• 2375 Citations
  • 28 h-Index
1984 …2022
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Research Output 1984 2019

2019

Hemorrhage simulated by lower body negative pressure provokes an oxidative stress response in healthy young adults

Park, F. S., Kay, V. L., Sprick, J. D., Rosenberg, A. J., Anderson, G. K., Mallet, R. T. & Rickards, C. A., 1 Mar 2019, In : Experimental Biology and Medicine. 244, 3, p. 272-278 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Lower Body Negative Pressure
Oxidative stress
Young Adult
Oxidative Stress
Hemorrhage

Inline flow sensor for ventriculoperitoneal shunts: Experimental evaluation in swine

Qin, C., Yurvati, A., Williams, A. G., Eskildsen, D., Mallet, R. T. & Dasgupta, P. K., 1 May 2019, In : Medical Engineering and Physics. 67, p. 66-72 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Ventriculoperitoneal Shunt
Cerebrospinal Fluid
Swine
Hydrocephalus
Cerebrospinal fluid

Ischaemic and hypoxic conditioning: potential for protection of vital organs

Sprick, J. D., Mallet, R. T., Przyklenk, K. & Rickards, C. A., 1 Mar 2019, In : Experimental Physiology. 104, 3, p. 278-294 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Ischemic Preconditioning
Exercise
Clinical Trials
Hypoxia-Inducible Factor 1
Microglia
2018
3 Citations (Scopus)

An in vitro oxygen–glucose deprivation model for studying ischemia–reperfusion injury of neuronal cells

Ryou, M. G. & Mallet, R. T., 1 Jan 2018, Methods in Molecular Biology. Humana Press Inc., p. 229-235 7 p. (Methods in Molecular Biology; vol. 1717).

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Wounds and Injuries
Oxygen
Cytoprotection
Heart Arrest
Reperfusion Injury
6 Citations (Scopus)

Cardioprotection by intermittent hypoxia conditioning: Evidence, mechanisms, and therapeutic potential

Mallet, R. T., Manukhina, E. B., Ruelas, S. S., Caffrey, J. L. & Downey, H. F., 1 Aug 2018, In : American Journal of Physiology - Heart and Circulatory Physiology. 315, 2, p. H216-H232

Research output: Contribution to journalReview articleResearchpeer-review

Ischemia
Myocardial Reperfusion
Coronary Occlusion
Sleep Apnea Syndromes
Tachycardia
4 Citations (Scopus)

Intermittent hypoxia training: Powerful, non-invasive cerebroprotection against ethanol withdrawal excitotoxicity

Jung, E. & Mallet, R. T., 1 Oct 2018, In : Respiratory Physiology and Neurobiology. 256, p. 67-78 12 p.

Research output: Contribution to journalReview articleResearchpeer-review

Ethanol
Amyloid
Glutamic Acid
Oxidative Stress
Adenosine Triphosphate
1 Citation (Scopus)

Pyruvate enhancement of cardiac performance: Cellular mechanisms and clinical application

Mallet, R. T., Yurvati, A. & Bünger, R., 1 Jan 2018, In : Experimental Biology and Medicine. 243, 2, p. 198-210 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Pyruvic Acid
Pyruvates
Cardiopulmonary Bypass
Adenosine
Free energy
1 Citation (Scopus)

Pyruvate-enriched resuscitation for shock

Mallet, R. T., Yurvati, A. & Bünger, R., 1 May 2018, In : Experimental Biology and Medicine. 243, 8, p. 663-664 2 p.

Research output: Contribution to journalComment/debateResearch

Resuscitation
Pyruvic Acid
Shock
Hemorrhagic Shock
Bioelectric potentials
2017

Enhanced cerebral perfusion during brief exposures to cyclic intermittent hypoxemia

Liu, X., Xu, D., Hall, J. R., Ross, S. E., Chen, S., Liu, H., Mallet, R. T. & Shi, X., 1 Dec 2017, In : Journal of applied physiology (Bethesda, Md. : 1985). 123, 6, p. 1689-1697 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Perfusion
Oxygen
Middle Cerebral Artery
Vasodilation
Hypoxia
6 Citations (Scopus)

Erythropoietin: Endogenous Protection of Ischemic Brain

Mallet, R. T., Ryou, M. G. & Ryou, M. G., 1 Jan 2017, Vitamins and Hormones. Academic Press Inc., p. 197-232 36 p. (Vitamins and Hormones; vol. 105).

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Erythropoietin
Brain
Ischemia
Heart Arrest
Brain Ischemia

Featured Article: Pyruvate preserves antiglycation defenses in porcine brain after cardiac arrest

Scott, G. F., Nguyen, A. Q., Cherry, B. H., Hollrah, R. A., Salinas, I., Williams, A. G., Ryou, M. G. & Mallet, R. T., 1 Jan 2017, In : Experimental Biology and Medicine. 242, 10, p. 1095-1103 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Resuscitation
Heart Arrest
Pyruvic Acid
Brain
Swine
5 Citations (Scopus)
Presenilin-1
Amyloid
Ethanol
Amyloid Precursor Protein Secretases
Heat-Shock Proteins
2016
9 Citations (Scopus)

Intermittent hypoxia training protects cerebrovascular function in Alzheimer's disease

Manukhina, E. B., Downey, H. F., Shi, X. & Mallet, R. T., 1 Jun 2016, In : Experimental Biology and Medicine. 241, 12, p. 1351-1363 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Alzheimer Disease
Cerebrovascular Circulation
Nitric Oxide
Pathology
Blood Vessels
4 Citations (Scopus)

Metabolomics and Receiver Operating Characteristic Analysis: A Promising Approach for Sepsis Diagnosis∗

Bünger, R. & Mallet, R. T., 1 Sep 2016, In : Critical Care Medicine. 44, 9, p. 1784-1785 2 p.

Research output: Contribution to journalEditorialResearch

Systemic Inflammatory Response Syndrome
Metabolomics
ROC Curve
Sepsis
9 Citations (Scopus)

δ-Opioid receptor (DOR) signaling and reactive oxygen species (ROS) mediate intermittent hypoxia induced protection of canine myocardium

Estrada, J. A., Williams, A. G., Sun, J., Gonzalez, L., Downey, H. F., Caffrey, J. L. & Mallet, R. T., 1 Mar 2016, In : Basic Research in Cardiology. 111, 2, p. 1-12 12 p., 17.

Research output: Contribution to journalArticleResearchpeer-review

Opioid Receptors
Canidae
Reactive Oxygen Species
Myocardium
Cardiac Arrhythmias
4 Citations (Scopus)

δ-Opioid receptors: Pivotal role in intermittent hypoxia-augmentation of cardiac parasympathetic control and plasticity

Estrada, J. A., Barlow, M. A., Yoshishige, D., Williams, A. G., Downey, H. F., Mallet, R. T. & Caffrey, J. L., 1 Jul 2016, In : Autonomic Neuroscience: Basic and Clinical. 198, p. 38-49 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Opioid Receptors
naltrindole
Vesicular Acetylcholine Transport Proteins
Adrenergic Agents
Cholinergic Agents
2015
2 Citations (Scopus)

Pyruvate stabilizes electrocardiographic and hemodynamic function in pigs recovering from cardiac arrest

Cherry, B. H., Nguyen, A. Q., Hollrah, R. A., Williams, A. G., Hoxha, B., Yurvati, A. & Mallet, R. T., 1 Dec 2015, In : Experimental Biology and Medicine. 240, 12, p. 1774-1784 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Hemodynamics
Heart Arrest
Pyruvic Acid
Swine
Recovery
2014
44 Citations (Scopus)

Erythropoietin: Powerful protection of ischemic and post-ischemic brain

Nguyen, A. Q., Cherry, B. H., Scott, G. F., Ryou, M. G. & Mallet, R. T., 1 Jan 2014, In : Experimental Biology and Medicine. 239, 11, p. 1461-1475 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Erythropoietin
Brain
Heart Arrest
Stroke
Hypothermia

Neuronal injury from cardiac arrest: aging years in minutes

Cherry, B. H., Sumien, N. & Mallet, R. T., 1 Jan 2014, In : Age. 36, 4

Research output: Contribution to journalArticleResearchpeer-review

Heart Arrest
Resuscitation
Wounds and Injuries
Brain
Survivors

Novel split chest tube improves post-surgical thoracic drainage

Yurvati, A., Cherry, B. H., Gurji, H. A., White, D. W., Tyler Newton, J., Scott, G. F., Hoxha, B., Gourlay, T. & Mallet, R. T., 1 Jan 2014, In : Journal of Clinical and Experimental Cardiology. 5, 7

Research output: Contribution to journalArticleResearchpeer-review

Chest Tubes
Drainage
Thorax
Thoracic Cavity
Sucrose
2 Citations (Scopus)

Protective effects of adaptation to hypoxia in experimental Alzheimer's disease

Manukhina, E. B., Goryacheva, A. V., Pshennikova, M. G., Malyshev, I. Y., Mallet, R. T. & Downey, H. F., 1 May 2014, Intermittent Hypoxia and Human Diseases. Springer-Verlag London Ltd, p. 155-171 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Alzheimer Disease
Aptitude
Brain
Pharmaceutical Preparations
Neurofibrillary Tangles
8 Citations (Scopus)

Pyruvate-enriched resuscitation: Metabolic support of post-ischemic hindlimb muscle in hypovolemic goats

Gurji, H. A., White, D. W., Hoxha, B., Sun, J., Harbor, J. P., Schulz, D. R., Williams, A. G., Yurvati, A. & Mallet, R. T., 1 Feb 2014, In : Experimental Biology and Medicine. 239, 2, p. 240-249 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Resuscitation
Hypovolemia
Hindlimb
Pyruvic Acid
Goats
2013

Cyclosporine a cardioprotection: Mechanisms and potential for clinical application

Bünger, R. & Mallet, R. T., 1 Apr 2013, In : Critical Care Medicine. 41, 4, p. 1156-1158 3 p.

Research output: Contribution to journalEditorialResearch

Myocardial Reperfusion Injury
Asphyxia
Cardiopulmonary Resuscitation
Immunosuppressive Agents
Cyclosporine
1 Citation (Scopus)

Intermittent hypoxia-induced cardio-and vasoprotection: Role of no stores

Manukhina, E. B., Vanin, A. F., Malyshev, I. Y., Mallet, R. T. & Downey, H. F., 1 Jan 2013, Intermittent Hypoxia: From Molecular Mechanisms To Clinical Applications. Nova Science Publishers, Inc., p. 79-112 34 p.

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Nitric Oxide
Hypoxia
S-Nitrosothiols
Nitrites
Cardiovascular System
15 Citations (Scopus)

Normobaric, intermittent hypoxia conditioning is cardio- and vasoprotective in rats

Manukhina, E. B., Belkina, L. M., Terekhina, O. L., Abramochkin, D. V., Smirnova, E. A., Budanova, O. P., Mallet, R. T. & Downey, H. F., 1 Dec 2013, In : Experimental Biology and Medicine. 238, 12, p. 1413-1420 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Reperfusion
Rats
Ischemia
Cardiac Arrhythmias
Acetylcholine
8 Citations (Scopus)

Pyruvate minimizes rtPA toxicity from in vitro oxygen-glucose deprivation and reoxygenation

Ryou, M. G., Choudhury, G. R., Winters, A., Xie, L., Mallet, R. T. & Yang, S., 12 Sep 2013, In : Brain Research. 1530, p. 66-75 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Tissue Plasminogen Activator
Pyruvic Acid
Oxygen
Glucose
NADP
1 Citation (Scopus)

β-Adrenergic signaling and ROS: Pivotal roles in intermittent, normobaric hypoxia-induced cardioprotection

Mallet, R. T., Ryou, M. G., Manukhina, E. B. & Downey, H. F., 1 Jan 2013, Intermittent Hypoxia: From Molecular Mechanisms To Clinical Applications. Nova Science Publishers, Inc., p. 151-174 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Adrenergic Agents
Nitric Oxide Synthase
Coronary Vessels
Myocardial Reperfusion
Metoprolol
2012
1 Citation (Scopus)

[Role of restricted nitric oxide overproduction in the cardioprotective effect of adaptation to intermittent hypoxia].

goriacheva, A. V., Belkina, L. M., Terekhina, O. L., Dawney, H. F., Mallet, R. T., Smirin, B. V., Smirnova, E. A., Mashina, S. I. & Manukhina, E. B., 1 Jan 2012, In : Patologicheskaia fiziologiia i èksperimental'naia terapiia. 1, p. 23-28 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Nitric Oxide
Reperfusion
Ischemia
Heart Ventricles
Myocardium
1 Citation (Scopus)

Inflammatory response and minimized cardiopulmonary bypass

Yurvati, A. & Mallet, R. T., 1 Apr 2012, Minimized Cardiopulmonary Bypass Techniques and Technologies. Elsevier Inc., p. 86-112 27 p.

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Cardiopulmonary Bypass
Antioxidants
Induced Heart Arrest
Hemodilution
Acetylcysteine
15 Citations (Scopus)

Intermittent hypoxia conditioning protects mitochondrial cytochrome c oxidase of rat cerebellum from ethanol withdrawal stress

Ju, X., Mallet, R. T., Downey, H. F., Metzger, D. B. & Jung, E., 15 May 2012, In : Journal of Applied Physiology. 112, 10, p. 1706-1714 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Electron Transport Complex IV
Cerebellum
Ethanol
Oxidoreductases
Cytochromes c

Invited commentary

Mallet, R. T. & Yurvati, A., 1 Apr 2012, In : Annals of Thoracic Surgery. 93, 4, p. 1186-1187 2 p.

Research output: Contribution to journalComment/debateResearch

Phototherapy
Vasodilation
Coronary Vessels

Plagiarism

Goodman, S. R. & Mallet, R. T., 1 Jul 2012, In : Experimental Biology and Medicine. 237, 7, 1 p.

Research output: Contribution to journalEditorialResearch

54 Citations (Scopus)

Pyruvate protects the brain against ischemia-reperfusion injury by activating the erythropoietin signaling pathway

Ryou, M. G., Liu, R., Ren, M., Sun, J., Mallet, R. T. & Yang, S., 1 Apr 2012, In : Stroke. 43, 4, p. 1101-1107 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Erythropoietin
Reperfusion Injury
Brain Ischemia
Pyruvic Acid
Hypoxia-Inducible Factor 1

Reply

Lyamina, N. P., Lyamina, S. V., Senchikhin, V. N., Mallet, R. T., Downey, H. F. & Manukhina, E. B., 1 Mar 2012, In : Journal of Hypertension. 30, 3, p. 626-627 2 p.

Research output: Contribution to journalLetterResearchpeer-review

2011

Gurji et al. respond

Gurji, H. A., White, D. W., Nelson, S., Daniels, E. Q., Yurvati, A. & Mallet, R. T., 1 Jul 2011, In : Lab Animal. 40, 7, p. 206-208 3 p.

Research output: Contribution to journalLetterResearchpeer-review

Intermittent hypoxia-induced cardio- and vasoprotection: Role of NO stores

Manukhina, E. B., Vanin, A. F., Malyshev, I. Y., Mallet, R. T. & Fred Downey, H., 1 Jan 2011, Intermittent Hypoxia: From Molecular Mechanisms To Clinical Applications. Nova Science Publishers, Inc., p. 79-112 34 p.

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

hypoxia
nitric oxide
cardiovascular system
mammals
exchanging
22 Citations (Scopus)

Intermittent hypoxia mobilizes hematopoietic progenitors and augments cellular and humoral elements of innate immunity in adult men

Serebrovskaya, T. V., Nikolsky, I. S., Nikolska, V. V., Mallet, R. T. & Ishchuk, V. A., 1 Oct 2011, In : High Altitude Medicine and Biology. 12, 3, p. 243-252 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Innate Immunity
Hematopoietic Stem Cells
Neutrophils
Therapeutics
Interleukin-4
40 Citations (Scopus)

Normobaric hypoxia conditioning reduces blood pressure and normalizes nitric oxide synthesis in patients with arterial hypertension

Lyamina, N. P., Lyamina, S. V., Senchiknin, V. N., Mallet, R. T., Downey, H. F. & Manukhina, E. B., 1 Nov 2011, In : Journal of Hypertension. 29, 11, p. 2265-2272 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Nitric Oxide
Blood Pressure
Hypertension
Hypoxia
Therapeutic Uses

β-Adrenergic signaling and ROS: Pivotal roles in intermittent, normobaric hypoxia-induced cardioprotection

Mallet, R. T., Ryou, M. G., Manukhina, E. B. & Fred Downey, H., 1 Jan 2011, Intermittent Hypoxia: From Molecular Mechanisms To Clinical Applications. Nova Science Publishers, Inc., p. 151-174 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

adrenergics
hypoxia
nitric oxide
conditioning
arteries
2010

Developments in cardiovascular valve technology

Yurvati, A., Mallet, R. T. & Fernandez, J., 1 Oct 2010, Biomaterials and Devices for the Circulatory System. Elsevier Inc., p. 89-122 34 p.

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Biocompatible Materials
Biomaterials
Physiology
7 Citations (Scopus)

Peri- and intra-operative management of the goat during acute surgical experimentation

Flaherty, D. C., Hoxha, B., Nelson, S., Sun, J., Gurji, H., Simecka, J., Mallet, R. T., Yurvati, A. & Daniels, E. Q., 1 Mar 2010, In : Lab Animal. 39, 3, p. 80-85 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Goats
goats
Animal Models
animal models
Coxiella burnetii
16 Citations (Scopus)

Pyruvate-enriched cardioplegia suppresses cardiopulmonary bypass-induced myocardial inflammation

Ryou, M. G., Flaherty, D. C., Hoxha, B., Gurji, H., Sun, J., Hodge, L. M., Yurvati, A. & Mallet, R. T., 1 Jan 2010, In : Annals of Thoracic Surgery. 90, 5, p. 1529-1535 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Induced Heart Arrest
Cardiopulmonary Bypass
Pyruvic Acid
Glutathione Disulfide
Inflammation
4 Citations (Scopus)

Pyruvate-enriched resuscitation protects hindlimb muscle from ischemia-reperfusion injury

Flaherty, D. C., Hoxha, B., Sun, J., Gurji, H., Simecka, J., Yurvati, A. & Mallet, R. T., 1 Jan 2010, In : Military Medicine. 175, 12, p. 1020-1026 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Hindlimb
Reperfusion Injury
Pyruvic Acid
Resuscitation
Muscles
24 Citations (Scopus)

Pyruvate-fortified fluid resuscitation improves hemodynamic stability while suppressing systemic inflammation and myocardial oxidative strees after hemorrhagic shock

Flaherty, D. C., Hoxha, B., Sun, J., Gurji, H., Simecka, J., Mallet, R. T. & Yurvati, A., 1 Jan 2010, In : Military Medicine. 175, 3, p. 166-172 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Hemorrhagic Shock
Pyruvic Acid
Resuscitation
Hemodynamics
Inflammation
4 Citations (Scopus)

Vagal modulation of heart rate variability during atrial fibrillation in pigs

Kneip, C. F., Mallet, R. T., Williams, A. G., Hamdan, M. H. & Smith, M. L., 1 Jan 2010, In : Experimental Biology and Medicine. 235, 8, p. 1007-1014 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Glycopyrrolate
Atrial Fibrillation
Swine
Heart Rate
Chemical activation
2009
16 Citations (Scopus)

Pyruvate-fortified cardioplegia evokes myocardial erythropoietin signaling in swine undergoing cardiopulmonary bypass

Ryou, M. G., Flaherty, D. C., Hoxha, B., Sun, J., Gurji, H., Rodriguez, S., Bell, G., Yurvati, A. & Mallet, R. T., 1 Nov 2009, In : American Journal of Physiology - Heart and Circulatory Physiology. 297, 5

Research output: Contribution to journalArticleResearchpeer-review

Induced Heart Arrest
Erythropoietin
Cardiopulmonary Bypass
Pyruvic Acid
Swine
2008
16 Citations (Scopus)

Hypoxic conditioning suppresses nitric oxide production upon myocardial reperfusion

Ryou, M. G., Sun, J., Oguayo, K. N., Manukhina, E. B., Downey, H. F. & Mallet, R. T., 1 Jun 2008, In : Experimental Biology and Medicine. 233, 6, p. 766-774 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Myocardial Reperfusion
Nitric Oxide
Nitric Oxide Synthase
Reperfusion
Protein Isoforms
81 Citations (Scopus)

Intermittent hypoxia: Cause of or therapy for systemic hypertension?

Serebrovskaya, T. V., Manukhina, E. B., Smith, M. L., Downey, H. F. & Mallet, R. T., 1 Jun 2008, In : Experimental Biology and Medicine. 233, 6, p. 627-650 24 p.

Research output: Contribution to journalShort surveyResearchpeer-review

Hypertension
Obstructive Sleep Apnea
Neurology
Therapeutics
Arterial Pressure
33 Citations (Scopus)

Intermittent hypoxia conditioning prevents behavioral deficit and brain oxidative stress in ethanol-withdrawn rats

Jung, E., Simpkins, J. W., Wilson, A. M., Downey, H. F. & Mallet, R. T., 1 Aug 2008, In : Journal of Applied Physiology. 105, 2, p. 510-517 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Oxidative Stress
Ethanol
Brain
Superoxides
Conditioning (Psychology)
23 Citations (Scopus)

Pyruvate enhances neurological recovery following cardiopulmonary arrest and resuscitation

Sharma, A. B., Barlow, M. A., Yang, S., Simpkins, J. W. & Mallet, R. T., 1 Jan 2008, In : Resuscitation. 76, 1, p. 108-119 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Cardiopulmonary Resuscitation
Heart Arrest
Pyruvic Acid
Dogs
Thorax