Projects per year
Personal profile
Area of Expertise
My current scholarly interests include educational psychology and innovative learning strategies for professional students. I am particularly interested in pre- and post-matriculation non-cognitive attributes that influence academic success.
During my career in biomedical research, I studied the structure and function of ligand-gated ion channels, with an emphasis on 5-Hydroxytryptamine3 (5-HT3) receptors. I investigated a putative alcohol-binding domain of the 5-HT3 receptor. Another project focused on the 5-HT ligand (5-HT) binding domain of the receptor, with an emphasis on amino residues that couple agonist binding to conformational changes in the N-termini that initiate channel opening. The NIH, American Heart Association, and Alcoholic Beverage Medical Research Foundation have funded my research in this area.
During my career in biomedical research, I studied the structure and function of ligand-gated ion channels, with an emphasis on 5-Hydroxytryptamine3 (5-HT3) receptors. I investigated a putative alcohol-binding domain of the 5-HT3 receptor. Another project focused on the 5-HT ligand (5-HT) binding domain of the receptor, with an emphasis on amino residues that couple agonist binding to conformational changes in the N-termini that initiate channel opening. The NIH, American Heart Association, and Alcoholic Beverage Medical Research Foundation have funded my research in this area.
Education/Academic qualification
BS in Pharmacy, University of Texas at Austin
PhD in Pharmacy, University of Texas at Austin
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Projects
- 8 Finished
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Ligand Binding Domains in the 5-HT3 Receptor
Machu, T. (CoPI) & Machu, T. (PI)
1/12/02 → 30/08/03
Project: Research
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Ligand Binding Domains in the 5-HT3 Receptor
Machu, T. (PI) & MACHU, T. K. (PI)
National Institute of Neurological Disorders and Stroke
1/12/02 → 30/11/08
Project: Research
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ALCOHOL MODULATORY SITES IN THE 5HT3A RECEPTOR
Machu, T. (CoPI) & Machu, T. (PI)
1/06/01 → 28/02/07
Project: Research
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ALCOHOL MODULATORY SITES IN THE 5HT3A RECEPTOR
Machu, T. (PI) & MACHU, T. K. (PI)
National Institute on Alcohol Abuse and Alcoholism
1/06/01 → 28/02/07
Project: Research
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ETHANOL AND PHOSPHORYLATION OF THE 5-HT3 RECEPTOR
Machu, T. (PI) & MACHU, T. (CoPI)
1/05/95 → 30/04/00
Project: Research
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Beta-adrenergic receptor characteristics of postnatal rat myocardial cell preparations
Welder, A. A., Machu, T., Leslie, S. W., Wilcox, R. E., Bradlaw, J. & Acosta, D., Aug 1988, In: In Vitro Cellular & Developmental Biology. 24, 8, p. 771-777 7 p.Research output: Contribution to journal › Article › peer-review
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Tyrosine kinase phosphorylation of GABAA receptors
Valenzuela, C. F., Machu, T. K., McKernan, R. M., Whiting, P., VanRenterghem, B. B., McManaman, J. L., Brozowski, S. J., Smith, G. B., Olsen, R. W. & Harris, R. A., Jul 1995, In: Molecular Brain Research. 31, 1-2, p. 165-172 8 p.Research output: Contribution to journal › Article › peer-review
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Ethanol sensitivity in ATP-gated P2X receptors is subunit dependent
Davies, D. L., Machu, T. K., Guo, Y. & Alkana, R. L., 2002, In: Alcoholism: Clinical and Experimental Research. 26, 6, p. 773-778 6 p.Research output: Contribution to journal › Article › peer-review
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SR57227A
Machu, T., 2007, xPharm: The Comprehensive Pharmacology Reference. Elsevier Inc., p. 1-2 2 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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(3 chlorophenyl) biguanide
Machu, T., 2007, xPharm: The Comprehensive Pharmacology Reference. Elsevier Inc., p. 1-2 2 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review