• 664 Citations
  • 13 h-Index
20102022
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Personal profile

Area of Expertise

Currently I am involved with Lipoprotein drug delivery research as it pertains to my training and experience with development of novel nanotechnology applications for theranostic purposes. The objective of my research is to develop lipoprotein based therapies and diagnostics. rHDL based therapy will significantly lower the off-target toxicities and will prolong the blood circulation time (Mean Residence Time) thereby increasing the selective delivery of the dose to cancer cells via SR-B1 receptor. These receptors are exclusively overexpressed on many cancer cells and extract the drug from rHDL nanoparticles without endocytosing them.
The projects in my lab will exploit recently developed technology of lipoprotein nanoparticles and will exploit unique interaction of rHDL and SR-B1 receptors for treatment of various cancers ( breast, prostate, ovarian, Ewing sarcoma, neuroblastoma, etc.). This new technology will be tested for in-vitro toxicity in various cell lines and ex-vivo 3D tissue models, and then studies will be carried out in small animal models, followed by patient-derived xenograft animal studies in collaboration with other institutions or commercial outfits.

Education/Academic qualification

PhD in Biomedical Sciences, UNT Health Science Center

MS in Industrial Pharmacy, St. John's University

BS in Pharmaceutical Science, Shivaji University

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Projects 2018 2022

Research Output 2010 2019

[ 99 mTc-HYNIC-N-dodecylamide]:a new hydrophobic tracer for labelling reconstituted high-density lipoproteins (rHDL) for radioimaging

Isaac-Olivé, K., Ocampo-García, B. E., Aranda-Lara, L., Santos-Cuevas, C. L., Jiménez-Mancilla, N. P., Luna-Gutiérrez, M. A., Medina, L. A., Nagarajan, B., Sabnis, N., Raut, S. L., Prokai, L. & Lacko, A. G., 14 Jan 2019, In : Nanoscale. 11, 2, p. 541-551 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Lipoproteins
HDL Lipoproteins
Labeling
Imaging techniques
Acids
1 Citation (Scopus)

Clotam enhances anti-proliferative effect of vincristine in Ewing sarcoma cells

Shelake, S., Sankpal, U. T., Eslin, D., Bowman, P., Simecka, J., Raut, S. L., Ray, A. & Basha, R. M., 15 Feb 2019, In : Apoptosis. 24, 1-2, p. 21-32 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Ewing's Sarcoma
Vincristine
Cells
Caspase 7
Cell Survival

Brain targeting of payload using mild magnetic field: Site specific delivery

Bommana, M. M. & Raut, S. L., 16 Feb 2018, Nanostructures for the Engineering of Cells, Tissues and Organs: From Design to Applications. Elsevier, p. 167-185 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Magnetic Fields
Nanoparticles
Brain
Magnetic fields
Neoplasms
1 Citation (Scopus)

Differences in the spatial distribution of actin in the left and right ventricles of functioning rabbit hearts

Nagwekar, J., Duggal, D., Rich, R., Fudala, R., Gryczynski, I., Raut, S. L., Gryczynski, Z. & Borejdo, J., 1 Mar 2018, In : Medical Photonics. 27, p. 1-8 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Heart Ventricles
Actins
Myosins
Rabbits
Muscles
1 Citation (Scopus)

Enhanced DNA detection using a multiple pulse pumping scheme with time-gating (MPPTG)

Kimball, J. D., Maliwal, B., Raut, S. L., Doan, H., Nurekeyev, Z., Gryczynski, I. & Gryczynski, Z., 21 Jun 2018, In : Analyst. 143, 12, p. 2819-2827 9 p.

Research output: Contribution to journalArticleResearchpeer-review

pumping
DNA
fluorescence
Fluorescence
Intercalating Agents