Projects per year
Personal profile
Area of Expertise
Research in my lab focuses on vascular physiology and pharmacology. Our long-term goal is to determine what molecular mechanisms facilitate maternal vascular adaptations in pregnancy and how these adaptations determine long-term maternal vascular health. Currently, we are studying the interaction between extracellular mitochondrial DNA and Toll-like receptor 9 to delineate the role of circulating mitochondrial DNA in the development of maternal vascular dysfunction in preeclampsia.
In a different project, we are studying the cross-talk between maternal adipose tissue and maternal arteries. We are interested in understanding how this cross-talk regulates maternal blood flow. We are also interested in understanding how maternal obesity impairs the relationship between maternal adipose tissue and arteries, leading to maternal vascular dysfunction and impaired blood flow to the uteroplacental unit.
Concepts/techniques: Vascular physiology (ex vivo assessment of vascular reactivity and myogenic tone, vascular cell cultures, blood pressure measurements in conscious rodents); Placental biology (placental tissue explants, trophoblast cell lines); Physiology of pregnancy (rodent models, pharmacological interventions); Other (immunohistochemistry, measurements of oxidative stress, ELISA techniques, Western blot, qPCR, laser capture microdissection).
In a different project, we are studying the cross-talk between maternal adipose tissue and maternal arteries. We are interested in understanding how this cross-talk regulates maternal blood flow. We are also interested in understanding how maternal obesity impairs the relationship between maternal adipose tissue and arteries, leading to maternal vascular dysfunction and impaired blood flow to the uteroplacental unit.
Concepts/techniques: Vascular physiology (ex vivo assessment of vascular reactivity and myogenic tone, vascular cell cultures, blood pressure measurements in conscious rodents); Placental biology (placental tissue explants, trophoblast cell lines); Physiology of pregnancy (rodent models, pharmacological interventions); Other (immunohistochemistry, measurements of oxidative stress, ELISA techniques, Western blot, qPCR, laser capture microdissection).
Education/Academic qualification
PhD in Exercise Physiology & Science, Syracuse University
Award Date: 1 Jan 2002
MS in Exercise Science, Syracuse University
Award Date: 1 Jan 2001
BS in Physical Education & Sports Science, Kapodistrian University of Athens
Award Date: 1 Jan 2000
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Projects
Trophoblast-induced Maternal Cardiovascular Dysfunction in Pregnancy (For:Spencer Cushen)
1/07/18 → 30/06/20
Project: Research
Nanosensing of Oxidized Cell-free mtDNA: Biomarkers of Inflammation and Mitochondrial Dysfunction
Phillips, N., Planz, J. & Goulopoulou, S.
1/06/17 → 31/05/18
Project: Research
Placental Oxygenation and Mitochondria-derived Damage-associated Molecular Patterns
1/07/16 → 31/01/18
Project: Research
Research Output
A free-choice high-fat, high-sucrose diet induces hyperphagia, obesity, and cardiovascular dysfunction in female cycling and pregnant rats
Ahmed, H., Hannan, J. L., Apolzan, J. W., Osikoya, O., Cushen, S. C., Romero, S. A. & Goulopoulou, S., 1 May 2019, In : American journal of physiology. Regulatory, integrative and comparative physiology. 316, 5, p. R472-R485Research output: Contribution to journal › Article
2
Scopus
citations
Paying the toll for inflammation: Immunoreceptor-mediated vascular dysfunction in hypertension
McCarthy, C. G., Goulopoulou, S. & Webb, R. C., 1 Mar 2019, In : Hypertension. 73, 3, p. 514-521 8 p.Research output: Contribution to journal › Article
1
Scopus
citations
Prenatal therapeutics and programming of cardiovascular function
Brennan, L. J., Goulopoulou, S. & Bourque, S. L., Jan 2019, In : Pharmacological Research. 139, p. 261-272 12 p.Research output: Contribution to journal › Review article
Uterine perivascular adipose tissue is a novel mediator of uterine artery blood flow and reactivity in rat pregnancy
Osikoya, O., Ahmed, H., Panahi, S., Bourque, S. L. & Goulopoulou, S., 1 Aug 2019, In : Journal of Physiology. 597, 15, p. 3833-3852 20 p.Research output: Contribution to journal › Article
Calpain a novel mediator of MPO (myeloperoxidase)-induced endothelial dysfunction
Goulopoulou, S., 1 Jan 2018, In : Hypertension. 71, 4, p. 574-576 3 p.Research output: Contribution to journal › Article