• 2376 Citations
  • 28 h-Index
1984 …2022
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Personal profile

Area of Expertise

Dr. Robert Mallet’s research focuses on developing treatments to protect the heart and brain from heart attack, stroke, and cardiac arrest. These three diseases, which result from interruptions in the blood flow to the heart and/or brain, are among the leading causes of death and disability in the United States. Dr. Mallet’s team has discovered that breathing air containing reduced amounts of oxygen, for a few daily exposures lasting a few minutes each, causes adaptations in the heart and brain that make these organs much more resistant to interruptions in their blood flow. As a result, the damage to the heart and brain inflicted by temporary loss of blood flow is greatly decreased, enabling these vital organs to recover and resume their normal function.
Current work in the Mallet laboratory is studying the favorable changes in the brain’s and heart’s biochemical makeup which underlie the adaptations to low oxygen, so that these adaptations can be safely harnessed to help human patients survive and recover from strokes, heart attacks, and cardiac arrest.

Education/Academic qualification

PhD in Physiology, George Washington University

BS in Biology, Catholic University of America

Fingerprint Dive into the research topics where Robert Mallet is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Research Output 1984 2019

Hemorrhage simulated by lower body negative pressure provokes an oxidative stress response in healthy young adults

Park, F. S., Kay, V. L., Sprick, J. D., Rosenberg, A. J., Anderson, G. K., Mallet, R. T. & Rickards, C. A., 1 Mar 2019, In : Experimental Biology and Medicine. 244, 3, p. 272-278 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Lower Body Negative Pressure
Oxidative stress
Young Adult
Oxidative Stress
Hemorrhage

Inline flow sensor for ventriculoperitoneal shunts: Experimental evaluation in swine

Qin, C., Yurvati, A., Williams, A. G., Eskildsen, D., Mallet, R. T. & Dasgupta, P. K., 1 May 2019, In : Medical Engineering and Physics. 67, p. 66-72 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Ventriculoperitoneal Shunt
Cerebrospinal Fluid
Swine
Hydrocephalus
Cerebrospinal fluid

Ischaemic and hypoxic conditioning: potential for protection of vital organs

Sprick, J. D., Mallet, R. T., Przyklenk, K. & Rickards, C. A., 1 Mar 2019, In : Experimental Physiology. 104, 3, p. 278-294 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Ischemic Preconditioning
Exercise
Clinical Trials
Hypoxia-Inducible Factor 1
Microglia
3 Citations (Scopus)

An in vitro oxygen–glucose deprivation model for studying ischemia–reperfusion injury of neuronal cells

Ryou, M. G. & Mallet, R. T., 1 Jan 2018, Methods in Molecular Biology. Humana Press Inc., p. 229-235 7 p. (Methods in Molecular Biology; vol. 1717).

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Wounds and Injuries
Oxygen
Cytoprotection
Heart Arrest
Reperfusion Injury
6 Citations (Scopus)

Cardioprotection by intermittent hypoxia conditioning: Evidence, mechanisms, and therapeutic potential

Mallet, R. T., Manukhina, E. B., Ruelas, S. S., Caffrey, J. L. & Downey, H. F., 1 Aug 2018, In : American Journal of Physiology - Heart and Circulatory Physiology. 315, 2, p. H216-H232

Research output: Contribution to journalReview articleResearchpeer-review

Ischemia
Myocardial Reperfusion
Coronary Occlusion
Sleep Apnea Syndromes
Tachycardia