Projects per year
Personal profile
Area of Expertise
My current research is focused on expanding the chemical toolbox for neural signaling and anti-inflammation/anti-oxidant pathways to help us understand the mechanism of action of the disease pathology associated with glaucomatous optic neuropathy, Alzheimer’s Diseases, Ischemic stroke, and angiogenesis. Our lab integrates medicinal chemistry, chemical biology, bio-engineering, and drug delivery using nanotechnology. We employ synthetic organic and organometallic chemistry to generate a small molecule library for low throughput as well as high throughput screening (target based as well as phenotypic). The ultimate goal of my lab is to produce novel therapeutic molecules which can be progressed to human clinical trials for these diseases.
Education/Academic qualification
PhD in Organic Chemistry, CSIR Indian Institute of Chemical Technology
Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.
Aldehydes
Medicine & Life Sciences
Ethers
Chemical Compounds
Copper
Medicine & Life Sciences
Esters
Chemical Compounds
Lewis Blood-Group System
Medicine & Life Sciences
Sterol Regulatory Element Binding Proteins
Medicine & Life Sciences
High Pressure Liquid Chromatography
Medicine & Life Sciences
Alcohols
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2017 2020
Evaluation of small molecules in ocular neovascularization (For: Daniel Larson)
5/06/17 → 31/05/18
Project: Research
Research Output 1996 2019
- 543 Citations
- 10 h-Index
- 16 Article
Novel Chitohexaose Analog Protects Young and Aged mice from CLP Induced Polymicrobial Sepsis
Das, P., Panda, S. K., Agarwal, B., Behera, S., Ali, S. M., Pulse, M. E., Solomkin, J. S., Opal, S. M., Bhandari, V. & Acharya, S., 1 Dec 2019, In : Scientific Reports. 9, 1, 2904.Research output: Contribution to journal › Article › Research › peer-review
Open Access
Punctures
Ligation
Sepsis
Cytokines
Interleukin-10
3
Citations
(Scopus)
Hybrid Nitric Oxide Donor and its Carrier for the Treatment of Peripheral Arterial Diseases
Le, D. Q., Kuriakose, A. E., Nguyen, D. X., Nguyen, K. T. & Acharya, S., 1 Dec 2017, In : Scientific Reports. 7, 1, 8692.Research output: Contribution to journal › Article › Research › peer-review
Nitric Oxide Donors
Peripheral Arterial Disease
Nitric Oxide
Endothelial Cells
Nanoparticles
4
Citations
(Scopus)
Design and synthesis of novel hybrid sydnonimine and prodrug useful for glaucomatous optic neuropathy
Acharya, S., Rogers, P., Krishnamoorthy, R., Stankowska, D. L., Dias, H. V. R. & Yorio, T., 1 Mar 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 5, p. 1490-1494 5 p.Research output: Contribution to journal › Article › Research › peer-review
Optic Nerve Diseases
Prodrugs
Optics
Photoreceptor Cells
Molecules
18
Citations
(Scopus)
Novel benzodifuran analogs as potent 5-HT2A receptor agonists with ocular hypotensive activity
Feng, Z., Acharya, S., Klimko, P. G., Hellberg, M. R., May, J. A., Kelly, C., Williams, G., McLaughlin, M. A. & Sharif, N. A., 1 Jun 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 11, p. 2998-3002 5 p.Research output: Contribution to journal › Article › Research › peer-review
Serotonin 5-HT2 Receptor Agonists
Receptor, Serotonin, 5-HT2A
Ether
Esters
Ophthalmic Administration
17
Citations
(Scopus)
Asymmetric synthesis of the stereoisomers of 11,12,15(S)-trihydroxyeicosa- 5(Z),8(Z),13(E)-trienoic acid, a potent endothelium-derived vasodilator
Falck, J. R., Barma, D., Acharya, S., Bandyopadhyay, A., Reddy, K. M., Qi, J. & Campbell, W., 4 Oct 2004, In : Bioorganic and Medicinal Chemistry Letters. 14, 19, p. 4987-4990 4 p.Research output: Contribution to journal › Article › Research › peer-review
Stereoisomerism
Bioassay
Vasodilator Agents
Biological Assay
Endothelium