• 3169 Citations
  • 22 h-Index
1987 …2017

Research output per year

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Personal profile

Area of Expertise

A properly functioning stress response is required for maintaining homeostasis. The endocrine arm of the stress response is sub-served by the hypothalamic pituitary adrenal (HPA) axis. Dysregulation of this axis is tightly correlated with the mood disorders of depression and post-traumatic stress disorder.
My lab is interested in the molecular mechanisms of stress response downregulation. Specifically, how the stress steroids, glucocorticoids, downregulate the peptide that triggers the stress response itself: corticotropin releasing hormone (CRH). We have provided evidence that a specific epigenetic repressive complex is necessary to effect downregulation. Further studies may pinpoint interaction of this complex with unique conformations of chromatin, and thus uncover novel drug targets, in particular for depression.

Education/Academic qualification

PhD in Molecular Neuroendocrinology, State University of New York

Award Date: 1 Jan 2002

MD, State University of New York

Award Date: 1 Jan 2001

BN, Columbia University

Award Date: 1 Jan 2000

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Projects

Research Output

  • 3169 Citations
  • 22 h-Index
  • 28 Article
  • 1 Review article
  • 4 Scopus citations
  • Mechanisms by which 17β-Estradiol (E2) Suppress Neuronal cox-2 gene expression

    Stacey, W., Bhave, S. & Uht, R. M., Sep 2016, In : PLoS ONE. 11, 9, e0161430.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Dexamethasone induces a putative repressor complex and chromatin modifications in the CRH promoter

    Sharma, D., Bhave, S., Gregg, E. & Uht, R., 1 Jul 2013, In : Molecular Endocrinology. 27, 7, p. 1142-1152 11 p.

    Research output: Contribution to journalArticle

  • 26 Scopus citations

    Hypothalamic and amygdalar cell lines differ markedly in mitochondrial rather than nuclear encoded gene expression

    Dalwadi, D. A. & Uht, R. M., 21 Jun 2013, In : BMC Genomics. 14, 1, 413.

    Research output: Contribution to journalArticle

  • 2 Scopus citations