Projects per year
Personal profile
Area of Expertise
My laboratory studies the role of the central nervous system in the regulation of the cardiovascular system, and water and electrolyte balance. We study how the brain participates in the normal maintenance of blood pressure and fluid balance, a process called homeostasis. We also investigate how changes in these CNS processes contribute to water retention associated with heart or liver disease and chronic diseases such as hypertension. Our goal is to achieve a better understanding of how the CNS contributes to health and diseases though its interactions with the cardiovascular system.
Education/Academic qualification
PhD in Biopsychology, University of Iowa
MS in Biopsychology, University of Iowa
BA in Psychology, Eastern Illinois University
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Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2012 2022
Central Mechanisms and Novel BioMarkers of the Salt-Sensitivity of Blood Pressure
1/05/18 → 28/02/22
Project: Research
Neural Regulation of Vasopresson Release in a model of Dilutaional Hyponatremia
Cunningham, T., Cunningham, R. & Yuan, J.
NHLBI: Nat Heart, Lung & Blood Institute
15/04/18 → 31/03/22
Project: Research
Promoting Diversity in Research Training for Health Professionals
Vishwanatha, J., Cunningham, T. & Schreihofer, A.
NHLBI: Nat Heart, Lung & Blood Institute
15/05/16 → 30/04/21
Project: Research
Research Output 1985 2019
Selectively Inhibiting the Median Preoptic Nucleus Attenuates Angiotensin II and Hyperosmotic-Induced Drinking Behavior and Vasopressin Release in Adult Male Rats
Marciante, A. B., Wang, L. A., Farmer, G. E. & Cunningham, J. T., 1 Mar 2019, In : eNeuro. 6, 2Research output: Contribution to journal › Article › Research › peer-review
Open Access
Drinking Behavior
Preoptic Area
Vasopressins
Angiotensin II
Designer Drugs
AT1a influences GABAA-mediated inhibition through regulation of KCC2 expression
Farmer, G. E., Balapattabi, K., Bachelor, M. E., Little, J. T. & Cunningham, J. T., 1 Nov 2018, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 315, 5, p. R972-R982Research output: Contribution to journal › Article › Research › peer-review
Preoptic Area
Angiotensins
Angiotensin Type 1 Receptor
Neurons
Angiotensin II
High salt loading increases brain derived neurotrophic factor in supraoptic vasopressin neurones
Balapattabi, K., Little, J. T., Farmer, G. E. & Cunningham, J. T., 1 Nov 2018, In : Journal of Neuroendocrinology. 30, 11, e12639.Research output: Contribution to journal › Article › Research › peer-review
Brain-Derived Neurotrophic Factor
Vasopressins
Salts
Supraoptic Nucleus
Neurons
2
Citations
(Scopus)
Transcription factor ΔFosB acts within the nucleus of the solitary tract to increase mean arterial pressure during exposures to intermittent hypoxia
Wu, Q., Cunningham, J. T. & Mifflin, S. W., 1 Feb 2018, In : American Journal of Physiology - Heart and Circulatory Physiology. 314, 2, p. H270-H277Research output: Contribution to journal › Article › Research › peer-review
Solitary Nucleus
Arterial Pressure
Transcription Factors
Sleep Apnea Syndromes
Green Fluorescent Proteins
5
Citations
(Scopus)
Angiotensin converting enzyme 1 in the median preoptic nucleus contributes to chronic intermittent hypoxia hypertension
Faulk, K. E., Nedungadi, T. P. & Cunningham, J. T., 1 May 2017, In : Physiological Reports. 5, 10, e13277.Research output: Contribution to journal › Article › Research › peer-review
Preoptic Area
Peptidyl-Dipeptidase A
Hypertension
Blood Pressure
Angiotensin I