Projects per year
Personal profile
Area of Expertise
Dr. Robert Mallet’s research focuses on developing treatments to protect the heart and brain from heart attack, stroke, and cardiac arrest. These three diseases, which result from interruptions in the blood flow to the heart and/or brain, are among the leading causes of death and disability in the United States. Dr. Mallet’s team has discovered that breathing air containing reduced amounts of oxygen, for a few daily exposures lasting a few minutes each, causes adaptations in the heart and brain that make these organs much more resistant to interruptions in their blood flow. As a result, the damage to the heart and brain inflicted by temporary loss of blood flow is greatly decreased, enabling these vital organs to recover and resume their normal function.
Current work in the Mallet laboratory is studying the favorable changes in the brain’s and heart’s biochemical makeup which underlie the adaptations to low oxygen, so that these adaptations can be safely harnessed to help human patients survive and recover from strokes, heart attacks, and cardiac arrest.
Current work in the Mallet laboratory is studying the favorable changes in the brain’s and heart’s biochemical makeup which underlie the adaptations to low oxygen, so that these adaptations can be safely harnessed to help human patients survive and recover from strokes, heart attacks, and cardiac arrest.
Education/Academic qualification
BS in Biology, Catholic University of America
PhD in Physiology, George Washington University
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Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Texas Center of Minority Health, Education, Research and Outreach - Admin/Development Core
Vishwanatha, J., Jones, H., He, J., Basha, R., Nandy, K., Mallet, R., Krishnamoorthy, R. & Simecka, J.
NIMHD: Natl Institute on Minority Health
23/09/17 → 31/05/22
Project: Research
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Texas Center of Minority Health, Education, Research and Outreach - Admin/Development Core
Vishwanatha, J., Mallet, R., Krishnamoorthy, R., Jones, H., Fulda, K., He, J., Basha, R. & Nandy, K.
NIMHD: Natl Institute on Minority Health
23/09/17 → 31/05/22
Project: Research
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Renal inflammation triggered by inhaled particulate matter (For: Bryan McGee)
5/06/17 → 31/05/18
Project: Research
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Intermittent Hypoxia: Salvaging Cerebral Function after Ischemic Stroke
Mallet, R. & Jung, E. (.
1/07/16 → 31/08/18
Project: Research
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Hypoxia and brain aging: Neurodegeneration or neuroprotection?
Burtscher, J., Mallet, R. T., Burtscher, M. & Millet, G. P., Jul 2021, In: Ageing Research Reviews. 68, 101343.Research output: Contribution to journal › Review article › peer-review
Open Access -
Impact of high altitude on cardiovascular health: Current perspectives
Mallet, R. T., Burtscher, J., Richalet, J. P., Millet, G. P. & Burtscher, M., 2021, In: Vascular Health and Risk Management. 17, p. 317-335 19 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
Store-operated calcium entry: Pivotal roles in renal physiology and pathophysiology
Chaudhari, S., Mallet, R. T., Shotorbani, P. Y., Tao, Y. & Ma, R., Feb 2021, In: Experimental Biology and Medicine. 246, 3, p. 305-316 12 p.Research output: Contribution to journal › Review article › peer-review
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Inhibition of interleukin-6 on matrix protein production by glomerular mesangial cells and the pathway involved
Chaudhari, S., Yazdizadeh Shotorbani, P., Tao, Y., Davis, M. E., Mallet, R. T. & Ma, R., 1 Jun 2020, In: American journal of physiology. Renal physiology. 318, 6, p. F1478-F1488Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Intermittent Hypoxia Training for Treating Mild Cognitive Impairment: A Pilot Study
Wang, H., Shi, X., Schenck, H., Hall, J. R., Ross, S. E., Kline, G. P., Chen, S., Mallet, R. T. & Chen, P., 2020, In: American journal of Alzheimer's disease and other dementias. 35Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations