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Area of Expertise
Population of diabetes mellitus continues to rise in the U.S. Diabetic kidney disease is a major complication of diabetes mellitus and is the most common cause of chronic kidney disease.
The research in our laboratory is directed at understanding the molecular mechanisms of the development of diabetic kidney disease. Specifically, we are interested in the role of different calcium signaling pathways in the diabetes-induced kidney injury. Toward this goal, we use both animal models of diabetes mellitus and cultured kidney cells to study how altering calcium signaling changes the function and structure of the kidney/kidney cells under a diabetic environment. We utilize quantitative immunological methods, immunohistochemistry, and RT-PCR to reliably measure both protein and message for various molecules in specific calcium signaling pathways in kidney tissues/kidney cells. We also employ multiple tools to evaluate kidney function under different conditions. It is our goal to better understand the molecular events involved in the kidney response to diabetes, so that we can target rational development of effective therapeutics to prevent/treat the disease.
The research in our laboratory is directed at understanding the molecular mechanisms of the development of diabetic kidney disease. Specifically, we are interested in the role of different calcium signaling pathways in the diabetes-induced kidney injury. Toward this goal, we use both animal models of diabetes mellitus and cultured kidney cells to study how altering calcium signaling changes the function and structure of the kidney/kidney cells under a diabetic environment. We utilize quantitative immunological methods, immunohistochemistry, and RT-PCR to reliably measure both protein and message for various molecules in specific calcium signaling pathways in kidney tissues/kidney cells. We also employ multiple tools to evaluate kidney function under different conditions. It is our goal to better understand the molecular events involved in the kidney response to diabetes, so that we can target rational development of effective therapeutics to prevent/treat the disease.
Education/Academic qualification
BS in Medicine, Anhui Medical University
MS in Physiology, Anhui Medical University
PhD in Physiology, University of Nebraska Medical Center
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Store-Operated Ca2+ Signaling in Kidney Glomerular Mesangial Cells
NIDDK: Diabetes & Digestive & Kidney
1/12/17 → 30/11/21
Project: Research
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Store-operated Ca2+ signaling and renal inflammation in diabetic kidney disease (For: Suna Burghul)
5/06/17 → 31/05/18
Project: Research
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Inhibitor of Myogenic Family a, Store-operated Ca2+ Channel, and Diabetic Nephropathy
NIDDK: Diabetes & Digestive & Kidney
11/07/16 → 30/06/18
Project: Research
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Store-operated Ca2+ Channel and Diabetic Kidney Disease (For: Elizabeth Chen)
1/06/16 → 31/05/17
Project: Research
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l-mfa, a Potential Therapeutic Target of Diabetic Nephropathy
American Heart Association - SouthWest
1/01/16 → 31/12/17
Project: Research
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Store-operated calcium entry: Pivotal roles in renal physiology and pathophysiology
Chaudhari, S., Mallet, R. T., Shotorbani, P. Y., Tao, Y. & Ma, R., Feb 2021, In: Experimental Biology and Medicine. 246, 3, p. 305-316 12 p.Research output: Contribution to journal › Review article › peer-review
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Inhibition of interleukin-6 on matrix protein production by glomerular mesangial cells and the pathway involved
Chaudhari, S., Yazdizadeh Shotorbani, P., Tao, Y., Davis, M. E., Mallet, R. T. & Ma, R., 1 Jun 2020, In: American journal of physiology. Renal physiology. 318, 6, p. F1478-F1488Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Inhibitor of myogenic differentiation family isoform a, a new positive regulator of fibronectin production by glomerular mesangial cells
Shotorbani, P. Y., Chaudhari, S., Tao, Y., Tsiokas, L. & Ma, R., 1 Mar 2020, In: American journal of physiology. Renal physiology. 318, 3, p. F673-F682Research output: Contribution to journal › Article › peer-review
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Comparison of diabetic nephropathy between male and female eNOS-/- db/db mice
Ma, Y., Li, W., Shotorbani, P. Y., Dubansky, B. H., Huang, L., Chaudhari, S., Wu, P., Wang, L. A., Ryou, M. G., Zhou, Z. & Ma, R., May 2019, In: American Journal of Physiology - Renal Physiology. 316, 5, p. F889-F897Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Glucagon-like peptide-1 receptor pathway inhibits extracellular matrix production by mesangial cells through store-operated Ca2+ channel
Huang, L., Ma, R., Lin, T., Chaudhari, S., Shotorbani, P. Y., Yang, L. & Wu, P., 1 Oct 2019, In: Experimental Biology and Medicine. 244, 14, p. 1193-1201 9 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations