Srikantha Thyagarajan

2017

Protocol for identifying natural agents that selectively affect adhesion, thickness, architecture, cellular phenotypes, extracellular matrix, and human white blood cell impenetrability of candida albicans biofilms

Park, Y. N., Srikantha, T., Daniels, K. J., Jacob, M. R., Agarwal, A. K., Li, X. C. & Solla, D. R., Nov 2017, In : Antimicrobial agents and chemotherapy. 61, 11, e01319-17.

Research output: Contribution to journal › Article

3 Scopus citations

2016

Binding sites in the EFG1 promoter for transcription factors in a proposed regulatory network: A functional analysis in the white and opaque phases of Candida albicans

Pujol, C., Srikantha, T., Park, Y. N., Daniels, K. J. & Soll, D. R., 1 Jan 2016, In : G3: Genes, Genomes, Genetics. 6, 6, p. 1725-1737 13 p.

Research output: Contribution to journal › Article

2015

Role of Tec1 in the development, architecture, and integrity of sexual biofilms of Candida albicans

Daniels, K. J., Srikantha, T., Pujol, C., Park, Y. N. & Soll, D. R., 1 Jan 2015, In : Eukaryotic Cell. 14, 3, p. 228-240 13 p.

Research output: Contribution to journal › Article

12 Scopus citations

2013

Candida albicans forms a specialized "sexual" as well as "pathogenic" biofilm

Park, Y. N., Daniels, K. J., Pujol, C., Srikantha, T. & Soll, D. R., 1 Aug 2013, In : Eukaryotic Cell. 12, 8, p. 1120-1131 12 p.

Research output: Contribution to journal › Article

32 Scopus citations

Identification of genes upregulated by the transcription factor bcr1 that are involved in impermeability, impenetrability, and drug resistance of Candida albicans a/α biofilms

Srikantha, T., Daniels, K. J., Pujol, C., Kim, E. & Soll, D. R., 1 Jun 2013, In : Eukaryotic Cell. 12, 6, p. 875-888 14 p.

Research output: Contribution to journal › Article

32 Scopus citations

Impact of environmental conditions on the form and function of Candida albicans biofilms

Daniels, K. J., Park, Y. N., Srikantha, T., Pujol, C. & Soll, D. R., 1 Oct 2013, In : Eukaryotic Cell. 12, 10, p. 1389-1402 14 p.

Research output: Contribution to journal › Article

30 Scopus citations

2012

Nonsex genes in the mating type locus of Candida albicans play roles in a/α biofilm formation, including impermeability and fluconazole resistance

Srikantha, T., Daniels, K. J., Pujol, C., Sahni, N., Yi, S. & Soll, D. R., 1 Jan 2012, In : PLoS Pathogens. 8, 1, e1002476.

Research output: Contribution to journal › Article

23 Scopus citations

The "finger," a Unique multicellular morphology of Candida albicans induced by CO₂ and dependent upon the ras1-cyclic AMP pathway

Daniels, K. J., Pujol, C., Srikantha, T. & Soll, D. R., 1 Oct 2012, In : Eukaryotic Cell. 11, 10, p. 1257-1267 11 p.

Research output: Contribution to journal › Article

8 Scopus citations

2011

Alternative mating type configurations (a/α versus a/a or α/α) of candida albicans result in alternative biofilms regulated by different pathways

Yi, S., Sahni, N., Daniels, K. J., Lu, K. L., Srikantha, T., Huang, G., Garnaas, A. M. & Soll, D. R., 1 Aug 2011, In : PLoS Biology. 9, 8, e1001117.

Research output: Contribution to journal › Article

67 Scopus citations

Fig1 facilitates calcium influx and localizes to membranes destined to undergo fusion during mating in Candida albicans

Yang, M., Brand, A., Srikantha, T., Daniels, K. J., Soll, D. R. & Gow, N. A. R., 1 Mar 2011, In : Eukaryotic Cell. 10, 3, p. 435-444 10 p.

Research output: Contribution to journal › Article

17 Scopus citations

Self-induction of a/a or α/α biofilms in Candida albicans is a pheromone-based paracrine system requiring switching

Yi, S., Sahni, N., Daniels, K. J., Lu, K. L., Huang, G., Srikantha, T. & Soll, D. R., 1 Jun 2011, In : Eukaryotic Cell. 10, 6, p. 753-760 8 p.

Research output: Contribution to journal › Article

21 Scopus citations

Target specificity of the Candida albicans Efg1 regulator

Lassak, T., Schneider, E., Bussmann, M., Kurtz, D., Manak, J. R., Srikantha, T., Soll, D. R. & Ernst, J. F., 1 Nov 2011, In : Molecular Microbiology. 82, 3, p. 602-618 17 p.

Research output: Contribution to journal › Article

43 Scopus citations

Utilization of the mating scaffold protein in the evolution of a new signal transduction pathway for biofilm development

Yi, S., Sahni, N., Daniels, K. J., Lu, K. L., Huang, G., Garnaas, A. M., Pujol, C., Srikantha, T. & Soll, D. R., 1 Jan 2011, In : mBio. 2, 1

Research output: Contribution to journal › Article

17 Scopus citations

2010

N-acetylglucosamine induces white to opaque switching, a mating prerequisite in Candida albicans

Huang, G., Yi, S., Sahni, N., Daniels, K. J., Srikantha, T. & Soll, D. R., 1 Mar 2010, In : PLoS Pathogens. 6, 3, e1000806.

Research output: Contribution to journal › Article

146 Scopus citations

Tec1 mediates the pheromone response of the white phenotype of Candida albicans: Insights into the evolution of new signal transduction pathways

Sahni, N., Yi, S., Daniels, K. J., Huang, G., Srikantha, T. & Soll, D. R., 1 May 2010, In : PLoS Biology. 8, 5

Research output: Contribution to journal › Article

60 Scopus citations

2009

A Candida albicans-specific region of the α-pheromone receptor plays a selective role in the white cell pheromone response

Yi, S., Sahni, N., Pujol, C., Daniels, K. J., Thyagarajan, S., Ma, N. & Soll, D. R., 1 Feb 2009, In : Molecular Microbiology. 71, 4, p. 925-947 23 p.

Research output: Contribution to journal › Article

28 Scopus citations

CO₂ Regulates White-to-Opaque Switching in Candida albicans

Huang, G., Srikantha, T., Sahni, N., Yi, S. & Soll, D. R., 24 Feb 2009, In : Current Biology. 19, 4, p. 330-334 5 p.

Research output: Contribution to journal › Article

118 Scopus citations

Evolution of pathogenicity and sexual reproduction in eight Candida genomes

Butler, G., Rasmussen, M. D., Lin, M. F., Santos, M. A. S., Sakthikumar, S., Munro, C. A., Rheinbay, E., Grabherr, M., Forche, A., Reedy, J. L., Agrafioti, I., Arnaud, M. B., Bates, S., Brown, A. J. P., Brunke, S., Costanzo, M. C., Fitzpatrick, D. A., De Groot, P. W. J., Harris, D., Hoyer, L. L. & 31 others, Hube, B., Klis, F. M., Kodira, C., Lennard, N., Logue, M. E., Martin, R., Neiman, A. M., Nikolaou, E., Quail, M. A., Quinn, J., Santos, M. C., Schmitzberger, F. F., Sherlock, G., Shah, P., Silverstein, K. A. T., Skrzypek, M. S., Soll, D., Staggs, R., Stansfield, I., Stumpf, M. P. H., Sudbery, P. E., Srikantha, T., Zeng, Q., Berman, J., Berriman, M., Heitman, J., Gow, N. A. R., Lorenz, M. C., Birren, B. W., Kellis, M. & Cuomo, C. A., 4 Jun 2009, In : Nature. 459, 7247, p. 657-662 6 p.

Research output: Contribution to journal › Article

631 Scopus citations

Genes selectively up-regulated by pheromone in white cells are involved in biofilm formation in Candida albicans.

Sahni, N., Yi, S., Daniels, K. J., Srikantha, T., Pujol, C. & Soll, D. R., Oct 2009, In : PLoS Pathogens. 5, 10, p. e1000601

Research output: Contribution to journal › Article

47 Scopus citations

2008

Dark brown is the more virulent of the switch phenotypes of Candida glabrata

Srikantha, T., Daniels, K. J., Wu, W., Lockhart, S. R., Yi, S., Sahni, N., Ma, N. & Soll, D. R., 15 Dec 2008, In : Microbiology. 154, 11, p. 3309-3318 10 p.

Research output: Contribution to journal › Article

17 Scopus citations

The same receptor, G protein, and mitogen-activated protein kinase pathway activate different downstream regulators in the alternative white and opaque pheromone responses of Candida albicans

Yi, S., Sahni, N., Daniels, K. J., Pujol, C., Srikantha, T. & Soll, D. R., 1 Mar 2008, In : Molecular Biology of the Cell. 19, 3, p. 957-970 14 p.

Research output: Contribution to journal › Article

49 Scopus citations

2007

Heterozygosity of genes on the sex chromosome regulates Candida albicans virulence

Wu, W., Lockhart, S. R., Pujol, C., Srikantha, T. & Soll, D. R., 1 Jun 2007, In : Molecular Microbiology. 64, 6, p. 1587-1604 18 p.

Research output: Contribution to journal › Article

54 Scopus citations

2006

Opaque cells signal white cells to form biofilms in Candida albicans

Daniels, K. J., Srikantha, T., Lockhart, S. R., Pujol, C. & Soll, D. R., 17 May 2006, In : EMBO Journal. 25, 10, p. 2240-2252 13 p.

Research output: Contribution to journal › Article

122 Scopus citations

The Shwachman-Bodian-Diamond syndrome gene encodes an RNA-binding protein that localizes to the pseudopod of Dictyostelium amoebae during chemotaxis

Wessels, D., Srikantha, T., Yi, S., Kuhl, S., Aravind, L. & Soll, D. R., 15 Jan 2006, In : Journal of Cell Science. 119, 2, p. 370-379 10 p.

Research output: Contribution to journal › Article

37 Scopus citations

TOS9 regulates white-opaque switching in Candida albicans

Srikantha, T., Borneman, A. R., Daniels, K. J., Pujol, C., Wu, W., Seringhaus, M. R., Gerstein, M., Yi, S., Snyder, M. & Soll, D. R., 1 Oct 2006, In : Eukaryotic Cell. 5, 10, p. 1674-1687MP

Research output: Contribution to journal › Article

144 Scopus citations

2005

Phenotypic switching in Candida glabrata accompanied by changes in expression of genes with deduced functions in copper detoxification and stress

Srikantha, T., Zhao, R., Daniels, K., Radke, J. & Soll, D. R., 1 Aug 2005, In : Eukaryotic Cell. 4, 8, p. 1434-1445 12 p.

Research output: Contribution to journal › Article

22 Scopus citations

2004

The closely related species Candida albicans and Candida dubliniensis can mate

Pujol, C., Daniels, K. J., Lockhart, S. R., Srikantha, T., Radke, J. B., Geiger, J. & Soll, D. R., 1 Aug 2004, In : Eukaryotic Cell. 3, 4, p. 1015-1027 13 p.

Research output: Contribution to journal › Article

75 Scopus citations

2003

Phenotypic Switching and Mating Type Switching of Candida glabrata at Sites of Colonization

Brockert, P. J., Lachke, S. A., Srikantha, T., Pujol, C., Galask, R. & Soll, D. R., 1 Dec 2003, In : Infection and Immunity. 71, 12, p. 7109-7118 10 p.

Research output: Contribution to journal › Article

47 Scopus citations

The regulation of EFG1 in white-opaque switching in Candida albicans involves overlapping promoters

Lachke, S. A., Srikantha, T. & Soll, D. R., 1 Apr 2003, In : Molecular Microbiology. 48, 2, p. 523-536 14 p.

Research output: Contribution to journal › Article

25 Scopus citations

Three mating type-like loci in Candida glabrata

Thyagarajan, S., Lachke, S. A. & Soll, D. R., 1 Apr 2003, In : Eukaryotic Cell. 2, 2, p. 328-340 13 p.

Research output: Contribution to journal › Article

46 Scopus citations

2001

A histone deacetylation inhibitor and mutant promote colony-type switching of the human pathogen Candida albicans

Klar, A. J. S., Thyagarajan, S. & Soll, D. R., 3 Jul 2001, In : Genetics. 158, 2, p. 919-924 6 p.

Research output: Contribution to journal › Article

60 Scopus citations

The histone deacetylase genes HDA1 and RPD3 play distinct roles in regulation of high-frequency phenotypic switching in Candida albicans

Srikantha, T., Tsai, L., Daniels, K., Klar, A. J. S. & Soll, D. R., 25 Jul 2001, In : Journal of Bacteriology. 183, 15, p. 4614-4625 12 p.

Research output: Contribution to journal › Article

91 Scopus citations

2000

EFG1 null mutants of Candida albicans switch but cannot express the complete phenotype of white-phase budding cells

Srikantha, T., Tsai, L. K., Daniels, K. & Soll, D. R., 1 Mar 2000, In : Journal of Bacteriology. 182, 6, p. 1580-1591 12 p.

Research output: Contribution to journal › Article

87 Scopus citations

Phenotypic switching in Candida glabrata involves phase-specific regulation of the metallothionein gene MT-II and the newly discovered hemolysin gene HLP

Lachke, S. A., Srikantha, T., Tsai, L. K., Daniels, K. & Soll, D. R., 1 Feb 2000, In : Infection and Immunity. 68, 2, p. 884-895 12 p.

Research output: Contribution to journal › Article

68 Scopus citations

1999

Microevolutionary changes in Candida albicans identified by the complex Ca3 fingerprinting probe involve insertions and deletions of the full-length repetitive sequence RPS at specific genomic sites

Pujol, C., Joly, S., Nolan, B., Srikantha, T. & Soll, D. R., Oct 1999, In : Microbiology. 145, 10, p. 2635-2646 12 p.

Research output: Contribution to journal › Article

46 Scopus citations

Misexpression of the opaque-phase-specific gene PEP1 (SAP1) in the white phase of Candida albicans confers increased virulence in a mouse model of cutaneous infection

Kvaal, C., Lachke, S. A., Srikantha, T., Daniels, K., Mccoy, J. & Soll, D. R., 1 Dec 1999, In : Infection and Immunity. 67, 12, p. 6652-6662 11 p.

Research output: Contribution to journal › Article

155 Scopus citations

1998

Advances in molecular genetics of Candida albicans and Candida glabrata

Brown, A. J. P., Cormack, B. P., Gow, N. A. R., Kvaal, C., Soll, D. R. & Thyagarajan, S., 1 Dec 1998, In : Journal of Medical and Veterinary Mycology. 3, p. 230-237 8 p.

Research output: Contribution to journal › Article

7 Scopus citations

A MADS box protein consensus binding site is necessary and sufficient for activation of the opaque-phase-specific gene OP4 of Candida albicans

Lockhart, S. R., Nguyen, M., Thyagarajan, S. & Soll, D. R., 1 Dec 1998, In : Journal of Bacteriology. 180, 24, p. 6607-6616 10 p.

Research output: Contribution to journal › Article

24 Scopus citations

Reporters for the analysis of gene regulation in fungi pathogenic to man

Soll, D. R. & Thyagarajan, S., 1 Jan 1998, In : Current Opinion in Microbiology. 1, 4, p. 400-405 6 p.

Research output: Contribution to journal › Article

5 Scopus citations

The two-component hybrid kinase regulator CaNIK1 of Candida albicans

Srikantha, T., Tsai, L., Daniels, K., Enger, L., Highley, K. & Soll, D. R., Oct 1998, In : Microbiology. 144, 10, p. 2715-2729 15 p.

Research output: Contribution to journal › Article

82 Scopus citations

1997

A novel repeat sequence (CKRS-1) containing a tandemly repeated sub-element (kre) accounts for differences between Candida krusei strains fingerprinted with the probe CkF1,2

Carlotti, A., Srikantha, T., Schröppel, K., Kvaal, C., Villard, J. & Soll, D. R., 1 Mar 1997, In : Current Genetics. 31, 3, p. 255-263 9 p.

Research output: Contribution to journal › Article

12 Scopus citations

Misexpression of the white-phase-specific gene WH11 in the opaque phase of Candida albicans affects switching and virulence

Kvaal, C. A., Thyagarajan, S. & Soll, D. R., 7 Nov 1997, In : Infection and Immunity. 65, 11, p. 4468-4475 8 p.

Research output: Contribution to journal › Article

98 Scopus citations

The WH11 gene of Candida albicans is regulated in two distinct developmental programs through the same transcription activation sequences

Srikantha, T., Tsai, L. K. & Soll, D. R., Jun 1997, In : Journal of Bacteriology. 179, 12, p. 3837-3844 8 p.

Research output: Contribution to journal › Article

23 Scopus citations

1996

Cytoplasmic localization of the white phase-specific WH11 gene product of Candida albicans

Schröppel, K., Srikantha, T., Wessels, D., DeCock, M., Lockhart, S. R. & Soll, D. R., Aug 1996, In : Microbiology. 142, 8, p. 2245-2254 10 p.

Research output: Contribution to journal › Article

10 Scopus citations

The sea pansy Renilla reniformis luciferase serves as a sensitive bioluminescent reporter for differential gene expression in Candida albicans

Srikantha, T., Klapach, A., Lorenz, W. W., Tsai, L. K., Laughlin, L. A., Gorman, J. A. & Soll, D. R., Jan 1996, In : Journal of Bacteriology. 178, 1, p. 121-129 9 p.

Research output: Contribution to journal › Article

127 Scopus citations

1995

Colonizing populations of Candida albicans are clonal in origin but undergo microevolution through C1 fragment reorganization as demonstrated by DNA fingerprinting and C1 sequencing

Lockhart, S. R., Fritch, J. J., Meier, A. S., Schroppel, K., Thyagarajan, S., Galask, R. & Soll, D. R., 1 Jan 1995, In : Journal of Clinical Microbiology. 33, 6, p. 1501-1509 9 p.

Research output: Contribution to journal › Article

126 Scopus citations

Functional analysis of the promoter of the phase-specific WH11 gene of Candida albicans

Thyagarajan, S., Chandrasekhar, A. & Soll, D. R., 1 Jan 1995, In : Molecular and Cellular Biology. 15, 3, p. 1797-1805 9 p.

Research output: Contribution to journal › Article

47 Scopus citations

The frequency of integrative transformation at phase-specific genes of Candida albicans correlates with their transcriptional state

Srikantha, T., Morrow, B., Schröppel, K. & Soll, D. R., 1 May 1995, In : MGG Molecular & General Genetics. 246, 3, p. 342-352 11 p.

Research output: Contribution to journal › Article

33 Scopus citations

1994

Developmental and molecular biology of switching in Candida albicans

Soll, D. R., Morrow, B., Srikantha, T., Vargas, K. & Wertz, P., Aug 1994, In : Oral Surgery, Oral Medicine, Oral Pathology. 78, 2, p. 194-201 8 p.

Research output: Contribution to journal › Article

12 Scopus citations

Partial nucleotide sequence of a single ribosomal RNA coding region and secondary structure of the large subunit 25 s rRNA of Candida albicans

Srikantha, T., Gutell, R. R., Morrow, B. & Soll, D. R., 1 Oct 1994, In : Current Genetics. 26, 4, p. 321-328 8 p.

Research output: Contribution to journal › Article

9 Scopus citations

Srikantha Thyagarajan, PhD