Calculated based on number of publications stored in Pure and citations from Scopus
20072022

Research activity per year

Personal profile

Research Interests

Visual Sciences, Glaucoma, Histology, and Molecular Mechanisms

 

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Area of Expertise

Our lab is dedicated to investigating the dysregulated molecular mechanisms involved in the pathogenesis of glaucoma. Specifically, we study primary human cells in the optic nerve head (ONH), ONH astrocytes and lamina cribrosa (LC) cells. In glaucoma, the increase in intraocular pressure is transmitted to the back of the eye, causing stretching and straining of the ONH cells. This results in ONH cells contributing to the extracellular remodeling within the LC region of the ONH in glaucoma. Our research is particularly interested in exploring the role of microRNAs (miRNAs) in the development of glaucoma. miRNAs are negative regulators of protein translation. We have found that TGF-beta 2 treated and glaucoma ONH cells from human donors have an increased expression of profibrotic miRNAs and a decreased expression of anti-fibrotic miRNAs. Investigating the role of miRNAs in glaucomatous ONH could lead to new therapeutic targets for glaucoma.

Techniques

Molecular biology techniques, cell culture, microscopy, histology

Education/Academic qualification

MS in Cell Biology & Genetics, UNT Health Science Center

PhD in Cell Biology & Genetics, UNT Health Science Center

BS in Biology, University of The Incarnate Word

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