• 332 Citations
  • 8 h-Index
20072020

Research output per year

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Personal profile

Area of Expertise

My research goal is to understand the pathology of the trabecular meshwork (TM) and the optic nerve head (ONH) in glaucoma. The TM is the main dynamic resistor that regulates the aqueous humor outflow and causes elevated intraocular pressure in the anterior chamber of the eye. This elevated pressure is transduced toward the back of the eye and results in a remodeling of the ONH. The ONH is the resident of two types of cells, ONH astrocytes and lamina cribrosa cells (LC). ONA and LC cells have been implicated in the pathophysiology of glaucoma.
I focus primarily on growth factors and their signaling pathways to determine if they alter mRNA and protein expression of the TM and the ONH cells. I wish to understand the roles of these growth factors in normal tissue and in the glaucoma pathophysiology.

Education/Academic qualification

MS in Cell Biology & Genetics, UNT Health Science Center

PhD in Cell Biology & Genetics, UNT Health Science Center

BS in Biology, University of The Incarnate Word

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Projects

Research Output

  • 332 Citations
  • 8 h-Index
  • 7 Article
  • 2 Short survey

Isolation and characterization of human optic nerve head astrocytes and lamina cribrosa cells

Lopez, N. N., Clark, A. F. & Tovar-Vidales, T., Aug 2020, In : Experimental eye research. 197, 108103.

Research output: Contribution to journalShort survey

  • Human trabecular meshwork cells express BMP antagonist mRNAs and proteins

    Tovar-Vidales, T., Fitzgerald, A. M. & Clark, A. F., 1 Jun 2016, In : Experimental eye research. 147, p. 156-160 5 p.

    Research output: Contribution to journalArticle

  • 12 Scopus citations

    Identification and localization of lamina cribrosa cells in the human optic nerve head

    Tovar-Vidales, T., Wordinger, R. J. & Clark, A., 1 Jun 2016, In : Experimental Eye Research. 147, p. 94-97 4 p.

    Research output: Contribution to journalArticle

  • 9 Scopus citations
  • 14 Scopus citations

    Focus on Molecules: Transglutaminase 2

    Tovar-Vidales, T., Clark, A. F. & Wordinger, R. J., Jul 2011, In : Experimental eye research. 93, 1, p. 2-3 2 p.

    Research output: Contribution to journalShort survey

    9 Scopus citations