Projects per year
Personal profile
Research Interests
Aging, Alzheimer disease, vascular dementia, cognitive decline,
Substance use disorder, Self-administration, cocaine, methamphetamine, Methylenedioxypyrovalerone, d-amphetamine, individual variation,
Rodent behavior, Nonhuman animal models, drug discrimination, conditioned place preference and Pavlovian conditioning.
Area of Expertise
I am a behavioral pharmacologist and a pharmacist by training. I have dedicated the last 15 years of my career to advancing the understanding of substance use disorders through preclinical research.
My research interests span into a wide range of crucial areas in the field of substance use disorders. I collaborate closely with a team of researchers at UNTHSC on an Addiction Treatment Discovery Program, which receives funding from the National Institute on Drug Abuse (NIDA). The goal of this program is to identify potential treatments for drug dependence. Moreover, within this team, I also collaborate with the Drug Enforcement Administration (DEA) to assess the abuse potential of emerging synthetic drugs. Understanding how these novel substances compare to well-known drugs helps in predicting their misuse potential and guiding regulatory decisions.
As an independent researcher, one of my goals is to identify genetic markers associated with drug-liking versus drug-dislike behavior. Genetic insights into such phenotypes could revolutionize our understanding of mechanisms of substance use susceptibility. Thus, paving the way for personalized therapies aimed at preventing dependence.
In this regard, Dr. Suchismita Acharya and I are collaborating on a pilot study to investigate the effects of novel small molecules to block methamphetamine-seeking behavior.
Education/Academic qualification
BS, Pharmaceutical Sciences, University of Mumbai
MS, Biomedical Sciences, University of North Texas Health Science Center
PhD in Biomedical Sciences, Pharmacology and Neuroscience , University of North Texas Health Science Center
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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Evaluation of Abuse Potential
Shetty, R. (PI), Forster, M. (CoI) & Gatch, M. (CoI)
4/02/25 → 3/02/26
Project: Research
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Evaluation of Abuse Potential
Shetty, R. (PI), Forster, M. (CoI) & Gatch, M. (CoI)
30/09/24 → 29/09/29
Project: Research
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UNTHSC Team Science - Team-based discovery and preclinical evaluation of cocaine addiction treatments
Colon-Perez, L. (CoPI), Forster, M. (CoPI), Emmitte, K. (CoPI), Siderovski, D. (CoPI) & Shetty, R. (CoI)
UNT Health Science Center Division of Research and Innovation
1/08/23 → …
Project: Research
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Using rodent behavioral models
Forster, M. (PI), Gatch, M. (CoI), Shetty, R. (CoI) & Sumien, N. (CoI)
NIDA: National Institute on Drug Abuse
4/01/23 → 3/01/28
Project: Research
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Creatine, creatine kinase, and aging
Sumien, N., Shetty, R. A. & Gonzales, E. B., 2018, Subcellular Biochemistry. Springer New York, p. 145-168 24 p. (Subcellular Biochemistry; vol. 90).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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Pharmacologic fibroblast reprogramming into photoreceptors restores vision
Mahato, B., Kaya, K. D., Fan, Y., Sumien, N., Shetty, R. A., Zhang, W., Davis, D., Mock, T., Batabyal, S., Ni, A., Mohanty, S., Han, Z., Farjo, R., Forster, M. J., Swaroop, A. & Chavala, S. H., 7 May 2020, In: Nature. 581, 7806, p. 83-88 6 p.Research output: Contribution to journal › Article › peer-review
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Sex differences in neurobehavioral consequences of methamphetamine exposure in adult mice
Davis, D. L., Metzger, D. B., Vann, P. H., Wong, J. M., Subasinghe, K. H., Garlotte, I. K., Phillips, N. R., Shetty, R. A., Forster, M. J. & Sumien, N., Jul 2022, In: Psychopharmacology. 239, 7, p. 2331-2349 19 p.Research output: Contribution to journal › Article › peer-review
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Prolonged intake of coenzyme Q10 impairs cognitive functions in mice
Sumien, N., Heinrich, K. R., Shetty, R. A., Sohal, R. S. & Forster, M. J., Oct 2009, In: Journal of Nutrition. 139, 10, p. 1926-1932 7 p.Research output: Contribution to journal › Article › peer-review
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Effects of chronic methamphetamine exposure on rewarding behavior and neurodegeneration markers in adult mice
Davis, D. L., Metzger, D. B., Vann, P. H., Wong, J. M., Shetty, R. A., Forster, M. J. & Sumien, N., Jun 2023, In: Psychopharmacology. 240, 6, p. 1343-1358 16 p.Research output: Contribution to journal › Article › peer-review