Tina Machu, PhD

  • 1300 Citations
  • 19 h-Index
19882011

Research output per year

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Research Output

  • 1300 Citations
  • 19 h-Index
  • 35 Article
  • 5 Chapter
  • 2 Review article
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Article
2009

Colchicine: A novel positive allosteric modulator of the human 5-Hydroxytryptamine 3A receptor

De Oliveira-Pierce, A. N., Zhang, R. & Machu, T. K., 1 May 2009, In : Journal of Pharmacology and Experimental Therapeutics. 329, 2, p. 838-847 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Hydrophobic photolabeling studies identify the lipid-protein interface of the 5-HT3A receptor

Sanghvi, M., Hamouda, A. K., Davis, M. I., Morton, R. A., Srivastava, S., Pandhare, A., Duddempudi, P. K., Machu, T. K., Lovinger, D. M., Cohen, J. B. & Blanton, M. P., 6 Oct 2009, In : Biochemistry. 48, 39, p. 9278-9286 9 p.

Research output: Contribution to journalArticle

10 Scopus citations
2007

The role of loop F residues in determining differential d-tubocurarine potencies in mouse and human 5-hydroxytryptamine 3A receptors

Zhang, R., Wen, X., Militante, J., Hester, B., Rhubottom, H. E., Sun, H., Leidenheimer, N. J., Yan, D., White, M. M. & Machu, T. K., 6 Feb 2007, In : Biochemistry. 46, 5, p. 1194-1204 11 p.

Research output: Contribution to journalArticle

13 Scopus citations
2006

Assessing the lipid requirements of the Torpedo californica nicotinic acetylcholine receptor

Hamouda, A. K., Sanghvi, M., Sauls, D., Machu, T. K. & Blanton, M. P., 4 Apr 2006, In : Biochemistry. 45, 13, p. 4327-4337 11 p.

Research output: Contribution to journalArticle

46 Scopus citations

Effects of ethanol on adenosine 5′-triphosphate-gated purinergic and 5-hydroxytryptamine 3 receptors

Davies, D. L., Asatryan, L., Kuo, S. T., Woodward, J. J., King, B. F., Alkana, R. L., Xiao, C., Ye, J. H., Sun, H., Zhang, L., Hu, X. Q., Hayrapetyan, V., Lovinger, D. M. & Machu, T. K., 1 Feb 2006, In : Alcoholism: Clinical and Experimental Research. 30, 2, p. 349-358 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Mutations of L293 in transmembrane two of the mouse 5-hydroxytryptamine 3A receptor alter gating and alcohol modulatory actions

Hu, X. Q., Hayrapetyan, V., Gadhiya, J. J., Rhubottom, H. E., Lovinger, D. M. & Machu, T. K., 1 May 2006, In : British Journal of Pharmacology. 148, 1, p. 88-101 14 p.

Research output: Contribution to journalArticle

15 Scopus citations

N-terminal domains in mouse and human 5-hydroxytryptamine3A receptors confer partial agonist and antagonist properties to benzylidene analogs of anabaseine

Zhang, R., White, N. A., Soti, F. S., Kem, W. R. & Machu, T. K., 1 Jun 2006, In : Journal of Pharmacology and Experimental Therapeutics. 317, 3, p. 1276-1284 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Temperature: An important experimental variable in studying PKC modulation of ligand-gated ion channels

Machu, T. K., Dillon, G. H., Huang, R-Q., Lovinger, D. M. & Leidenheimer, N. J., 1 May 2006, In : Brain Research. 1086, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

13 Scopus citations
2005

Co-expression of the 5-HT3B subunit with the 5-HT3A receptor reduces alcohol sensitivity

Hayrapetyan, V., Jenschke, M., Dillon, G. H. & Machu, T. K., 14 Dec 2005, In : Molecular Brain Research. 142, 2, p. 146-150 5 p.

Research output: Contribution to journalArticle

22 Scopus citations
2004

Serotonin-3 Receptors in the Actions of Alcohol, Alcohol Reinforcement, and Alcoholism

McBride, W. J., Lovinger, D. M., Machu, T., Thielen, R. J., Rodd, Z. A., Murphy, J. M., Roache, J. D. & Johnson, B. A., 1 Feb 2004, In : Alcoholism: Clinical and Experimental Research. 28, 2, p. 257-267 11 p.

Research output: Contribution to journalArticle

61 Scopus citations
2003

A mutation in transmembrane domain II of the 5-hydroxytryptamine3A receptor stabilizes channel opening and alters alcohol modulatory actions

Sessoms-Sikes, J. S., Hamilton, M. E., Liu, L. X., Lovinger, D. M. & Machu, T. K., 1 Aug 2003, In : Journal of Pharmacology and Experimental Therapeutics. 306, 2, p. 595-604 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

The GABAA receptor antagonist picrotoxin inhibits 5-hydroxytryptamine type 3A receptors

Das, P., Bell-Horner, C. L., Machu, T. K. & Dillon, G. H., 1 Jan 2003, In : Neuropharmacology. 44, 4, p. 431-438 8 p.

Research output: Contribution to journalArticle

32 Scopus citations
2002

ATA2-mediated amino acid uptake following partial hepatectomy is regulated by redistribution to the plasma membrane

Freeman, T. L., Thiele, G. M., Tuma, D. J., Machu, T. K. & Mailliard, M. E., 15 Apr 2002, In : Archives of Biochemistry and Biophysics. 400, 2, p. 215-222 8 p.

Research output: Contribution to journalArticle

7 Scopus citations
10 Scopus citations

Ethanol sensitivity in ATP-gated P2X receptors is subunit dependent

Davies, D. L., Machu, T. K., Guo, Y. & Alkana, R. L., 2 Jul 2002, In : Alcoholism: Clinical and Experimental Research. 26, 6, p. 773-778 6 p.

Research output: Contribution to journalArticle

46 Scopus citations
2001

Benzylidene analogs of anabaseine display partial agonist and antagonist properties at the mouse 5-hydroxytryptamine3A receptor

Machu, T. K., Hamilton, M. E., Frye, T. F., Shanklin, C. L., Harris, M. C., Sun, H., Tenner, T. E., Soti, F. S. & Kem, W. R., 12 Dec 2001, In : Journal of Pharmacology and Experimental Therapeutics. 299, 3, p. 1112-1119 8 p.

Research output: Contribution to journalArticle

28 Scopus citations
2000

Bicuculline antagonizes 5-HT(3A) and α2 glycine receptors expressed in Xenopus oocytes

Sun, H. & Machu, T. K., 17 Mar 2000, In : European Journal of Pharmacology. 391, 3, p. 243-249 7 p.

Research output: Contribution to journalArticle

18 Scopus citations
1999
12 Scopus citations

Competitive antagonism of the mouse 5-hydroxytryptamine3 receptor by bisindolylmaleimide I, a 'selective' protein kinase C inhibitor

Coultrap, S. J., Sun, H., Tenner, T. E. & Machu, T. K., 1 Jul 1999, In : Journal of Pharmacology and Experimental Therapeutics. 290, 1, p. 76-82 7 p.

Research output: Contribution to journalArticle

31 Scopus citations

Mutation of putative phosphorylation sites in the 5-hydroxytryptamine3 receptor does not eliminate its modulation by ethanol

Machu, T. K., Coultrap, S. J., Denae' Waugh, M. & Hamilton, M. E., 1 Jan 1999, In : Alcoholism: Clinical and Experimental Research. 23, 1, p. 12-17 6 p.

Research output: Contribution to journalArticle

3 Scopus citations
1998

Colchicine competitively antagonizes glycine receptors expressed in Xenopus oocytes

Machu, T. K., 1 Mar 1998, In : Neuropharmacology. 37, 3, p. 391-396 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

Direct channel-gating and modulatory effects of triiodothyronine on recombinant GABA(A) receptors

Chapell, R., Martin, J., MacHu, T. K. & Leidenheimer, N. J., 15 May 1998, In : European Journal of Pharmacology. 349, 1, p. 115-121 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

Selective actions of a detergent on ligand-gated ion channels expressed in Xenopus oocytes

Machu, T. K., Mihic, S. J. & Dildy-Mayfield, J. E., 1 Jan 1998, In : Journal of Pharmacology and Experimental Therapeutics. 284, 1, p. 32-36 5 p.

Research output: Contribution to journalArticle

10 Scopus citations
1996

Enhancement of homomeric glycine receptor function by long-chain alcohols and anaesthetics

Mascia, M. P., Machu, T. K. & Harris, R. A., 1 Jan 1996, In : British Journal of Pharmacology. 119, 7, p. 1331-1336 6 p.

Research output: Contribution to journalArticle

187 Scopus citations
1995

Tyrosine kinase phosphorylation of GABAA receptors

Valenzuela, C. F., Machu, T. K., McKernan, R. M., Whiting, P., VanRenterghem, B. B., McManaman, J. L., Brozowski, S. J., Smith, G. B., Olsen, R. W. & Harris, R. A., Jul 1995, In : Molecular Brain Research. 31, 1-2, p. 165-172 8 p.

Research output: Contribution to journalArticle

73 Scopus citations
1994
120 Scopus citations
1993
60 Scopus citations

Immunochemical Characterization of the β2 Subunit of the GABAA Receptor

Machu, T. K., Olsen, R. W. & Browning, M. D., Dec 1993, In : Journal of Neurochemistry. 61, 6, p. 2034-2040 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Phosphorylation of cytochrome P4502E1 (CYP2E1) by calmodulin dependent protein kinase protein kinase C and cAMP dependent protein kinase

Menez, J. F., Machu, T. K., Song, B. J., Browning, M. D. & Deitrich, R. A., 1 Jul 1993, In : Alcohol and Alcoholism. 28, 4, p. 445-451 7 p.

Research output: Contribution to journalArticle

24 Scopus citations
1992

Ethanol and voltage- or receptor-mediated increases in cytosolic Ca2+ in brain cells

Dildy-Mayfield, J. E., Machu, T. & Leslie, S. W., 1 Jan 1992, In : Alcohol. 9, 1, p. 63-69 7 p.

Research output: Contribution to journalArticle

20 Scopus citations
1991

Cyclic AMP‐Dependent Protein Kinase Decreases γ‐Aminobutyric AcidA Receptor‐Mediated 36Q1 Uptake by Brain Microsacs

Leidenheimer, N. J., Machu, T. K., Endo, S., Olsen, R. W., Harris, R. A. & Browning, M. D., Aug 1991, In : Journal of Neurochemistry. 57, 2, p. 722-725 4 p.

Research output: Contribution to journalArticle

53 Scopus citations
23 Scopus citations
1990

Chronic ethanol treatment alters ω-conotoxin and Bay K 8644 sensitive calcium channels in rat striatal synaptosomes

Woodward, J. J., Machu, T. & Leslie, S. W., 1 Jan 1990, In : Alcohol. 7, 4, p. 279-284 6 p.

Research output: Contribution to journalArticle

17 Scopus citations
1989

Ethanol and inositol 1,4,5-trisphosphate mobilize calcium from rat brain microsomes

Machu, T. K., Woodward, J. J. & Leslie, S. W., 1 Jan 1989, In : Alcohol. 6, 6, p. 431-436 6 p.

Research output: Contribution to journalArticle

14 Scopus citations
1988

Beta-adrenergic receptor characteristics of postnatal rat myocardial cell preparations

Welder, A. A., Machu, T. K., Leslie, S. W., Wilcox, R. E., Bradlaw, J. & Acosta, D., 1 Aug 1988, In : In Vitro Cellular & Developmental Biology. 24, 8, p. 771-777 7 p.

Research output: Contribution to journalArticle

3 Scopus citations