• 2583 Citations
  • 28 h-Index
1984 …2020

Research output per year

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Personal profile

Area of Expertise

Dr. Robert Mallet’s research focuses on developing treatments to protect the heart and brain from heart attack, stroke, and cardiac arrest. These three diseases, which result from interruptions in the blood flow to the heart and/or brain, are among the leading causes of death and disability in the United States. Dr. Mallet’s team has discovered that breathing air containing reduced amounts of oxygen, for a few daily exposures lasting a few minutes each, causes adaptations in the heart and brain that make these organs much more resistant to interruptions in their blood flow. As a result, the damage to the heart and brain inflicted by temporary loss of blood flow is greatly decreased, enabling these vital organs to recover and resume their normal function.
Current work in the Mallet laboratory is studying the favorable changes in the brain’s and heart’s biochemical makeup which underlie the adaptations to low oxygen, so that these adaptations can be safely harnessed to help human patients survive and recover from strokes, heart attacks, and cardiac arrest.

Education/Academic qualification

BS in Biology, Catholic University of America

PhD in Physiology, George Washington University

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Projects

Research Output

Inhibition of interleukin-6 on matrix protein production by glomerular mesangial cells and the pathway involved

Chaudhari, S., Yazdizadeh Shotorbani, P., Tao, Y., Davis, M. E., Mallet, R. T. & Ma, R., 1 Jun 2020, In : American journal of physiology. Renal physiology. 318, 6, p. F1478-F1488

Research output: Contribution to journalArticle

  • Intermittent Hypoxia Training for Treating Mild Cognitive Impairment: A Pilot Study

    Wang, H., Shi, X., Schenck, H., Hall, J. R., Ross, S. E., Kline, G. P., Chen, S., Mallet, R. T. & Chen, P., 1 Jan 2020, In : American journal of Alzheimer's disease and other dementias. 35, p. 1533317519896725

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations
  • Hemorrhage simulated by lower body negative pressure provokes an oxidative stress response in healthy young adults

    Park, F. S., Kay, V. L., Sprick, J. D., Rosenberg, A. J., Anderson, G. K., Mallet, R. T. & Rickards, C. A., 1 Mar 2019, In : Experimental Biology and Medicine. 244, 3, p. 272-278 7 p.

    Research output: Contribution to journalArticle

  • Inline flow sensor for ventriculoperitoneal shunts: Experimental evaluation in swine

    Qin, C., Olivencia-Yurvati, A. H., Williams, A. G., Eskildsen, D., Mallet, R. T. & Dasgupta, P. K., May 2019, In : Medical Engineering and Physics. 67, p. 66-72 7 p.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations