• 295 Citations
  • 9 h-Index
20042020
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Personal profile

Area of Expertise

My research focuses on the pathological mechanisms of glaucoma. The characteristic events occurring during progression of glaucoma are the death of nerve cells in the eye (retinal ganglion cells) and damage to the optic nerve. We are testing the hypothesis that transcription factors, the proteins controlling gene expression, and astrocytes—one type of supporting cell in the nervous system—play a crucial role in both events. Therefore, my efforts are dedicated to understanding the interaction of nerve cells and astrocytes, and to reveal the roles of transcription factors in neuronal cell death, particularly through the activation of astrocytes.

Education/Academic qualification

PhD in Pharmacology and Neuroscience, UNT Health Science Center

MS in Immunology, Peking Union Medical College

BS in Microbiology, Yunnan University

Fingerprint Dive into the research topics where Shaoqing He is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 9 Similar Profiles
Retinal Ganglion Cells Medicine & Life Sciences
Glaucoma Medicine & Life Sciences
Endothelin-1 Medicine & Life Sciences
Intraocular Pressure Medicine & Life Sciences
Endothelin B Receptors Medicine & Life Sciences
Endothelin Receptors Medicine & Life Sciences
Up-Regulation Medicine & Life Sciences
Astrocytes Medicine & Life Sciences

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Projects 2017 2020

Research Output 2004 2018

  • 295 Citations
  • 9 h-Index
  • 16 Article
4 Citations (Scopus)

Targets of neuroprotection in glaucoma

He, S., Stankowska, D. L., Ellis, D. Z., Krishnamoorthy, R. & Yorio, T., 1 Jan 2018, In : Journal of Ocular Pharmacology and Therapeutics. 34, 1-2, p. 85-106 22 p.

Research output: Contribution to journalArticleResearchpeer-review

Glaucoma
Retinal Diseases
Western World
Retinal Ganglion Cells
Aqueous Humor

A feed-forward regulation of endothelin receptors by c-Jun in human non-pigmented ciliary epithelial cells and retinal ganglion cells

Wang, J., Ma, H. Y., Krishnamoorthy, R., Yorio, T. & He, S., 1 Sep 2017, In : PLoS ONE. 12, 9, e0185390.

Research output: Contribution to journalArticleResearchpeer-review

CCAAT-Enhancer-Binding Proteins
Endothelin Receptors
food law
endothelins
Endothelin B Receptors
4 Citations (Scopus)

Sigma-1 receptor regulates mitochondrial function in glucose-and oxygen-deprived retinal ganglion cells

Ellis, D. Z., Li, L., Park, Y., He, S., Mueller, B. & Yorio, T., 1 May 2017, In : Investigative Ophthalmology and Visual Science. 58, 5, p. 2755-2764 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Retinal Ganglion Cells
Oxygen
Glucose
Mitochondrial Membrane Potential
Electron Transport Complex IV
8 Citations (Scopus)

Upregulation of the endothelin A (ETA) receptor and its association with neurodegeneration in a rodent model of glaucoma

McGrady, N. R., Minton, A. Z., Stankowska, D. L., He, S., Jefferies, H. B. & Krishnamoorthy, R., 1 Mar 2017, In : BMC Neuroscience. 18, 1, 27.

Research output: Contribution to journalArticleResearchpeer-review

Endothelin A Receptors
Intraocular Pressure
Glaucoma
Rodentia
Up-Regulation
4 Citations (Scopus)

Involvement of ampa receptor and its flip and flop isoforms in retinal ganglion cell death following oxygen/glucose deprivation

Park, Y. H., Broyles, H. V., He, S., McGrady, N. R., Li, L. & Yorio, T., 1 Feb 2016, In : Investigative Ophthalmology and Visual Science. 57, 2, p. 508-526 19 p.

Research output: Contribution to journalArticleResearchpeer-review

AMPA Receptors
Retinal Ganglion Cells
Protein Isoforms
Cell Death
Oxygen