Projects per year
Personal profile
Area of Expertise
My current research is focused on expanding the chemical toolbox for neural signaling and anti-inflammation/anti-oxidant pathways to help us understand the mechanism of action of the disease pathology associated with glaucomatous optic neuropathy, Alzheimer’s Diseases, Ischemic stroke, and angiogenesis. Our lab integrates medicinal chemistry, chemical biology, bio-engineering, and drug delivery using nanotechnology. We employ synthetic organic and organometallic chemistry to generate a small molecule library for low throughput as well as high throughput screening (target based as well as phenotypic). The ultimate goal of my lab is to produce novel therapeutic molecules which can be progressed to human clinical trials for these diseases.
Education/Academic qualification
PhD in Organic Chemistry, CSIR - Indian Institute of Chemical Technology
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Collaborations and top research areas from the last five years
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Projects
- 4 Finished
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Sex differences in in vitro and in vivo glaucoma models may predict gender specific dose adjustment needs
Acharya, S. (PI)
1/03/20 → 31/08/25
Project: Research
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Novel Hybrid Molecule with Bot
Millar, C. (CoI) & Acharya, S. (PI)
1/03/20 → 31/08/25
Project: Research
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Bi-functional Molecule for Glaucomatous Optic Neuropathy
Acharya, S. (PI) & Stankowska, D. (CoI)
1/07/18 → 30/12/20
Project: Research
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Evaluation of small molecules in ocular neovascularization (For: Daniel Larson)
Acharya, S. (PI)
5/06/17 → 31/05/18
Project: Research
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Neuroprotective and Anti-Inflammatory Activities of Hybrid Small-Molecule SA-10 in Ischemia/Reperfusion-Induced Retinal Neuronal Injury Models
Amankwa, C. E., Acha, L. G., Dibas, A., Chavala, S. H., Roth, S., Mathew, B. & Acharya, S., Mar 2024, In: Cells. 13, 5, 396.Research output: Contribution to journal › Article › peer-review
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Erratum: Hybrid compound SA-2 is neuroprotective in animal models of retinal ganglion cell death (Investigative Ophthalmology and Visual Science (2019) 60 (3064–3073) DOI: 10.1167/iovs.18-25999)
Stankowska, D. L., Dibas, A., Li, L., Zhang, W., Krishnamoorthy, V. R., Chavala, S. H., Nguyen, T. P., Yorio, T., Ellis, D. Z. & Acharya, S., 1 Sep 2019, In: Investigative Ophthalmology and Visual Science. 60, 12, p. 3717 1 p.Research output: Contribution to journal › Comment/debate
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Novel Chitohexaose Analog Protects Young and Aged mice from CLP Induced Polymicrobial Sepsis
Das, P., Panda, S. K., Agarwal, B., Behera, S., Ali, S. M., Pulse, M. E., Solomkin, J. S., Opal, S. M., Bhandari, V. & Acharya, S., 1 Dec 2019, In: Scientific Reports. 9, 1, 2904.Research output: Contribution to journal › Article › peer-review
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Tetramethylethylenediammonium dichromate (TMEDADC): A new selective oxidation reagent
Chandrasekhar, S., Takhi, M. & Mohapatra, S., 1996, In: Synthetic Communications. 26, 21, p. 3947-3951 5 p.Research output: Contribution to journal › Article › peer-review
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Asymmetric synthesis of anti-convulsive drug (S)-Vigabatrin®
Chandrasekhar, S. & Mohapatra, S., 27 Aug 1998, In: Tetrahedron Letters. 39, 35, p. 6415-6418 4 p.Research output: Contribution to journal › Article › peer-review