• 1157 Citations
  • 18 h-Index
20022019

Research output per year

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Personal profile

Area of Expertise

Research in my laboratory is primarily focused on identifying and developing innovative approaches for cancer diagnostics and treatment. The strategy involves identifying novel compounds that have anti-cancer activity, target differentially expressed cancer specific genes, and work synergistically with standard therapeutic treatments.
The current focus is on targeting proteins such as the transcription factors (Specificity protein family) and inhibitor of apoptosis proteins (IAP family).
Another area of research being pursued is the health disparity in breast cancer. Mortality rates among black women with breast cancer is significantly higher compared to white women. Besides factors like socio-economic status, education level, or access to healthcare that play an important role, there is strong evidence for inherent differences in biology of the tumors between different racial groups. We are currently investigating markers that are differentially expressed among various racial background for use as potential diagnostic and therapeutic targets.

Education/Academic qualification

PhD in Biochemistry, Indian Institute of Science Bangalore

Award Date: 1 Jan 2002

MS in Biotechnology, Indian Institute of Technology

Award Date: 1 Jan 2001

BS in Chemistry, Bombay University

Award Date: 1 Jan 2000

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Projects

Research Output

  • 1157 Citations
  • 18 h-Index
  • 31 Article
  • 5 Review article
  • 1 Comment/debate

Clotam enhances anti-proliferative effect of vincristine in Ewing sarcoma cells

Shelake, S., Sankpal, U. T., Eslin, D., Bowman, W. P., Simecka, J. W., Raut, S., Ray, A. & Basha, R., 15 Feb 2019, In : Apoptosis. 24, 1-2, p. 21-32 12 p.

Research output: Contribution to journalArticle

  • 1 Scopus citations

    Combination of clotam and vincristine enhances anti-proliferative effect in medulloblastoma cells

    Patil, S., Sankpal, U. T., Hurtado, M., Bowman, W. P., Murray, J., Borgmann, K., Ghorpade, A., Sutphin, R., Eslin, D. & Basha, R., 15 Jul 2019, In : Gene. 705, p. 67-76 10 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Copper-tolfenamic acid: evaluation of stability and anti-cancer activity

    Hurtado, M., Sankpal, U. T., Chhabra, J., Brown, D. T., Maram, R., Patel, R., Gurung, R. K., Simecka, J., Holder, A. A. & Basha, R., 15 Feb 2019, In : Investigational New Drugs. 37, 1, p. 27-34 8 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Investigational agents to enhance the efficacy of chemotherapy or radiation in pancreatic cancer

    Hurtado, M., Sankpal, U. T., Ranjan, A., Maram, R., Vishwanatha, J. K., Nagaraju, G. P., El-Rayes, B. F. & Basha, R., Jun 2018, In : Critical Reviews in Oncology/Hematology. 126, p. 201-207 7 p.

    Research output: Contribution to journalReview article

  • 8 Scopus citations

    Novel survivin inhibitor for suppressing pancreatic cancer cells growth via downregulating Sp1 and Sp3 transcription factors

    Hurtado, M., Sankpal, U. T., Kaba, A., Mahammad, S., Chhabra, J., Brown, D. T., Gurung, R. K., Holder, A. A., Vishwanatha, J. K. & Basha, R., 1 Dec 2018, In : Cellular Physiology and Biochemistry. 51, 4, p. 1894-1907 14 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations