Projects per year
Personal profile
Area of Expertise
My current research is focused on expanding the chemical toolbox for neural signaling and anti-inflammation/anti-oxidant pathways to help us understand the mechanism of action of the disease pathology associated with glaucomatous optic neuropathy, Alzheimer’s Diseases, Ischemic stroke, and angiogenesis. Our lab integrates medicinal chemistry, chemical biology, bio-engineering, and drug delivery using nanotechnology. We employ synthetic organic and organometallic chemistry to generate a small molecule library for low throughput as well as high throughput screening (target based as well as phenotypic). The ultimate goal of my lab is to produce novel therapeutic molecules which can be progressed to human clinical trials for these diseases.
Education/Academic qualification
PhD in Organic Chemistry, CSIR - Indian Institute of Chemical Technology
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Projects
- 2 Finished
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Evaluation of small molecules in ocular neovascularization (For: Daniel Larson)
5/06/17 → 31/05/18
Project: Research
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Chitin-derived AVR-48 prevents experimental bronchopulmonary dysplasia (BPD) and BPD-associated pulmonary hypertension in newborn mice
Das, P., Acharya, S., Prahaladan, V. M., Kumova, O. K., Malaeb, S., Behera, S., Agarwal, B., Christensen, D. J., Carey, A. J. & Bhandari, V., Aug 2021, In: International journal of molecular sciences. 22, 16, 8547.Research output: Contribution to journal › Article › peer-review
Open Access -
Nanoencapsulated hybrid compound sa-2 with long-lasting intraocular pressure–lowering activity in rodent eyes
Stankowska, D. L., Millar, J. C., Kodati, B., Behera, S., Chaphalkar, R. M., Nguyen, T., Nguyen, K. T., Krishnamoorthy, R. R., Ellis, D. Z. & Acharya, S., 2021, In: Molecular vision. 27, p. 37-49 13 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Nano encapsulated novel compound SA-10 with therapeutic activity in both acute and chronic murine hindlimb ischemia models
Hinkle, L., Le, D., Nguyen, T., Tran, V., Amankwa, C. E., Weston, C., Shen, H., Nguyen, K. T., Rahimi, M. & Acharya, S., Jul 2021, In: Nanomedicine: Nanotechnology, Biology, and Medicine. 35, 102400.Research output: Contribution to journal › Article › peer-review
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Novel thiol containing hybrid antioxidant-nitric oxide donor small molecules for treatment of glaucoma
Amankwa, C. E., Gondi, S. R., Dibas, A., Weston, C., Funk, A., Nguyen, T., Nguyen, K. T., Ellis, D. Z. & Acharya, S., Apr 2021, In: Antioxidants. 10, 4, 575.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Small immunomodulatory molecules as potential therapeutics in experimental murine models of acute lung injury (Ali)/acute respiratory distress syndrome (ards)
Shah, D., Das, P., Acharya, S., Agarwal, B., Christensen, D. J., Robertson, S. M. & Bhandari, V., 1 Mar 2021, In: International journal of molecular sciences. 22, 5, p. 1-20 20 p., 2573.Research output: Contribution to journal › Article › peer-review
Open Access