• 276 Citations
  • 6 h-Index
20072019
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Personal profile

Area of Expertise

My research goal is to understand the pathology of the trabecular meshwork (TM) and the optic nerve head (ONH) in glaucoma. The TM is the main dynamic resistor that regulates the aqueous humor outflow and causes elevated intraocular pressure in the anterior chamber of the eye. This elevated pressure is transduced toward the back of the eye and results in a remodeling of the ONH. The ONH is the resident of two types of cells, ONH astrocytes and lamina cribrosa cells (LC). ONA and LC cells have been implicated in the pathophysiology of glaucoma.
I focus primarily on growth factors and their signaling pathways to determine if they alter mRNA and protein expression of the TM and the ONH cells. I wish to understand the roles of these growth factors in normal tissue and in the glaucoma pathophysiology.

Education/Academic qualification

PhD in Cell Biology & Genetics, UNT Health Science Center

MS in Cell Biology & Genetics, UNT Health Science Center

BS in Biology, University of The Incarnate Word

Fingerprint Dive into the research topics where Tara Tovar-Vidales is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 10 Similar Profiles
Trabecular Meshwork Medicine & Life Sciences
Glaucoma Medicine & Life Sciences
Transforming Growth Factor beta2 Medicine & Life Sciences
Transforming Growth Factors Medicine & Life Sciences
Bone Morphogenetic Proteins Medicine & Life Sciences
Extracellular Matrix Medicine & Life Sciences
Bone Morphogenetic Protein 4 Medicine & Life Sciences
Proteins Medicine & Life Sciences

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Projects 2017 2019

Research Output 2007 2016

  • 276 Citations
  • 6 h-Index
  • 7 Article
  • 1 Short survey
5 Citations (Scopus)

Human trabecular meshwork cells express BMP antagonist mRNAs and proteins

Tovar-Vidales, T., Fitzgerald, A. M. & Clark, A., 1 Jun 2016, In : Experimental Eye Research. 147, p. 156-160 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Trabecular Meshwork
Bone Morphogenetic Proteins
Transforming Growth Factor beta2
Messenger RNA
Proteins
6 Citations (Scopus)

Identification and localization of lamina cribrosa cells in the human optic nerve head

Tovar-Vidales, T., Wordinger, R. J. & Clark, A., 1 Jun 2016, In : Experimental Eye Research. 147, p. 94-97 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Optic Disk
Glial Fibrillary Acidic Protein
Astrocytes
Glaucoma
Retinal Ganglion Cells
12 Citations (Scopus)

Transforming growth factor-β2 induces expression of biologically active bone morphogenetic protein-1 in human trabecular meshwork cells

Tovar-Vidales, T., Fitzgerald, A. M., Clark, A. & Wordinger, R. J., 23 Jul 2013, In : Investigative Ophthalmology and Visual Science. 54, 7, p. 4741-4748 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Trabecular Meshwork
Transforming Growth Factors
Bone and Bones
Proteins
Protein-Lysine 6-Oxidase
6 Citations (Scopus)

Focus on Molecules: Transglutaminase 2

Tovar-Vidales, T., Clark, A. & Wordinger, R. J., 1 Jul 2011, In : Experimental eye research. 93, 1, p. 2-3 2 p.

Research output: Contribution to journalShort surveyResearchpeer-review

Trabecular Meshwork
Transglutaminases
Eye Diseases
GTP-Binding Proteins
Lenses
25 Citations (Scopus)

Perfusion-cultured bovine anterior segments as an ex vivo model for studying glucocorticoid-induced ocular hypertension and glaucoma

Mao, W., Tovar-Vidales, T., Yorio, T., Wordinger, R. J. & Clark, A., 1 Oct 2011, In : Investigative Ophthalmology and Visual Science. 52, 11, p. 8068-8075 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Ocular Hypertension
Glaucoma
Dexamethasone
Glucocorticoids
Perfusion