Projects per year
Personal profile
Area of Expertise
My current research is focused on expanding the chemical toolbox for neural signaling and anti-inflammation/anti-oxidant pathways to help us understand the mechanism of action of the disease pathology associated with glaucomatous optic neuropathy, Alzheimer’s Diseases, Ischemic stroke, and angiogenesis. Our lab integrates medicinal chemistry, chemical biology, bio-engineering, and drug delivery using nanotechnology. We employ synthetic organic and organometallic chemistry to generate a small molecule library for low throughput as well as high throughput screening (target based as well as phenotypic). The ultimate goal of my lab is to produce novel therapeutic molecules which can be progressed to human clinical trials for these diseases.
Education/Academic qualification
PhD in Organic Chemistry, CSIR - Indian Institute of Chemical Technology
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Collaborations and top research areas from the last five years
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Sex differences in in vitro and in vivo glaucoma models may predict gender specific dose adjustment needs
Acharya, S. (PI)
1/03/20 → 31/08/25
Project: Research
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Novel Hybrid Molecule with Bot
Millar, C. (CoI) & Acharya, S. (PI)
1/03/20 → 31/08/25
Project: Research
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Bi-functional Molecule for Glaucomatous Optic Neuropathy
Acharya, S. (PI) & Stankowska, D. (CoI)
1/07/18 → 30/06/20
Project: Research
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Evaluation of small molecules in ocular neovascularization (For: Daniel Larson)
Acharya, S. (PI)
5/06/17 → 31/05/18
Project: Research
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Chitin-derived AVR-48 prevents experimental bronchopulmonary dysplasia (BPD) and BPD-associated pulmonary hypertension in newborn mice
Das, P., Acharya, S., Prahaladan, V. M., Kumova, O. K., Malaeb, S., Behera, S., Agarwal, B., Christensen, D. J., Carey, A. J. & Bhandari, V., Aug 2021, In: International journal of molecular sciences. 22, 16, 8547.Research output: Contribution to journal › Article › peer-review
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Small immunomodulatory molecules as potential therapeutics in experimental murine models of acute lung injury (Ali)/acute respiratory distress syndrome (ards)
Shah, D., Das, P., Acharya, S., Agarwal, B., Christensen, D. J., Robertson, S. M. & Bhandari, V., 1 Mar 2021, In: International journal of molecular sciences. 22, 5, p. 1-20 20 p., 2573.Research output: Contribution to journal › Article › peer-review
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Novel Small Molecules with Anti-Inflammatory and Anti-Angiogenic Activity in a Mouse Model of Oxygen-Induced Retinopathy
Dayoub, A. S., Acharya, E., Dibas, A., Jones, H. P. & Acharya, S., Aug 2024, In: Cells. 13, 16, 1371.Research output: Contribution to journal › Article › peer-review
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Hybrid compound sa-2 is neuroprotective in animal models of retinal ganglion cell death
Stankowska, D. L., Dibas, A., Li, L., Zhang, W., Krishnamoorthy, V. R., Chavala, S. H., Nguyen, T. P., Yorio, T., Ellis, D. Z. & Acharya, S., Jul 2019, In: Investigative Ophthalmology and Visual Science. 60, 8, p. 3064-3073 10 p.Research output: Contribution to journal › Article › peer-review
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Neuroprotection of Rodent and Human Retinal Ganglion Cells In Vitro/Ex Vivo by the Hybrid Small Molecule SA-2
Pham, J. H., Johnson, G. A., Rangan, R. S., Amankwa, C. E., Acharya, S. & Stankowska, D. L., Dec 2022, In: Cells. 11, 23, 3741.Research output: Contribution to journal › Article › peer-review