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Personal profile

Area of Expertise

My laboratory is interested in developing and characterizing safe and effective drugs that can be used for the treatment of individuals afflicted with Parkinson’s disease, Alzheimer’s disease, schizophrenia, Tourette syndrome, and dystonia. We have also worked to develop drugs that can be used to assist in the rehabilitation of individuals who abuse cocaine. These studies have provided insights on the role of dopamine and sigma receptors in the brain.

Education/Academic qualification

PhD in Immunology, University of Pennsylvania

BS in Microbiology, University of Illinois at Urbana-Champaign

BA in Chemistry, University of Illinois at Urbana-Champaign

Fingerprint Dive into the research topics where Robert Luedtke is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Dopamine D3 Receptors Medicine & Life Sciences
Dopamine D2 Receptors Medicine & Life Sciences
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Dopamine Receptors Medicine & Life Sciences
Cocaine Medicine & Life Sciences
Pharmacology Medicine & Life Sciences
Adenylyl Cyclases Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2009 2023

Research Output 1980 2019

  • 2426 Citations
  • 29 h-Index
  • 92 Article
  • 3 Comment/debate
  • 1 Chapter
  • 1 Short survey

Design, synthesis, and evaluation of N-(4-(4-phenyl piperazin-1-yl)butyl)-4-(thiophen-3-yl)benzamides as selective dopamine D3 receptor ligands

Chen, P. J., Taylor, M., Griffin, S. A., Amani, A., Hayatshahi, H., Korzekwa, K., Ye, M., Mach, R. H., Liu, J., Luedtke, R. T., Gordon, J. C. & Blass, B. E., 15 Sep 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 18, p. 2690-2694 5 p.

Research output: Contribution to journalArticle

Benzamides
Dopamine D3 Receptors
Pharmacokinetics
Dopamine Receptors
Substance-Related Disorders

Leveraging a Low-Affinity Diazaspiro Orthosteric Fragment to Reduce Dopamine D 3 Receptor (D 3 R) Ligand Promiscuity across Highly Conserved Aminergic G-Protein-Coupled Receptors (GPCRs)

Reilly, S. W., Riad, A. A., Hsieh, C. J., Sahlholm, K., Jacome, D. A., Griffin, S., Taylor, M., Weng, C. C., Xu, K., Kirschner, N., Luedtke, R. T., Parry, C., Malhotra, S., Karanicolas, J. & Mach, R. H., 23 May 2019, In : Journal of Medicinal Chemistry. 62, 10, p. 5132-5147 16 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Dopamine
Ligands
Adrenergic Agents
Pharmaceutical Preparations
Biochemistry
Dopamine Receptors
Cocaine
Animal Care Committees
Pharmacology
5 Citations (Scopus)

Analogues of Arylamide Phenylpiperazine Ligands to Investigate the Factors Influencing D3 Dopamine Receptor Bitropic Binding and Receptor Subtype Selectivity

Hayatshahi, H. S., Xu, K., Griffin, S. A., Taylor, M., Mach, R. H., Liu, J. & Luedtke, R. T., 19 Dec 2018, In : ACS Chemical Neuroscience. 9, 12, p. 2972-2983 12 p.

Research output: Contribution to journalArticle

Dopamine D3 Receptors
Ligands
Dopamine D2 Receptors
Dopamine Receptors
Nitrogen
6 Citations (Scopus)
Positron emission tomography
Positron-Emission Tomography
Dopamine D2 Receptors
Dopamine
Dopamine D3 Receptors