Projects per year
Personal profile
Area of Expertise
My current scholarly interests include educational psychology and innovative learning strategies for professional students. I am particularly interested in pre- and post-matriculation non-cognitive attributes that influence academic success.
During my career in biomedical research, I studied the structure and function of ligand-gated ion channels, with an emphasis on 5-Hydroxytryptamine3 (5-HT3) receptors. I investigated a putative alcohol-binding domain of the 5-HT3 receptor. Another project focused on the 5-HT ligand (5-HT) binding domain of the receptor, with an emphasis on amino residues that couple agonist binding to conformational changes in the N-termini that initiate channel opening. The NIH, American Heart Association, and Alcoholic Beverage Medical Research Foundation have funded my research in this area.
During my career in biomedical research, I studied the structure and function of ligand-gated ion channels, with an emphasis on 5-Hydroxytryptamine3 (5-HT3) receptors. I investigated a putative alcohol-binding domain of the 5-HT3 receptor. Another project focused on the 5-HT ligand (5-HT) binding domain of the receptor, with an emphasis on amino residues that couple agonist binding to conformational changes in the N-termini that initiate channel opening. The NIH, American Heart Association, and Alcoholic Beverage Medical Research Foundation have funded my research in this area.
Education/Academic qualification
BS in Pharmacy, University of Texas at Austin
PhD in Pharmacy, University of Texas at Austin
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- 1 Similar Profiles
Projects
- 8 Finished
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Ligand Binding Domains in the 5-HT3 Receptor
Machu, T. (CoPI) & Machu, T. (PI)
1/12/02 → 30/08/03
Project: Research
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Ligand Binding Domains in the 5-HT3 Receptor
Machu, T. (PI) & MACHU, T. K. (PI)
National Institute of Neurological Disorders and Stroke
1/12/02 → 30/11/08
Project: Research
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ALCOHOL MODULATORY SITES IN THE 5HT3A RECEPTOR
Machu, T. (PI) & MACHU, T. K. (PI)
National Institute on Alcohol Abuse and Alcoholism
1/06/01 → 28/02/07
Project: Research
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ALCOHOL MODULATORY SITES IN THE 5HT3A RECEPTOR
Machu, T. (CoPI) & Machu, T. (PI)
1/06/01 → 28/02/07
Project: Research
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ETHANOL AND PHOSPHORYLATION OF THE 5-HT3 RECEPTOR
Machu, T. (PI) & MACHU, T. (CoPI)
1/05/95 → 30/04/00
Project: Research
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The GABAA receptor antagonist picrotoxin inhibits 5-hydroxytryptamine type 3A receptors
Das, P., Bell-Horner, C. L., Machu, T. K. & Dillon, G. H., Mar 2003, In: Neuropharmacology. 44, 4, p. 431-438 8 p.Research output: Contribution to journal › Article › peer-review
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Assessing the lipid requirements of the Torpedo californica nicotinic acetylcholine receptor
Hamouda, A. K., Sanghvi, M., Sauls, D., Machu, T. K. & Blanton, M. P., 4 Apr 2006, In: Biochemistry. 45, 13, p. 4327-4337 11 p.Research output: Contribution to journal › Article › peer-review
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Direct channel-gating and modulatory effects of triiodothyronine on recombinant GABA(A) receptors
Chapell, R., Martin, J., MacHu, T. K. & Leidenheimer, N. J., 15 May 1998, In: European Journal of Pharmacology. 349, 1, p. 115-121 7 p.Research output: Contribution to journal › Article › peer-review
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Tyrosine kinase phosphorylation of GABAA receptors
Valenzuela, C. F., Machu, T. K., McKernan, R. M., Whiting, P., VanRenterghem, B. B., McManaman, J. L., Brozowski, S. J., Smith, G. B., Olsen, R. W. & Harris, R. A., Jul 1995, In: Molecular Brain Research. 31, 1-2, p. 165-172 8 p.Research output: Contribution to journal › Article › peer-review
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Ethanol sensitivity in ATP-gated P2X receptors is subunit dependent
Davies, D. L., Machu, T. K., Guo, Y. & Alkana, R. L., 2002, In: Alcoholism: Clinical and Experimental Research. 26, 6, p. 773-778 6 p.Research output: Contribution to journal › Article › peer-review