Research Output per year
Personal profile
Area of Expertise
My current scholarly interests include educational psychology and innovative learning strategies for professional students. I am particularly interested in pre- and post-matriculation non-cognitive attributes that influence academic success.
During my career in biomedical research, I studied the structure and function of ligand-gated ion channels, with an emphasis on 5-Hydroxytryptamine3 (5-HT3) receptors. I investigated a putative alcohol-binding domain of the 5-HT3 receptor. Another project focused on the 5-HT ligand (5-HT) binding domain of the receptor, with an emphasis on amino residues that couple agonist binding to conformational changes in the N-termini that initiate channel opening. The NIH, American Heart Association, and Alcoholic Beverage Medical Research Foundation have funded my research in this area.
During my career in biomedical research, I studied the structure and function of ligand-gated ion channels, with an emphasis on 5-Hydroxytryptamine3 (5-HT3) receptors. I investigated a putative alcohol-binding domain of the 5-HT3 receptor. Another project focused on the 5-HT ligand (5-HT) binding domain of the receptor, with an emphasis on amino residues that couple agonist binding to conformational changes in the N-termini that initiate channel opening. The NIH, American Heart Association, and Alcoholic Beverage Medical Research Foundation have funded my research in this area.
Education/Academic qualification
PhD in Pharmacy, University of Texas at Austin
BS in Pharmacy, University of Texas at Austin
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Serotonin Receptors
Medicine & Life Sciences
Ethanol
Medicine & Life Sciences
Oocytes
Medicine & Life Sciences
Serotonin
Medicine & Life Sciences
GABA-A Receptors
Medicine & Life Sciences
Receptors, Serotonin, 5-HT3
Medicine & Life Sciences
Phosphorylation
Chemical Compounds
Ligand-Gated Ion Channels
Medicine & Life Sciences
Research Output 1988 2011
43
Citations
(Scopus)
Therapeutics of 5-HT3 receptor antagonists: Current uses and future directions
Machu, T. K., 1 Jan 2011, In : Pharmacology and Therapeutics. 130, 3, p. 338-347 10 p.Research output: Contribution to journal › Review article › Research › peer-review
Vomiting
Serotonin Receptors
Nausea
Ligand-Gated Ion Channels
Gastrointestinal Motility
6
Citations
(Scopus)
Colchicine: A novel positive allosteric modulator of the human 5-Hydroxytryptamine 3A receptor
De Oliveira-Pierce, A. N., Zhang, R. & Machu, T. K., 1 May 2009, In : Journal of Pharmacology and Experimental Therapeutics. 329, 2, p. 838-847 10 p.Research output: Contribution to journal › Article › Research › peer-review
Serotonin Receptors
Colchicine
Oocytes
Serotonin
Indazoles
10
Citations
(Scopus)
Hydrophobic photolabeling studies identify the lipid-protein interface of the 5-HT3A receptor
Sanghvi, M., Hamouda, A. K., Davis, M. I., Morton, R. A., Srivastava, S., Pandhare, A., Duddempudi, P. K., Machu, T. K., Lovinger, D. M., Cohen, J. B. & Blanton, M. P., 6 Oct 2009, In : Biochemistry. 48, 39, p. 9278-9286 9 p.Research output: Contribution to journal › Article › Research › peer-review
Bungarotoxins
Lipids
Proteins
Torpedo
Nicotinic Receptors
(3 chlorophenyl) biguanide
Machu, T. K., 1 Jan 2007, xPharm: The Comprehensive Pharmacology Reference. Elsevier Inc., p. 1-2 2 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › Research › peer-review
Biguanides
Serotonin Receptors
1-(3-chlorophenyl)biguanide
GR65630
Machu, T. K., 1 Jan 2007, xPharm: The Comprehensive Pharmacology Reference. Elsevier Inc., p. 1-2 2 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › Research › peer-review
Serotonin Receptors
Serotonin
GR 65630