Projects per year
Personal profile
Area of Expertise
Research in my laboratory is primarily focused on identifying and developing innovative approaches for cancer diagnostics and treatment. The strategy involves identifying novel compounds that have anti-cancer activity, target differentially expressed cancer specific genes, and work synergistically with standard therapeutic treatments.
The current focus is on targeting proteins such as the transcription factors (Specificity protein family) and inhibitor of apoptosis proteins (IAP family).
Another area of research being pursued is the health disparity in breast cancer. Mortality rates among black women with breast cancer is significantly higher compared to white women. Besides factors like socio-economic status, education level, or access to healthcare that play an important role, there is strong evidence for inherent differences in biology of the tumors between different racial groups. We are currently investigating markers that are differentially expressed among various racial background for use as potential diagnostic and therapeutic targets.
The current focus is on targeting proteins such as the transcription factors (Specificity protein family) and inhibitor of apoptosis proteins (IAP family).
Another area of research being pursued is the health disparity in breast cancer. Mortality rates among black women with breast cancer is significantly higher compared to white women. Besides factors like socio-economic status, education level, or access to healthcare that play an important role, there is strong evidence for inherent differences in biology of the tumors between different racial groups. We are currently investigating markers that are differentially expressed among various racial background for use as potential diagnostic and therapeutic targets.
Education/Academic qualification
BS in Chemistry, Bombay University
PhD in Biochemistry, Indian Institute of Science Bangalore
MS in Biotechnology, Indian Institute of Technology
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Projects
- 1 Finished
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A Novel Approach to Target Surviving Gene Expression in Medulloblastoma
1/03/15 → 28/02/17
Project: Research
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Association of specificity protein 1 with hepatocellular carcinoma
Iloani, N., Hafeez, A., Bao, S., Dulemba, V., Lambring, C., Sankpal, U. T. & Basha, R., 1 Jan 2022, Theranostics and Precision Medicine for the Management of Hepatocellular Carcinoma, Volume 2: Diagnosis, Therapeutic Targets, and Molecular Mechanisms. Elsevier, p. 185-193 9 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
1 Scopus citations -
Next generation sequencing and functional pathway analysis to understand the mechanism of action of copper-tolfenamic acid against pancreatic cancer cells
Hurtado, M., Prokai, L., Sankpal, U. T., Levesque, B., Maram, R., Chhabra, J., Brown, D. T., Gurung, R. K., Holder, A. A., Vishwanatha, J. K. & Basha, R., Feb 2020, In: Process Biochemistry. 89, p. 155-164 10 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Targeted molecular therapeutic options for hepatocellular carcinoma
Sridhar, S., Sharma, I., Sankpal, U. T., Ghabach, B., Narra, K., Neerukonda, L. & Basha, R., 2020, In: Critical Reviews in Oncogenesis. 25, 1, p. 47-55 9 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Clotam enhances anti-proliferative effect of vincristine in Ewing sarcoma cells
Shelake, S., Sankpal, U. T., Eslin, D., Bowman, W. P., Simecka, J. W., Raut, S., Ray, A. & Basha, R., 15 Feb 2019, In: Apoptosis. 24, 1-2, p. 21-32 12 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Combination of clotam and vincristine enhances anti-proliferative effect in medulloblastoma cells
Patil, S., Sankpal, U. T., Hurtado, M., Bowman, W. P., Murray, J., Borgmann, K., Ghorpade, A., Sutphin, R., Eslin, D. & Basha, R., 15 Jul 2019, In: Gene. 705, p. 67-76 10 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations