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Personal profile

Area of Expertise

My laboratory is interested in developing and characterizing safe and effective drugs that can be used for the treatment of individuals afflicted with Parkinson’s disease, Alzheimer’s disease, schizophrenia, Tourette syndrome, and dystonia. We have also worked to develop drugs that can be used to assist in the rehabilitation of individuals who abuse cocaine. These studies have provided insights on the role of dopamine and sigma receptors in the brain.

Education/Academic qualification

PhD in Immunology, University of Pennsylvania

BS in Microbiology, University of Illinois at Urbana-Champaign

BA in Chemistry, University of Illinois at Urbana-Champaign

Fingerprint Dive into the research topics where Robert Luedtke is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 7 Similar Profiles
Dopamine D3 Receptors Medicine & Life Sciences
Dopamine D2 Receptors Medicine & Life Sciences
Dopamine Medicine & Life Sciences
Ligands Medicine & Life Sciences
Cocaine Medicine & Life Sciences
Dopamine Receptors Medicine & Life Sciences
Pharmacology Medicine & Life Sciences
Adenylyl Cyclases Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2009 2023

Research Output 1980 2019

  • 2406 Citations
  • 29 h-Index
  • 91 Article
  • 3 Comment/debate
  • 1 Chapter
  • 1 Short survey

Leveraging a Low-Affinity Diazaspiro Orthosteric Fragment to Reduce Dopamine D 3 Receptor (D 3 R) Ligand Promiscuity across Highly Conserved Aminergic G-Protein-Coupled Receptors (GPCRs)

Reilly, S. W., Riad, A. A., Hsieh, C. J., Sahlholm, K., Jacome, D. A., Griffin, S., Taylor, M., Weng, C. C., Xu, K., Kirschner, N., Luedtke, R. T., Parry, C., Malhotra, S., Karanicolas, J. & Mach, R. H., 23 May 2019, In : Journal of Medicinal Chemistry. 62, 10, p. 5132-5147 16 p.

Research output: Contribution to journalArticleResearchpeer-review

G-Protein-Coupled Receptors
Dopamine
Ligands
Adrenergic Agents
Pharmaceutical Preparations

Retraction notice to “Dopamine Ds3 receptor partial agonist LS-3-134 attenuates cocaine-motivated behaviors” [Pharmacology, Biochemistry and Behavior 171 (2018) 46–53](S0091305718300236)(10.1016/j.pbb.2018.05.015)

Powell, G. L., Bonadonna, J. P., Vannan, A., Xu, K., Mach, R. H., Luedtke, R. T. & Neisewander, J. L., 1 Jan 2019, In : Pharmacology Biochemistry and Behavior. 176, 1 p.

Research output: Contribution to journalComment/debateResearch

Biochemistry
Dopamine Receptors
Cocaine
Animal Care Committees
Pharmacology
1 Citation (Scopus)

Analogues of Arylamide Phenylpiperazine Ligands to Investigate the Factors Influencing D3 Dopamine Receptor Bitropic Binding and Receptor Subtype Selectivity

Hayatshahi, H. S., Xu, K., Griffin, S. A., Taylor, M., Mach, R. H., Liu, J. & Luedtke, R. T., 19 Dec 2018, In : ACS Chemical Neuroscience. 9, 12, p. 2972-2983 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Dopamine D3 Receptors
Ligands
Dopamine D2 Receptors
Dopamine Receptors
Nitrogen
6 Citations (Scopus)

Challenges in the development of dopamine D2- and D3-selective radiotracers for PET imaging studies

Mach, R. H. & Luedtke, R. T., 1 Mar 2018, In : Journal of Labelled Compounds and Radiopharmaceuticals. 61, 3, p. 291-298 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Positron emission tomography
Positron-Emission Tomography
Dopamine D2 Receptors
Dopamine
Dopamine D3 Receptors
12 Citations (Scopus)

Dissociation of striatal dopamine and tyrosine hydroxylase expression from aging-related motor decline: Evidence from calorie restriction intervention

Salvatore, M. F., Terrebonne, J., Cantu, M. A., McInnis, T. R., Venable, K., Kelley, P., Kasanga, E. A., Latimer, B., Owens, C. L., Pruett, B. S., Yu, Y., Luedtke, R. T., Forster, M. J., Sumien, N. & Ingram, D. K., 1 Jan 2018, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 73, 1, p. 11-20 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Corpus Striatum
Tyrosine 3-Monooxygenase
Dopamine
Locomotion
Hypokinesia