Projects per year
Personal profile
Research Interests
Classical Transient receptor potential channel (TRPC)
Store-operated calcium channel (SOC)
Renal hemodynamics
Diabetic kidney disease
Area of Expertise
Population of diabetes mellitus continues to rise in the U.S. Diabetic kidney disease is a major complication of diabetes mellitus and is the most common cause of chronic kidney disease.
The research in our laboratory is directed at understanding the molecular mechanisms of the development of diabetic kidney disease. Specifically, we are interested in the role of different calcium signaling pathways in the diabetes-induced kidney injury. Toward this goal, we use both animal models of diabetes mellitus and cultured kidney cells to study how altering calcium signaling changes the function and structure of the kidney/kidney cells under a diabetic environment. We utilize quantitative immunological methods, immunohistochemistry, and RT-PCR to reliably measure both protein and message for various molecules in specific calcium signaling pathways in kidney tissues/kidney cells. We also employ multiple tools to evaluate kidney function under different conditions. It is our goal to better understand the molecular events involved in the kidney response to diabetes, so that we can target rational development of effective therapeutics to prevent/treat the disease.
Techniques
in vivo measurement of glomerular filtration rate in mice, animal surgery, genotyping, IF, cell culture, Ca2+ imaging, Western blot, cell contraction assay,
Education/Academic qualification
BS in Medicine, Anhui Medical University
MS in Physiology, Anhui Medical University
PhD in Physiology, University of Nebraska Medical Center
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Collaborations and top research areas from the last five years
Projects
- 17 Finished
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Store-operated Ca2+ signaling in kidney glomerular mesangial cells
National Institute of Diabetes and Digestive and Kidney Diseases
1/12/17 → 30/11/21
Project: Research
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Store-Operated Ca2+ Signaling in Kidney Glomerular Mesangial Cells
NIDDK: Diabetes & Digestive & Kidney
1/12/17 → 30/11/21
Project: Research
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Store-operated Ca2+ signaling and renal inflammation in diabetic kidney disease (For: Suna Burghul)
5/06/17 → 31/05/18
Project: Research
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Inhibitor of myogenic family a, store-operated Ca2+ channel, and diabetic nephropathy
11/07/16 → 30/06/18
Project: Research
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Inhibitor of Myogenic Family a, Store-operated Ca2+ Channel, and Diabetic Nephropathy
NIDDK: Diabetes & Digestive & Kidney
11/07/16 → 30/06/18
Project: Research
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Sex and strain differences in renal hemodynamics in mice
Tao, Y., Young-Stubbs, C., Yazdizadeh Shotorbani, P., Su, D. M., Mathis, K. W. & Ma, R., Mar 2023, In: Physiological Reports. 11, 6, e15644.Research output: Contribution to journal › Article › peer-review
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Inhibition of interleukin-6 on matrix protein production by glomerular mesangial cells and the pathway involved
Chaudhari, S., Yazdizadeh Shotorbani, P., Tao, Y., Davis, M. E., Mallet, R. T. & Ma, R., 1 Jun 2020, In: American journal of physiology. Renal physiology. 318, 6, p. F1478-F1488Research output: Contribution to journal › Article › peer-review
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Effects of Shu Gan Jian Pi formula on rats with carbon tetrachloride-induced Liver fibrosis using serum metabonomics based on gas chromatography-time of flight mass spectrometry
Jiang, H., Qin, X. J., Li, W. P., Ma, R., Wang, T. & Li, Z. Q., Oct 2017, In: Molecular Medicine Reports. 16, 4, p. 3901-3909 9 p.Research output: Contribution to journal › Article › peer-review
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Astragaloside IV prevents damage to human mesangial cells through the inhibition of the NADPH oxidase/ROS/Akt/NF-κB pathway under high glucose conditions
Sun, L. I., Li, W., Li, W., Xiong, L. I., Li, G. & Ma, R., Jul 2014, In: International journal of molecular medicine. 34, 1, p. 167-176 10 p.Research output: Contribution to journal › Article › peer-review
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Epidermal growth factor activates store-operated calcium channels in human glomerular mesangial cells
Ma, R. & Sansom, S. C., 2001, In: Journal of the American Society of Nephrology. 12, 1, p. 47-53 7 p.Research output: Contribution to journal › Article › peer-review