Projects per year
Personal profile
Area of Expertise
My current scholarly interests include educational psychology and innovative learning strategies for professional students. I am particularly interested in pre- and post-matriculation non-cognitive attributes that influence academic success.
During my career in biomedical research, I studied the structure and function of ligand-gated ion channels, with an emphasis on 5-Hydroxytryptamine3 (5-HT3) receptors. I investigated a putative alcohol-binding domain of the 5-HT3 receptor. Another project focused on the 5-HT ligand (5-HT) binding domain of the receptor, with an emphasis on amino residues that couple agonist binding to conformational changes in the N-termini that initiate channel opening. The NIH, American Heart Association, and Alcoholic Beverage Medical Research Foundation have funded my research in this area.
During my career in biomedical research, I studied the structure and function of ligand-gated ion channels, with an emphasis on 5-Hydroxytryptamine3 (5-HT3) receptors. I investigated a putative alcohol-binding domain of the 5-HT3 receptor. Another project focused on the 5-HT ligand (5-HT) binding domain of the receptor, with an emphasis on amino residues that couple agonist binding to conformational changes in the N-termini that initiate channel opening. The NIH, American Heart Association, and Alcoholic Beverage Medical Research Foundation have funded my research in this area.
Education/Academic qualification
BS in Pharmacy, University of Texas at Austin
PhD in Pharmacy, University of Texas at Austin
Fingerprint
Dive into the research topics where Tina Machu is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Projects
- 8 Finished
-
Ligand Binding Domains in the 5-HT3 Receptor
Machu, T. & MACHU, T. K.
National Institute of Neurological Disorders and Stroke
1/12/02 → 30/11/08
Project: Research
-
-
ALCOHOL MODULATORY SITES IN THE 5HT3A RECEPTOR
Machu, T. & MACHU, T. K.
National Institute on Alcohol Abuse and Alcoholism
1/06/01 → 28/02/07
Project: Research
-
-
ETHANOL AND PHOSPHORYLATION OF THE 5-HT3 RECEPTOR
Machu, T. & MACHU, T.
1/05/95 → 30/04/00
Project: Research
-
Therapeutics of 5-HT3 receptor antagonists: Current uses and future directions
MacHu, T. K., Jun 2011, In: Pharmacology and Therapeutics. 130, 3, p. 338-347 10 p.Research output: Contribution to journal › Review article › peer-review
70 Scopus citations -
Colchicine: A novel positive allosteric modulator of the human 5-Hydroxytryptamine 3A receptor
De Oliveira-Pierce, A. N., Zhang, R. & Machu, T. K., May 2009, In: Journal of Pharmacology and Experimental Therapeutics. 329, 2, p. 838-847 10 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Hydrophobic photolabeling studies identify the lipid-protein interface of the 5-HT3A receptor
Sanghvi, M., Hamouda, A. K., Davis, M. I., Morton, R. A., Srivastava, S., Pandhare, A., Duddempudi, P. K., Machu, T. K., Lovinger, D. M., Cohen, J. B. & Blanton, M. P., 6 Oct 2009, In: Biochemistry. 48, 39, p. 9278-9286 9 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
(3 chlorophenyl) biguanide
Machu, T., 1 Jan 2007, xPharm: The Comprehensive Pharmacology Reference. Elsevier Inc., p. 1-2 2 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
-
GR65630
Machu, T., 1 Jan 2007, xPharm: The Comprehensive Pharmacology Reference. Elsevier Inc., p. 1-2 2 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review