• 3461 Citations
  • 31 h-Index
1973 …2020

Research output per year

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Research Output

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Article
2020
Open Access
1 Scopus citations
2019

Hybrid compound sa-2 is neuroprotective in animal models of retinal ganglion cell death

Stankowska, D. L., Dibas, A., Li, L., Zhang, W., Krishnamoorthy, V. R., Chavala, S. H., Nguyen, T. P., Yorio, T., Ellis, D. Z. & Acharya, S., Jul 2019, In : Investigative Ophthalmology and Visual Science. 60, 8, p. 3064-3073 10 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

Neuroprotective Effects of Psalmotoxin-1, an Acid-Sensing Ion Channel (ASIC) Inhibitor, in Ischemia Reperfusion in Mouse Eyes

Dibas, A., Millar, C., Al-Farra, A. & Yorio, T., 3 Jul 2018, In : Current Eye Research. 43, 7, p. 921-933 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Targets of neuroprotection in glaucoma

He, S., Stankowska, D. L., Ellis, D. Z., Krishnamoorthy, R. R. & Yorio, T., 1 Jan 2018, In : Journal of Ocular Pharmacology and Therapeutics. 34, 1-2, p. 85-106 22 p.

Research output: Contribution to journalArticle

6 Scopus citations
2017

Sigma-1 receptor regulates mitochondrial function in glucose-and oxygen-deprived retinal ganglion cells

Ellis, D. Z., Li, L., Park, Y., He, S., Mueller, B. & Yorio, T., May 2017, In : Investigative Ophthalmology and Visual Science. 58, 5, p. 2755-2764 10 p.

Research output: Contribution to journalArticle

7 Scopus citations
2016
9 Scopus citations

Glucocorticoid therapy and ocular hypertension

Dibas, A. & Yorio, T., 1 Jan 2016, In : European Journal of Pharmacology. 787, p. 57-71 15 p.

Research output: Contribution to journalArticle

21 Scopus citations

Involvement of ampa receptor and its flip and flop isoforms in retinal ganglion cell death following oxygen/glucose deprivation

Park, Y. H., Broyles, H. V., He, S., McGrady, N. R., Li, L. & Yorio, T., Feb 2016, In : Investigative Ophthalmology and Visual Science. 57, 2, p. 508-526 19 p.

Research output: Contribution to journalArticle

5 Scopus citations
2015

AMPA receptor desensitization is the determinant of AMPA receptor mediated excitotoxicity in purified retinal ganglion cells

Park, Y. H., Mueller, B. H., McGrady, N. R., Ma, H. Y. & Yorio, T., 1 Mar 2015, In : Experimental eye research. 132, p. 136-150 15 p.

Research output: Contribution to journalArticle

13 Scopus citations

Endothelin-mediated changes in gene expression in isolated purified rat retinal ganglion cells

He, S., Park, Y. H., Yorio, T. & Krishnamoorthy, R., 1 Jan 2015, In : Investigative Ophthalmology and Visual Science. 56, 10, p. 6144-6161 18 p.

Research output: Contribution to journalArticle

11 Scopus citations

Neuroprotective effects of transcription factor brn3b in an ocular hypertension rat model of glaucoma

Stankowska, D. L., Minton, A. Z., Rutledge, M. A., Mueller, B. H., Phatak, N. R., He, S., Ma, H. Y., Forster, M. J., Yorio, T. & Krishnamoorthy, R. R., 1 Jan 2015, In : Investigative Ophthalmology and Visual Science. 56, 2, p. 893-907 15 p.

Research output: Contribution to journalArticle

11 Scopus citations
2014

Methylene blue promotes quiescence of rat neural progenitor cells

Xie, L., Choudhury, G. R., Wang, J., Park, Y., Liu, R., Yuan, F., Zhang, C. L., Yorio, T., Jin, K. & Yang, S. H., 7 Oct 2014, In : Frontiers in Cellular Neuroscience. 8, OCT, 315.

Research output: Contribution to journalArticle

4 Scopus citations

Sigma-1 receptor stimulation protects retinal ganglion cells from ischemia-like insult through the activation of extracellular-signal-regulated kinases 1/2

Mueller, B. H., Park, Y., Ma, H. Y., Dibas, A., Ellis, D. Z., Clark, A. F. & Yorio, T., 1 Nov 2014, In : Experimental eye research. 128, p. 156-169 14 p.

Research output: Contribution to journalArticle

18 Scopus citations
2013

Effects of thailanstatins on glucocorticoid response in trabecular meshwork and steroid-induced glaucoma

Jain, A., Liu, X., Wordinger, R. J., Yorio, T., Cheng, Y. Q. & Clark, A. F., 10 May 2013, In : Investigative Ophthalmology and Visual Science. 54, 5, p. 3137-3142 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Sigma-1 receptor stimulation attenuates calcium influx through activated L-type Voltage Gated Calcium Channels in purified retinal ganglion cells

Mueller, B. H., Park, Y., Daudt, D. R., Ma, H. Y., Akopova, I., Stankowska, D. L., Clark, A. F. & Yorio, T., 1 Feb 2013, In : Experimental eye research. 107, p. 21-31 11 p.

Research output: Contribution to journalArticle

41 Scopus citations
2012
4 Scopus citations

Methylene blue protects primary rat retinal ganglion cells from cellular senescence

Daudt, D. R., Mueller, B., Park, Y. H., Wen, Y. & Yorio, T., 1 Jul 2012, In : Investigative Ophthalmology and Visual Science. 53, 8, p. 4657-4667 11 p.

Research output: Contribution to journalArticle

23 Scopus citations
24 Scopus citations
2011

Endothelin, astrocytes and glaucoma

Prasanna, G., Krishnamoorthy, R. & Yorio, T., 1 Aug 2011, In : Experimental eye research. 93, 2, p. 170-177 8 p.

Research output: Contribution to journalArticle

47 Scopus citations

FKBP51 protects 661w cell culture from staurosporine-induced apoptosis

Daudt, D. R. & Yorio, T., 30 May 2011, In : Molecular Vision. 17, p. 1172-1181 10 p.

Research output: Contribution to journalArticle

11 Scopus citations
30 Scopus citations

Protein Profiling of human nonpigmented ciliary epithelium cell secretome: The differentiation factors characterization for retinal ganglion cell line

Chung, T. W., Yang, M. H., Krishnamoorthy, R. R., Jong, S. B., Chu, P. Y., Yang, Y. H., Chen, W. C., Chen, S. C. J., Dibas, A., Yorio, T. & Tyan, Y. C., 12 Oct 2011, In : Journal of Biomedicine and Biotechnology. 2011, 901329.

Research output: Contribution to journalArticle

6 Scopus citations
2010

Assessment of SNPs associated with the human glucocorticoid receptor in primary open-angle glaucoma and steroid responders

Fingert, J. H., Alward, W. L., Wang, K., Yorio, T. & Clark, A. F., 23 Aug 2010, In : Molecular vision. 16, p. 596-601 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

Canonical Transient Receptor Potential 6 (TRPC6), a redox-regulated cation channel

Graham, S., Ding, M., Ding, Y., Sours-Brothers, S., Luchowski, R., Gryczynski, Z., Yorio, T., Ma, H. & Ma, R., 23 Jul 2010, In : Journal of Biological Chemistry. 285, 30, p. 23466-23476 11 p.

Research output: Contribution to journalArticle

58 Scopus citations

Changes in ocular aquaporin expression following optic nerve crush

Dibas, A., Oku, H., Fukuhara, M., Kurimoto, T., Ikeda, T., Patil, R. V., Sharif, N. A. & Yorio, T., 20 Aug 2010, In : Molecular vision. 16, p. 330-340 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Thrombin-induced endothelin-1 synthesis and secretion in retinal pigment epithelial cells is Rho kinase dependent

Narayan, S., Prasanna, G., Tchedre, K., Krishnamoorthy, R. & Yorio, T., 1 Oct 2010, In : Journal of Ocular Pharmacology and Therapeutics. 26, 5, p. 389-397 9 p.

Research output: Contribution to journalArticle

7 Scopus citations
2009

The role of glia, mitochondria, and the immune system in glaucoma

Tezel, G., Ben-Hur, T., Gibson, G. E., Stevens, B., Streit, W. J., Wekerle, H., Bhattacharya, S. K., Borras, T., Burgoyne, C. F., Caspi, R. R., Chauhan, B. C., Clark, A. F., Crowston, J., Danias, J., Dick, A. D., Flammer, J., Foster, C. S., Grosskreutz, C. L., Grus, F. H., Guy, J. & 48 others, Hernandez, M. R., Johnson, E., Kaplan, H. J., Kuehn, M. H., Lenaers, G., Levin, L. A., Lindsey, J. D., Malina, H., Nickells, R. W., Osborne, N., Quigley, H. A., Rao, N., Rosenbaum, J. T., Sadun, A. A., Schwartz, M., Sun, D., Trounce, I., Wax, M. B., Yorio, T., Abrams, G. W., Atherton, S. S., Boatright, J. H., Chu, J., Dowling, J., Ferris, F. L., Garway-Heath, D., Gregory, M., Grzybowski, D. M., Gupta, N., Inman, D., Ju, W. K., Kang, K. D., Kaufman, H. E., Kaufman, P. L., Larssen, L. I., Liebmann, J., Lupien, C., Miller, R. F., Niesman, M., O'Brien, C., Petrash, J. M., Prasanna, G., Ritch, R., Shestopalov, V., Wirostko, B., WoldeMussie, E., Yue, B. & Zimmerman, T. J., 1 Mar 2009, In : Investigative Ophthalmology and Visual Science. 50, 3, p. 1001-1012 12 p.

Research output: Contribution to journalArticle

103 Scopus citations
2008

Changes in ocular aquaporin-4 (AQP4) expression following retinal injury

Dibas, A., Yang, M. H., He, S., Bobich, J. & Yorio, T., 1 Jan 2008, In : Molecular Vision. 14, p. 1770-1783 14 p.

Research output: Contribution to journalArticle

30 Scopus citations

Drug delivery to posterior intraocular tissues: Third annual ARVO/Pfizer ophthalmics research institute conference

Edelhauser, H. F., Boatright, J. H., Nickerson, J. M., Edelhauser, H. F., Abrams, G., Adamis, A., Aguirre, G. D., Ambati, J., Becerra, P., Behar-Cohen, F., Berglin, L., Bernstein, S., Boatright, J., Crouch, R., Freeman, W., Friedlander, M., Geroski, D., Grossniklaus, H., Heckenlively, J., Kempen, J. & 16 others, Kompella, U., Laties, A., LaVail, M., McGinnis, J., Marc, R., Miller, J., Nickerson, J., O'Brien, J., Olsen, T., Palanker, D., Robinson, M., Saperstein, D., Sternberg, P., Stout, J. T., Williams, G. & Yorio, T., 1 Nov 2008, In : Investigative Ophthalmology and Visual Science. 49, 11, p. 4712-4720 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Endothelin-1 mediated regulation of extracellular matrix collagens in cells of human lamina cribrosa

Rao, V. R., Krishnamoorthy, R. R. & Yorio, T., 1 Jun 2008, In : Experimental eye research. 86, 6, p. 886-894 9 p.

Research output: Contribution to journalArticle

23 Scopus citations
79 Scopus citations

Role of the ETB receptor in retinal ganglion cell death in glaucoma

Krishnamoorthy, R., Rao, V. R., Dauphin, R., Prasanna, G., Johnson, C. & Yorio, T., 1 Jun 2008, In : Canadian Journal of Physiology and Pharmacology. 86, 6, p. 380-393 14 p.

Research output: Contribution to journalArticle

40 Scopus citations

Sigma-1 receptor regulation of voltage-gated calcium channels involves a direct interaction

Tchedre, K. T., Huang, R-Q., Dibas, A., Krishnamoorthy, R., Dillon, G. H. & Yorio, T., 1 Nov 2008, In : Investigative Ophthalmology and Visual Science. 49, 11, p. 4993-5002 10 p.

Research output: Contribution to journalArticle

99 Scopus citations
70 Scopus citations
2007

Dexamethasone inhibition of trabecular meshwork cell phagocytosis and its modulation by glucocorticoid receptor β

Zhang, X., Ognibene, C. M., Clark, A. & Yorio, T., 1 Feb 2007, In : Experimental Eye Research. 84, 2, p. 275-284 10 p.

Research output: Contribution to journalArticle

88 Scopus citations

Downregulation of TRPC6 protein expression by high glucose, a possible mechanism for the impaired Ca2+ signaling in glomerular mesangial cells in diabetes

Graham, S., Ding, M., Sours-Brothers, S., Yorio, T., Ma, J. X. & Ma, R., 1 Oct 2007, In : American Journal of Physiology - Renal Physiology. 293, 4, p. F1381-F1390

Research output: Contribution to journalArticle

65 Scopus citations
19 Scopus citations
54 Scopus citations

Parallel signaling pathways in endothelin-1-induced proliferation of U373MG astrocytoma cells

He, S., Dibas, A., Yorio, T. & Prasanna, G., 1 Mar 2007, In : Experimental Biology and Medicine. 232, 3, p. 370-384 15 p.

Research output: Contribution to journalArticle

10 Scopus citations

Stress-induced changes in neuronal Aquaporin-9 (AQP9) in a retinal ganglion cell-line

Dibas, A., Yang, M. H., Bobich, J. & Yorio, T., 1 May 2007, In : Pharmacological Research. 55, 5, p. 378-384 7 p.

Research output: Contribution to journalArticle

27 Scopus citations
2006
26 Scopus citations
2005
3 Scopus citations

Effect of elevated intraocular pressure on endothelin-1 in a rat model of glaucoma

Prasanna, G., Hulet, C., Desai, D., Krishnamoorthy, R. R., Narayan, S., Brun, A. M., Suburo, A. M. & Yorio, T., 1 Jan 2005, In : Pharmacological Research. 51, 1, p. 41-50 10 p.

Research output: Contribution to journalArticle

77 Scopus citations

Endothelin-1 modulates anterograde fast axonal transport in the central nervous system

Stokely, M. E., Yorio, T. & King, M. A., 1 Mar 2005, In : Journal of Neuroscience Research. 79, 5, p. 598-607 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

Localization of endothelin-converting enzyme in bovine optic nerve and retina

Dibas, A., Prasanna, G. & Yorio, T., 1 Aug 2005, In : Journal of Ocular Pharmacology and Therapeutics. 21, 4, p. 288-297 10 p.

Research output: Contribution to journalArticle

9 Scopus citations
57 Scopus citations
2004

Endothelin-1 distribution and basolateral secretion in the retinal pigment epithelium

Narayan, S., Brun, A. M. & Yorio, T., 1 Jul 2004, In : Experimental eye research. 79, 1, p. 11-19 9 p.

Research output: Contribution to journalArticle

21 Scopus citations
44 Scopus citations
2003

Dexamethasone regulates endothelin-1 and endothelin receptors in human non-pigmented ciliary epithelial (HNPE) cells

Zhang, X., Krishnamoorthy, R. R., Prasanna, G., Narayan, S., Clark, A. & Yorio, T., 1 Mar 2003, In : Experimental eye research. 76, 3, p. 261-272 12 p.

Research output: Contribution to journalArticle

26 Scopus citations