• 4532 Citations
  • 36 h-Index
1993 …2022

Research output per year

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Personal profile

Area of Expertise

Work in my lab is focused on how an individuals’ genetic makeup impacts their risk for Alzheimer’s disease, as well as their age at symptom onset and the rate of disease progression. The goal of our research is to use a combination of genetic variation, demographics, and environmental factors to predict disease risk, age at onset, and progression rate. We are also interested in how disease mechanisms and risk factors differ among ethnic groups, particularly between Mexican Americans and non-Hispanic whites. Research in our group is highly collaborative and active projects are ongoing with labs and scientists across the state and nation.
A second area of research we are interested in is how an individual gut bacteria profile may impact risk for neurodegeneration and the age at onset of cognitive decline.

Education/Academic qualification

PhD in Genetics, Texas A & M University

Award Date: 1 Jan 2002

MS in Marine Biology, Texas A & M University

Award Date: 1 Jan 2001

BS in Biology, Tulane University

Award Date: 1 Jan 2000

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Projects

Research Output

Two-stage Bayesian GWAS of 9576 individuals identifies SNP regions that are targeted by miRNAs inversely expressed in Alzheimer's and cancer

for the Alzheimer's Disease Neuroimaging Initiative, Breast and Prostate Cancer Cohort Consortium, and Alzheimer's Disease Genetics Consortium, 1 Jan 2020, In : Alzheimer's and Dementia. 16, 1, p. 162-177 16 p.

Research output: Contribution to journalArticle

Open Access
  • Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (Nature Genetics, (2019), 51, 3, (414-430), 10.1038/s41588-019-0358-2)

    Alzheimer Disease Genetics Consortium (ADGC), The European Alzheimer’s Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE) & Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES), 1 Sep 2019, In : Nature Genetics. 51, 9, p. 1423-1424 2 p.

    Research output: Contribution to journalComment/debate

    Open Access
  • Circulating mitochondrial DNA: New indices of type 2 diabetes-related cognitive impairment in Mexican Americans

    Silzer, T., Barber, R., Sun, J., Pathak, G., Johnson, L., O’Bryant, S. & Phillips, N., Mar 2019, In : PLoS ONE. 14, 3, e0213527.

    Research output: Contribution to journalArticle

    Open Access
  • 3 Scopus citations

    Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

    Alzheimer Disease Genetics Consortium (ADGC), The European Alzheimer’s Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), & Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES), 1 Mar 2019, In : Nature Genetics. 51, 3, p. 414-430 17 p.

    Research output: Contribution to journalArticle

  • 103 Scopus citations

    Genome-Wide Methylation of Mild Cognitive Impairment in Mexican Americans Highlights Genes Involved in Synaptic Transport, Alzheimer's Disease-Precursor Phenotypes, and Metabolic Morbidities

    Pathak, G. A., Silzer, T. K., Sun, J., Zhou, Z., Daniel, A. A., Johnson, L., O'Bryant, S., Phillips, N. R. & Barber, R. C., 1 Jan 2019, In : Journal of Alzheimer's Disease. 72, 3, p. 733-749 17 p.

    Research output: Contribution to journalArticle