Projects per year
Personal profile
Area of Expertise
Dr. Stephen Mathew’s research focuses on understanding the role of natural killer (NK) cell receptors in different disease models like cancer and lupus. Natural killer (NK) cells are cells of the immune system that form the first line of defense against cancer and viral infections. The molecular basis of NK cell recognition and activation by target cells is poorly understood. The research in the laboratory is concentrated toward unraveling the molecular basis of tumor cell recognition by the NK cell and its multiple receptor-ligand interactions. Specifically, in collaboration with pediatric oncologists and basic science researchers, Dr. Mathew is investigating the role of immune receptors in acute lymphoblastic leukemia (ALL) in children. This will provide important insights into the etiology of childhood leukemia as well as the development of new treatments that may improve the outcome of children with leukemia by modifying the function of immune cells in these patients.
The other projects in the laboratory deal with deciphering the role of immune receptors 2B4, CS1 and LLT1 in prostate cancer, breast cancer, Ewing sarcoma, and lupus.
The other projects in the laboratory deal with deciphering the role of immune receptors 2B4, CS1 and LLT1 in prostate cancer, breast cancer, Ewing sarcoma, and lupus.
Education/Academic qualification
BS in Biology, R.D. University
MS in Microbiology, R.D. University
PhD in Microbiology, R.D. University
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Projects
- 2 Finished
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Molecular Characterization of NKp44 Ligand on Astrocytes
NINDS: Neurological Disorders & Stroke
1/02/17 → 31/01/19
Project: Research
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CS1-Targeted Immunotherapy for Acute Lymphoblastic Leukemia (ALL) in Children
Mathew, S., Mathew, P. & Bowman, P.
1/09/13 → 31/08/15
Project: Research
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The many faces of innate immunity in SARS-CoV-2 infection
Hanan, N., Doud, R. L., Park, I. W., Jones, H. P. & Mathew, S. O., Jun 2021, In: Vaccines. 9, 6, 596.Research output: Contribution to journal › Article › peer-review
Open Access -
Roles of nk cell receptors 2b4 (Cd244), cs1 (cd319), and llt1 (clec2d) in cancer
Buller, C. W., Mathew, P. A. & Mathew, S. O., Jul 2020, In: Cancers. 12, 7, p. 1-15 15 p., 1755.Research output: Contribution to journal › Review article › peer-review
Open Access3 Scopus citations -
Impact of the microbiome on the immune system
Lambring, C. B., Siraj, S., Patel, K., Sankpal, U. T., Mathew, S. & Basha, R., 2019, In: Critical Reviews in Immunology. 39, 5, p. 313-328 16 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
A novel ligand on astrocytes interacts with natural cytotoxicity receptor NKp44 regulating immune response mediated by NK cells
Bowen, K. E., Mathew, S. O., Borgmann, K., Ghorpade, A. & Mathew, P. A., Feb 2018, In: PLoS ONE. 13, 2, e0193008.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Blimp-1/PRDM1 regulates the transcription of human CS1 (SLAMF7) gene in NK and B cells
Kim, J. R., Mathew, S. O. & Mathew, P. A., Jan 2016, In: Immunobiology. 221, 1, p. 31-39 9 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations