Projects per year
Personal profile
Research Interests
Classical Transient receptor potential channel (TRPC)
Store-operated calcium channel (SOC)
Renal hemodynamics
Diabetic kidney disease
Area of Expertise
Population of diabetes mellitus continues to rise in the U.S. Diabetic kidney disease is a major complication of diabetes mellitus and is the most common cause of chronic kidney disease.
The research in our laboratory is directed at understanding the molecular mechanisms of the development of diabetic kidney disease. Specifically, we are interested in the role of different calcium signaling pathways in the diabetes-induced kidney injury. Toward this goal, we use both animal models of diabetes mellitus and cultured kidney cells to study how altering calcium signaling changes the function and structure of the kidney/kidney cells under a diabetic environment. We utilize quantitative immunological methods, immunohistochemistry, and RT-PCR to reliably measure both protein and message for various molecules in specific calcium signaling pathways in kidney tissues/kidney cells. We also employ multiple tools to evaluate kidney function under different conditions. It is our goal to better understand the molecular events involved in the kidney response to diabetes, so that we can target rational development of effective therapeutics to prevent/treat the disease.
Techniques
in vivo measurement of glomerular filtration rate in mice, animal surgery, genotyping, IF, cell culture, Ca2+ imaging, Western blot, cell contraction assay,
Education/Academic qualification
BS in Medicine, Anhui Medical University
MS in Physiology, Anhui Medical University
PhD in Physiology, University of Nebraska Medical Center
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Collaborations and top research areas from the last five years
Projects
- 22 Finished
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Enhanced store-operated calcium entry contributes to high glucose-included podocyte injury
Ma, R. (PI)
1/07/22 → 30/06/24
Project: Research
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Enhanced Store-Operated Ca2+ Entry Contributes to High Glucose-Induced Podocyte Injury
Ma, R. (PI)
1/01/22 → 31/12/22
Project: Research
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Store Operated Calcium Entry in Mesengial Cells Suppresses Renal Inflammation and Injury in Diabetic Nephropathy
Ma, R. (PI)
1/01/20 → 31/12/21
Project: Research
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Epidermal Growth Factor Activates Store-operated Ca2+ Channels through an Inositol 1,4,5-Trisphosphate-independent Pathway in Human Glomerular Mesangial Cells
Li, W. P., Tsiokas, L., Sansom, S. C. & Ma, R., 6 Feb 2004, In: Journal of Biological Chemistry. 279, 6, p. 4570-4577 8 p.Research output: Contribution to journal › Article › peer-review
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Reduced NO enhances the central gain of cardiac sympathetic afferent reflex in dogs with heart failure
Ma, R., Zucker, I. H. & Wang, W., Jan 1999, In: American Journal of Physiology - Heart and Circulatory Physiology. 276, 1 45-1, p. H19-H26Research output: Contribution to journal › Article › peer-review
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Canonical Transient Receptor Potential (TRPC) channels in renal microcirculation
Sours-Brothers, S. & Ma, R., 1 Apr 2009, Microcirculation: Function, Malfunction and Measurement. Nova Science Publishers, Inc., p. 25-38 14 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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Renal TLR-7/TNF-α pathway as a potential female-specific mechanism in the pathogenesis of autoimmune-induced hypertension
Chaudhari, S., D'Souza, B. M., Morales, J. Y., Young-Stubbs, C. M., Shimoura, C. G., Ma, R. & Mathis, K. W., 1 Dec 2022, In: American journal of physiology. Heart and circulatory physiology. 323, 6, p. H1331-H1342Research output: Contribution to journal › Article › peer-review
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Sex and strain differences in renal hemodynamics in mice
Tao, Y., Young-Stubbs, C., Yazdizadeh Shotorbani, P., Su, D. M., Mathis, K. W. & Ma, R., Mar 2023, In: Physiological Reports. 11, 6, e15644.Research output: Contribution to journal › Article › peer-review