Projects per year
Personal profile
Area of Expertise
My current research is focused on expanding the chemical toolbox for neural signaling and anti-inflammation/anti-oxidant pathways to help us understand the mechanism of action of the disease pathology associated with glaucomatous optic neuropathy, Alzheimer’s Diseases, Ischemic stroke, and angiogenesis. Our lab integrates medicinal chemistry, chemical biology, bio-engineering, and drug delivery using nanotechnology. We employ synthetic organic and organometallic chemistry to generate a small molecule library for low throughput as well as high throughput screening (target based as well as phenotypic). The ultimate goal of my lab is to produce novel therapeutic molecules which can be progressed to human clinical trials for these diseases.
Education/Academic qualification
PhD in Organic Chemistry, CSIR - Indian Institute of Chemical Technology
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Sex differences in in vitro and in vivo glaucoma models may predict gender specific dose adjustment needs
Acharya, S. (PI)
1/03/20 → 31/08/25
Project: Research
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Novel Hybrid Molecule with Bot
Millar, C. (CoI) & Acharya, S. (PI)
1/03/20 → 31/08/25
Project: Research
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Bi-functional Molecule for Glaucomatous Optic Neuropathy
Acharya, S. (PI) & Stankowska, D. (CoI)
1/07/18 → 30/06/20
Project: Research
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Evaluation of small molecules in ocular neovascularization (For: Daniel Larson)
Acharya, S. (PI)
5/06/17 → 31/05/18
Project: Research
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Novel benzodifuran analogs as potent 5-HT2A receptor agonists with ocular hypotensive activity
Feng, Z., Mohapatra, S., Klimko, P. G., Hellberg, M. R., May, J. A., Kelly, C., Williams, G., McLaughlin, M. A. & Sharif, N. A., 1 Jun 2007, In: Bioorganic and Medicinal Chemistry Letters. 17, 11, p. 2998-3002 5 p.Research output: Contribution to journal › Article › peer-review
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Hybrid Nitric Oxide Donor and its Carrier for the Treatment of Peripheral Arterial Diseases
Le, D. Q., Kuriakose, A. E., Nguyen, D. X., Nguyen, K. T. & Acharya, S., 1 Dec 2017, In: Scientific Reports. 7, 1, 8692.Research output: Contribution to journal › Article › peer-review
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Erratum: Hybrid compound SA-2 is neuroprotective in animal models of retinal ganglion cell death (Investigative Ophthalmology and Visual Science (2019) 60 (3064–3073) DOI: 10.1167/iovs.18-25999)
Stankowska, D. L., Dibas, A., Li, L., Zhang, W., Krishnamoorthy, V. R., Chavala, S. H., Nguyen, T. P., Yorio, T., Ellis, D. Z. & Acharya, S., 1 Sep 2019, In: Investigative Ophthalmology and Visual Science. 60, 12, p. 3717 1 p.Research output: Contribution to journal › Comment/debate
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Nanoencapsulated hybrid compound sa-2 with long-lasting intraocular pressure–lowering activity in rodent eyes
Stankowska, D. L., Millar, J. C., Kodati, B., Behera, S., Chaphalkar, R. M., Nguyen, T., Nguyen, K. T., Krishnamoorthy, R. R., Ellis, D. Z. & Acharya, S., 2021, In: Molecular vision. 27, p. 37-49 13 p.Research output: Contribution to journal › Article › peer-review
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Neighbouring group assisted sulfonamide cleavage of sharpless aminols under acetonation conditions
Chandrasekhar, S. & Mohapatra, S., 12 Feb 1998, In: Tetrahedron Letters. 39, 7, p. 695-698 4 p.Research output: Contribution to journal › Article › peer-review