Projects per year
Personal profile
Area of Expertise
My research goal is to understand the pathology of the trabecular meshwork (TM) and the optic nerve head (ONH) in glaucoma. The TM is the main dynamic resistor that regulates the aqueous humor outflow and causes elevated intraocular pressure in the anterior chamber of the eye. This elevated pressure is transduced toward the back of the eye and results in a remodeling of the ONH. The ONH is the resident of two types of cells, ONH astrocytes and lamina cribrosa cells (LC). ONA and LC cells have been implicated in the pathophysiology of glaucoma.
I focus primarily on growth factors and their signaling pathways to determine if they alter mRNA and protein expression of the TM and the ONH cells. I wish to understand the roles of these growth factors in normal tissue and in the glaucoma pathophysiology.
I focus primarily on growth factors and their signaling pathways to determine if they alter mRNA and protein expression of the TM and the ONH cells. I wish to understand the roles of these growth factors in normal tissue and in the glaucoma pathophysiology.
Education/Academic qualification
MS in Cell Biology & Genetics, UNT Health Science Center
PhD in Cell Biology & Genetics, UNT Health Science Center
BS in Biology, University of The Incarnate Word
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Collaborations and top research areas from the last five years
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Projects
- 2 Finished
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Preclinical Evaluation of Graybug Vision Compound
Clark, A., Tovar-Vidales, T., Liu, Y. & Millar, C.
5/06/17 → 4/06/19
Project: Research
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Role of MicroRNAs(miRNAs) in the Pathologic Fibrosis in the Glaucomatous Optic Nerve Head
16/02/17 → 15/02/18
Project: Research
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Identification and localization of lamina cribrosa cells in the human optic nerve head
Tovar-Vidales, T., Wordinger, R. J. & Clark, A. F., 1 Jun 2016, In: Experimental eye research. 147, p. 94-97 4 p.Research output: Contribution to journal › Article › peer-review
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Transforming growth factor-β2 induces expression of biologically active bone morphogenetic protein-1 in human trabecular meshwork cells
Tovar-Vidales, T., Fitzgerald, A. M., Clark, A. F. & Wordinger, R. J., 2013, In: Investigative Ophthalmology and Visual Science. 54, 7, p. 4741-4748 8 p.Research output: Contribution to journal › Article › peer-review
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Focus on Molecules: Transglutaminase 2
Tovar-Vidales, T., Clark, A. F. & Wordinger, R. J., Jul 2011, In: Experimental eye research. 93, 1, p. 2-3 2 p.Research output: Contribution to journal › Short survey › peer-review
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Tissue transglutaminase expression and activity in normal and glaucomatous human trabecular meshwork cells and tissues
Tovar-Vidales, T., Roque, R., Clark, A. F. & Wordinger, R. J., Feb 2008, In: Investigative Ophthalmology and Visual Science. 49, 2, p. 622-628 7 p.Research output: Contribution to journal › Article › peer-review
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Expression of procollagen C-proteinase enhancer 1 in human trabecular meshwork tissues and cells
Rangan, R., Sad do Valle, R. & Tovar-Vidales, T., Dec 2022, In: Experimental eye research. 225, 109280.Research output: Contribution to journal › Article › peer-review