• 1049 Citations
  • 20 h-Index
20042020
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Personal profile

Area of Expertise

Research in my lab focuses on vascular physiology and pharmacology. Our long-term goal is to determine what molecular mechanisms facilitate maternal vascular adaptations in pregnancy and how these adaptations determine long-term maternal vascular health. Currently, we are studying the interaction between extracellular mitochondrial DNA and Toll-like receptor 9 to delineate the role of circulating mitochondrial DNA in the development of maternal vascular dysfunction in preeclampsia.
In a different project, we are studying the cross-talk between maternal adipose tissue and maternal arteries. We are interested in understanding how this cross-talk regulates maternal blood flow. We are also interested in understanding how maternal obesity impairs the relationship between maternal adipose tissue and arteries, leading to maternal vascular dysfunction and impaired blood flow to the uteroplacental unit.
Concepts/techniques: Vascular physiology (ex vivo assessment of vascular reactivity and myogenic tone, vascular cell cultures, blood pressure measurements in conscious rodents); Placental biology (placental tissue explants, trophoblast cell lines); Physiology of pregnancy (rodent models, pharmacological interventions); Other (immunohistochemistry, measurements of oxidative stress, ELISA techniques, Western blot, qPCR, laser capture microdissection).

Education/Academic qualification

PhD in Exercise Physiology & Science, Syracuse University

MS in Exercise Science, Syracuse University

BS in Physical Education & Sports Science, Kapodistrian University of Athens

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Projects 2014 2020

Research Output 2004 2019

  • 1049 Citations
  • 20 h-Index
  • 41 Article
  • 7 Review article
  • 1 Comment/debate
  • 1 Editorial

A free-choice high-fat, high-sucrose diet induces hyperphagia, obesity, and cardiovascular dysfunction in female cycling and pregnant rats

Ahmed, H., Hannan, J. L., Apolzan, J. W., Osikoya, O., Cushen, S. C., Romero, S. A. & Goulopoulou, S., 1 May 2019, In : American journal of physiology. Regulatory, integrative and comparative physiology. 316, 5, p. R472-R485

Research output: Contribution to journalArticleResearchpeer-review

Hyperphagia
High Fat Diet
Sucrose
Obesity
Mothers

Paying the toll for inflammation: Immunoreceptor-mediated vascular dysfunction in hypertension

McCarthy, C. G., Goulopoulou, S. & Webb, R. C., 1 Mar 2019, In : Hypertension. 73, 3, p. 514-521 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Blood Vessels
Hypertension
Inflammation

Prenatal therapeutics and programming of cardiovascular function

Brennan, L. J., Goulopoulou, S. & Bourque, S. L., 1 Jan 2019, In : Pharmacological Research. 139, p. 261-272 12 p.

Research output: Contribution to journalReview articleResearchpeer-review

Embryonic and Fetal Development
Cardiovascular Diseases
Pregnancy
Disease Susceptibility
Health

Calpain a novel mediator of MPO (myeloperoxidase)-induced endothelial dysfunction

Goulopoulou, S., 1 Jan 2018, In : Hypertension. 71, 4, p. 574-576 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Calpain
Peroxidase

Mechanisms of Sex Disparities in Cardiovascular Function and Remodeling

Chaudhari, S., Cushen, S. C., Osikoya, O., Jaini, P. A., Posey, R., Mathis, K. & Goulopoulou, S., 13 Dec 2018, In : Comprehensive Physiology. 9, 1, p. 375-411 37 p.

Research output: Contribution to journalArticleResearchpeer-review

Cardiovascular Diseases
Sex Characteristics
Cardiovascular Physiological Phenomena
Estrogens
Androgens