Projects per year
Personal profile
Area of Expertise
My current scholarly interests include educational psychology and innovative learning strategies for professional students. I am particularly interested in pre- and post-matriculation non-cognitive attributes that influence academic success.
During my career in biomedical research, I studied the structure and function of ligand-gated ion channels, with an emphasis on 5-Hydroxytryptamine3 (5-HT3) receptors. I investigated a putative alcohol-binding domain of the 5-HT3 receptor. Another project focused on the 5-HT ligand (5-HT) binding domain of the receptor, with an emphasis on amino residues that couple agonist binding to conformational changes in the N-termini that initiate channel opening. The NIH, American Heart Association, and Alcoholic Beverage Medical Research Foundation have funded my research in this area.
During my career in biomedical research, I studied the structure and function of ligand-gated ion channels, with an emphasis on 5-Hydroxytryptamine3 (5-HT3) receptors. I investigated a putative alcohol-binding domain of the 5-HT3 receptor. Another project focused on the 5-HT ligand (5-HT) binding domain of the receptor, with an emphasis on amino residues that couple agonist binding to conformational changes in the N-termini that initiate channel opening. The NIH, American Heart Association, and Alcoholic Beverage Medical Research Foundation have funded my research in this area.
Education/Academic qualification
BS in Pharmacy, University of Texas at Austin
PhD in Pharmacy, University of Texas at Austin
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Projects
- 8 Finished
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Ligand Binding Domains in the 5-HT3 Receptor
Machu, T. & MACHU, T. K.
National Institute of Neurological Disorders and Stroke
1/12/02 → 30/11/08
Project: Research
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ALCOHOL MODULATORY SITES IN THE 5HT3A RECEPTOR
Machu, T. & MACHU, T. K.
National Institute on Alcohol Abuse and Alcoholism
1/06/01 → 28/02/07
Project: Research
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ETHANOL AND PHOSPHORYLATION OF THE 5-HT3 RECEPTOR
National Institute on Alcohol Abuse and Alcoholism
1/05/95 → 30/04/00
Project: Research
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Therapeutics of 5-HT3 receptor antagonists: Current uses and future directions
MacHu, T. K., Jun 2011, In: Pharmacology and Therapeutics. 130, 3, p. 338-347 10 p.Research output: Contribution to journal › Review article › peer-review
54 Scopus citations -
Colchicine: A novel positive allosteric modulator of the human 5-Hydroxytryptamine 3A receptor
De Oliveira-Pierce, A. N., Zhang, R. & Machu, T. K., May 2009, In: Journal of Pharmacology and Experimental Therapeutics. 329, 2, p. 838-847 10 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Hydrophobic photolabeling studies identify the lipid-protein interface of the 5-HT3A receptor
Sanghvi, M., Hamouda, A. K., Davis, M. I., Morton, R. A., Srivastava, S., Pandhare, A., Duddempudi, P. K., Machu, T. K., Lovinger, D. M., Cohen, J. B. & Blanton, M. P., 6 Oct 2009, In: Biochemistry. 48, 39, p. 9278-9286 9 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
(3 chlorophenyl) biguanide
Machu, T., 1 Jan 2007, xPharm: The Comprehensive Pharmacology Reference. Elsevier Inc., p. 1-2 2 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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GR65630
Machu, T., 1 Jan 2007, xPharm: The Comprehensive Pharmacology Reference. Elsevier Inc., p. 1-2 2 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review