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Personal profile

Area of Expertise

Dr. Stephen Mathew’s research focuses on understanding the role of natural killer (NK) cell receptors in different disease models like cancer and lupus. Natural killer (NK) cells are cells of the immune system that form the first line of defense against cancer and viral infections. The molecular basis of NK cell recognition and activation by target cells is poorly understood. The research in the laboratory is concentrated toward unraveling the molecular basis of tumor cell recognition by the NK cell and its multiple receptor-ligand interactions. Specifically, in collaboration with pediatric oncologists and basic science researchers, Dr. Mathew is investigating the role of immune receptors in acute lymphoblastic leukemia (ALL) in children. This will provide important insights into the etiology of childhood leukemia as well as the development of new treatments that may improve the outcome of children with leukemia by modifying the function of immune cells in these patients.
The other projects in the laboratory deal with deciphering the role of immune receptors 2B4, CS1 and LLT1 in prostate cancer, breast cancer, Ewing sarcoma, and lupus.

Education/Academic qualification

PhD in Microbiology, R.D. University

MS in Microbiology, R.D. University

BS in Biology, R.D. University

Fingerprint Dive into the research topics where Stephen Mathew is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 18 Similar Profiles
Natural Killer Cells Medicine & Life Sciences
B-Lymphocytes Medicine & Life Sciences
T-cells Chemical Compounds
Cytotoxicity Chemical Compounds
natural killer cells Agriculture & Biology
Monocytes Medicine & Life Sciences
Natural Killer Cell Receptors Medicine & Life Sciences
Cytokines Medicine & Life Sciences

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Projects 2013 2019

Research Output 2005 2018

  • 213 Citations
  • 9 h-Index
  • 13 Article

A novel ligand on astrocytes interacts with natural cytotoxicity receptor NKp44 regulating immune response mediated by NK cells

Bowen, K. E., Mathew, S. O., Borgmann, K., Ghorpade, A. & Mathew, P., 1 Feb 2018, In : PLoS ONE. 13, 2, e0193008.

Research output: Contribution to journalArticleResearchpeer-review

Natural Cytotoxicity Triggering Receptor 2
astrocytes
natural killer cells
Cytotoxicity
Astrocytes
4 Citations (Scopus)

Blimp-1/PRDM1 regulates the transcription of human CS1 (SLAMF7) gene in NK and B cells

Kim, J. R., Mathew, S. O. & Mathew, P., 1 Jan 2016, In : Immunobiology. 221, 1, p. 31-39 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Natural Killer Cells
B-Lymphocytes
Multiple Myeloma
Genetic Promoter Regions
Genes
4 Citations (Scopus)

Overexpression of LLT1 (OCIL, CLEC2D) on prostate cancer cells inhibits NK cell-mediated killing through LLT1-NKRP1A (CD161) interaction

Mathew, S. O., Chaudhary, P., Powers, S. B., Vishwanatha, J. K. & Mathew, P., 1 Jan 2016, In : Oncotarget. 7, 42, p. 68650-68661 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Natural Killer Cells
Prostatic Neoplasms
Natural Killer Cell Receptors
Cell Line
Second Primary Neoplasms
17 Citations (Scopus)

CS1 (SLAMF7) inhibits production of proinflammatory cytokines by activated monocytes

Kim, J. R., Horton, N. C., Mathew, S. O. & Mathew, P., 1 Aug 2013, In : Inflammation Research. 62, 8, p. 765-772 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Monocytes
Cytokines
NF-kappa B
Phosphatidylinositol 3-Kinases
Lymphocyte Activation
23 Citations (Scopus)

Novel Interaction between Proliferating Cell Nuclear Antigen and HLA I on the Surface of Tumor Cells Inhibits NK Cell Function through NKp44

Horton, N. C., Mathew, S. O. & Mathew, P., 19 Mar 2013, In : PLoS ONE. 8, 3, e59552.

Research output: Contribution to journalArticleResearchpeer-review

proliferating cell nuclear antigen
natural killer cells
Proliferating Cell Nuclear Antigen
Natural Killer Cells
Tumors