Projects per year
Personal profile
Area of Expertise
The research in our laboratory is directed at understanding the molecular mechanisms of the development of diabetic kidney disease. Specifically, we are interested in the role of different calcium signaling pathways in the diabetes-induced kidney injury. Toward this goal, we use both animal models of diabetes mellitus and cultured kidney cells to study how altering calcium signaling changes the function and structure of the kidney/kidney cells under a diabetic environment. We utilize quantitative immunological methods, immunohistochemistry, and RT-PCR to reliably measure both protein and message for various molecules in specific calcium signaling pathways in kidney tissues/kidney cells. We also employ multiple tools to evaluate kidney function under different conditions. It is our goal to better understand the molecular events involved in the kidney response to diabetes, so that we can target rational development of effective therapeutics to prevent/treat the disease.
Education/Academic qualification
BS in Medicine, Anhui Medical University
MS in Physiology, Anhui Medical University
PhD in Physiology, University of Nebraska Medical Center
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Network
Projects
- 17 Finished
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Store-operated Ca2+ signaling in kidney glomerular mesangial cells
National Institute of Diabetes and Digestive and Kidney Diseases
1/12/17 → 30/11/21
Project: Research
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Store-Operated Ca2+ Signaling in Kidney Glomerular Mesangial Cells
NIDDK: Diabetes & Digestive & Kidney
1/12/17 → 30/11/21
Project: Research
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Store-operated Ca2+ signaling and renal inflammation in diabetic kidney disease (For: Suna Burghul)
5/06/17 → 31/05/18
Project: Research
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Inhibitor of Myogenic Family a, Store-operated Ca2+ Channel, and Diabetic Nephropathy
NIDDK: Diabetes & Digestive & Kidney
11/07/16 → 30/06/18
Project: Research
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Inhibitor of myogenic family a, store-operated Ca2+ channel, and diabetic nephropathy
11/07/16 → 30/06/18
Project: Research
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Enhanced Orai1-mediated store-operated Ca2+ channel/calpain signaling contributes to high glucose-induced podocyte injury
Tao, Y., Chaudhari, S., Shotorbani, P. Y., Ding, Y., Chen, Z., Kasetti, R., Zode, G. & Ma, R., 1 Jun 2022, In: Journal of Biological Chemistry. 298, 6, 101990.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Neogenin pathway positively regulates fibronectin production by glomerular mesangial cells
Chaudhari, S., Shotorbani, P. Y., Tao, Y., Kasetti, R., Zode, G., Mathis, K. W. & Ma, R., Jul 2022, In: American Journal of Physiology - Cell Physiology. 323, 1, p. C226-C235Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Store-operated Ca2+ channel signaling: Novel mechanism for podocyte injury in kidney disease
Tao, Y., Mallet, R. T., Mathis, K. W. & Ma, R., 2022, (Accepted/In press) In: Experimental Biology and Medicine.Research output: Contribution to journal › Short survey › peer-review
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Store-operated calcium entry: Pivotal roles in renal physiology and pathophysiology
Chaudhari, S., Mallet, R. T., Shotorbani, P. Y., Tao, Y. & Ma, R., Feb 2021, In: Experimental Biology and Medicine. 246, 3, p. 305-316 12 p.Research output: Contribution to journal › Review article › peer-review
6 Scopus citations -
Inhibition of interleukin-6 on matrix protein production by glomerular mesangial cells and the pathway involved
Chaudhari, S., Yazdizadeh Shotorbani, P., Tao, Y., Davis, M. E., Mallet, R. T. & Ma, R., 1 Jun 2020, In: American journal of physiology. Renal physiology. 318, 6, p. F1478-F1488Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations