Projects per year
Personal profile
Area of Expertise
My current scholarly interests include educational psychology and innovative learning strategies for professional students. I am particularly interested in pre- and post-matriculation non-cognitive attributes that influence academic success.
During my career in biomedical research, I studied the structure and function of ligand-gated ion channels, with an emphasis on 5-Hydroxytryptamine3 (5-HT3) receptors. I investigated a putative alcohol-binding domain of the 5-HT3 receptor. Another project focused on the 5-HT ligand (5-HT) binding domain of the receptor, with an emphasis on amino residues that couple agonist binding to conformational changes in the N-termini that initiate channel opening. The NIH, American Heart Association, and Alcoholic Beverage Medical Research Foundation have funded my research in this area.
During my career in biomedical research, I studied the structure and function of ligand-gated ion channels, with an emphasis on 5-Hydroxytryptamine3 (5-HT3) receptors. I investigated a putative alcohol-binding domain of the 5-HT3 receptor. Another project focused on the 5-HT ligand (5-HT) binding domain of the receptor, with an emphasis on amino residues that couple agonist binding to conformational changes in the N-termini that initiate channel opening. The NIH, American Heart Association, and Alcoholic Beverage Medical Research Foundation have funded my research in this area.
Education/Academic qualification
BS in Pharmacy, University of Texas at Austin
PhD in Pharmacy, University of Texas at Austin
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Projects
- 8 Finished
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Ligand Binding Domains in the 5-HT3 Receptor
Machu, T. (CoPI) & Machu, T. (PI)
1/12/02 → 30/08/03
Project: Research
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Ligand Binding Domains in the 5-HT3 Receptor
Machu, T. (PI) & MACHU, T. K. (PI)
National Institute of Neurological Disorders and Stroke
1/12/02 → 30/11/08
Project: Research
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ALCOHOL MODULATORY SITES IN THE 5HT3A RECEPTOR
Machu, T. (CoPI) & Machu, T. (PI)
1/06/01 → 28/02/07
Project: Research
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ALCOHOL MODULATORY SITES IN THE 5HT3A RECEPTOR
Machu, T. (PI) & MACHU, T. K. (PI)
National Institute on Alcohol Abuse and Alcoholism
1/06/01 → 28/02/07
Project: Research
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ETHANOL AND PHOSPHORYLATION OF THE 5-HT3 RECEPTOR
Machu, T. (PI) & MACHU, T. (CoPI)
1/05/95 → 30/04/00
Project: Research
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LY278584
Machu, T., 2007, xPharm: The Comprehensive Pharmacology Reference. Elsevier Inc., p. 1-2 2 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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GR65630
Machu, T., 2007, xPharm: The Comprehensive Pharmacology Reference. Elsevier Inc., p. 1-2 2 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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Mutation of putative phosphorylation sites in the 5-hydroxytryptamine3 receptor does not eliminate its modulation by ethanol
Machu, T. K., Coultrap, S. J., Denae' Waugh, M. & Hamilton, M. E., Jan 1999, In: Alcoholism: Clinical and Experimental Research. 23, 1, p. 12-17 6 p.Research output: Contribution to journal › Article › peer-review
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Ethanol sensitivity in ATP-gated P2X receptors is subunit dependent
Davies, D. L., Machu, T. K., Guo, Y. & Alkana, R. L., 2002, In: Alcoholism: Clinical and Experimental Research. 26, 6, p. 773-778 6 p.Research output: Contribution to journal › Article › peer-review
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Serotonin-3 Receptors in the Actions of Alcohol, Alcohol Reinforcement, and Alcoholism
McBride, W. J., Lovinger, D. M., Machu, T., Thielen, R. J., Rodd, Z. A., Murphy, J. M., Roache, J. D. & Johnson, B. A., Feb 2004, In: Alcoholism: Clinical and Experimental Research. 28, 2, p. 257-267 11 p.Research output: Contribution to journal › Article › peer-review