Projects per year
Personal profile
Area of Expertise
My current scholarly interests include educational psychology and innovative learning strategies for professional students. I am particularly interested in pre- and post-matriculation non-cognitive attributes that influence academic success.
During my career in biomedical research, I studied the structure and function of ligand-gated ion channels, with an emphasis on 5-Hydroxytryptamine3 (5-HT3) receptors. I investigated a putative alcohol-binding domain of the 5-HT3 receptor. Another project focused on the 5-HT ligand (5-HT) binding domain of the receptor, with an emphasis on amino residues that couple agonist binding to conformational changes in the N-termini that initiate channel opening. The NIH, American Heart Association, and Alcoholic Beverage Medical Research Foundation have funded my research in this area.
During my career in biomedical research, I studied the structure and function of ligand-gated ion channels, with an emphasis on 5-Hydroxytryptamine3 (5-HT3) receptors. I investigated a putative alcohol-binding domain of the 5-HT3 receptor. Another project focused on the 5-HT ligand (5-HT) binding domain of the receptor, with an emphasis on amino residues that couple agonist binding to conformational changes in the N-termini that initiate channel opening. The NIH, American Heart Association, and Alcoholic Beverage Medical Research Foundation have funded my research in this area.
Education/Academic qualification
BS in Pharmacy, University of Texas at Austin
PhD in Pharmacy, University of Texas at Austin
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Projects
- 8 Finished
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Ligand Binding Domains in the 5-HT3 Receptor
Machu, T. & MACHU, T. K.
National Institute of Neurological Disorders and Stroke
1/12/02 → 30/11/08
Project: Research
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ALCOHOL MODULATORY SITES IN THE 5HT3A RECEPTOR
Machu, T. & MACHU, T. K.
National Institute on Alcohol Abuse and Alcoholism
1/06/01 → 28/02/07
Project: Research
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ETHANOL AND PHOSPHORYLATION OF THE 5-HT3 RECEPTOR
Machu, T. & MACHU, T.
1/05/95 → 30/04/00
Project: Research
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Immunochemical Characterization of the β2 Subunit of the GABAA Receptor
Machu, T. K., Olsen, R. W. & Browning, M. D., Dec 1993, In: Journal of Neurochemistry. 61, 6, p. 2034-2040 7 p.Research output: Contribution to journal › Article › peer-review
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Ca2+/Calmodulin‐Dependent Protein Kinase II and Protein Kinase C Phosphorylate a Synthetic Peptide Corresponding to a Sequence That Is Specific for the γ2L Subunit of the GABAA Receptor
Machu, T. K., Firestone, J. A. & Browning, M. D., Jul 1993, In: Journal of Neurochemistry. 61, 1, p. 375-377 3 p.Research output: Contribution to journal › Article › peer-review
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Alcohols and anesthetics enhance the function of 5-hydroxytryptamine3 receptors expressed in Xenopus laevis oocytes
Machu, T. K. & Harris, R. A., 1994, In: Journal of Pharmacology and Experimental Therapeutics. 271, 2, p. 898-905 8 p.Research output: Contribution to journal › Article › peer-review
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Serotonin-3 Receptors in the Actions of Alcohol, Alcohol Reinforcement, and Alcoholism
McBride, W. J., Lovinger, D. M., Machu, T., Thielen, R. J., Rodd, Z. A., Murphy, J. M., Roache, J. D. & Johnson, B. A., Feb 2004, In: Alcoholism: Clinical and Experimental Research. 28, 2, p. 257-267 11 p.Research output: Contribution to journal › Article › peer-review
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Bicuculline antagonizes 5-HT(3A) and α2 glycine receptors expressed in Xenopus oocytes
Sun, H. & Machu, T. K., 17 Mar 2000, In: European Journal of Pharmacology. 391, 3, p. 243-249 7 p.Research output: Contribution to journal › Article › peer-review