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Research Output 1973 2019

2019

Hybrid compound sa-2 is neuroprotective in animal models of retinal ganglion cell death

Stankowska, D. L., Dibas, A., Li, L., Zhang, W., Krishnamoorthy, V. R., Chavala, S., Nguyen, T. P., Yorio, T., Ellis, D. Z. & Acharya, S., 1 Jul 2019, In : Investigative Ophthalmology and Visual Science. 60, 8, p. 3064-3073 10 p.

Research output: Contribution to journalArticle

Open Access
Retinal Ganglion Cells
Cell Death
Nerve Crush
Animal Models
Retina
2018
9 Citations (Scopus)

Consensus recommendations for trabecular meshwork cell isolation, characterization and culture

Keller, K. E., Bhattacharya, S. K., Borrás, T., Brunner, T. M., Chansangpetch, S., Clark, A., Dismuke, W. M., Du, Y., Elliott, M. H., Ethier, C. R., Faralli, J. A., Freddo, T. F., Fuchshofer, R., Giovingo, M., Gong, H., Gonzalez, P., Huang, A., Johnstone, M. A., Kaufman, P. L., Kelley, M. J. & 37 others, Knepper, P. A., Kopczynski, C. C., Kuchtey, J. G., Kuchtey, R. W., Kuehn, M. H., Lieberman, R. L., Lin, S. C., Liton, P., Liu, Y., Lütjen-Drecoll, E., Mao, W., Masis-Solano, M., McDonnell, F., McDowell, C. M., Overby, D. R., Pattabiraman, P. P., Raghunathan, V. K., Rao, P. V., Rhee, D. J., Chowdhury, U. R., Russell, P., Samples, J. R., Schwartz, D., Stubbs, E. B., Tamm, E. R., Tan, J. C., Toris, C. B., Torrejon, K. Y., Vranka, J. A., Wirtz, M. K., Yorio, T., Zhang, J., Zode, G., Fautsch, M. P., Peters, D. M., Acott, T. S. & Stamer, W. D., 1 Jun 2018, In : Experimental eye research. 171, p. 164-173 10 p.

Research output: Contribution to journalShort survey

Trabecular Meshwork
Cell Separation
Cell Culture Techniques
Ocular Hypertension
Intraocular Pressure

Introduction to volume 1 of JOPT special issue

Sharif, N., Ohia, S. & Yorio, T., 1 Jan 2018, In : Journal of Ocular Pharmacology and Therapeutics. 34, 1-2, p. 1-2 2 p.

Research output: Contribution to journalEditorial

Introduction to volume 2 of JOPT special issue

Sharif, N., Ohia, S. & Yorio, T., 1 Jan 2018, In : Journal of Ocular Pharmacology and Therapeutics. 34, 1-2, 1 p.

Research output: Contribution to journalEditorial

4 Citations (Scopus)

Neuroprotective Effects of Psalmotoxin-1, an Acid-Sensing Ion Channel (ASIC) Inhibitor, in Ischemia Reperfusion in Mouse Eyes

Dibas, A., Millar, J. C., Al-Farra, A. & Yorio, T., 3 Jul 2018, In : Current Eye Research. 43, 7, p. 921-933 13 p.

Research output: Contribution to journalArticle

Acid Sensing Ion Channel Blockers
Retinal Ganglion Cells
Neuroprotective Agents
Reperfusion
Ischemia
4 Citations (Scopus)

Targets of neuroprotection in glaucoma

He, S., Stankowska, D. L., Ellis, D. Z., Krishnamoorthy, R. & Yorio, T., 1 Jan 2018, In : Journal of Ocular Pharmacology and Therapeutics. 34, 1-2, p. 85-106 22 p.

Research output: Contribution to journalArticle

Glaucoma
Retinal Diseases
Western World
Retinal Ganglion Cells
Aqueous Humor
2017
CCAAT-Enhancer-Binding Proteins
Endothelin Receptors
food law
endothelins
Endothelin B Receptors

Principles of ocular pharmacology

Park, Y., Ellis, D. Z., Mueller, B., Stankowska, D. L. & Yorio, T., 1 Jan 2017, Handbook of Experimental Pharmacology. Springer New York LLC, p. 3-30 28 p. (Handbook of Experimental Pharmacology; vol. 242).

Research output: Chapter in Book/Report/Conference proceedingChapter

Eye Diseases
Pharmacology
Pharmaceutical Preparations
Memory Disorders
Macular Degeneration
4 Citations (Scopus)

Sigma-1 receptor regulates mitochondrial function in glucose-and oxygen-deprived retinal ganglion cells

Ellis, D. Z., Li, L., Park, Y., He, S., Mueller, B. & Yorio, T., May 2017, In : Investigative Ophthalmology and Visual Science. 58, 5, p. 2755-2764 10 p.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Oxygen
Glucose
Mitochondrial Membrane Potential
Electron Transport Complex IV
2016
4 Citations (Scopus)
Optic Nerve Diseases
Prodrugs
Optics
Photoreceptor Cells
Molecules
16 Citations (Scopus)

Glucocorticoid therapy and ocular hypertension

Dibas, A. & Yorio, T., 1 Jan 2016, In : European Journal of Pharmacology. 787, p. 57-71 15 p.

Research output: Contribution to journalArticle

Ocular Hypertension
Glucocorticoids
Macular Degeneration
Diabetic Retinopathy
Glaucoma
4 Citations (Scopus)

Involvement of ampa receptor and its flip and flop isoforms in retinal ganglion cell death following oxygen/glucose deprivation

Park, Y. H., Broyles, H. V., He, S., McGrady, N. R., Li, L. & Yorio, T., 1 Feb 2016, In : Investigative Ophthalmology and Visual Science. 57, 2, p. 508-526 19 p.

Research output: Contribution to journalArticle

AMPA Receptors
Retinal Ganglion Cells
Protein Isoforms
Cell Death
Oxygen

Thank you to our reviewers

Yorio, T., 1 Jun 2016, In : Investigative Ophthalmology and Visual Science. 57, 7, 1 p.

Research output: Contribution to journalEditorial

2015
11 Citations (Scopus)

AMPA receptor desensitization is the determinant of AMPA receptor mediated excitotoxicity in purified retinal ganglion cells

Park, Y. H., Mueller, B. H., McGrady, N. R., Ma, H. Y. & Yorio, T., 1 Mar 2015, In : Experimental eye research. 132, p. 136-150 15 p.

Research output: Contribution to journalArticle

AMPA Receptors
Retinal Ganglion Cells
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Caspase 7
Calcium

A new transition

Yorio, T., 1 Jan 2015, In : Investigative Ophthalmology and Visual Science. 56, 5, 1 p.

Research output: Contribution to journalEditorial

Ophthalmology
9 Citations (Scopus)

Endothelin-mediated changes in gene expression in isolated purified rat retinal ganglion cells

He, S., Park, Y. H., Yorio, T. & Krishnamoorthy, R., 1 Jan 2015, In : Investigative Ophthalmology and Visual Science. 56, 10, p. 6144-6161 18 p.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Endothelins
Gene Expression
Endothelin-1
Endothelin-2
10 Citations (Scopus)

Neuroprotective effects of transcription factor brn3b in an ocular hypertension rat model of glaucoma

Stankowska, D. L., Minton, A. Z., Rutledge, M. A., Mueller, B. H., Phatak, N. R., He, S., Ma, H. Y., Forster, M. J., Yorio, T. & Krishnamoorthy, R., 1 Jan 2015, In : Investigative Ophthalmology and Visual Science. 56, 2, p. 893-907 15 p.

Research output: Contribution to journalArticle

Ocular Hypertension
Neuroprotective Agents
Intraocular Pressure
Glaucoma
Transcription Factors
1 Citation (Scopus)

Open access coming to IOVS

Yorio, T., 1 Jan 2015, In : Investigative Ophthalmology and Visual Science. 56, 9, 1 p.

Research output: Contribution to journalEditorial

2014
2 Citations (Scopus)

Erratum: Characterization of a transformed rat retinal ganglion cell line (Brain Research Molecular Brain Research (2001) 86 (1-12))

Krishnamoorthy, R., Agarwal, P., Prasanna, G., Vopat, K., Lambert, W., Sheedlo, H. J., Pang, I-H., Shade, D., Wordinger, R. J., Yorio, T., Clark, A. & Agarwal, N., 28 Jan 2014, In : Brain Research. 1544, 1 p.

Research output: Contribution to journalComment/debate

Retinal Ganglion Cells
Cell Line
Brain
Research
4 Citations (Scopus)

Methylene blue promotes quiescence of rat neural progenitor cells

Xie, L., Choudhury, G. R., Wang, J., Park, Y., Liu, R., Yuan, F., Zhang, C. L., Yorio, T., Jin, K. & Yang, S., 7 Oct 2014, In : Frontiers in Cellular Neuroscience. 8, OCT, 315.

Research output: Contribution to journalArticle

Methylene Blue
Stem Cells
Intraventricular Infusions
Cyclins
Neural Stem Cells
12 Citations (Scopus)

Role of the alternatively spliced glucocorticoid receptor isoform GRβ in steroid responsiveness and glaucoma

Jain, A., Wordinger, R. J., Yorio, T. & Clark, A., 1 Mar 2014, In : Journal of Ocular Pharmacology and Therapeutics. 30, 2-3, p. 121-127 7 p.

Research output: Contribution to journalReview article

Glucocorticoid Receptors
Glaucoma
Glucocorticoids
Protein Isoforms
Trabecular Meshwork
17 Citations (Scopus)

Sigma-1 receptor stimulation protects retinal ganglion cells from ischemia-like insult through the activation of extracellular-signal-regulated kinases 1/2

Mueller, B. H., Park, Y., Ma, H. Y., Dibas, A., Ellis, D. Z., Clark, A. & Yorio, T., 1 Nov 2014, In : Experimental Eye Research. 128, p. 156-169 14 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase 3
Retinal Ganglion Cells
Mitogen-Activated Protein Kinase 1
Ischemia
Pentazocine
2013
73 Citations (Scopus)

A forensic path to RGC-5 cell line identification: Lessons learned

Krishnamoorthy, R., Clark, A., Daudt, D., Vishwanatha, J. K. & Yorio, T., 30 Aug 2013, In : Investigative Ophthalmology and Visual Science. 54, 8, p. 5712-5719 8 p.

Research output: Contribution to journalEditorial

Retinal Ganglion Cells
Cell Line
Transformed Cell Line
Karyotyping
Photoreceptor Cells
10 Citations (Scopus)

Effects of thailanstatins on glucocorticoid response in trabecular meshwork and steroid-induced glaucoma

Jain, A., Liu, X., Wordinger, R. J., Yorio, T., Cheng, Y. & Clark, A., 10 May 2013, In : Investigative Ophthalmology and Visual Science. 54, 5, p. 3137-3142 6 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Glaucoma
Glucocorticoids
Steroids
Intraocular Pressure
34 Citations (Scopus)

Sigma-1 receptor stimulation attenuates calcium influx through activated L-type Voltage Gated Calcium Channels in purified retinal ganglion cells

Mueller, B. H., Park, Y., Daudt, D. R., Ma, H. Y., Akopova, I., Stankowska, D. L., Clark, A. F. & Yorio, T., 1 Feb 2013, In : Experimental Eye Research. 107, p. 21-31 11 p.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Calcium Channels
Calcium
Calcium Channel Blockers
Ions
2012
3 Citations (Scopus)
Trabecular Meshwork
Protein Isoforms
Dexamethasone
Proteins
tanespimycin
22 Citations (Scopus)

Methylene blue protects primary rat retinal ganglion cells from cellular senescence

Daudt, D. R., Mueller, B., Park, Y. H., Wen, Y. & Yorio, T., 1 Jul 2012, In : Investigative Ophthalmology and Visual Science. 53, 8, p. 4657-4667 11 p.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Cell Aging
Methylene Blue
Electron Transport Complex IV
Rotenone
23 Citations (Scopus)
Spliceosomes
Trabecular Meshwork
Glucocorticoid Receptors
Glucocorticoids
Protein Isoforms
2011
42 Citations (Scopus)

Endothelin, astrocytes and glaucoma

Prasanna, G., Krishnamoorthy, R. & Yorio, T., 1 Aug 2011, In : Experimental eye research. 93, 2, p. 170-177 8 p.

Research output: Contribution to journalArticle

Endothelins
Astrocytes
Glaucoma
Gliosis
Central Nervous System
10 Citations (Scopus)

FKBP51 protects 661w cell culture from staurosporine-induced apoptosis

Daudt, D. R. & Yorio, T., 30 May 2011, In : Molecular Vision. 17, p. 1172-1181 10 p.

Research output: Contribution to journalArticle

Tacrolimus Binding Proteins
Staurosporine
Cell Culture Techniques
Tacrolimus
Apoptosis
25 Citations (Scopus)
Ocular Hypertension
Glaucoma
Dexamethasone
Glucocorticoids
Perfusion
5 Citations (Scopus)

Protein Profiling of human nonpigmented ciliary epithelium cell secretome: The differentiation factors characterization for retinal ganglion cell line

Chung, T. W., Yang, M. H., Krishnamoorthy, R., Jong, S. B., Chu, P. Y., Yang, Y. H., Chen, W. C., Chen, S. C. J., Dibas, A., Yorio, T. & Tyan, Y. C., 12 Oct 2011, In : Journal of Biomedicine and Biotechnology. 2011, 901329.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Epithelium
Cell Line
Epithelial Cells
Proteins
2010
23 Citations (Scopus)

Assessment of SNPs associated with the human glucocorticoid receptor in primary open-angle glaucoma and steroid responders

Fingert, J. H., Alward, W. L., Wang, K., Yorio, T. & Clark, A., 23 Aug 2010, In : Molecular Vision. 16, p. 596-601 6 p.

Research output: Contribution to journalArticle

Glucocorticoid Receptors
Single Nucleotide Polymorphism
Steroids
Glucocorticoids
Ocular Hypertension
53 Citations (Scopus)

Canonical Transient Receptor Potential 6 (TRPC6), a redox-regulated cation channel

Graham, S., Ding, M., Ding, Y., Sours-Brothers, S., Luchowski, R., Gryczynski, Z., Yorio, T., Ma, H. & Ma, R., 23 Jul 2010, In : Journal of Biological Chemistry. 285, 30, p. 23466-23476 11 p.

Research output: Contribution to journalArticle

Arginine Vasopressin
Oxidation-Reduction
Cations
Vasopressin Receptors
Ethylmaleimide
21 Citations (Scopus)

Changes in ocular aquaporin expression following optic nerve crush

Dibas, A., Oku, H., Fukuhara, M., Kurimoto, T., Ikeda, T., Patil, R. V., Sharif, N. A. & Yorio, T., 20 Aug 2010, In : Molecular Vision. 16, p. 330-340 11 p.

Research output: Contribution to journalArticle

Nerve Crush
Aquaporins
Optic Nerve
Retinal Ganglion Cells
Glial Fibrillary Acidic Protein
4 Citations (Scopus)

Steroid-induced glaucoma

Clark, A., Zhang, X. & Yorio, T., 1 Dec 2010, Ocular Disease: Mechanisms and Management. Elsevier Inc., p. 146-152 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Glaucoma
Steroids
6 Citations (Scopus)

Thrombin-induced endothelin-1 synthesis and secretion in retinal pigment epithelial cells is Rho kinase dependent

Narayan, S., Prasanna, G., Tchedre, K., Krishnamoorthy, R. & Yorio, T., 1 Oct 2010, In : Journal of Ocular Pharmacology and Therapeutics. 26, 5, p. 389-397 9 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Retinal Pigments
Endothelin-1
Thrombin
Epithelial Cells
2009
94 Citations (Scopus)

The role of glia, mitochondria, and the immune system in glaucoma

Tezel, G., Ben-Hur, T., Gibson, G. E., Stevens, B., Streit, W. J., Wekerle, H., Bhattacharya, S. K., Borras, T., Burgoyne, C. F., Caspi, R. R., Chauhan, B. C., Clark, A., Crowston, J., Danias, J., Dick, A. D., Flammer, J., Foster, C. S., Grosskreutz, C. L., Grus, F. H., Guy, J. & 48 others, Hernandez, M. R., Johnson, E., Kaplan, H. J., Kuehn, M. H., Lenaers, G., Levin, L. A., Lindsey, J. D., Malina, H., Nickells, R. W., Osborne, N., Quigley, H. A., Rao, N., Rosenbaum, J. T., Sadun, A. A., Schwartz, M., Sun, D., Trounce, I., Wax, M. B., Yorio, T., Abrams, G. W., Atherton, S. S., Boatright, J. H., Chu, J., Dowling, J., Ferris, F. L., Garway-Heath, D., Gregory, M., Grzybowski, D. M., Gupta, N., Inman, D. M., Ju, W. K., Kang, K. D., Kaufman, H. E., Kaufman, P. L., Larssen, L. I., Liebmann, J., Lupien, C., Miller, R. F., Niesman, M., O'Brien, C., Petrash, J. M., Prasanna, G., Ritch, R., Shestopalov, V., Wirostko, B., WoldeMussie, E., Yue, B. & Zimmerman, T. J., 1 Mar 2009, In : Investigative Ophthalmology and Visual Science. 50, 3, p. 1001-1012 12 p.

Research output: Contribution to journalArticle

2008
30 Citations (Scopus)

Changes in ocular aquaporin-4 (AQP4) expression following retinal injury

Dibas, A., Yang, M. H., He, S., Bobich, J. & Yorio, T., 1 Jan 2008, In : Molecular Vision. 14, p. 1770-1783 14 p.

Research output: Contribution to journalArticle

Aquaporin 4
Ubiquitination
Intraocular Pressure
Wounds and Injuries
Glial Fibrillary Acidic Protein
10 Citations (Scopus)

Drug delivery to posterior intraocular tissues: Third annual ARVO/Pfizer ophthalmics research institute conference

Edelhauser, H. F., Boatright, J. H., Nickerson, J. M., Edelhauser, H. F., Abrams, G., Adamis, A., Aguirre, G. D., Ambati, J., Becerra, P., Behar-Cohen, F., Berglin, L., Bernstein, S., Boatright, J., Crouch, R., Freeman, W., Friedlander, M., Geroski, D., Grossniklaus, H., Heckenlively, J., Kempen, J. & 16 others, Kompella, U., Laties, A., LaVail, M., McGinnis, J., Marc, R., Miller, J., Nickerson, J., O'Brien, J., Olsen, T., Palanker, D., Robinson, M., Saperstein, D., Sternberg, P., Stout, J. T., Williams, G. & Yorio, T., 1 Nov 2008, In : Investigative Ophthalmology and Visual Science. 49, 11, p. 4712-4720 9 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Endothelin-1 mediated regulation of extracellular matrix collagens in cells of human lamina cribrosa

Rao, V. R., Krishnamoorthy, R. R. & Yorio, T., 1 Jun 2008, In : Experimental eye research. 86, 6, p. 886-894 9 p.

Research output: Contribution to journalArticle

Endothelin-1
Extracellular Matrix
Collagen
Collagen Type I
Collagen Type VI
71 Citations (Scopus)
Tacrolimus Binding Proteins
Cell Nucleus Active Transport
Glucocorticoid Receptors
Dexamethasone
Glucocorticoids
2 Citations (Scopus)

Ocular Therapeutics

Yorio, T., Clark, A. & Wax, M. B., 1 Jan 2008, Elsevier Ltd.

Research output: Book/ReportBook

Eye Diseases
Research Personnel
Blindness
Therapeutics
Glaucoma

Preface

Yorio, T., Clark, A. & Wax, M. B., 1 Dec 2008, Ocular Therapeutics. Elsevier Ltd

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript

34 Citations (Scopus)

Role of the ETB receptor in retinal ganglion cell death in glaucoma

Krishnamoorthy, R., Rao, V. R., Dauphin, R., Prasanna, G., Johnson, C. & Yorio, T., 1 Jun 2008, In : Canadian Journal of Physiology and Pharmacology. 86, 6, p. 380-393 14 p.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Endothelin-1
Glaucoma
Cell Death
Apoptosis
93 Citations (Scopus)

Sigma-1 receptor regulation of voltage-gated calcium channels involves a direct interaction

Tchedre, K. T., Huang, R-Q., Dibas, A., Krishnamoorthy, R., Dillon, G. H. & Yorio, T., 1 Nov 2008, In : Investigative Ophthalmology and Visual Science. 49, 11, p. 4993-5002 10 p.

Research output: Contribution to journalArticle

Calcium Channels
Calcium
Potassium Chloride
Retinal Ganglion Cells
Homeostasis

The Ciliary Body: A Potential Multifaceted Functional Neuroendocrine Unit

Yorio, T., Prasanna, G. & Coca-Prados, M., 1 Dec 2008, Ocular Therapeutics. Elsevier Ltd, p. 69-85 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Ciliary Body
1 Citation (Scopus)

The Eye as a Drug Target

Yorio, T., Clark, A. & Wax, M. B., 1 Dec 2008, Ocular Therapeutics. Elsevier Ltd, p. 3-6 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Pharmaceutical Preparations
11 Citations (Scopus)
Certification
health science
Medical Schools
qualification
certification
69 Citations (Scopus)
Caspase 3
Glutamic Acid
Apoptosis
Calcium
Cell Death