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Personal profile

Area of Expertise

A properly functioning stress response is required for maintaining homeostasis. The endocrine arm of the stress response is sub-served by the hypothalamic pituitary adrenal (HPA) axis. Dysregulation of this axis is tightly correlated with the mood disorders of depression and post-traumatic stress disorder.
My lab is interested in the molecular mechanisms of stress response downregulation. Specifically, how the stress steroids, glucocorticoids, downregulate the peptide that triggers the stress response itself: corticotropin releasing hormone (CRH). We have provided evidence that a specific epigenetic repressive complex is necessary to effect downregulation. Further studies may pinpoint interaction of this complex with unique conformations of chromatin, and thus uncover novel drug targets, in particular for depression.

Education/Academic qualification

PhD in Molecular Neuroendocrinology, State University of New York

MD, State University of New York

BN, Columbia University

Fingerprint Dive into the research topics where Rosalie Uht is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Projects 2009 2016

Research Output 1987 2017

  • 3110 Citations
  • 22 h-Index
  • 28 Article
  • 1 Review article
1 Citation (Scopus)

CpG methylation and the methyl CpG binding protein 2 (MeCP2) are required for restraining corticotropin releasing hormone (CRH) gene expression

Bhave, S. A. & Uht, R. M., 15 Oct 2017, In : Molecular and Cellular Endocrinology. 454, p. 158-164 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Methyl-CpG-Binding Protein 2
Methylation
Corticotropin-Releasing Hormone
Gene expression
Gene Expression

Estradiol (E2)- and tamoxifen (Tmx)-bound ER-alpha (ERα) interact differentially with histone deacetylases 1 and 3 (HDACs 1 and 3)

Sharma, D., Liu, Y. & Uht, R. M., 1 Nov 2017, In : Journal of Steroid Biochemistry and Molecular Biology. 174, p. 128-132 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Histone Deacetylases
Tamoxifen
Estradiol
Ligands
Chemical activation
1 Citation (Scopus)

Mechanisms by which 17β-Estradiol (E2) Suppress Neuronal cox-2 gene expression

Stacey, W., Bhave, S. & Uht, R. M., 1 Sep 2016, In : PLoS ONE. 11, 9, e0161430.

Research output: Contribution to journalArticleResearchpeer-review

Gene expression
estradiol
Estradiol
trichostatin A
Cyclooxygenase 2
22 Citations (Scopus)

Dexamethasone induces a putative repressor complex and chromatin modifications in the CRH promoter

Sharma, D., Bhave, S., Gregg, E. & Uht, R. M., 1 Jul 2013, In : Molecular Endocrinology. 27, 7, p. 1142-1152 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Histone Deacetylase 1
Glucocorticoid Receptors
Dexamethasone
Chromatin
Carrier Proteins
2 Citations (Scopus)

Hypothalamic and amygdalar cell lines differ markedly in mitochondrial rather than nuclear encoded gene expression

Dalwadi, D. A. & Uht, R. M., 21 Jun 2013, In : BMC Genomics. 14, 1, 413.

Research output: Contribution to journalArticleResearchpeer-review

Gene Expression
Cell Line
Genes
Corticotropin-Releasing Hormone
Amygdala