Projects per year
Personal profile
Area of Expertise
My current scholarly interests include educational psychology and innovative learning strategies for professional students. I am particularly interested in pre- and post-matriculation non-cognitive attributes that influence academic success.
During my career in biomedical research, I studied the structure and function of ligand-gated ion channels, with an emphasis on 5-Hydroxytryptamine3 (5-HT3) receptors. I investigated a putative alcohol-binding domain of the 5-HT3 receptor. Another project focused on the 5-HT ligand (5-HT) binding domain of the receptor, with an emphasis on amino residues that couple agonist binding to conformational changes in the N-termini that initiate channel opening. The NIH, American Heart Association, and Alcoholic Beverage Medical Research Foundation have funded my research in this area.
During my career in biomedical research, I studied the structure and function of ligand-gated ion channels, with an emphasis on 5-Hydroxytryptamine3 (5-HT3) receptors. I investigated a putative alcohol-binding domain of the 5-HT3 receptor. Another project focused on the 5-HT ligand (5-HT) binding domain of the receptor, with an emphasis on amino residues that couple agonist binding to conformational changes in the N-termini that initiate channel opening. The NIH, American Heart Association, and Alcoholic Beverage Medical Research Foundation have funded my research in this area.
Education/Academic qualification
BS in Pharmacy, University of Texas at Austin
PhD in Pharmacy, University of Texas at Austin
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Projects
- 8 Finished
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Ligand Binding Domains in the 5-HT3 Receptor
Machu, T. (PI) & MACHU, T. K. (PI)
National Institute of Neurological Disorders and Stroke
1/12/02 → 30/11/08
Project: Research
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Ligand Binding Domains in the 5-HT3 Receptor
Machu, T. (CoPI) & Machu, T. (PI)
1/12/02 → 30/08/03
Project: Research
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ALCOHOL MODULATORY SITES IN THE 5HT3A RECEPTOR
Machu, T. (CoPI) & Machu, T. (PI)
1/06/01 → 28/02/07
Project: Research
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ALCOHOL MODULATORY SITES IN THE 5HT3A RECEPTOR
Machu, T. (PI) & MACHU, T. K. (PI)
National Institute on Alcohol Abuse and Alcoholism
1/06/01 → 28/02/07
Project: Research
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ETHANOL AND PHOSPHORYLATION OF THE 5-HT3 RECEPTOR
Machu, T. (PI) & MACHU, T. (CoPI)
1/05/95 → 30/04/00
Project: Research
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Tyrosine kinase phosphorylation of GABAA receptors
Valenzuela, C. F., Machu, T. K., McKernan, R. M., Whiting, P., VanRenterghem, B. B., McManaman, J. L., Brozowski, S. J., Smith, G. B., Olsen, R. W. & Harris, R. A., Jul 1995, In: Molecular Brain Research. 31, 1-2, p. 165-172 8 p.Research output: Contribution to journal › Article › peer-review
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Mutations of L293 in transmembrane two of the mouse 5-hydroxytryptamine 3A receptor alter gating and alcohol modulatory actions
Hu, X. Q., Hayrapetyan, V., Gadhiya, J. J., Rhubottom, H. E., Lovinger, D. M. & Machu, T. K., May 2006, In: British Journal of Pharmacology. 148, 1, p. 88-101 14 p.Research output: Contribution to journal › Article › peer-review
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Ethanol Has No Effect on CAMP‐Dependent Protein Kinase‐, Protein Kinase C‐, or Ca2+‐Calmodulin‐Dependent Protein Kinase II‐Stimulated Phosphorylation of Highly Purified Substrates in Vitro
Machu, T. K., Olsen, R. W. & Browning, M. D., Nov 1991, In: Alcoholism: Clinical and Experimental Research. 15, 6, p. 1040-1044 5 p.Research output: Contribution to journal › Article › peer-review
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Temperature: An important experimental variable in studying PKC modulation of ligand-gated ion channels
Machu, T. K., Dillon, G. H., Huang, R. Q., Lovinger, D. M. & Leidenheimer, N. J., 1 May 2006, In: Brain Research. 1086, 1, p. 1-8 8 p.Research output: Contribution to journal › Article › peer-review
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Phosphorylation of cytochrome P4502E1 (CYP2E1) by calmodulin dependent protein kinase protein kinase C and cAMP dependent protein kinase
Menez, J. F., Machu, T. K., Song, B. J., Browning, M. D. & Deitrich, R. A., Jul 1993, In: Alcohol and Alcoholism. 28, 4, p. 445-451 7 p.Research output: Contribution to journal › Article › peer-review