Projects per year
Personal profile
Research Interests
- Cancer Therapeutics
- Health Disparities
- Small molecules
- Transcription factors
- Cancer drug resistance
Area of Expertise
Dr. Basha's research is in the area of experimental therapeutics. The aberrant expression of certain molecular markers is associated with aggressive disease and poor prognosis in a variety of human malignancies. His lab is working on targeting c-Met (a receptor for hepatocyte growth factor), Specificity protein 1 (Sp1) transcription factor and survivin or baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5), an inhibitor of anti-apoptotic protein for enhancing therapeutic efficacy in cancer. These markers are associated with resistance to chemo- and radiation therapies and impact the disease progression and prognosis of cancer patients. We are testing certain investigational agents that have the ability to target these candidates focusing on developing strategies to improve therapeutic efficacy in breast cancer, Ewing sarcoma, Hepatocellular carcinoma, ovarian and pancreatic cancers using preclinical models and clinical specimens. We are also evaluating the combination of investigational agents and standard chemotherapeutic agents to enhance the therapeutic efficacy and reducing morbidity. In addition, cancer health disparities, collaborating with Artificial Intelligence/Machine Learning (AI/ML) experts, oncologists, geneticists and molecular pathologists on genetic testing and pharmacogenomics to precisely understand individualized response to therapies. Dr. Basha’s research projects designed to exploit the genomic biomarkers, genomic profiling/sequencing, and liquid biopsy for identifying precise therapeutic options. Dr. Basha is actively working with the collaborators (physicians and translational researchers) in DFW area including Cook Children’s and JPS and other institutions including NCI-designated comprehensive cancer centers for developing less toxic and effective strategies for treating human cancers.
Techniques
- Molecular biology
- Proteomics
- NGS
Education/Academic qualification
BS in Biology and Chemistry, Sri Venkateswara University
MS in Molecular Physiology, Sri Venkateswara University
PhD in Neurobiology, Sri Venkateswara University
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Collaborations and top research areas from the last five years
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Summer Undergraduate Research
Jones, H. (PI) & Basha, R. (CoI)
NIDA: National Institute on Drug Abuse
1/12/23 → 30/11/28
Project: Research
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AIM-AHEAD Coordinating Center
Vishwanatha, J. (PI), Jones, H. (CoI), Basha, R. (CoI), Sambamoorthi, U. (CoI) & Zhou, B. (CoI)
17/09/21 → 16/03/25
Project: Research
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Bridge2AI - Clinical Care and
Vishwanatha, J. (PI) & Basha, R. (CoI)
17/09/21 → 31/07/25
Project: Research
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HSC Scholars in Cancer Researc
Vishwanatha, J. (PI), Yurvati, A. (CoI), Jones, H. (CoI), Smith, M. (CoI), Berg, R. (CoI), Basha, R. (CoI), Bunnell, B. (CoI) & Mathew, S. (CoI)
Cancer Prevention & Res Inst of TX
31/08/21 → 30/08/26
Project: Research
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Build Integrated Pathways to I
Jones, H. (PI), Phillips, N. (CoI), Barber, R. (CoI) & Basha, R. (CoI)
Xavier University of Louisiana
1/09/20 → 30/06/25
Project: Research
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Angiogenesis: An update and potential drug approaches (Review)
Abdelrahim, M., Konduri, S., Basha, M. R., Philip, P. A. & Baker, C. H., Jan 2010, In: International journal of oncology. 36, 1, p. 5-18 14 p.Research output: Contribution to journal › Review article › peer-review
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Docking and molecular dynamic simulations of Mithramycin-A and Tolfenamic acid against Sp1 and survivin
Lambring, C. B., Fiadjoe, H., Behera, S. K. & Basha, R., Feb 2024, In: Process Biochemistry. 137, p. 207-216 10 p.Research output: Contribution to journal › Article › peer-review
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Tolfenamic acid decreases c-Met expression through Sp proteins degradation and inhibits lung cancer cells growth and tumor formation in orthotopic mice
Colon, J., Basha, M. R., Madero-Visbal, R., Konduri, S., Baker, C. H., Herrera, L. J., Safe, S., Sheikh-Hamad, D., Abudayyeh, A., Alvarado, B. & Abdelrahim, M., Feb 2011, In: Investigational New Drugs. 29, 1, p. 41-51 11 p.Research output: Contribution to journal › Article › peer-review
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Tolfenamic acid inhibits neuroblastoma cell proliferation and induces apoptosis: A novel therapeutic agent for neuroblastoma
Eslin, D., Sankpal, U. T., Lee, C., Sutphin, R. M., Maliakal, P., Currier, E., Sholler, G., Khan, M. & Basha, R., May 2013, In: Molecular Carcinogenesis. 52, 5, p. 377-386 10 p.Research output: Contribution to journal › Article › peer-review
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Clotam enhances anti-proliferative effect of vincristine in Ewing sarcoma cells
Shelake, S., Sankpal, U. T., Eslin, D., Bowman, W. P., Simecka, J. W., Raut, S., Ray, A. & Basha, R., 15 Feb 2019, In: Apoptosis. 24, 1-2, p. 21-32 12 p.Research output: Contribution to journal › Article › peer-review