Tina Machu, PhD

  • 1272 Citations
  • 19 h-Index
19882011
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Personal profile

Area of Expertise

My current scholarly interests include educational psychology and innovative learning strategies for professional students. I am particularly interested in pre- and post-matriculation non-cognitive attributes that influence academic success.
During my career in biomedical research, I studied the structure and function of ligand-gated ion channels, with an emphasis on 5-Hydroxytryptamine3 (5-HT3) receptors. I investigated a putative alcohol-binding domain of the 5-HT3 receptor. Another project focused on the 5-HT ligand (5-HT) binding domain of the receptor, with an emphasis on amino residues that couple agonist binding to conformational changes in the N-termini that initiate channel opening. The NIH, American Heart Association, and Alcoholic Beverage Medical Research Foundation have funded my research in this area.

Education/Academic qualification

PhD in Pharmacy, University of Texas at Austin

BS in Pharmacy, University of Texas at Austin

Fingerprint Dive into the research topics where Tina Machu is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 1 Similar Profiles
Serotonin Receptors Medicine & Life Sciences
Ethanol Medicine & Life Sciences
Oocytes Medicine & Life Sciences
Serotonin Medicine & Life Sciences
GABA-A Receptors Medicine & Life Sciences
Receptors, Serotonin, 5-HT3 Medicine & Life Sciences
Phosphorylation Chemical Compounds
Ligand-Gated Ion Channels Medicine & Life Sciences

Research Output 1988 2011

  • 1272 Citations
  • 19 h-Index
  • 35 Article
  • 5 Chapter
  • 2 Review article
43 Citations (Scopus)

Therapeutics of 5-HT3 receptor antagonists: Current uses and future directions

Machu, T. K., 1 Jan 2011, In : Pharmacology and Therapeutics. 130, 3, p. 338-347 10 p.

Research output: Contribution to journalReview articleResearchpeer-review

Vomiting
Serotonin Receptors
Nausea
Ligand-Gated Ion Channels
Gastrointestinal Motility
6 Citations (Scopus)

Colchicine: A novel positive allosteric modulator of the human 5-Hydroxytryptamine 3A receptor

De Oliveira-Pierce, A. N., Zhang, R. & Machu, T. K., 1 May 2009, In : Journal of Pharmacology and Experimental Therapeutics. 329, 2, p. 838-847 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Serotonin Receptors
Colchicine
Oocytes
Serotonin
Indazoles
10 Citations (Scopus)

Hydrophobic photolabeling studies identify the lipid-protein interface of the 5-HT3A receptor

Sanghvi, M., Hamouda, A. K., Davis, M. I., Morton, R. A., Srivastava, S., Pandhare, A., Duddempudi, P. K., Machu, T. K., Lovinger, D. M., Cohen, J. B. & Blanton, M. P., 6 Oct 2009, In : Biochemistry. 48, 39, p. 9278-9286 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Bungarotoxins
Lipids
Proteins
Torpedo
Nicotinic Receptors

(3 chlorophenyl) biguanide

Machu, T. K., 1 Jan 2007, xPharm: The Comprehensive Pharmacology Reference. Elsevier Inc., p. 1-2 2 p.

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Biguanides
Serotonin Receptors
1-(3-chlorophenyl)biguanide

GR65630

Machu, T. K., 1 Jan 2007, xPharm: The Comprehensive Pharmacology Reference. Elsevier Inc., p. 1-2 2 p.

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Serotonin Receptors
Serotonin
GR 65630