Tina Machu, PhD

  • 1317 Citations
  • 19 h-Index
19882011

Research output per year

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Personal profile

Area of Expertise

My current scholarly interests include educational psychology and innovative learning strategies for professional students. I am particularly interested in pre- and post-matriculation non-cognitive attributes that influence academic success.
During my career in biomedical research, I studied the structure and function of ligand-gated ion channels, with an emphasis on 5-Hydroxytryptamine3 (5-HT3) receptors. I investigated a putative alcohol-binding domain of the 5-HT3 receptor. Another project focused on the 5-HT ligand (5-HT) binding domain of the receptor, with an emphasis on amino residues that couple agonist binding to conformational changes in the N-termini that initiate channel opening. The NIH, American Heart Association, and Alcoholic Beverage Medical Research Foundation have funded my research in this area.

Education/Academic qualification

BS in Pharmacy, University of Texas at Austin

PhD in Pharmacy, University of Texas at Austin

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Projects

Ligand Binding Domains in the 5-HT3 Receptor

Machu, T.

1/12/0230/08/03

Project: Research

ALCOHOL MODULATORY SITES IN THE 5HT3A RECEPTOR

Machu, T.

1/06/0128/02/02

Project: Research

Research Output

  • 1317 Citations
  • 19 h-Index
  • 35 Article
  • 5 Chapter
  • 2 Review article

Therapeutics of 5-HT3 receptor antagonists: Current uses and future directions

MacHu, T. K., Jun 2011, In : Pharmacology and Therapeutics. 130, 3, p. 338-347 10 p.

Research output: Contribution to journalReview article

  • 50 Scopus citations

    Colchicine: A novel positive allosteric modulator of the human 5-Hydroxytryptamine 3A receptor

    De Oliveira-Pierce, A. N., Zhang, R. & Machu, T. K., May 2009, In : Journal of Pharmacology and Experimental Therapeutics. 329, 2, p. 838-847 10 p.

    Research output: Contribution to journalArticle

  • 7 Scopus citations

    Hydrophobic photolabeling studies identify the lipid-protein interface of the 5-HT3A receptor

    Sanghvi, M., Hamouda, A. K., Davis, M. I., Morton, R. A., Srivastava, S., Pandhare, A., Duddempudi, P. K., Machu, T. K., Lovinger, D. M., Cohen, J. B. & Blanton, M. P., 6 Oct 2009, In : Biochemistry. 48, 39, p. 9278-9286 9 p.

    Research output: Contribution to journalArticle

  • 10 Scopus citations

    (3 chlorophenyl) biguanide

    Machu, T., 1 Jan 2007, xPharm: The Comprehensive Pharmacology Reference. Elsevier Inc., p. 1-2 2 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  • GR65630

    Machu, T., 1 Jan 2007, xPharm: The Comprehensive Pharmacology Reference. Elsevier Inc., p. 1-2 2 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter