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Stephen Mathew, PhD

  • 236 Citations
  • 10 h-Index
20052019

Research output per year

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Personal profile

Area of Expertise

Dr. Stephen Mathew’s research focuses on understanding the role of natural killer (NK) cell receptors in different disease models like cancer and lupus. Natural killer (NK) cells are cells of the immune system that form the first line of defense against cancer and viral infections. The molecular basis of NK cell recognition and activation by target cells is poorly understood. The research in the laboratory is concentrated toward unraveling the molecular basis of tumor cell recognition by the NK cell and its multiple receptor-ligand interactions. Specifically, in collaboration with pediatric oncologists and basic science researchers, Dr. Mathew is investigating the role of immune receptors in acute lymphoblastic leukemia (ALL) in children. This will provide important insights into the etiology of childhood leukemia as well as the development of new treatments that may improve the outcome of children with leukemia by modifying the function of immune cells in these patients.
The other projects in the laboratory deal with deciphering the role of immune receptors 2B4, CS1 and LLT1 in prostate cancer, breast cancer, Ewing sarcoma, and lupus.

Education/Academic qualification

PhD in Microbiology, R.D. University

Award Date: 1 Jan 2002

MS in Microbiology, R.D. University

Award Date: 1 Jan 2001

BS in Biology, R.D. University

Award Date: 1 Jan 2000

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Projects

Molecular Characterization of NKp44 Ligand on Astrocytes

Mathew, P. & Mathew, S.

NINDS: Neurological Disorders & Stroke

1/02/17 → 31/01/19

Project: Research

CS1-Targeted Immunotherapy for Acute Lymphoblastic Leukemia (ALL) in Children

Mathew, S., Mathew, P. & Bowman, P.

Intramural Research(UNTHSC)

1/09/13 → 31/08/15

Project: Research

Research Output

  • 236 Citations
  • 10 h-Index
  • 13 Article

A novel ligand on astrocytes interacts with natural cytotoxicity receptor NKp44 regulating immune response mediated by NK cells

Bowen, K. E., Mathew, S. O., Borgmann, K., Ghorpade, A. & Mathew, P. A., Feb 2018, In : PLoS ONE. 13, 2, e0193008.

Research output: Contribution to journal › Article

    • 1 Scopus citations

    Blimp-1/PRDM1 regulates the transcription of human CS1 (SLAMF7) gene in NK and B cells

    Kim, J. R., Mathew, S. O. & Mathew, P., 1 Jan 2016, In : Immunobiology. 221, 1, p. 31-39 9 p.

    Research output: Contribution to journal › Article

    • 7 Scopus citations

    Overexpression of LLT1 (OCIL, CLEC2D) on prostate cancer cells inhibits NK cell-mediated killing through LLT1-NKRP1A (CD161) interaction

    Mathew, S. O., Chaudhary, P., Powers, S. B., Vishwanatha, J. K. & Mathew, P. A., 1 Jan 2016, In : Oncotarget. 7, 42, p. 68650-68661 12 p.

    Research output: Contribution to journal › Article

    • 10 Scopus citations

    CS1 (SLAMF7) inhibits production of proinflammatory cytokines by activated monocytes

    Kim, J. R., Horton, N. C., Mathew, S. O. & Mathew, P. A., 1 Aug 2013, In : Inflammation Research. 62, 8, p. 765-772 8 p.

    Research output: Contribution to journal › Article

    • 19 Scopus citations

    Novel Interaction between Proliferating Cell Nuclear Antigen and HLA I on the Surface of Tumor Cells Inhibits NK Cell Function through NKp44

    Horton, N. C., Mathew, S. O. & Mathew, P. A., 19 Mar 2013, In : PLoS ONE. 8, 3, e59552.

    Research output: Contribution to journal › Article

    • 30 Scopus citations