Projects per year
Personal profile
Area of Expertise
Dr. Robert Mallet’s research focuses on developing treatments to protect the heart and brain from heart attack, stroke, and cardiac arrest. These three diseases, which result from interruptions in the blood flow to the heart and/or brain, are among the leading causes of death and disability in the United States. Dr. Mallet’s team has discovered that breathing air containing reduced amounts of oxygen, for a few daily exposures lasting a few minutes each, causes adaptations in the heart and brain that make these organs much more resistant to interruptions in their blood flow. As a result, the damage to the heart and brain inflicted by temporary loss of blood flow is greatly decreased, enabling these vital organs to recover and resume their normal function.
Current work in the Mallet laboratory is studying the favorable changes in the brain’s and heart’s biochemical makeup which underlie the adaptations to low oxygen, so that these adaptations can be safely harnessed to help human patients survive and recover from strokes, heart attacks, and cardiac arrest.
Current work in the Mallet laboratory is studying the favorable changes in the brain’s and heart’s biochemical makeup which underlie the adaptations to low oxygen, so that these adaptations can be safely harnessed to help human patients survive and recover from strokes, heart attacks, and cardiac arrest.
Education/Academic qualification
PhD in Physiology, George Washington University
Award Date: 1 Jan 2001
BS in Biology, Catholic University of America
Award Date: 1 Jan 2000
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Projects
Renal inflammation triggered by inhaled particulate matter (For: Bryan McGee)
5/06/17 → 31/05/18
Project: Research
Research Output
Intermittent Hypoxia Training for Treating Mild Cognitive Impairment: A Pilot Study
Wang, H., Shi, X., Schenck, H., Hall, J. R., Ross, S. E., Kline, G. P., Chen, S., Mallet, R. T. & Chen, P., 1 Jan 2020, In : American journal of Alzheimer's disease and other dementias. 35, p. 1533317519896725Research output: Contribution to journal › Article
Open Access
Reduced cerebrovascular and cardioventilatory responses to intermittent hypoxia in elderly
Liu, X., Chen, X., Kline, G., Ross, S. E., Hall, J. R., Ding, Y., Mallet, R. T. & Shi, X., Jan 2020, In : Respiratory Physiology and Neurobiology. 271, 103306.Research output: Contribution to journal › Article
Hemorrhage simulated by lower body negative pressure provokes an oxidative stress response in healthy young adults
Park, F. S., Kay, V. L., Sprick, J. D., Rosenberg, A. J., Anderson, G. K., Mallet, R. T. & Rickards, C. A., 1 Mar 2019, In : Experimental Biology and Medicine. 244, 3, p. 272-278 7 p.Research output: Contribution to journal › Article
Inline flow sensor for ventriculoperitoneal shunts: Experimental evaluation in swine
Qin, C., Olivencia-Yurvati, A. H., Williams, A. G., Eskildsen, D., Mallet, R. T. & Dasgupta, P. K., May 2019, In : Medical Engineering and Physics. 67, p. 66-72 7 p.Research output: Contribution to journal › Article
Open Access
Ischaemic and hypoxic conditioning: potential for protection of vital organs
Sprick, J. D., Mallet, R. T., Przyklenk, K. & Rickards, C. A., 1 Mar 2019, In : Experimental physiology. 104, 3, p. 278-294 17 p.Research output: Contribution to journal › Article
7
Scopus
citations