If you made any changes in Pure, your changes will be visible here soon.

Research Output 1973 2019

Filter
Article
2019

Hybrid compound sa-2 is neuroprotective in animal models of retinal ganglion cell death

Stankowska, D. L., Dibas, A., Li, L., Zhang, W., Krishnamoorthy, V. R., Chavala, S. H., Nguyen, T. P., Yorio, T., Ellis, D. Z. & Acharya, S., Jul 2019, In : Investigative Ophthalmology and Visual Science. 60, 8, p. 3064-3073 10 p.

Research output: Contribution to journalArticle

Open Access
Retinal Ganglion Cells
Cell Death
Nerve Crush
Animal Models
Retina
2018
4 Citations (Scopus)

Neuroprotective Effects of Psalmotoxin-1, an Acid-Sensing Ion Channel (ASIC) Inhibitor, in Ischemia Reperfusion in Mouse Eyes

Dibas, A., Millar, J. C., Al-Farra, A. & Yorio, T., 3 Jul 2018, In : Current Eye Research. 43, 7, p. 921-933 13 p.

Research output: Contribution to journalArticle

Acid Sensing Ion Channel Blockers
Retinal Ganglion Cells
Neuroprotective Agents
Reperfusion
Ischemia
5 Citations (Scopus)

Targets of neuroprotection in glaucoma

He, S., Stankowska, D. L., Ellis, D. Z., Krishnamoorthy, R. & Yorio, T., 1 Jan 2018, In : Journal of Ocular Pharmacology and Therapeutics. 34, 1-2, p. 85-106 22 p.

Research output: Contribution to journalArticle

Glaucoma
Retinal Diseases
Western World
Retinal Ganglion Cells
Aqueous Humor
2017
CCAAT-Enhancer-Binding Proteins
Endothelin Receptors
food law
endothelins
Endothelin B Receptors
6 Citations (Scopus)

Sigma-1 receptor regulates mitochondrial function in glucose-and oxygen-deprived retinal ganglion cells

Ellis, D. Z., Li, L., Park, Y., He, S., Mueller, B. & Yorio, T., May 2017, In : Investigative Ophthalmology and Visual Science. 58, 5, p. 2755-2764 10 p.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Oxygen
Glucose
Mitochondrial Membrane Potential
Electron Transport Complex IV
2016
5 Citations (Scopus)
Optic Nerve Diseases
Prodrugs
Optics
Photoreceptor Cells
Molecules
17 Citations (Scopus)

Glucocorticoid therapy and ocular hypertension

Dibas, A. & Yorio, T., 1 Jan 2016, In : European Journal of Pharmacology. 787, p. 57-71 15 p.

Research output: Contribution to journalArticle

Ocular Hypertension
Glucocorticoids
Macular Degeneration
Diabetic Retinopathy
Glaucoma
4 Citations (Scopus)

Involvement of ampa receptor and its flip and flop isoforms in retinal ganglion cell death following oxygen/glucose deprivation

Park, Y. H., Broyles, H. V., He, S., McGrady, N. R., Li, L. & Yorio, T., 1 Feb 2016, In : Investigative Ophthalmology and Visual Science. 57, 2, p. 508-526 19 p.

Research output: Contribution to journalArticle

AMPA Receptors
Retinal Ganglion Cells
Protein Isoforms
Cell Death
Oxygen
2015
11 Citations (Scopus)

AMPA receptor desensitization is the determinant of AMPA receptor mediated excitotoxicity in purified retinal ganglion cells

Park, Y. H., Mueller, B. H., McGrady, N. R., Ma, H. Y. & Yorio, T., 1 Mar 2015, In : Experimental eye research. 132, p. 136-150 15 p.

Research output: Contribution to journalArticle

AMPA Receptors
Retinal Ganglion Cells
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Caspase 7
Calcium
9 Citations (Scopus)

Endothelin-mediated changes in gene expression in isolated purified rat retinal ganglion cells

He, S., Park, Y. H., Yorio, T. & Krishnamoorthy, R., 1 Jan 2015, In : Investigative Ophthalmology and Visual Science. 56, 10, p. 6144-6161 18 p.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Endothelins
Gene Expression
Endothelin-1
Endothelin-2
10 Citations (Scopus)

Neuroprotective effects of transcription factor brn3b in an ocular hypertension rat model of glaucoma

Stankowska, D. L., Minton, A. Z., Rutledge, M. A., Mueller, B. H., Phatak, N. R., He, S., Ma, H. Y., Forster, M. J., Yorio, T. & Krishnamoorthy, R., 1 Jan 2015, In : Investigative Ophthalmology and Visual Science. 56, 2, p. 893-907 15 p.

Research output: Contribution to journalArticle

Ocular Hypertension
Neuroprotective Agents
Intraocular Pressure
Glaucoma
Transcription Factors
2014
4 Citations (Scopus)

Methylene blue promotes quiescence of rat neural progenitor cells

Xie, L., Choudhury, G. R., Wang, J., Park, Y., Liu, R., Yuan, F., Zhang, C. L., Yorio, T., Jin, K. & Yang, S., 7 Oct 2014, In : Frontiers in Cellular Neuroscience. 8, OCT, 315.

Research output: Contribution to journalArticle

Methylene Blue
Stem Cells
Intraventricular Infusions
Cyclins
Neural Stem Cells
17 Citations (Scopus)

Sigma-1 receptor stimulation protects retinal ganglion cells from ischemia-like insult through the activation of extracellular-signal-regulated kinases 1/2

Mueller, B. H., Park, Y., Ma, H. Y., Dibas, A., Ellis, D. Z., Clark, A. & Yorio, T., 1 Nov 2014, In : Experimental Eye Research. 128, p. 156-169 14 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase 3
Retinal Ganglion Cells
Mitogen-Activated Protein Kinase 1
Ischemia
Pentazocine
2013
10 Citations (Scopus)

Effects of thailanstatins on glucocorticoid response in trabecular meshwork and steroid-induced glaucoma

Jain, A., Liu, X., Wordinger, R. J., Yorio, T., Cheng, Y. Q. & Clark, A. F., 10 May 2013, In : Investigative Ophthalmology and Visual Science. 54, 5, p. 3137-3142 6 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Glaucoma
Glucocorticoids
Steroids
Intraocular Pressure
37 Citations (Scopus)

Sigma-1 receptor stimulation attenuates calcium influx through activated L-type Voltage Gated Calcium Channels in purified retinal ganglion cells

Mueller, B. H., Park, Y., Daudt, D. R., Ma, H. Y., Akopova, I., Stankowska, D. L., Clark, A. F. & Yorio, T., 1 Feb 2013, In : Experimental Eye Research. 107, p. 21-31 11 p.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Calcium Channels
Calcium
Calcium Channel Blockers
Ions
2012
3 Citations (Scopus)
Trabecular Meshwork
Protein Isoforms
Dexamethasone
Proteins
tanespimycin
23 Citations (Scopus)

Methylene blue protects primary rat retinal ganglion cells from cellular senescence

Daudt, D. R., Mueller, B., Park, Y. H., Wen, Y. & Yorio, T., 1 Jul 2012, In : Investigative Ophthalmology and Visual Science. 53, 8, p. 4657-4667 11 p.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Cell Aging
Methylene Blue
Electron Transport Complex IV
Rotenone
24 Citations (Scopus)
Spliceosomes
Trabecular Meshwork
Glucocorticoid Receptors
Glucocorticoids
Protein Isoforms
2011
44 Citations (Scopus)

Endothelin, astrocytes and glaucoma

Prasanna, G., Krishnamoorthy, R. & Yorio, T., 1 Aug 2011, In : Experimental eye research. 93, 2, p. 170-177 8 p.

Research output: Contribution to journalArticle

Endothelins
Astrocytes
Glaucoma
Gliosis
Central Nervous System
10 Citations (Scopus)

FKBP51 protects 661w cell culture from staurosporine-induced apoptosis

Daudt, D. R. & Yorio, T., 30 May 2011, In : Molecular Vision. 17, p. 1172-1181 10 p.

Research output: Contribution to journalArticle

Tacrolimus Binding Proteins
Staurosporine
Cell Culture Techniques
Tacrolimus
Apoptosis
27 Citations (Scopus)
Ocular Hypertension
Glaucoma
Dexamethasone
Glucocorticoids
Perfusion
6 Citations (Scopus)

Protein Profiling of human nonpigmented ciliary epithelium cell secretome: The differentiation factors characterization for retinal ganglion cell line

Chung, T. W., Yang, M. H., Krishnamoorthy, R., Jong, S. B., Chu, P. Y., Yang, Y. H., Chen, W. C., Chen, S. C. J., Dibas, A., Yorio, T. & Tyan, Y. C., 12 Oct 2011, In : Journal of Biomedicine and Biotechnology. 2011, 901329.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Epithelium
Cell Line
Epithelial Cells
Proteins
2010
23 Citations (Scopus)

Assessment of SNPs associated with the human glucocorticoid receptor in primary open-angle glaucoma and steroid responders

Fingert, J. H., Alward, W. L., Wang, K., Yorio, T. & Clark, A. F., 23 Aug 2010, In : Molecular Vision. 16, p. 596-601 6 p.

Research output: Contribution to journalArticle

Glucocorticoid Receptors
Single Nucleotide Polymorphism
Steroids
Glucocorticoids
Ocular Hypertension
56 Citations (Scopus)

Canonical Transient Receptor Potential 6 (TRPC6), a redox-regulated cation channel

Graham, S., Ding, M., Ding, Y., Sours-Brothers, S., Luchowski, R., Gryczynski, Z., Yorio, T., Ma, H. & Ma, R., 23 Jul 2010, In : Journal of Biological Chemistry. 285, 30, p. 23466-23476 11 p.

Research output: Contribution to journalArticle

Arginine Vasopressin
Oxidation-Reduction
Cations
Vasopressin Receptors
Ethylmaleimide
21 Citations (Scopus)

Changes in ocular aquaporin expression following optic nerve crush

Dibas, A., Oku, H., Fukuhara, M., Kurimoto, T., Ikeda, T., Patil, R. V., Sharif, N. A. & Yorio, T., 20 Aug 2010, In : Molecular Vision. 16, p. 330-340 11 p.

Research output: Contribution to journalArticle

Nerve Crush
Aquaporins
Optic Nerve
Retinal Ganglion Cells
Glial Fibrillary Acidic Protein
7 Citations (Scopus)

Thrombin-induced endothelin-1 synthesis and secretion in retinal pigment epithelial cells is Rho kinase dependent

Narayan, S., Prasanna, G., Tchedre, K., Krishnamoorthy, R. & Yorio, T., 1 Oct 2010, In : Journal of Ocular Pharmacology and Therapeutics. 26, 5, p. 389-397 9 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Retinal Pigments
Endothelin-1
Thrombin
Epithelial Cells
2009
96 Citations (Scopus)

The role of glia, mitochondria, and the immune system in glaucoma

Tezel, G., Ben-Hur, T., Gibson, G. E., Stevens, B., Streit, W. J., Wekerle, H., Bhattacharya, S. K., Borras, T., Burgoyne, C. F., Caspi, R. R., Chauhan, B. C., Clark, A. F., Crowston, J., Danias, J., Dick, A. D., Flammer, J., Foster, C. S., Grosskreutz, C. L., Grus, F. H., Guy, J. & 48 others, Hernandez, M. R., Johnson, E., Kaplan, H. J., Kuehn, M. H., Lenaers, G., Levin, L. A., Lindsey, J. D., Malina, H., Nickells, R. W., Osborne, N., Quigley, H. A., Rao, N., Rosenbaum, J. T., Sadun, A. A., Schwartz, M., Sun, D., Trounce, I., Wax, M. B., Yorio, T., Abrams, G. W., Atherton, S. S., Boatright, J. H., Chu, J., Dowling, J., Ferris, F. L., Garway-Heath, D., Gregory, M., Grzybowski, D. M., Gupta, N., Inman, D., Ju, W. K., Kang, K. D., Kaufman, H. E., Kaufman, P. L., Larssen, L. I., Liebmann, J., Lupien, C., Miller, R. F., Niesman, M., O'Brien, C., Petrash, J. M., Prasanna, G., Ritch, R., Shestopalov, V., Wirostko, B., WoldeMussie, E., Yue, B. & Zimmerman, T. J., 1 Mar 2009, In : Investigative Ophthalmology and Visual Science. 50, 3, p. 1001-1012 12 p.

Research output: Contribution to journalArticle

2008
30 Citations (Scopus)

Changes in ocular aquaporin-4 (AQP4) expression following retinal injury

Dibas, A., Yang, M. H., He, S., Bobich, J. & Yorio, T., 1 Jan 2008, In : Molecular Vision. 14, p. 1770-1783 14 p.

Research output: Contribution to journalArticle

Aquaporin 4
Ubiquitination
Intraocular Pressure
Wounds and Injuries
Glial Fibrillary Acidic Protein
10 Citations (Scopus)

Drug delivery to posterior intraocular tissues: Third annual ARVO/Pfizer ophthalmics research institute conference

Edelhauser, H. F., Boatright, J. H., Nickerson, J. M., Edelhauser, H. F., Abrams, G., Adamis, A., Aguirre, G. D., Ambati, J., Becerra, P., Behar-Cohen, F., Berglin, L., Bernstein, S., Boatright, J., Crouch, R., Freeman, W., Friedlander, M., Geroski, D., Grossniklaus, H., Heckenlively, J., Kempen, J. & 16 others, Kompella, U., Laties, A., LaVail, M., McGinnis, J., Marc, R., Miller, J., Nickerson, J., O'Brien, J., Olsen, T., Palanker, D., Robinson, M., Saperstein, D., Sternberg, P., Stout, J. T., Williams, G. & Yorio, T., 1 Nov 2008, In : Investigative Ophthalmology and Visual Science. 49, 11, p. 4712-4720 9 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Endothelin-1 mediated regulation of extracellular matrix collagens in cells of human lamina cribrosa

Rao, V. R., Krishnamoorthy, R. R. & Yorio, T., 1 Jun 2008, In : Experimental eye research. 86, 6, p. 886-894 9 p.

Research output: Contribution to journalArticle

Endothelin-1
Extracellular Matrix
Collagen
Collagen Type I
Collagen Type VI
75 Citations (Scopus)
Tacrolimus Binding Proteins
Cell Nucleus Active Transport
Glucocorticoid Receptors
Dexamethasone
Glucocorticoids
35 Citations (Scopus)

Role of the ETB receptor in retinal ganglion cell death in glaucoma

Krishnamoorthy, R., Rao, V. R., Dauphin, R., Prasanna, G., Johnson, C. & Yorio, T., 1 Jun 2008, In : Canadian Journal of Physiology and Pharmacology. 86, 6, p. 380-393 14 p.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Endothelin-1
Glaucoma
Cell Death
Apoptosis
95 Citations (Scopus)

Sigma-1 receptor regulation of voltage-gated calcium channels involves a direct interaction

Tchedre, K. T., Huang, R-Q., Dibas, A., Krishnamoorthy, R., Dillon, G. H. & Yorio, T., 1 Nov 2008, In : Investigative Ophthalmology and Visual Science. 49, 11, p. 4993-5002 10 p.

Research output: Contribution to journalArticle

Calcium Channels
Calcium
Potassium Chloride
Retinal Ganglion Cells
Homeostasis
70 Citations (Scopus)
Caspase 3
Glutamic Acid
Apoptosis
Calcium
Cell Death
2007
82 Citations (Scopus)

Dexamethasone inhibition of trabecular meshwork cell phagocytosis and its modulation by glucocorticoid receptor β

Zhang, X., Ognibene, C. M., Clark, A. & Yorio, T., 1 Feb 2007, In : Experimental Eye Research. 84, 2, p. 275-284 10 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Cytophagocytosis
Glucocorticoid Receptors
Dexamethasone
Glucocorticoids
64 Citations (Scopus)

Downregulation of TRPC6 protein expression by high glucose, a possible mechanism for the impaired Ca2+ signaling in glomerular mesangial cells in diabetes

Graham, S., Ding, M., Sours-Brothers, S., Yorio, T., Ma, J. X. & Ma, R., 1 Oct 2007, In : American Journal of Physiology - Renal Physiology. 293, 4, p. F1381-F1390

Research output: Contribution to journalArticle

Mesangial Cells
Down-Regulation
Glucose
Angiotensin II
Proteins
16 Citations (Scopus)
Endothelin B Receptors
Endothelin A Receptors
Endothelin-1
Pharmacology
Optic Nerve Diseases
54 Citations (Scopus)
Tissue Inhibitor of Metalloproteinases
Matrix Metalloproteinase Inhibitors
Endothelin-1
Matrix Metalloproteinases
Astrocytes
10 Citations (Scopus)

Parallel signaling pathways in endothelin-1-induced proliferation of U373MG astrocytoma cells

He, S., Dibas, A., Yorio, T. & Prasanna, G., 1 Mar 2007, In : Experimental Biology and Medicine. 232, 3, p. 370-384 15 p.

Research output: Contribution to journalArticle

Astrocytoma
Endothelin-1
Phosphorylation
Cell proliferation
Mitogen-Activated Protein Kinases
27 Citations (Scopus)

Stress-induced changes in neuronal Aquaporin-9 (AQP9) in a retinal ganglion cell-line

Dibas, A., Yang, M. H., Bobich, J. & Yorio, T., 1 May 2007, In : Pharmacological Research. 55, 5, p. 378-384 7 p.

Research output: Contribution to journalArticle

Aquaporins
Retinal Ganglion Cells
Cell Line
Real-Time Polymerase Chain Reaction
Osmotic Pressure
2006
25 Citations (Scopus)
HSP90 Heat-Shock Proteins
Molecular Chaperones
Cell Nucleus Active Transport
Glucocorticoid Receptors
tanespimycin
2005
3 Citations (Scopus)
Endothelin-1
Epithelial Cells
Cell Line
Cathepsins
Cell Membrane
75 Citations (Scopus)

Effect of elevated intraocular pressure on endothelin-1 in a rat model of glaucoma

Prasanna, G., Hulet, C., Desai, D., Krishnamoorthy, R. R., Narayan, S., Brun, A. M., Suburo, A. M. & Yorio, T., 1 Jan 2005, In : Pharmacological Research. 51, 1, p. 41-50 10 p.

Research output: Contribution to journalArticle

Endothelin-1
Intraocular Pressure
Glaucoma
Optic Disk
Optic Nerve
28 Citations (Scopus)

Endothelin-1 modulates anterograde fast axonal transport in the central nervous system

Stokely, M. E., Yorio, T. & King, M. A., 1 Mar 2005, In : Journal of Neuroscience Research. 79, 5, p. 598-607 10 p.

Research output: Contribution to journalArticle

Axonal Transport
Endothelin-1
Central Nervous System
Nerve Tissue
Endothelins
8 Citations (Scopus)

Localization of endothelin-converting enzyme in bovine optic nerve and retina

Dibas, A., Prasanna, G. & Yorio, T., 1 Aug 2005, In : Journal of Ocular Pharmacology and Therapeutics. 21, 4, p. 288-297 10 p.

Research output: Contribution to journalArticle

Endothelin-1
Optic Nerve
Retina
Cathepsins
Cell Membrane
54 Citations (Scopus)
Trabecular Meshwork
Glucocorticoid Receptors
Glucocorticoids
Luciferases
Dexamethasone
2004
21 Citations (Scopus)

Endothelin-1 distribution and basolateral secretion in the retinal pigment epithelium

Narayan, S., Brun, A. M. & Yorio, T., 1 Jul 2004, In : Experimental eye research. 79, 1, p. 11-19 9 p.

Research output: Contribution to journalArticle

Retinal Pigment Epithelium
Endothelin-1
Retinal Vessels
Retinal Pigments
Endothelins
43 Citations (Scopus)
Optic Disk
Cell proliferation
Endothelin-1
Astrocytes
Optics
2003
25 Citations (Scopus)

Dexamethasone regulates endothelin-1 and endothelin receptors in human non-pigmented ciliary epithelial (HNPE) cells

Zhang, X., Krishnamoorthy, R., Prasanna, G., Narayan, S., Clark, A. & Yorio, T., 1 Mar 2003, In : Experimental eye research. 76, 3, p. 261-272 12 p.

Research output: Contribution to journalArticle

Endothelin A Receptors
Endothelin Receptors
Dexamethasone
Endothelin B Receptors
Endothelin-1
48 Citations (Scopus)
Retinal Pigments
Endothelin-1
Cholinergic Agents
Epithelial Cells
Retinal Pigment Epithelium