• 543 Citations
  • 10 h-Index
19962020
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Personal profile

Area of Expertise

My current research is focused on expanding the chemical toolbox for neural signaling and anti-inflammation/anti-oxidant pathways to help us understand the mechanism of action of the disease pathology associated with glaucomatous optic neuropathy, Alzheimer’s Diseases, Ischemic stroke, and angiogenesis. Our lab integrates medicinal chemistry, chemical biology, bio-engineering, and drug delivery using nanotechnology. We employ synthetic organic and organometallic chemistry to generate a small molecule library for low throughput as well as high throughput screening (target based as well as phenotypic). The ultimate goal of my lab is to produce novel therapeutic molecules which can be progressed to human clinical trials for these diseases.

Education/Academic qualification

PhD in Organic Chemistry, CSIR Indian Institute of Chemical Technology

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

Aldehydes Medicine & Life Sciences
Ethers Chemical Compounds
Copper Medicine & Life Sciences
Esters Chemical Compounds
Lewis Blood-Group System Medicine & Life Sciences
Sterol Regulatory Element Binding Proteins Medicine & Life Sciences
High Pressure Liquid Chromatography Medicine & Life Sciences
Alcohols Medicine & Life Sciences

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Projects 2017 2020

Research Output 1996 2019

  • 543 Citations
  • 10 h-Index
  • 16 Article

Novel Chitohexaose Analog Protects Young and Aged mice from CLP Induced Polymicrobial Sepsis

Das, P., Panda, S. K., Agarwal, B., Behera, S., Ali, S. M., Pulse, M. E., Solomkin, J. S., Opal, S. M., Bhandari, V. & Acharya, S., 1 Dec 2019, In : Scientific Reports. 9, 1, 2904.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Punctures
Ligation
Sepsis
Cytokines
Interleukin-10
3 Citations (Scopus)

Hybrid Nitric Oxide Donor and its Carrier for the Treatment of Peripheral Arterial Diseases

Le, D. Q., Kuriakose, A. E., Nguyen, D. X., Nguyen, K. T. & Acharya, S., 1 Dec 2017, In : Scientific Reports. 7, 1, 8692.

Research output: Contribution to journalArticleResearchpeer-review

Nitric Oxide Donors
Peripheral Arterial Disease
Nitric Oxide
Endothelial Cells
Nanoparticles
4 Citations (Scopus)

Design and synthesis of novel hybrid sydnonimine and prodrug useful for glaucomatous optic neuropathy

Acharya, S., Rogers, P., Krishnamoorthy, R., Stankowska, D. L., Dias, H. V. R. & Yorio, T., 1 Mar 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 5, p. 1490-1494 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Optic Nerve Diseases
Prodrugs
Optics
Photoreceptor Cells
Molecules
18 Citations (Scopus)

Novel benzodifuran analogs as potent 5-HT2A receptor agonists with ocular hypotensive activity

Feng, Z., Acharya, S., Klimko, P. G., Hellberg, M. R., May, J. A., Kelly, C., Williams, G., McLaughlin, M. A. & Sharif, N. A., 1 Jun 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 11, p. 2998-3002 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Serotonin 5-HT2 Receptor Agonists
Receptor, Serotonin, 5-HT2A
Ether
Esters
Ophthalmic Administration
17 Citations (Scopus)

Asymmetric synthesis of the stereoisomers of 11,12,15(S)-trihydroxyeicosa- 5(Z),8(Z),13(E)-trienoic acid, a potent endothelium-derived vasodilator

Falck, J. R., Barma, D., Acharya, S., Bandyopadhyay, A., Reddy, K. M., Qi, J. & Campbell, W., 4 Oct 2004, In : Bioorganic and Medicinal Chemistry Letters. 14, 19, p. 4987-4990 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Stereoisomerism
Bioassay
Vasodilator Agents
Biological Assay
Endothelium