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Research Output 1973 2019

2007
82 Citations (Scopus)

Dexamethasone inhibition of trabecular meshwork cell phagocytosis and its modulation by glucocorticoid receptor β

Zhang, X., Ognibene, C. M., Clark, A. & Yorio, T., 1 Feb 2007, In : Experimental Eye Research. 84, 2, p. 275-284 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Trabecular Meshwork
Cytophagocytosis
Glucocorticoid Receptors
Dexamethasone
Glucocorticoids
64 Citations (Scopus)

Downregulation of TRPC6 protein expression by high glucose, a possible mechanism for the impaired Ca2+ signaling in glomerular mesangial cells in diabetes

Graham, S., Ding, M., Sours-Brothers, S., Yorio, T., Ma, J. X. & Ma, R., 1 Oct 2007, In : American Journal of Physiology - Renal Physiology. 293, 4

Research output: Contribution to journalArticleResearchpeer-review

Mesangial Cells
Down-Regulation
Glucose
Angiotensin II
Proteins
16 Citations (Scopus)

Endothelin-1, endothelin A and B receptor expression and their pharmacological properties in GFAP negative human lamina cribrosa cells

Rao, V. R., Krishnamoorthy, R. & Yorio, T., 1 Jun 2007, In : Experimental eye research. 84, 6, p. 1115-1124 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Endothelin B Receptors
Endothelin A Receptors
Endothelin-1
Pharmacology
Optic Nerve Diseases
54 Citations (Scopus)

Endothelin-1-mediated signaling in the expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in astrocytes

He, S., Prasanna, G. & Yorio, T., 1 Aug 2007, In : Investigative Ophthalmology and Visual Science. 48, 8, p. 3737-3745 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Tissue Inhibitor of Metalloproteinases
Matrix Metalloproteinase Inhibitors
Endothelin-1
Matrix Metalloproteinases
Astrocytes
10 Citations (Scopus)

Parallel signaling pathways in endothelin-1-induced proliferation of U373MG astrocytoma cells

He, S., Dibas, A., Yorio, T. & Prasanna, G., 1 Mar 2007, In : Experimental Biology and Medicine. 232, 3, p. 370-384 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Astrocytoma
Endothelin-1
Phosphorylation
Cell proliferation
Mitogen-Activated Protein Kinases
27 Citations (Scopus)

Stress-induced changes in neuronal Aquaporin-9 (AQP9) in a retinal ganglion cell-line

Dibas, A., Yang, M. H., Bobich, J. & Yorio, T., 1 May 2007, In : Pharmacological Research. 55, 5, p. 378-384 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Aquaporins
Retinal Ganglion Cells
Cell Line
Real-Time Polymerase Chain Reaction
Osmotic Pressure
2006
25 Citations (Scopus)

Heat shock protein 90 is an essential molecular chaperone for nuclear transport of glucocorticoid receptor β

Zhang, X., Clark, A. & Yorio, T., 1 Feb 2006, In : Investigative Ophthalmology and Visual Science. 47, 2, p. 700-708 9 p.

Research output: Contribution to journalArticleResearchpeer-review

HSP90 Heat-Shock Proteins
Molecular Chaperones
Cell Nucleus Active Transport
Glucocorticoid Receptors
tanespimycin
2005
3 Citations (Scopus)

Characterization of endothelin-converting enzyme activities in ARPE-19 cells, a human retinal pigmented epithelial cell line

Dibas, A., Prasanna, G. & Yorio, T., 1 Jun 2005, In : Journal of Ocular Pharmacology and Therapeutics. 21, 3, p. 196-204 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Endothelin-1
Epithelial Cells
Cell Line
Cathepsins
Cell Membrane
75 Citations (Scopus)

Effect of elevated intraocular pressure on endothelin-1 in a rat model of glaucoma

Prasanna, G., Hulet, C., Desai, D., Krishnamoorthy, R., Narayan, S., Brun, A. M., Suburo, A. M. & Yorio, T., 1 Jan 2005, In : Pharmacological Research. 51, 1, p. 41-50 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Endothelin-1
Intraocular Pressure
Glaucoma
Optic Disk
Optic Nerve
28 Citations (Scopus)

Endothelin-1 modulates anterograde fast axonal transport in the central nervous system

Stokely, M. E., Yorio, T. & King, M. A., 1 Mar 2005, In : Journal of Neuroscience Research. 79, 5, p. 598-607 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Axonal Transport
Endothelin-1
Central Nervous System
Nerve Tissue
Endothelins
8 Citations (Scopus)

Localization of endothelin-converting enzyme in bovine optic nerve and retina

Dibas, A., Prasanna, G. & Yorio, T., 1 Aug 2005, In : Journal of Ocular Pharmacology and Therapeutics. 21, 4, p. 288-297 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Endothelin-1
Optic Nerve
Retina
Cathepsins
Cell Membrane
52 Citations (Scopus)

Regulation of glucocorticoid responsiveness in glaucomatous trabecular meshwork cells by glucocorticoid receptor-β

Zhang, X., Clark, A. & Yorio, T., 1 Dec 2005, In : Investigative Ophthalmology and Visual Science. 46, 12, p. 4607-4616 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Trabecular Meshwork
Glucocorticoid Receptors
Glucocorticoids
Luciferases
Dexamethasone
2004
21 Citations (Scopus)

Endothelin-1 distribution and basolateral secretion in the retinal pigment epithelium

Narayan, S., Brun, A. M. & Yorio, T., 1 Jul 2004, In : Experimental eye research. 79, 1, p. 11-19 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Retinal Pigment Epithelium
Endothelin-1
Retinal Vessels
Retinal Pigments
Endothelins
41 Citations (Scopus)

Hypoxia augments TNF-α-mediated endothelin-1 release and cell proliferation in human optic nerve head astrocytes

Desai, D., He, S., Yorio, T., Krishnamoorthy, R. & Prasanna, G., 4 Jun 2004, In : Biochemical and Biophysical Research Communications. 318, 3, p. 642-648 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Optic Disk
Cell proliferation
Endothelin-1
Astrocytes
Optics
1 Citation (Scopus)

New therapies for glaucoma: Are they all up to the task?

Yorio, T. & Dibas, A., 1 Dec 2004, In : Expert Opinion on Therapeutic Patents. 14, 12, p. 1743-1762 20 p.

Research output: Contribution to journalReview articleResearchpeer-review

Glaucoma
Pharmaceutical Preparations
Therapeutics
Patents
Selection Bias
2003
25 Citations (Scopus)

Dexamethasone regulates endothelin-1 and endothelin receptors in human non-pigmented ciliary epithelial (HNPE) cells

Zhang, X., Krishnamoorthy, R., Prasanna, G., Narayan, S., Clark, A. & Yorio, T., 1 Mar 2003, In : Experimental eye research. 76, 3, p. 261-272 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Endothelin A Receptors
Endothelin Receptors
Dexamethasone
Endothelin B Receptors
Endothelin-1
48 Citations (Scopus)

Endothelin-1 Synthesis and Secretion in Human Retinal Pigment Epithelial Cells (ARPE-19): Differential Regulation by Cholinergics and TNF-α

Narayan, S., Prasanna, G., Krishnamoorthy, R., Zhang, X. & Yorio, T., 1 Nov 2003, In : Investigative Ophthalmology and Visual Science. 44, 11, p. 4885-4894 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Retinal Pigments
Endothelin-1
Cholinergic Agents
Epithelial Cells
Retinal Pigment Epithelium
45 Citations (Scopus)

Eyeing endothelins: A cellular perspective

Prasanna, G., Narayan, S., Krishnamoorthy, R. & Yorio, T., 1 Nov 2003, In : Molecular and Cellular Biochemistry. 253, 1-2, p. 71-88 18 p.

Research output: Contribution to journalReview articleResearchpeer-review

Endothelin Receptors
Endothelins
Vasoconstrictor Agents
Glaucoma
Peptides
20 Citations (Scopus)

Interactions of Endothelin-1 with Dexamethasone in Primary Cultured Human Trabecular Meshwork Cells

Zhang, X., Clark, A. & Yorio, T., 1 Dec 2003, In : Investigative Ophthalmology and Visual Science. 44, 12, p. 5301-5308 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Trabecular Meshwork
Endothelin-1
Endothelin A Receptors
Dexamethasone
Endothelin B Receptors
78 Citations (Scopus)

Ophthalmic drug discovery

Clark, A. & Yorio, T., 1 Jun 2003, In : Nature Reviews Drug Discovery. 2, 6, p. 448-459 12 p.

Research output: Contribution to journalReview articleResearchpeer-review

Drug Discovery
Macular Degeneration
Glaucoma
Eye Diseases
Blindness
5 Citations (Scopus)

Regulation of Na,K-ATPase Expression by Endothelin-1 in Transformed Human Ciliary Non-Pigmented Epithelial (HNPE) Cells

Krishnamoorthy, R., Prasanna, G., Dauphin, R., Hulet, C., Agarwal, N. & Yorio, T., 1 Jan 2003, In : Journal of Ocular Pharmacology and Therapeutics. 19, 5, p. 465-481 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Endothelin-1
Epithelial Cells
Monensin
Aqueous Humor
Ouabain
2002
61 Citations (Scopus)

Effects of endothelin-1 on components of anterograde axonal transport in optic nerve

Stokely, M. E., Brady, S. T. & Yorio, T., 1 Oct 2002, In : Investigative Ophthalmology and Visual Science. 43, 10, p. 3223-3230 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Axonal Transport
Endothelin-1
Optic Nerve
Endothelins
Glaucoma
124 Citations (Scopus)

Endothelin: Is it a contributor to glaucoma pathophysiology?

Yorio, T., Krishnamoorthy, R. & Prasanna, G., 1 Jan 2002, In : Journal of Glaucoma. 11, 3, p. 259-270 12 p.

Research output: Contribution to journalReview articleResearchpeer-review

Endothelins
Glaucoma
Endothelin Receptors
Aqueous Humor
Optic Disk
101 Citations (Scopus)

Human optic nerve head astrocytes as a target for endothelin-1

Prasanna, G., Krishnamoorthy, R., Clark, A., Wordinger, R. J. & Yorio, T., 5 Aug 2002, In : Investigative Ophthalmology and Visual Science. 43, 8, p. 2704-2713 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Optic Disk
Endothelin-1
Astrocytes
Cell Proliferation
Glaucoma
2001
296 Citations (Scopus)

Characterization of a transformed rat retinal ganglion cell line

Krishnamoorthy, R., Agarwal, P., Prasanna, G., Vopat, K., Lambert, W., Sheedlo, H. J., Pang, I-H., Shade, D., Wordinger, R. J., Yorio, T., Clark, A. & Agarwal, N., 31 Jan 2001, In : Molecular Brain Research. 86, 1-2, p. 1-12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Retinal Ganglion Cells
Cell Line
Nerve Growth Factors
Clone Cells
Apoptosis
24 Citations (Scopus)

Inhibition of Na+/K+-ATPase by endothelin-1 in human nonpigmented ciliary epithelial cells

Prasanna, G., Dibas, A., Hulet, C. & Yorio, T., 14 Mar 2001, In : Journal of Pharmacology and Experimental Therapeutics. 296, 3, p. 966-971 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Endothelin-1
Epithelial Cells
Aqueous Humor
Ion Transport
Intraocular Pressure
2000
21 Citations (Scopus)

Cholinergic and adrenergic modulation of the Ca2+ response to endothelin-1 in human ciliary muscle cells

Prasanna, G., Dibas, A. & Yorio, T., 15 Apr 2000, In : Investigative Ophthalmology and Visual Science. 41, 5, p. 1142-1148 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Endothelin-1
Adrenergic Agents
Muscle Cells
Cholinergic Agents
Carbachol
33 Citations (Scopus)

Dependence of insulin secretion from permeabilized pancreatic β-cells on the activation of Ca2+/calmodulin-dependent protein kinase II: A re-evaluation of inhibitor studies

Bhatt, H. S., Conner, B. P., Prasanna, G., Yorio, T. & Easom, R. A., 1 Dec 2000, In : Biochemical Pharmacology. 60, 11, p. 1655-1663 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Calcium-Calmodulin-Dependent Protein Kinase Type 2
KN 62
Chemical activation
Insulin
Peptides
14 Citations (Scopus)

Endothelin-1 induces nitric oxide synthase-2 expression in human non-pigmented ciliary epithelial cells

Prasanna, G., Krishnamoorthy, R., Hulet, C., Zhang, H., Zhang, X. & Yorio, T., 1 Jan 2000, In : Experimental eye research. 71, 5, p. 535-539 5 p.

Research output: Contribution to journalEditorialResearch

Endothelin-1
Nitric Oxide Synthase
Epithelial Cells
5 Citations (Scopus)

Microfilament network is needed for the endocytosis of water channels and not for apical membrane insertion upon vasopressin action

Dibas, A., Mia, A. & Yorio, T., 1 Jan 2000, In : Proceedings of the Society for Experimental Biology and Medicine. 223, 2, p. 203-209 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Aquaporins
Endocytosis
Vasopressins
Actin Cytoskeleton
Membranes
1999
1 Citation (Scopus)

1998 Louisa Burns Memorial Lecture: Can teaching and research coexist?

Yorio, T., 1 Jan 1999, In : Journal of the American Osteopathic Association. 99, 3

Research output: Contribution to journalReview articleResearchpeer-review

Burns
Teaching
Health
Research
Aquaporins
Vasopressins
Medicine
Water
7 Citations (Scopus)

Identification of endothelin converting enzyme-1 in human non-pigmented ciliary epithelial cells

Prasanna, G., Dibas, A., Finkley, A. & Yorio, T., 1 Jan 1999, In : Experimental Eye Research. 69, 2, p. 175-183 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Endothelin-1
Epithelial Cells
Metalloproteases
Proteins
Endothelins
2 Citations (Scopus)

Phenylarsine oxide inhibits phosphate uptake in human ciliary non- pigmented epithelial cells

Dibas, A., Prasanna, G. & Yorio, T., 1 Jan 1999, In : Journal of Ocular Pharmacology and Therapeutics. 15, 3, p. 241-250 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Epithelial Cells
Phosphates
Sulfhydryl Reagents
Adenosine Triphosphate
Sodium
1998
13 Citations (Scopus)

Activation of protein kinase c by tumor necrosis factor-α in human non- pigmented ciliary epithelium

Prasanna, G., Dibas, A., Brown, K. & Yorio, T., 1 Jan 1998, In : Journal of Ocular Pharmacology and Therapeutics. 14, 5, p. 401-412 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Protein Kinases
Protein Kinase C
Diglycerides
Epithelium
Tumor Necrosis Factor-alpha
34 Citations (Scopus)

Aquaporins (Water channels): Role in vasopressin-activated water transport

Dibas, A., Mia, A. J. & Yorio, T., 1 Dec 1998, In : Proceedings of the Society for Experimental Biology and Medicine. 219, 3, p. 183-199 17 p.

Research output: Contribution to journalShort surveyResearchpeer-review

Aquaporins
Vasopressins
Aquaporin 3
Water
Collecting Kidney Tubules
1 Citation (Scopus)

Effect of temperature on apical membrane remodeling in ADH-stimulated toad urinary bladders

Mia, A. J., Oakford, L. X., Wood, J., Dibas, A. & Yorio, T., 1 Sep 1998, In : Proceedings of the Society for Experimental Biology and Medicine. 218, 4, p. 307-315 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Anura
Urinary Bladder
Tissue
Membranes
Temperature
39 Citations (Scopus)

Endothelin receptor A is expressed and mediates the [Ca2+](i) mobilization of cells in human ciliary smooth muscle, ciliary nonpigmented epithelium, and trabecular meshwork

Tao, W., Prasanna, G., Dimitrijevich, S. & Yorio, T., 28 Jan 1998, In : Current Eye Research. 17, 1, p. 31-38 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Trabecular Meshwork
Endothelin A Receptors
Smooth Muscle
Epithelium
Endothelin-1
36 Citations (Scopus)

Regulation of endothelin-1 in human non-pigmented ciliary epithelial cells by tumor necrosis factor-α

Prasanna, G., Dibas, A., Tao, W., White, K. & Yorio, T., 1 Jan 1998, In : Experimental Eye Research. 66, 1, p. 9-18 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Endothelin-1
Tumor Necrosis Factor-alpha
Epithelial Cells
Aqueous Humor
Cytokines
1997
4 Citations (Scopus)

A new chromatographic method for measurement of rubidium transport activities in cultured bovine retinal pigment epithelial cells

Crider, J. Y., Williams, G. W., Yorio, T., Sharif, N. A. & Griffin, B. W., 1 Jan 1997, In : Ophthalmic Research. 29, 3, p. 117-123 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Rubidium
Retinal Pigments
Ouabain
Cations
Epithelial Cells
2 Citations (Scopus)

Bicarbonate and CO2 transport across the skin of the leopard frog, Rana pipiens: Effect of PGF(2α)

Candia, O. A. & Yorio, T., 11 Apr 1997, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 272, 2 41-2

Research output: Contribution to journalArticleResearchpeer-review

Rana pipiens
Prostaglandins F
Bicarbonates
Skin
Acetazolamide
10 Citations (Scopus)

Evidence of basolateral water permeability regulation in amphibian urinary bladder

Candia, O. A., Mia, A. & Yorio, T., 1 Jan 1997, In : Biology of the Cell. 89, 5-6, p. 331-339 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Arginine Vasopressin
Amphibians
Permeability
Urinary Bladder
Osmolar Concentration
10 Citations (Scopus)

Mechanism of vasopressin-induced increase in intracellular Ca2+ in LLC-PK1 porcine kidney cells

Dibas, A., Rezazadeh, S. M., Vassan, R., Mia, A. J. & Yorio, T., 1 Mar 1997, In : American Journal of Physiology - Cell Physiology. 272, 3 41-3

Research output: Contribution to journalArticleResearchpeer-review

LLC-PK1 Cells
Vasopressins
Swine
Kidney
Hepatocytes
48 Citations (Scopus)

Ocular actions of endothelins

Pang, I-H. & Yorio, T., 1 May 1997, In : Proceedings of the Society for Experimental Biology and Medicine. 215, 1, p. 21-34 14 p.

Research output: Contribution to journalShort surveyResearchpeer-review

Endothelin Receptors
Signal transduction
Endothelins
Second Messenger Systems
Animals

The ATP-depleting reagent "iodacetamide" induces the degradation of protein kinase C alpha (PKCα) in LLC-PK1 pig kidney cells

Dibas, A., Mia, A. J. & Yorio, T., 1 Dec 1997, In : FASEB Journal. 11, 3

Research output: Contribution to journalArticleResearchpeer-review

Protein Kinase C-alpha
protein kinase C
kidney cells
Iodoacetamide
Swine
4 Citations (Scopus)

The ATP-depleting reagent iodoacetamide induces the degradation of protein kinase C alpha (PKCα) in LLC-PK1 pig kidney cells

Dibas, A., Wood, J., Mia, A. J. & Yorio, T., 19 Sep 1997, In : Life Sciences. 61, 17, p. 1697-1704 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Iodoacetamide
Protein Kinase C-alpha
Swine
Adenosine Triphosphate
Kidney
14 Citations (Scopus)

The effects of elevated glucose on Na+/K+-ATPpase of cultured bovine retinal pigment epithelial cells measured by a new nonradioactive rubidium uptake assay

Crider, J. Y., Yorio, T., Sharif, N. A. & Griffin, B. W., 1 Jan 1997, In : Journal of Ocular Pharmacology and Therapeutics. 13, 4, p. 337-352 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Rubidium
Retinal Pigments
Epithelial Cells
Hyperglycemia
Glucose
2 Citations (Scopus)
Second Messenger Systems
Protein Kinases
Phospholipids
Protein Isoforms
Tumor Necrosis Factor-alpha
1996
3 Citations (Scopus)

A novel use for coomassie brilliant blue (R-250) in protein gel-drying procedure and assessing the electro-transferring efficiency

Dibas, A. & Yorio, T., 27 Mar 1996, In : Biochemical and Biophysical Research Communications. 220, 3, p. 929-932 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Drying
Gels
Proteins
Staining and Labeling
Collodion
32 Citations (Scopus)

Endothelin-induced changes of second messengers in cultured human ciliary muscle cells

Matsumoto, S., Yorio, T., Magnino, P. E., Desantis, L. & Pang, I-H., 1 May 1996, In : Investigative Ophthalmology and Visual Science. 37, 6, p. 1058-1066 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Endothelins
Second Messenger Systems
Endothelin-1
Muscle Cells
Type C Phospholipases