of Technology
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Collaborations and top research areas from the last five years
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Projects
- 1 Finished
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A Novel Approach to Target Surviving Gene Expression in Medulloblastoma
Sankpal, U. (PI)
1/03/15 → 28/02/17
Project: Research
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Nexus between hepatic enzyme modulation and cancer
Maliakal, C., Pius, H., Lee, C. M. & Sankpal, U. T., Oct 2011, In: Current Trends in Biotechnology and Pharmacy. 5, 4, p. 1372-1382 11 p.Research output: Contribution to journal › Article › peer-review
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Tolfenamic acid inhibits neuroblastoma cell proliferation and induces apoptosis: A novel therapeutic agent for neuroblastoma
Eslin, D., Sankpal, U. T., Lee, C., Sutphin, R. M., Maliakal, P., Currier, E., Sholler, G., Khan, M. & Basha, R., May 2013, In: Molecular Carcinogenesis. 52, 5, p. 377-386 10 p.Research output: Contribution to journal › Article › peer-review
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Anti-leukemic response of a NSAID, tolfenamic acid
Sutphin, R. M., Connelly, S. F., Lee, C. M., Sankpal, U. T., Eslin, D., Khan, M., Pius, H. & Basha, R., Jun 2014, In: Targeted Oncology. 9, 2, p. 135-144 10 p.Research output: Contribution to journal › Article › peer-review
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Cellular and organismal toxicity of the anti-cancer small molecule, tolfenamic acid: A pre-clinical evaluation
Sankpal, U. T., Lee, C. M., Connelly, S. F., Kayaleh, O., Eslin, D., Sutphin, R., Goodison, S., Adwan, L., Zawia, N. H., Lichtenberger, L. M. & Basha, R., 2013, In: Cellular Physiology and Biochemistry. 32, 3, p. 675-686 12 p.Research output: Contribution to journal › Article › peer-review
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Erratum: Water-assisted dual mode cofactor recognition by HhaI DNA methyltransferase (Journal of Biological Chemistry (2002) 277 (4042-4049))
Swaminathan, C. P., Sankpal, U. T., Rao, D. N. & Surolia, A., 10 May 2002, In: Journal of Biological Chemistry. 277, 19, p. 17374 1 p.Research output: Contribution to journal › Comment/debate