Projects per year
Personal profile
Area of Expertise
Research in my lab focuses on vascular physiology and pharmacology. Our long-term goal is to determine what molecular mechanisms facilitate maternal vascular adaptations in pregnancy and how these adaptations determine long-term maternal vascular health. Currently, we are studying the interaction between extracellular mitochondrial DNA and Toll-like receptor 9 to delineate the role of circulating mitochondrial DNA in the development of maternal vascular dysfunction in preeclampsia.
In a different project, we are studying the cross-talk between maternal adipose tissue and maternal arteries. We are interested in understanding how this cross-talk regulates maternal blood flow. We are also interested in understanding how maternal obesity impairs the relationship between maternal adipose tissue and arteries, leading to maternal vascular dysfunction and impaired blood flow to the uteroplacental unit.
Concepts/techniques: Vascular physiology (ex vivo assessment of vascular reactivity and myogenic tone, vascular cell cultures, blood pressure measurements in conscious rodents); Placental biology (placental tissue explants, trophoblast cell lines); Physiology of pregnancy (rodent models, pharmacological interventions); Other (immunohistochemistry, measurements of oxidative stress, ELISA techniques, Western blot, qPCR, laser capture microdissection).
In a different project, we are studying the cross-talk between maternal adipose tissue and maternal arteries. We are interested in understanding how this cross-talk regulates maternal blood flow. We are also interested in understanding how maternal obesity impairs the relationship between maternal adipose tissue and arteries, leading to maternal vascular dysfunction and impaired blood flow to the uteroplacental unit.
Concepts/techniques: Vascular physiology (ex vivo assessment of vascular reactivity and myogenic tone, vascular cell cultures, blood pressure measurements in conscious rodents); Placental biology (placental tissue explants, trophoblast cell lines); Physiology of pregnancy (rodent models, pharmacological interventions); Other (immunohistochemistry, measurements of oxidative stress, ELISA techniques, Western blot, qPCR, laser capture microdissection).
Education/Academic qualification
BS in Physical Education & Sports Science, Kapodistrian University of Athens
MS in Exercise Science, Syracuse University
PhD in Exercise Physiology & Science, Syracuse University
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Projects
Maternal vascular responses to extracellular mitochondrial DNA during pregnancy
1/01/20 → 31/12/20
Project: Research
Trophoblast-induced Maternal Cardiovascular Dysfunction in Pregnancy (For:Spencer Cushen)
1/07/18 → 30/06/20
Project: Research
Nanosensing of Oxidized Cell-free mtDNA: Biomarkers of Inflammation and Mitochondrial Dysfunction
Phillips, N., Planz, J. & Goulopoulou, S.
1/06/17 → 31/05/18
Project: Research
Research Output
Cell-free mitochondrial DNA increases in maternal circulation during healthy pregnancy: A prospective, longitudinal study
Cushen, S. C., Sprouse, M. L., Blessing, A., Sun, J., Jarvis, S. S., Okada, Y., Fu, Q., Romero, S. A., Phillips, N. R. & Goulopoulou, S., Feb 2020, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 318, 2, p. R445-R452Research output: Contribution to journal › Article
1
Scopus
citations
A free-choice high-fat, high-sucrose diet induces hyperphagia, obesity, and cardiovascular dysfunction in female cycling and pregnant rats
Ahmed, H., Hannan, J. L., Apolzan, J. W., Osikoya, O., Cushen, S. C., Romero, S. A. & Goulopoulou, S., 1 May 2019, In : American journal of physiology. Regulatory, integrative and comparative physiology. 316, 5, p. R472-R485Research output: Contribution to journal › Article
2
Scopus
citations
Paying the toll for inflammation: Immunoreceptor-mediated vascular dysfunction in hypertension
McCarthy, C. G., Goulopoulou, S. & Webb, R. C., 1 Mar 2019, In : Hypertension. 73, 3, p. 514-521 8 p.Research output: Contribution to journal › Article
2
Scopus
citations
Prenatal therapeutics and programming of cardiovascular function
Brennan, L. J., Goulopoulou, S. & Bourque, S. L., Jan 2019, In : Pharmacological Research. 139, p. 261-272 12 p.Research output: Contribution to journal › Review article
1
Scopus
citations
Sex differences in developmental origins of cardiovascular disease
Loria, A. S., Goulopoulou, S., Bourque, S. L. & Davidge, S. T., 1 Jan 2019, Sex Differences in Cardiovascular Physiology and Pathophysiology. Elsevier, p. 253-289 37 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
1
Scopus
citations