• 1700 Citations
  • 28 h-Index
1990 …2021

Research output per year

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Personal profile

Area of Expertise

Population of diabetes mellitus continues to rise in the U.S. Diabetic kidney disease is a major complication of diabetes mellitus and is the most common cause of chronic kidney disease.
The research in our laboratory is directed at understanding the molecular mechanisms of the development of diabetic kidney disease. Specifically, we are interested in the role of different calcium signaling pathways in the diabetes-induced kidney injury. Toward this goal, we use both animal models of diabetes mellitus and cultured kidney cells to study how altering calcium signaling changes the function and structure of the kidney/kidney cells under a diabetic environment. We utilize quantitative immunological methods, immunohistochemistry, and RT-PCR to reliably measure both protein and message for various molecules in specific calcium signaling pathways in kidney tissues/kidney cells. We also employ multiple tools to evaluate kidney function under different conditions. It is our goal to better understand the molecular events involved in the kidney response to diabetes, so that we can target rational development of effective therapeutics to prevent/treat the disease.

Education/Academic qualification

PhD in Physiology, University of Nebraska Medical Center

Award Date: 1 Jan 2002

MS in Physiology, Anhui Medical University

Award Date: 1 Jan 2001

BS in Medicine, Anhui Medical University

Award Date: 1 Jan 2000

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Projects

Research Output

  • 1700 Citations
  • 28 h-Index
  • 55 Article
  • 7 Review article
  • 1 Chapter
  • 1 Short survey

Comparison of diabetic nephropathy between male and female eNOS-/- db/db mice

Ma, Y., Li, W., Shotorbani, P. Y., Dubansky, B. H., Huang, L., Chaudhari, S., Wu, P., Wang, L. A., Ryou, M. G., Zhou, Z. & Ma, R., May 2019, In : American Journal of Physiology - Renal Physiology. 316, 5, p. F889-F897

Research output: Contribution to journalArticle

  • 2 Scopus citations

    Glucagon-like peptide-1 receptor pathway inhibits extracellular matrix production by mesangial cells through store-operated Ca2+ channel

    Huang, L., Ma, R., Lin, T., Chaudhari, S., Shotorbani, P. Y., Yang, L. & Wu, P., 1 Oct 2019, In : Experimental Biology and Medicine. 244, 14, p. 1193-1201 9 p.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations

    Short-term high-glucose treatment decreased abundance of Orai1 protein through posttranslational mechanisms in rat Mesangial cells

    Jiang, H., Zou, S., Chaudhari, S. & Ma, R., 1 Jan 2018, In : American Journal of Physiology - Renal Physiology. 314, 5, p. F855-F863

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Effects of Shu Gan Jian Pi formula on rats with carbon tetrachloride-induced Liver fibrosis using serum metabonomics based on gas chromatography-time of flight mass spectrometry

    Jiang, H., Qin, X. J., Li, W. P., Ma, R., Wang, T. & Li, Z. Q., Oct 2017, In : Molecular Medicine Reports. 16, 4, p. 3901-3909 9 p.

    Research output: Contribution to journalArticle

  • 7 Scopus citations

    Increased glomerular filtration rate and impaired contractile function of mesangial cells in TRPC6 knockout mice

    Li, W., Ding, Y., Smedley, C., Wang, Y., Chaudhari, S., Birnbaumer, L. & Ma, R., 1 Dec 2017, In : Scientific Reports. 7, 1, 4145.

    Research output: Contribution to journalArticle

  • 3 Scopus citations