Projects per year
Personal profile
Research Interests
- Cancer Therapeutics
- Health Disparities
- Small molecules
- Transcription factors
- Cancer drug resistance
Area of Expertise
Dr. Basha's research is in the area of experimental therapeutics. The aberrant expression of certain molecular markers is associated with aggressive disease and poor prognosis in a variety of human malignancies. His lab is working on targeting c-Met (a receptor for hepatocyte growth factor), Specificity protein 1 (Sp1) transcription factor and survivin or baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5), an inhibitor of anti-apoptotic protein for enhancing therapeutic efficacy in cancer. These markers are associated with resistance to chemo- and radiation therapies and impact the disease progression and prognosis of cancer patients. We are testing certain investigational agents that have the ability to target these candidates focusing on developing strategies to improve therapeutic efficacy in breast cancer, Ewing sarcoma, Hepatocellular carcinoma, ovarian and pancreatic cancers using preclinical models and clinical specimens. We are also evaluating the combination of investigational agents and standard chemotherapeutic agents to enhance the therapeutic efficacy and reducing morbidity. In addition, cancer health disparities, collaborating with Artificial Intelligence/Machine Learning (AI/ML) experts, oncologists, geneticists and molecular pathologists on genetic testing and pharmacogenomics to precisely understand individualized response to therapies. Dr. Basha’s research projects designed to exploit the genomic biomarkers, genomic profiling/sequencing, and liquid biopsy for identifying precise therapeutic options. Dr. Basha is actively working with the collaborators (physicians and translational researchers) in DFW area including Cook Children’s and JPS and other institutions including NCI-designated comprehensive cancer centers for developing less toxic and effective strategies for treating human cancers.
Techniques
- Molecular biology
- Proteomics
- NGS
Education/Academic qualification
BS in Biology and Chemistry, Sri Venkateswara University
MS in Molecular Physiology, Sri Venkateswara University
PhD in Neurobiology, Sri Venkateswara University
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Collaborations and top research areas from the last five years
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IMSD@UNTHSC
Jones, H. (PI) & Basha, R. (CoI)
NIGMS: General Medical Sciences
1/02/25 → 31/01/30
Project: Research
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Summer Undergraduate Research
Jones, H. (PI) & Basha, R. (CoI)
NIDA: National Institute on Drug Abuse
1/12/23 → 30/11/28
Project: Research
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AIM-AHEAD Coordinating Center
Vishwanatha, J. (PI), Jones, H. (CoI), Sambamoorthi, U. (CoI) & Basha, R. (CoI)
17/09/21 → 31/07/25
Project: Research
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AIM-AHEAD Coordinating Center
Vishwanatha, J. (PI), Jones, H. (CoI), Basha, R. (CoI), Sambamoorthi, U. (CoI) & Zhou, B. (CoI)
17/09/21 → 31/07/25
Project: Research
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Bridge2AI - Clinical Care and
Vishwanatha, J. (PI) & Basha, R. (CoI)
17/09/21 → 31/07/25
Project: Research
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Tolfenamic acid inhibits neuroblastoma cell proliferation and induces apoptosis: A novel therapeutic agent for neuroblastoma
Eslin, D., Sankpal, U. T., Lee, C., Sutphin, R. M., Maliakal, P., Currier, E., Sholler, G., Khan, M. & Basha, R., May 2013, In: Molecular Carcinogenesis. 52, 5, p. 377-386 10 p.Research output: Contribution to journal › Article › peer-review
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Anti-leukemic response of a NSAID, tolfenamic acid
Sutphin, R. M., Connelly, S. F., Lee, C. M., Sankpal, U. T., Eslin, D., Khan, M., Pius, H. & Basha, R., Jun 2014, In: Targeted Oncology. 9, 2, p. 135-144 10 p.Research output: Contribution to journal › Article › peer-review
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Cellular and organismal toxicity of the anti-cancer small molecule, tolfenamic acid: A pre-clinical evaluation
Sankpal, U. T., Lee, C. M., Connelly, S. F., Kayaleh, O., Eslin, D., Sutphin, R., Goodison, S., Adwan, L., Zawia, N. H., Lichtenberger, L. M. & Basha, R., 2013, In: Cellular Physiology and Biochemistry. 32, 3, p. 675-686 12 p.Research output: Contribution to journal › Article › peer-review
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Environmental risk factors and the developmental basis for Alzheimer's disease
Zawia, N. H. & Basha, M. R., 2005, In: Reviews in the Neurosciences. 16, 4, p. 325-337 13 p.Research output: Contribution to journal › Review article › peer-review
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Surgical Primary Tumor Resection Reduces Accumulation of CD11b+ Myeloid Cells in the Lungs Augmenting the Efficacy of an Intranasal Cancer Vaccination against Secondary Lung Metastasis
Donkor, M., Choe, J. Y., Reid, D. M., Fiadjoe, H. K., Quinn, B., Ranjan, A., Pulse, M., Chaudhary, P., Basha, R. & Jones, H. P., Jan 2024, In: Pharmaceuticals. 17, 1, 51.Research output: Contribution to journal › Article › peer-review